Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates.

abstract：:We examined the effects of high-dosage vitamin E treatment over a 12-month period on the vascular reactivity of micro- and macrocirculation and left ventricular function in diabetic patients. Subjects (n = 89) were randomized to vitamin E (1,800 IU daily) or placebo and were followed for 12 months. High-resolution ult...

journal_title：Diabetes

authors： Economides PA,Khaodhiar L,Caselli A,Caballero AE,Keenan H,Bursell SE,King GL,Johnstone MT,Horton ES,Veves A

更新日期：2005-01-01 00:00:00

abstract：:With the aim of investigating glucose-mediated glucose disposal (glucose effectiveness [GE]) in 15 (3 female and 12 male subjects) insulin-resistant normoglycemic relatives of patients with type 2 diabetes (DM2), and 15 age-, sex-, and BMI-matched control subjects without a family history of DM2, we performed 2 studie...

journal_title：Diabetes

authors： Henriksen JE,Levin K,Thye-Rønn P,Alford F,Hother-Nielsen O,Holst JJ,Beck-Nielsen H

更新日期：2000-07-01 00:00:00

abstract：:The sulfonylurea receptor (SUR) is the important regulatory subunit of ATP-sensitive K+ channels. It is an ATP-binding cassette protein comprising 17 transmembrane helices. SUR is endowed with binding sites for channel blockers like the antidiabetic sulfonylurea glibenclamide and for the chemically very heterogeneous ...

journal_title：Diabetes

authors： Hambrock A,Kayar T,Stumpp D,Osswald H

更新日期：2004-12-01 00:00:00

abstract：:The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...

journal_title：Diabetes

authors： Suga A,Hirano T,Kageyama H,Kashiba M,Oka J,Osaka T,Namba Y,Tsuji M,Miura M,Adachi M,Inoue S

更新日期：1999-10-01 00:00:00

abstract：:Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose metabolism. Hepatic glucokinase (GK) is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabetic animal models. Here, we explored t...

journal_title：Diabetes

authors： Desai UJ,Slosberg ED,Boettcher BR,Caplan SL,Fanelli B,Stephan Z,Gunther VJ,Kaleko M,Connelly S

更新日期：2001-10-01 00:00:00

abstract：:Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistanc...

journal_title：Diabetes

authors： Kanatani Y,Usui I,Ishizuka K,Bukhari A,Fujisaka S,Urakaze M,Haruta T,Kishimoto T,Naka T,Kobayashi M

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms responsible for pancreatic β-cell dysfunction in type 2 diabetes remain unresolved. Increased expression of the helix-loop-helix protein Id1 has been found in islets of diabetic mice and in vitro models of β-cell dysfunction. Here, we investigated the role of Id1 in insulin secretion ...

journal_title：Diabetes

authors： Akerfeldt MC,Laybutt DR

更新日期：2011-10-01 00:00:00

abstract：:In 112 obese compared with 42 lean children, we found that serum leptin is elevated early in the evolution of childhood-onset obesity (28.4 +/- 1.4 vs. 4.5 +/- 0.4 ng/ml in lean children, P < 0.0001) and correlates with adiposity. Obese children also had higher serum leptin normalized to fat mass. Despite high serum l...

journal_title：Diabetes

authors： Lahlou N,Landais P,De Boissieu D,Bougnères PF

更新日期：1997-06-01 00:00:00

abstract：:Ectopic lipid accumulation in the liver is an almost universal feature of human and rodent models of generalized lipodystrophy and is also a common feature of type 2 diabetes, obesity, and metabolic syndrome. Here we explore the progression of fatty liver disease using a mouse model of lipodystrophy created by a fat-s...

journal_title：Diabetes

authors： Softic S,Boucher J,Solheim MH,Fujisaka S,Haering MF,Homan EP,Winnay J,Perez-Atayde AR,Kahn CR

更新日期：2016-08-01 00:00:00

abstract：:The role of interferons, either pathogenic or protective, during autoimmune diabetes remains controversial. Herein, we examine the progression of diabetes in NOD mice lacking the type I (IFNAR) or type II (IFNGR) interferon receptor and, for the first time, in mice deficient in both receptors (double knockout [DKO]). ...

journal_title：Diabetes

authors： Carrero JA,Benshoff ND,Nalley K,Unanue ER

更新日期：2018-09-01 00:00:00

abstract：:Studies have shown associations between exposure to hypoglycemia and increased mortality, raising the possibility that hypoglycemia has adverse cardiovascular effects. In this study, we determined the acute effects of hypoglycemia on cardiovascular autonomic control. Seventeen healthy volunteers were exposed to experi...

journal_title：Diabetes

authors： Rao AD,Bonyhay I,Dankwa J,Baimas-George M,Kneen L,Ballatori S,Freeman R,Adler GK

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:Exosomes are important for intercellular communication, but the role of exosomes in the communication between adipose tissue (AT) and the liver remains unknown. The aim of this study is to determine the contribution of AT-derived exosomes in nonalcoholic fatty liver disease (NAFLD). Exosome components, liver fat conte...

journal_title：Diabetes

authors： Yan C,Tian X,Li J,Liu D,Ye D,Xie Z,Han Y,Zou MH

更新日期：2021-02-01 00:00:00

abstract：:Diabetic patients have reduced antioxidant defenses and suffer from an increased risk of free radical-mediated diseases such as coronary heart disease. Epidemiological evidence has suggested that antioxidant dietary flavonoids may protect against heart disease, but a biological effect has yet to be demonstrated direct...

journal_title：Diabetes

authors： Lean ME,Noroozi M,Kelly I,Burns J,Talwar D,Sattar N,Crozier A

更新日期：1999-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotoci...

journal_title：Diabetes

authors： Kim YB,Kim WB,Jung WW,Jin X,Kim YS,Kim B,Han HC,Block GD,Colwell CS,Kim YI

更新日期：2018-03-01 00:00:00

abstract：:We have recently demonstrated that the exposure to hyperglycemia in utero impairs nephrogenesis in rat fetuses (Amri K et al., Diabetes 48:2240-2245, 1999). Diabetic pregnancy is commonly associated with alterations in the IGF system in fetal tissues. It has also been shown that both IGF-I and IGF-II are produced with...

journal_title：Diabetes

authors： Amri K,Freund N,Duong Van Huyen JP,Merlet-Bénichou C,Lelièvre-Pégorier M

更新日期：2001-05-01 00:00:00

abstract：:Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion f...

journal_title：Diabetes

authors： Laukkanen O,Lindström J,Eriksson J,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Uusitupa M,Laakso M,Finnish Diabetes Prevention Study.

更新日期：2005-07-01 00:00:00

abstract：:High glucose concentrations such as are seen in diabetes mellitus are known to have deleterious effects on cells, but the pathways by which glucose induces these effects are unknown. One hypothesis is that metabolism of glucose to glucosamine might be involved. For example, it has been shown that glucosamine is more p...

journal_title：Diabetes

authors： Crook ED,Daniels MC,Smith TM,McClain DA

更新日期：1993-09-01 00:00:00

abstract：:Vasculopathy is a major complication of diabetes; however, molecular mechanisms mediating the development of vasculopathy and potential strategies for prevention have not been identified. We have previously reported that C-peptide prevents diabetic vasculopathy by inhibiting reactive oxygen species (ROS)-mediated endo...

journal_title：Diabetes

authors： Bhatt MP,Lim YC,Kim YM,Ha KS

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Normal human myocardium switches substrate metabolism preference, adapting to the prevailing plasma substrate levels and hormonal milieu, but in type 1 diabetes, the myocardium relies heavily on fatty acid metabolism for energy. Whether conditions that affect myocardial glucose use and fatty acid utilization,...

journal_title：Diabetes

authors： Peterson LR,Herrero P,McGill J,Schechtman KB,Kisrieva-Ware Z,Lesniak D,Gropler RJ

更新日期：2008-01-01 00:00:00

abstract：:Persistent nutrient excess results in a compensatory increase in the β-cell number in mammals. It is unknown whether this response occurs in nonmammalian vertebrates, including zebrafish, a model for genetics and chemical genetics. We investigated the response of zebrafish β-cells to nutrient excess and the underlying...

journal_title：Diabetes

authors： Maddison LA,Chen W

更新日期：2012-10-01 00:00:00

abstract：:This article examines the role of the autonomic nervous system in mediating the increase of glucagon secretion observed during insulin-induced hypoglycemia (IIH). In the first section, we briefly review the importance of the alpha-cell response in recovery from hypoglycemia under both physiologic conditions and pathop...

journal_title：Diabetes

authors： Taborsky GJ Jr,Ahrén B,Havel PJ

更新日期：1998-07-01 00:00:00

abstract：:Signaling pathways activated by leptin in metabolically important organs have largely been studied only in animal and/or cell culture studies. In this study, we examined whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and whether the response would be different in lean and...

journal_title：Diabetes

authors： Moon HS,Huh JY,Dincer F,Schneider BE,Hasselgren PO,Mantzoros CS

更新日期：2015-03-01 00:00:00

abstract：:The beta-3 adrenergic receptor (ADRB3) has been implicated as a regulator of energy expenditure, and a polymorphism in codon 64 of this gene (Trp64Arg) has been associated in some studies with obesity and insulin resistance. However, many studies have failed to detect an effect of this variant, and the importance of t...

journal_title：Diabetes

authors： Mitchell BD,Cole SA,Comuzzie AG,Almasy L,Blangero J,MacCluer JW,Hixson JE

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The G-protein-coupled receptor Gpr40 is expressed in beta-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion. However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 was recently shown to bi...

journal_title：Diabetes

authors： Edfalk S,Steneberg P,Edlund H

更新日期：2008-09-01 00:00:00

abstract：:The minor hemoglobins AIa, AIb, and AIc were studied in mice with either genetic or chemically induced diabetes. Hemoglobin AIc was elevated approximately twofold in all the phenotypically diabetic mice studied (C57BL/KsJ-db/db, C57BL/KsJ-ob/ob, C57BL/6J-db/db, and alloxan- and streptozotocin-treated mice). Elevation ...

journal_title：Diabetes

authors： Koenig RJ,Araujo DC,Cerami A

更新日期：1976-01-01 00:00:00

abstract：:C57BL/6 (B6) mice develop glucose intolerance with age, whereas C3H/He (C3H) mice do not. In this study, we examined whether this differential glucose homeostasis was associated with differences of proteolytic activation of pancreatic prohormones. Radioimmunoassays showed comparable levels of fasting plasma insulin be...

journal_title：Diabetes

authors： Schmidt G,Sirois F,Anini Y,Kauri LM,Gyamera-Acheampong C,Fleck E,Scott FW,Chrétien M,Mbikay M

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Paracrine signaling via gamma-aminobutyric acid (GABA) and GABA(A) receptors (GABA(A)Rs) has been documented in rodent islets. Here we have studied the importance of GABAergic signaling in human pancreatic islets. RESEARCH DESIGN AND METHODS:Expression of GABA(A)Rs in islet cells was investigated by quantita...

journal_title：Diabetes

authors： Braun M,Ramracheya R,Bengtsson M,Clark A,Walker JN,Johnson PR,Rorsman P

更新日期：2010-07-01 00:00:00

abstract：:We previously described a prosthetic group methodology for incorporating 18F into peptides and showed that 18F-labeled insulin (18F-insulin) binds to insulin receptors on human cells (IM-9 lymphoblastoid cells) with affinity equal to that of native insulin (1). We now report studies using 18F-insulin with positron emi...

journal_title：Diabetes

authors： Eastman RC,Carson RE,Jacobson KA,Shai Y,Channing MA,Dunn BB,Bacher JD,Baas E,Jones E,Kirk KL

更新日期：1992-07-01 00:00:00

abstract：:Ectopic lipids in peripheral tissues have been implicated in attenuating insulin action in vivo. The botanical extract of Artemisia dracunculus L. (PMI 5011) improves insulin action, yet the precise mechanism is not known. We sought to determine whether the mechanism by which PMI 5011 improves insulin signaling is thr...

journal_title：Diabetes

authors： Obanda DN,Hernandez A,Ribnicky D,Yu Y,Zhang XH,Wang ZQ,Cefalu WT

更新日期：2012-03-01 00:00:00