Relationship between cerebrospinal fluid visfatin (PBEF/Nampt) levels and adiposity in humans.

abstract：:We studied certain metabolic requirements for insulin-induced increases in phospholipids, and the relationship of phospholipid changes to the insulin-induced activation of pyruvate dehydrogenase, in rat adipocytes and fat pads in vitro. Increases in the contents of phosphatidylinositol and phosphatidylserine mass were...

journal_title：Diabetes

authors： Farese RV,Farese RV Jr,Sabir MA,Larson RE,Trudeau WL 3rd,Barnes D

更新日期：1984-07-01 00:00:00

abstract：:In man a small dose of somatostatin (50 micrograms/h) suppressed moderately basal insulin (5 microU/ml) and glucagon (40 pg/ml) levels. This resulted in a short-lasting hypoglycemia, which was then followed by marginal hyperglycemia throughout the experiment. The addition of a minimal dose of glucagon (0.50 ng/kg/min)...

journal_title：Diabetes

authors： Lins PE,Wajngot A,Adamson U,Vranic M,Efendić S

更新日期：1983-07-01 00:00:00

abstract：:Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized that the MGO scavenge...

journal_title：Diabetes

authors： Li H,O'Meara M,Zhang X,Zhang K,Seyoum B,Yi Z,Kaufman RJ,Monks TJ,Wang JM

更新日期：2019-06-01 00:00:00

abstract：:By closing ATP-sensitive K+ (K+-ATP) channels, glucose promotes depolarization-dependent Ca2+ entry and cytoplasmic free Ca2+ concentration ([Ca2+]i) rise in beta-cells. Ca2+-dependent exocytosis of insulin granules is then potentiated by a K+-ATP channel-independent action of glucose. The underlying mechanisms of thi...

journal_title：Diabetes

authors： Sato Y,Henquin JC

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To characterize normal and malformed embryos within the same litters from control and diabetic rats for expression of genes related to metabolism of reactive oxygen species (ROS) or glucose as well as developmental genes. RESEARCH DESIGN AND METHODS:Embryos from nondiabetic and streptozotocin-induced diabeti...

journal_title：Diabetes

authors： Wentzel P,Gäreskog M,Eriksson UJ

更新日期：2008-12-01 00:00:00

abstract：:Adults with diabetes are 2-4 times more likely to suffer from heart disease or ischemic stroke than adults without diabetes, yet standard antiplatelet therapy, which is the cornerstone for primary and secondary prevention of cardiovascular disease, fails in many patients with diabetes. Three independent but often inte...

journal_title：Diabetes

authors： Arthur JF,Jandeleit-Dahm K,Andrews RK

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Diabetic nephropathy clusters in families, suggesting that genetic factors play a role in its pathogenesis. We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes. RESEARCH DESIGN AND METHODS:The FinnDiane Study has character...

journal_title：Diabetes

authors： Hietala K,Forsblom C,Summanen P,Groop PH,FinnDiane Study Group.

更新日期：2008-08-01 00:00:00

abstract：:We tested the hypothesis that activation of the protective arm of the renin angiotensin system, the angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [Ang-(1-7)]/Mas receptor axis, corrects the vasoreparative dysfunction typically seen in the CD34(+) cells isolated from diabetic individuals. Peripheral blood CD...

journal_title：Diabetes

authors： Jarajapu YP,Bhatwadekar AD,Caballero S,Hazra S,Shenoy V,Medina R,Kent D,Stitt AW,Thut C,Finney EM,Raizada MK,Grant MB

更新日期：2013-04-01 00:00:00

abstract：:Data based on the prospective study of Job et al. are reanalyzed while initial number of microaneurysms and duration of patient follow-up are controlled. The reported statistical difference in the rate of microaneurysm increase between the single- and the multiple-daily-injection groups may be due to a difference in a...

journal_title：Diabetes

authors： Ashikaga T,Borodic G,Sims EA

更新日期：1978-05-01 00:00:00

abstract：:GLUT4 is necessary for acute insulin- and contraction-induced skeletal muscle glucose uptake, but its role in chronic muscle loading (overload)-induced glucose uptake is unknown. Our goal was to determine whether GLUT4 is required for overload-induced glucose uptake. Overload was induced in mouse plantaris muscle by u...

journal_title：Diabetes

authors： McMillin SL,Schmidt DL,Kahn BB,Witczak CA

更新日期：2017-06-01 00:00:00

abstract：:Birth weights of infants of 35 gestational diabetic mothers treated with calorie restriction alone (1200-1800 kcal) were compared with those of infants of 2337 nondiabetic women, including two control groups (A and B) matched for race, body mass index, age, and parity. All women were screened for gestational diabetes ...

journal_title：Diabetes

authors： Dornhorst A,Nicholls JS,Probst F,Paterson CM,Hollier KL,Elkeles RS,Beard RW

更新日期：1991-12-01 00:00:00

abstract：:Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphatase (G6Pase), and glucose-6-phosphate dehydrogenase (G6PDHase). The expression of these genes is also abnormally regulated in type 2 diabetes. We demonstrate here that treatment of hepatoma cells with 5-aminoimidazole-4-...

journal_title：Diabetes

authors： Lochhead PA,Salt IP,Walker KS,Hardie DG,Sutherland C

更新日期：2000-06-01 00:00:00

abstract：:Fetal hyperinsulinemia causes fetal arterial hypoxia because fetal O2 use increases, whereas the supply of O2 to the fetus does not. To find which of the fetal tissues accounts for such an increase in fetal O2 use, we examined the effect of plasma hyperinsulinemia on O2, glucose, and lactate use by the hindquarters of...

journal_title：Diabetes

authors： Milley JR,Papacostas JS

更新日期：1989-05-01 00:00:00

abstract：:Long before reaching diagnostic cutoff levels for type 2 diabetes, fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young European sib-pairs including obese children, with adjustment for sex, age, and BMI. We identified...

journal_title：Diabetes

authors： Fradin D,Heath S,Lathrop M,Bougnères P

更新日期：2007-06-01 00:00:00

abstract：:Susceptibility of mice to experimental insulin-dependent diabetes as induced by multiple subdiabetogenic doses of streptozotocin has been shown to be strongly gender-dependent, males being much more susceptible than females. We examined this gender difference further in two strains of genetically susceptible mice to d...

journal_title：Diabetes

authors： Paik SG,Michelis MA,Kim YT,Shin S

更新日期：1982-08-01 00:00:00

abstract：:The effect of three calcium antagonists (verapamil, diltiazem, and nifedipine) on insulin effects was investigated in isolated rat soleus muscles. Soleus muscles were incubated in the presence of insulin (100 microU/ml), a concentration that stimulates the rates of lactate formation and glycogen synthesis half-maximal...

journal_title：Diabetes

authors： Foot EA,Leighton B

更新日期：1994-01-01 00:00:00

abstract：:The impaired Na(+)-K(+)-ATPase activity in peripheral nerve from diabetic rats is prevented by dietary myo-inositol (MI) supplementation in vivo and corrected by protein kinase C (PKC) agonists in vitro, suggesting that PKC may mediate the effects of nerve MI depletion on Na(+)-K(+)-ATPase activity. However, little is...

journal_title：Diabetes

authors： Kim J,Rushovich EH,Thomas TP,Ueda T,Agranoff BW,Greene DA

更新日期：1991-11-01 00:00:00

abstract：:It is unknown whether and to what extent changes in various endothelial functions and adrenergic responsiveness are related to the development of microvascular complications in type 1 diabetes. Therefore, endothelium-dependent and endothelium-independent vasodilatation, endothelium-dependent hemostatic factors, and on...

journal_title：Diabetes

authors： Huvers FC,De Leeuw PW,Houben AJ,De Haan CH,Hamulyak K,Schouten H,Wolffenbuttel BH,Schaper NC

更新日期：1999-06-01 00:00:00

abstract：:Molecular mechanisms underlying lipolysis, as defined by mobilization of fatty acids from adipose tissue, are not fully understood. A database search for enzymes with alpha/beta hydrolase folds, the GXSXG motif for serine esterase and the His-Gly dipeptide motif, has provided a previously unannotated gene that is indu...

journal_title：Diabetes

authors： Okazaki H,Igarashi M,Nishi M,Tajima M,Sekiya M,Okazaki S,Yahagi N,Ohashi K,Tsukamoto K,Amemiya-Kudo M,Matsuzaka T,Shimano H,Yamada N,Aoki J,Morikawa R,Takanezawa Y,Arai H,Nagai R,Kadowaki T,Osuga J,Ishibashi S

更新日期：2006-07-01 00:00:00

abstract：:Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control of the porcine insul...

journal_title：Diabetes

authors： Klymiuk N,van Buerck L,Bähr A,Offers M,Kessler B,Wuensch A,Kurome M,Thormann M,Lochner K,Nagashima H,Herbach N,Wanke R,Seissler J,Wolf E

更新日期：2012-06-01 00:00:00

abstract：:In pancreatic beta-cells, glucose metabolism signals insulin secretion by altering the cellular array of messenger molecules. ATP is particularly important, given its role in regulating cation channel activity, exocytosis, and events dependent upon its hydrolysis. Uncoupling protein (UCP)-2 is proposed to catalyze a m...

journal_title：Diabetes

authors： Chan CB,De Leo D,Joseph JW,McQuaid TS,Ha XF,Xu F,Tsushima RG,Pennefather PS,Salapatek AM,Wheeler MB

更新日期：2001-06-01 00:00:00

abstract：:Previous studies of diabetic renovascular complications have measured morphologic changes in relatively few glomerular vessels by electron microscopy. The present study samples 20,000 to 80,000 glomeruli from each of ten nondiabetic and ten diabetic age- and sex-matched subjects. Glomeruli were isolated and fractionat...

journal_title：Diabetes

authors： Klein L,Butcher DL,Sudilovsky O,Kikkawa R,Miller M

更新日期：1975-12-01 00:00:00

abstract：:Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy expenditure, and lipid and carbohydrate metabolism. This review will address the biology, actions, and regulation of three adipocyte hormones-leptin, acylation stimulating protein (ASP), and adiponectin-with an emphasis...

journal_title：Diabetes

authors： Havel PJ

更新日期：2004-02-01 00:00:00

abstract：:The expression of nephropathy in type 2 diabetes has several levels of abnormalities. To define the primary abnormalities of diabetic nephropathy, we conducted an autopsy study of 186 consecutive patients with type 2 diabetes to determine correlations among the aldose reductase gene, renal histopathologies, extracellu...

journal_title：Diabetes

authors： Zhao HL,Tong PC,Lai FM,Tomlinson B,Chan JC

更新日期：2004-11-01 00:00:00

abstract：:Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation domain when glucos...

journal_title：Diabetes

authors： Zhang P,Kumar A,Katz LS,Li L,Paulynice M,Herman MA,Scott DK

更新日期：2015-12-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：:Rats with classic Goldblatt (two-kidney) hypertension had diabetes induced by streptozotocin. After four months of diabetes, glomeruli of the unclipped kidney of hypertensive diabetic rats had markedly increased diabetic changes, including mesangial matrix thickening and mesangial immunoglobulin (IgG and IgM) and comp...

journal_title：Diabetes

authors： Mauer SM,Steffes MW,Azar S,Sandberg SK,Brown DM

更新日期：1978-07-01 00:00:00

abstract：:We have applied cell-attached capacitance measurements to investigate whether synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma and primary pancreatic beta-cells. SLMV and large dense-core vesicle (LDCV) exocytosis was increased 1.6- and 2.4-fold upon stimulation with 10 mmol/l glucose in ...

journal_title：Diabetes

authors： MacDonald PE,Obermüller S,Vikman J,Galvanovskis J,Rorsman P,Eliasson L

更新日期：2005-03-01 00:00:00

abstract：:Diabetes is associated with a loss of somatosensory and motor function, leading to impairments in gait, balance, and manual dexterity. Data-driven neuroimaging studies frequently report a negative impact of diabetes on sensorimotor regions in the brain; however, relationships with sensorimotor behavior are rarely cons...

journal_title：Diabetes

authors： Ferris JK,Inglis JT,Madden KM,Boyd LA

更新日期：2020-01-01 00:00:00

abstract：:We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic male subjects were used for assessment of 3-hydroxy-Acyl-CoA-dehydrogenase (HAD) and cit...

journal_title：Diabetes

authors： Mogensen M,Sahlin K,Fernström M,Glintborg D,Vind BF,Beck-Nielsen H,Højlund K

更新日期：2007-06-01 00:00:00