Abstract:
:Long before reaching diagnostic cutoff levels for type 2 diabetes, fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young European sib-pairs including obese children, with adjustment for sex, age, and BMI. We identified more quantitative trait loci specific to fasting glucose and more significant than would be found by simple chance estimated by permutation tests. The strongest linkage was on chromosome 2q (logarithm of odds [LOD] = 3.00) in a region previously linked to type 2 diabetes as a disease. We also found linkage signals of fasting glucose with 7q (LOD = 2.03), 8q (1.28), 17p (2.12), 17q (1.4), and 11p (1.33). These findings suggest that the quantitative genetics of fasting glucose could contribute to the search for type 2 diabetes genes.
journal_name
Diabetesjournal_title
Diabetesauthors
Fradin D,Heath S,Lathrop M,Bougnères Pdoi
10.2337/db06-1329subject
Has Abstractpub_date
2007-06-01 00:00:00pages
1742-5issue
6eissn
0012-1797issn
1939-327Xpii
db06-1329journal_volume
56pub_type
杂志文章相关文献
DIABETES文献大全abstract::Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two i...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.12.3582
更新日期:2005-12-01 00:00:00
abstract::Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas ina...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-1296
更新日期:2013-05-01 00:00:00
abstract::The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow. The optimal d...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.6.509
更新日期:1976-06-01 00:00:00
abstract:OBJECTIVE:To examine the prospective association between objectively measured time spent sedentary and insulin resistance and whether this association is independent of moderate- and vigorous-intensity physical activity (MVPA) and other relevant confounders. RESEARCH DESIGN AND METHODS:This was a population-based stud...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-1773
更新日期:2009-08-01 00:00:00
abstract::The insulin resistance syndrome is characterized by several risk factors for cardiovascular disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside (AICAR) has been shown to augment insulin action, upregulate mitochondrial enz...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.7.2199
更新日期:2002-07-01 00:00:00
abstract::The autoimmune disease type 1 diabetes is characterized by effector T-cell responses to pancreatic β-cell-derived peptides presented by HLA class I and class II molecules, leading ultimately to β-cell demise and insulin insufficiency. Although a given HLA molecule presents a vast array of peptides, only those recogniz...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/dbi19-0022
更新日期:2020-07-01 00:00:00
abstract::With the aim of investigating glucose-mediated glucose disposal (glucose effectiveness [GE]) in 15 (3 female and 12 male subjects) insulin-resistant normoglycemic relatives of patients with type 2 diabetes (DM2), and 15 age-, sex-, and BMI-matched control subjects without a family history of DM2, we performed 2 studie...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.7.1209
更新日期:2000-07-01 00:00:00
abstract::We examined the metabolic characteristics that attend the development of type 2 diabetes (T2DM) in 441 impaired glucose tolerance (IGT) subjects who participated in the ACT NOW Study and had complete end-of-study metabolic measurements. Subjects were randomized to receive pioglitazone (PGZ; 45 mg/day) or placebo and w...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db13-0265
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this ...
journal_title:Diabetes
pub_type: 杂志文章,多中心研究
doi:10.2337/db07-0484
更新日期:2008-02-01 00:00:00
abstract::Pancreatic beta-cells are more sensitive to several toxins (e.g., streptozotocin, alloxan, cytokines) than the other three endocrine cell types in the islets of Langerhans. Cytokine-induced free radicals in beta-cells may be involved in beta-cell-specific destruction in type 1 diabetes. To investigate if this sensitiv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.12.2324
更新日期:1999-12-01 00:00:00
abstract::Increased glomerular filtration rate and kidney size early in the course of experimental and human diabetes may be important in the pathogenesis of diabetic nephropathy. Factors causing these renal functional changes are unknown. The isolated, perfused rat kidney (IPRK) was used to study the effects of elevated glucos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.4.360
更新日期:1985-04-01 00:00:00
abstract::The effects of elevated EPI and CORT levels on KG, SI, and SG were studied in dogs with alloxan-induced diabetes. Conscious dogs received SAL, EPI 20 ng.kg-1.min-1 for 30 min (short EPI) or 72 h (long EPI), or CORT 200 micrograms.kg-1.min-1 for 60 min (short CORT) or 72 h (long CORT) before assessment of glucose metab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.11.1446
更新日期:1992-11-01 00:00:00
abstract::Recently, a missense mutation replacing tryptophan with arginine at codon 64 of the beta 3-adrenergic receptor gene was shown to be associated with insulin resistance in nondiabetic subjects and to an earlier onset of NIDDM in Pima Indians. We studied whether the codon 64 amino acid polymorphism of the beta 3-adrenerg...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.8.1115
更新日期:1996-08-01 00:00:00
abstract::Islet β-cells adapt to insulin resistance through increased insulin secretion and expansion. Type 2 diabetes typically occurs when prolonged insulin resistance exceeds the adaptive capacity of β-cells. Our prior screening efforts led to the discovery that adenosine kinase (ADK) inhibitors stimulate β-cell replication....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0816
更新日期:2017-07-01 00:00:00
abstract::Cardiovascular (CV) disease fatality rates are higher for women compared with men with diabetes despite lower rates of obstructive coronary artery disease (CAD). Impaired coronary flow reserve (CFR), the ratio of adenosine-stimulated to rest myocardial blood flow (MBF), is an indicator of coronary microvascular dysfun...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db18-0650
更新日期:2019-03-01 00:00:00
abstract::Adiponectin, one of the most abundant gene transcript proteins in human fat cells, has been shown to improve insulin action and is also suggested to exert antiatherogenic effects. We measured circulating adiponectin levels and risk factors for atherosclerosis in 45 healthy first-degree relatives of type 2 diabetic sub...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.5.1182
更新日期:2003-05-01 00:00:00
abstract::Acute elevations of plasma free fatty acid (FFA) levels augment glucose-stimulated insulin secretion (GSIS). Prolonged elevations of FFA levels reportedly impair GSIS, but no one has previously compared GSIS after prolonged exposure to saturated or unsaturated fat. Rats received a low-fat diet (Low-Fat) or one enriche...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.6.1825
更新日期:2002-06-01 00:00:00
abstract::To investigate the effects of insulin on platelets in obesity and in non-insulin-dependent diabetes mellitus (NIDDM)--classic insulin-resistant states--we determined ADP-induced platelet aggregation and platelet cGMP (guanosine 3',5'-cyclic monophosphate) content in platelet-rich plasma obtained from nine obese subjec...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.11.1318
更新日期:1995-11-01 00:00:00
abstract::Although type 1 diabetes (T1D) is primarily perceived as a T cell-driven autoimmune disease, islet autoantibodies are the best currently available biomarker for autoimmunity and disease risk. These antibodies are produced by autoreactive B cells, the activation of which is largely dependent on the function of CD4+CXCR...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0714
更新日期:2017-02-01 00:00:00
abstract::It has been proposed that insulin-mediated changes in muscle perfusion modulate insulin-mediated glucose uptake. However, the putative effects of insulin on the microcirculation that permit such modulation have not been studied in humans. We examined the effects of systemic hyperinsulinemia on skin microvascular funct...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/diabetes.51.5.1515
更新日期:2002-05-01 00:00:00
abstract::Insulin resistance is an underappreciated facet of type 1 diabetes that occurs with remarkable consistency and considerable magnitude. Although therapeutic innovations are continuing to normalize dysglycemia, a sizable body of data suggests a second metabolic abnormality-iatrogenic hyperinsulinemia-principally drives ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi19-0026
更新日期:2020-05-01 00:00:00
abstract::Hyperactivation of the mammalian target of rapamycin complex 1 (mTORC1) in β-cells is usually found as a consequence of increased metabolic load. Although it plays an essential role in β-cell compensatory mechanisms, mTORC1 negatively regulates autophagy. Using a mouse model with β-cell-specific deletion of Tsc2 (βTsc...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-0970
更新日期:2014-09-01 00:00:00
abstract::Ghrelin stimulates, while glucagon-like peptide-1 (GLP-1) and peptide YY(3-36) [PYY(3-36)] inhibit, food intake and gastric emptying in rats. We determined the dose-dependent effects of a 3-h intravenous infusion of ghrelin at dark onset on food intake in freely feeding rats, and on the inhibitory effects of intraveno...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0730
更新日期:2006-11-01 00:00:00
abstract::Peptide-YY (PYY) is secreted from endocrine L-cells of the gastrointestinal tract in response to caloric ingestion and may mediate postprandial satiety through the hypothalamic neuropeptide Y2 receptor (Y2R). We examined whether variants in the genes encoding PYY and Y2R might be associated with obesity-related phenot...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.9.2461
更新日期:2004-09-01 00:00:00
abstract::Brain dopaminergic pathways play a major role in the control of movement. Absence of the murine dopamine D2 receptor gene (drd2) produces bradykinesia and hypothermia. A Ser311Cys mutation of the human DRD2 produces a marked functional impairment of the receptor and is associated with higher BMI in some populations. W...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.4.901
更新日期:2001-04-01 00:00:00
abstract::Leptin administration has been shown to increase renal, adrenal, and lumbar sympathetic nerve activity. However, this generalized sympathoexcitatory activity is not always followed by an increase in arterial pressure. The present study tested the hypothesis that leptin induces a release of nitric oxide (NO) that oppos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.4.903
更新日期:1999-04-01 00:00:00
abstract::The N6-methyladenosine (m6A) RNA modification is essential during embryonic development of various organs. However, its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA methyltransferase-like 3/14 (Mettl3/14) were deleted in Ngn3+ endocrine progenitors (Mettl3/14 ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0906
更新日期:2020-08-01 00:00:00
abstract::Adiponectin is an adipose tissue-specific protein with insulin-sensitizing and antiatherogenic properties. Therefore, the adiponectin gene is a promising candidate gene for type 2 diabetes. We investigated the single nucleotide polymorphisms (SNPs) +45T/G and +276G/T of the adiponectin gene as predictors for the conve...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.3.893
更新日期:2005-03-01 00:00:00
abstract::We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors effici...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.4.745
更新日期:1999-04-01 00:00:00