Effects of calcium antagonists on insulin-mediated glucose metabolism in skeletal muscle.

abstract：:We have recently reported an A to G transition at nucleotide position 3243 in the mitochondrial DNA (mtDNA) tRNA(Leu(UUR)) gene in a large family with non-insulin-dependent diabetes mellitus (NIDDM). Characteristic was its maternal transmission and an associated sensorineural hearing loss. In a screening of a Dutch an...

journal_title：Diabetes

authors： van den Ouweland JM,Lemkes HH,Trembath RC,Ross R,Velho G,Cohen D,Froguel P,Maassen JA

更新日期：1994-06-01 00:00:00

abstract：:The natural history of progression from normal glucose tolerance (NGT) to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes is not well defined. We studied this progression using biennial oral glucose tolerance tests performed in the Baltimore Longitudinal Study of Aging and surviva...

journal_title：Diabetes

authors： Meigs JB,Muller DC,Nathan DM,Blake DR,Andres R,Baltimore Longitudinal Study of Aging.

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing. In humans, a germline mutation in the VHL gene leads to the von Hippel-Lindau disease, a familial syndrome characterized by benign and malignant tumors of the kidney...

journal_title：Diabetes

authors： Puri S,Cano DA,Hebrok M

更新日期：2009-02-01 00:00:00

abstract：:Functional changes in slow-twitch soleus and fast-twitch extensor digitorum longus muscles were assessed after 2 mo of streptozocin-induced diabetes in rats. For soleus, there was a slowing of twitch times both for contraction and relaxation and a reduction of maximum tetanic relaxation rate. There was little effect o...

journal_title：Diabetes

authors： Cameron NE,Cotter MA,Robertson S

更新日期：1990-04-01 00:00:00

abstract：:The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in...

journal_title：Diabetes

authors： Dunmore SJ,Al-Derawi AS,Nayak AU,Narshi A,Nevill AM,Hellwig A,Majebi A,Kirkham P,Brown JE,Singh BM

更新日期：2018-01-01 00:00:00

abstract：:Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism and are also involved in glucose metabolism. However, the functional role of LXRs in human skeletal muscle is at present unknown. This study demonstrates that chronic ligand activation of LXRs by a synthetic LXR agonist increases the...

journal_title：Diabetes

authors： Kase ET,Wensaas AJ,Aas V,Højlund K,Levin K,Thoresen GH,Beck-Nielsen H,Rustan AC,Gaster M

更新日期：2005-04-01 00:00:00

abstract：:The onset of insulin-dependent (type I) diabetes is predictable before hyperglycemia by the presence of islet cell autoantibodies (ICAs) and competitive insulin autoantibodies (CIAAs). CIAA+ICA+ first-degree relatives of individuals with type I diabetes have increased numbers of CD4 cells bearing the CD45R antigen and...

journal_title：Diabetes

authors： Faustman D,Schoenfeld D,Ziegler R

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:Increased intramuscular triacylglycerol (IMTG) storage is a characteristic of the obese insulin-resistant state. We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity. RESEARCH DESIGN AND METHODS:Forearm skeletal musc...

journal_title：Diabetes

authors： Jocken JW,Roepstorff C,Goossens GH,van der Baan P,van Baak M,Saris WH,Kiens B,Blaak EE

更新日期：2008-07-01 00:00:00

abstract：:A monoclonal islet cell antibody, HISL-19, reactive with human, bovine, and porcine pancreatic islets has been used to identify and characterize a novel group of islet cell proteins (p120, p69, p67, and p56). Besides the islets, HISL-19-reactive antigenic determinants are also expressed on selected cell types, namely,...

journal_title：Diabetes

authors： Srikanta S,Krisch K,Eisenbarth GS

更新日期：1986-03-01 00:00:00

abstract：:GAD autoantibodies (GADAs) are sensitive markers of islet autoimmunity and type 1 diabetes. They form the basis of robust prediction models and are widely used for the recruitment of subjects at high risk of type 1 diabetes to prevention trials. However, GADAs are also found in many individuals at low risk of diabetes...

journal_title：Diabetes

authors： Williams AJ,Lampasona V,Schlosser M,Mueller PW,Pittman DL,Winter WE,Akolkar B,Wyatt R,Brigatti C,Krause S,Achenbach P,Participating Laboratories.

更新日期：2015-09-01 00:00:00

abstract：:Liver IGF-1 deficient (LID) mice demonstrate a 75% reduction in circulating IGF-1 levels and a corresponding fourfold increase in growth hormone (GH) levels. At 16 weeks of age, LID mice demonstrate, using the hyperinsulinemic-euglycemic clamp, insulin insensitivity in muscle, liver, and fat tissues. In contrast, mice...

journal_title：Diabetes

authors： Haluzik M,Yakar S,Gavrilova O,Setser J,Boisclair Y,LeRoith D

更新日期：2003-10-01 00:00:00

abstract：:Activity of the vascular large conductance Ca(2+)-activated K(+) (BK) channel is tightly regulated by its accessory β(1) subunit (BK-β(1)). Downregulation of BK-β(1) expression in diabetic vessels is associated with upregulation of the forkhead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only pro...

journal_title：Diabetes

authors： Lu T,Chai Q,Yu L,d'Uscio LV,Katusic ZS,He T,Lee HC

更新日期：2012-07-01 00:00:00

abstract：:Repeated large-volume blood withdrawals started at a young age previously appeared to correct lymphopenia and prevent diabetes in Ottawa diabetes-prone BB (BBdp) rats. Therefore, we sought an early effect 24 h after withdrawal of 25% of estimated blood volume and then reexamined the long-term effects in BBdp rats. The...

journal_title：Diabetes

authors： Marliss EB,Métroz-Dayer MD,Montambault M,Faucher M,Grose M

更新日期：1990-09-01 00:00:00

abstract：:During the development to overt nephropathy, diabetic patients go through several characteristic stages of renal disease, moving from normo- to micro- to macroalbuminuria. Microalbuminuria is defined as a urinary albumin excretion between 20 and 200 microg/min; values <20 microg/min are designated as normoalbuminuria,...

journal_title：Diabetes

authors： Mogensen CE

更新日期：1997-09-01 00:00:00

abstract：:Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two i...

journal_title：Diabetes

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Tsurumaru M,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2005-12-01 00:00:00

abstract：:GLUT2 glucose transporter mRNA has been shown to be underexpressed in pancreatic islets of numerous animal models of non-insulin-dependent diabetes mellitus (NIDDM). It has been proposed that this molecular defect contributes to the pathogenesis of diabetes, although information concerning the expression of GLUT2 in h...

journal_title：Diabetes

authors： Ferrer J,Benito C,Gomis R

更新日期：1995-12-01 00:00:00

abstract：:Immunosuppressive drugs are routinely used to provide tolerance after whole pancreas and islet cell transplantations. While they are essential in inhibiting graft rejection, little is known about their effect on islet function and beta-cell viability. In this study, we report that tacrolimus, sirolimus, and mycophenol...

journal_title：Diabetes

authors： Hui H,Khoury N,Zhao X,Balkir L,D'Amico E,Bullotta A,Nguyen ED,Gambotto A,Perfetti R

更新日期：2005-02-01 00:00:00

abstract：:Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or expansion of endog...

journal_title：Diabetes

authors： Dhawan S,Dirice E,Kulkarni RN,Bhushan A

更新日期：2016-05-01 00:00:00

abstract：:Diabetic microangiopathy is a slowly progressive condition that usually manifests itself years after the onset of the carbohydrate-metabolism disturbance. It is a far more striking problem in some diabetics than in others. Differences in the pattern of its effect in several body systems suggest that the local vascular...

journal_title：Diabetes

authors： McMillan DE

更新日期：1976-01-01 00:00:00

abstract：:Ghrelin, an endogenous ligand for growth hormone secretagogue (GHS) receptor originally isolated from the stomach, occurs in the hypothalamic arcuate nucleus and may play a role in energy homeostasis. Synthetic GHSs have activated the hypothalamic arcuate neurons containing neuropeptide Y (NPY), suggesting the involve...

journal_title：Diabetes

authors： Shintani M,Ogawa Y,Ebihara K,Aizawa-Abe M,Miyanaga F,Takaya K,Hayashi T,Inoue G,Hosoda K,Kojima M,Kangawa K,Nakao K

更新日期：2001-02-01 00:00:00

abstract：:Successful islet transplantation depends on the infusion of sufficiently large quantities of islets, but only a fraction of transplanted islets can survive and become engrafted, and yet the underlying mechanism remains unclear. In this study, we examined the effect of sirolimus, a key component of the immunosuppressiv...

journal_title：Diabetes

authors： Zhang N,Su D,Qu S,Tse T,Bottino R,Balamurugan AN,Xu J,Bromberg JS,Dong HH

更新日期：2006-09-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase (CaMK) activation induces mitochondrial biogenesis in response to increasing cytosolic calcium concentrations. Calcium leak from the ryanodine receptor (RyR) is regulated by reactive oxygen species (ROS), which is increased with high-fat feeding. We examined whether ROS-indu...

journal_title：Diabetes

authors： Jain SS,Paglialunga S,Vigna C,Ludzki A,Herbst EA,Lally JS,Schrauwen P,Hoeks J,Tupling AR,Bonen A,Holloway GP

更新日期：2014-06-01 00:00:00

abstract：:Islets from male B10.BR mice (H-2k) were isolated by the collagenase technique, handpicked with a Pasteur pipette, and incubated (either intact or after dispersion with Dispase) for 0, 3, 5, 7, 10, or 14 days in tissue culture medium supplemented with either lymphokine supernatants or recombinant murine interferon-gam...

journal_title：Diabetes

authors： Wright JR Jr,Lacy PE,Unanue ER,Muszynski C,Hauptfeld V

更新日期：1986-10-01 00:00:00

abstract：:The present study was performed to assess the potential relationship between the low T3 syndrome and hypothyroidism. Comparative studies were performed on the relative effects of diabetes and insulin on heparin-releasable adipose lipoprotein lipase (LPL) in the intact and hypothyroid rat. Hypothyroidism for 10 days (T...

journal_title：Diabetes

authors： Gavin LA,McMahon F,Moeller M

更新日期：1985-12-01 00:00:00

abstract：:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...

journal_title：Diabetes

authors： Hayward AR,Herberger M

更新日期：1984-04-01 00:00:00

abstract：:Infants with congenital hyperinsulinism owing to inactivating mutations in the K(ATP) channel (K(ATP)HI) who are unresponsive to medical therapy will require pancreatectomy to control the hypoglycemia. In preclinical studies, we showed that the GLP-1 receptor antagonist exendin-(9-39) suppresses insulin secretion and ...

journal_title：Diabetes

authors： Calabria AC,Li C,Gallagher PR,Stanley CA,De León DD

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Obesity-associated insulin resistance is characterized by a state of chronic, low-grade inflammation that is associated with the accumulation of M1 proinflammatory macrophages in adipose tissue. Although different evidence explains the mechanisms linking the expansion of adipose tissue and adipose tissue macr...

journal_title：Diabetes

authors： Prieur X,Mok CY,Velagapudi VR,Núñez V,Fuentes L,Montaner D,Ishikawa K,Camacho A,Barbarroja N,O'Rahilly S,Sethi JK,Dopazo J,Orešič M,Ricote M,Vidal-Puig A

更新日期：2011-03-01 00:00:00

abstract：:Pancreatic islets contain enzyme activity which catalyzes the phosphorylation by MgATP of cardiac, skeletal, or smooth muscle myosin light chains. The enzyme is activated by calcium (Ka = 10 microM) and calmodulin (Ka = 2 nM) and inhibited by trifluoperazine (Ki = 10 microM), a known inhibitor of calmodulin and of ins...

journal_title：Diabetes

authors： MacDonald MJ,Kowluru A

更新日期：1982-06-01 00:00:00

abstract：:A key pathophysiologic role for activated T-cells in mediating adipose inflammation and insulin resistance (IR) has been recently postulated. However, mechanisms underlying their activation are poorly understood. In this study, we demonstrated a previously unrecognized homeostatic role for the costimulatory B7 molecul...

journal_title：Diabetes

authors： Zhong J,Rao X,Braunstein Z,Taylor A,Narula V,Hazey J,Mikami D,Needleman B,Rutsky J,Sun Q,Deiuliis JA,Satoskar AR,Rajagopalan S

更新日期：2014-04-01 00:00:00

abstract：:Pancreatic β-cells play a pivotal role in maintaining normoglycemia. Recent studies have revealed that the β-cell is not a homogeneous cell population but, rather, is heterogeneous in a number of properties such as electrical activity, gene expression, and cell surface markers. Identification of specific β-cell subpop...

journal_title：Diabetes

authors： Dybala MP,Hara M

更新日期：2019-06-01 00:00:00