Abstract:
:The aim of the present study was to evaluate and cor-relate islet to brown and white adipose tissue (WAT) blood perfusion in one obese rat and one nonobese rat with type 2 diabetes (obese Zucker [OZ] and GK rats, respectively). We measured blood perfusion with a microsphere technique in anesthetized animals and subsequently estimated the blood flow to seven different WAT depots and brown adipose tissue, in addition to the whole pancreas and pancreatic islets. Both GK and OZ rats had higher islet blood perfusion than their respective control strains. Adipose tissue blood flow (ATBF) was similar to or lower than that of controls in the normoglycemic OZ rats. GK rats, however, had 5-10 times higher blood perfusion than control Wistar rats in most WAT depots. Vascular density and macrophage numbers in WAT did not differ between the different strains. The discrepancy in ATBF between the obese-normoglycemic and type 2 diabetic rats opens the intriguing possibility that changes in this blood perfusion may influence and/or modulate the beta-cell dysfunction in type 2 diabetes.
journal_name
Diabetesjournal_title
Diabetesauthors
Kampf C,Bodin B,Källskog O,Carlsson C,Jansson Ldoi
10.2337/diabetes.54.9.2620subject
Has Abstractpub_date
2005-09-01 00:00:00pages
2620-7issue
9eissn
0012-1797issn
1939-327Xpii
54/9/2620journal_volume
54pub_type
杂志文章相关文献
DIABETES文献大全abstract::By closing ATP-sensitive K+ (K+-ATP) channels, glucose promotes depolarization-dependent Ca2+ entry and cytoplasmic free Ca2+ concentration ([Ca2+]i) rise in beta-cells. Ca2+-dependent exocytosis of insulin granules is then potentiated by a K+-ATP channel-independent action of glucose. The underlying mechanisms of thi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.47.11.1713
更新日期:1998-11-01 00:00:00
abstract::Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31+CD14+CD34+ monocyte subset via three-dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the effica...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0705
更新日期:2018-03-01 00:00:00
abstract::Insulin resistance is of pathogenic importance in several common human disorders including type 2 diabetes, hypertension, obesity and hyperlipidemia, but the underlying mechanisms are unknown. The spontaneously hypertensive rat (SHR) is a model of these human insulin resistance syndromes. Quantitative trait loci (QTLs...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.12.2222
更新日期:2000-12-01 00:00:00
abstract::Currently, the major indications for solitary islet transplantation are recurrent severe hypoglycemia and labile glucose control. Quantifying these problems remains subjective. We have developed a scoring system for both hypoglycemia and glycemic lability, established normative data, and used them in patients who have...
journal_title:Diabetes
pub_type: 杂志文章,多中心研究
doi:10.2337/diabetes.53.4.955
更新日期:2004-04-01 00:00:00
abstract::Tight glycemic control by intensive insulin therapy effectively delays the onset and slows the progression of diabetic complications but is associated with frequent dose adjustments and a high incidence of hypoglycemia. Successful pancreas transplantation corrects abnormal glucose metabolism but subjects patients to m...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.3.342
更新日期:1996-03-01 00:00:00
abstract::Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated with islet β-cell dysfunction, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and states of diabetes. Very few LDs...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0281
更新日期:2020-03-01 00:00:00
abstract::Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.53.2007.s12
更新日期:2004-02-01 00:00:00
abstract::Glucokinase from rat liver or transplantable, radiation-induced insulinomas was partially purified by ion exchange chromatography using DEAE-Cibacron Blue F3GA agarose. Phosphorylation of alpha,beta-D-mannose by glucokinase occurred with cooperative rate dependence on mannose concentration (nH: 1.50). Half-maximal pho...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.12.1146
更新日期:1983-12-01 00:00:00
abstract::Hepatocyte growth factor (HGF) is a mitogen required for β-cell replication during pregnancy. To determine whether HGF/c-Met signaling is required for β-cell regeneration, we characterized mice with pancreatic deletion of the HGF receptor, c-Met (PancMet KO mice), in two models of reduced β-cell mass and regeneration:...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-0333
更新日期:2014-01-01 00:00:00
abstract::Obesity and family history of diabetes are both risk factors for non-insulin-dependent diabetes mellitus (NIDDM), but it has been proposed that lean individuals with NIDDM have a greater load of diabetes susceptibility genes. If this is the case, one might expect a high prevalence of NIDDM in relatives of diabetic ind...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.4.418
更新日期:1995-04-01 00:00:00
abstract::Altered muscle fatty acid (FA) metabolism may contribute to the presence of muscle insulin resistance in the genetically obese Zucker rat. To determine whether FA uptake and disposal are altered in insulin-resistant muscle, we measured palmitate uptake, oxidation, and incorporation into di- and triglycerides in isolat...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.6.1389
更新日期:2001-06-01 00:00:00
abstract::The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diabetes.53.6.1614
更新日期:2004-06-01 00:00:00
abstract::Subjects with low serum HDL cholesterol levels are reported to be susceptible to diabetes, with insulin resistance believed to be the underlying pathological mechanism. Apolipoprotein M (apoM) is a carrier of sphingosine-1-phosphate (S1P), a multifunctional lipid mediator, on HDL, and the pleiotropic effects of HDL ar...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0811
更新日期:2020-05-01 00:00:00
abstract::The impaired Na(+)-K(+)-ATPase activity in peripheral nerve from diabetic rats is prevented by dietary myo-inositol (MI) supplementation in vivo and corrected by protein kinase C (PKC) agonists in vitro, suggesting that PKC may mediate the effects of nerve MI depletion on Na(+)-K(+)-ATPase activity. However, little is...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.11.1545
更新日期:1991-11-01 00:00:00
abstract::The allelic forms of the human leukocyte antigen (HLA)-DQ beta-chain (DQB1) have been recognized as the best markers of insulin-dependent diabetes mellitus (IDDM) susceptibility. We describe a method that allows the recognition of these DQB1 alleles without the use of either allele-specific oligonucleotide probes or r...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.12.1617
更新日期:1989-12-01 00:00:00
abstract::O-linked N-acetylglucosamine transferase (OGT) catalyzes the attachment ofN-acetylglucosamine (GlcNAc) monosaccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway. Glucose-induced insulin resistance is mediated by increased ac...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.12.2407
更新日期:1999-12-01 00:00:00
abstract::The Diabetes Association of greater Cleveland screened 307,000 individuals in the metropolitan area for diabetes with a 75-gm. oral load of carbohydrate. Of these subjects 12,600 (4.1 per cent) had a two-capillary blood glucose level of greater than 139 mg. per cent and were defined as positive. Seventy per cent of th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.12.1110
更新日期:1976-12-01 00:00:00
abstract::Total lymphoid irradiation (TLI) at doses of 2200 rads or greater prevented diabetes in susceptible BB/W rats. Two of 29 (7%) treated rats became diabetic compared with 23 of 39 (59%) controls (P less than 0.001). TLI did not, however, prevent insulitis or thyroiditis in nondiabetic rats, nor did it restore the depres...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.6.543
更新日期:1984-06-01 00:00:00
abstract::Endothelial cells in culture retain many of the functional properties of the endothelium in vivo. At high cell density, they become contact-inhibited. Endothelial cells, like vascular smooth muscle cells and fibroblasts, express binding sites for low density lipoprotein when depleted of sterol. In contact-inhibited en...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.2.s19
更新日期:1981-01-01 00:00:00
abstract::Postheparin plasma hepatic lipase (HL) activity has been shown to correlate with features of the metabolic syndrome and type 2 diabetes in humans. We examined HL postheparin plasma enzyme activity, hepatocyte mRNA, and protein mass in the insulin-resistant, fructose-fed Syrian golden hamster, and the response of the i...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.11.2893
更新日期:2004-11-01 00:00:00
abstract::The risk of insulin-dependent diabetes mellitus (IDDM) was examined in siblings of an unselected population (n = 194) of newly diagnosed diabetic individuals less than 30 yr old. From 1 July 1984 to 30 June 1987, diabetic subjects (proband) identified within a geographically defined area of southern Wisconsin were stu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.7.831
更新日期:1991-07-01 00:00:00
abstract::The presence of the enzyme aldose reductase is increasingly being linked to diabetic complications. The distribution of this enzyme in human cornea, lens, retina, and optic nerve has been studied using specific antibodies against purified human placental aldose reductase raised in both rabbit and goat. The antisera fr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.6.562
更新日期:1984-06-01 00:00:00
abstract::p21(cip1), a regulatory molecule upstream of the G(1/0) checkpoint, is increased in beta-cells in response to mitogenic stimulation. Whereas p21(cip1) can variably stimulate or inhibit cell cycle progression, in vitro studies suggest that p21(cip1) acts as an inhibitor in the pancreatic beta-cell. To determine the fun...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0627
更新日期:2006-12-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR)gamma is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARgamma display lipodystrophy and extreme insulin resistance. For this reason it was c...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0389
更新日期:2006-10-01 00:00:00
abstract::Mice respond to fatty acid synthase (FAS) inhibitors by profoundly reducing their food intake and body weight. Evidence indicates that the central nervous system (CNS) may be the critical site of action; however, a peripheral contribution cannot be ruled out. We compared doses of the FAS inhibitor C75 in the CNS (thir...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.11.3196
更新日期:2002-11-01 00:00:00
abstract::Insulin resistance and dysregulation of free fatty acid (FFA) metabolism are core defects in type 2 diabetic (T2DM) and obese normal glucose tolerant (NGT) individuals. Impaired muscle mitochondrial function (reduced ATP synthesis) also has been described in insulin-resistant T2DM and obese subjects. We examined wheth...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-1130
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:Observations of elevated circulating concentrations of visfatin (PBEF/Nampt) in obesity and diabetes suggest that this recently described adipokine is involved in the regulation of body weight and metabolism. We examined in humans whether visfatin is found in cerebrospinal fluid (CSF) and, if so, how CSF visf...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-1176
更新日期:2009-03-01 00:00:00
abstract::Identifying new causes of permanent neonatal diabetes (PNDM) (diagnosis <6 months) provides important insights into β-cell biology. Patients with Down syndrome (DS) resulting from trisomy 21 are four times more likely to have childhood diabetes with an intermediate HLA association. It is not known whether DS can cause...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0045
更新日期:2019-07-01 00:00:00
abstract::Accumulation of triosephosphates arising from high cytosolic glucose concentrations in hyperglycemia is the trigger for biochemical dysfunction leading to the development of diabetic nephropathy-a common complication of diabetes associated with a high risk of cardiovascular disease and mortality. Here we report that s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.8.2110
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS:Eight subjects with risk-conferring TCF7L2 genotypes (TT o...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1169
更新日期:2010-02-01 00:00:00