Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance.

abstract：:Continuous subcutaneous insulin infusion (CSII) was combined with antirejection therapy in four diabetic recipients of pancreas and kidney grafts with persisting hyperglycemia due to pancreas rejection. In three of the patients, full function of the pancreas was restored after as many as 40, 86, and 139 days of CSII. ...

journal_title：Diabetes

authors： Bartos V,Vanĕk I,Dryáková M,Saudek F,Malý J

更新日期：1989-01-01 00:00:00

abstract：:EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic co...

journal_title：Diabetes

authors： Sun H,Lee P,Yan C,Gao N,Wang J,Fan X,Yu FS

更新日期：2018-06-01 00:00:00

abstract：:Counterregulatory hormonal responses were studied in six patients after 4-18 mo treatment with a continuous subcutaneous insulin infusion pump. In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of...

journal_title：Diabetes

authors： Bergenstal RM,Polonsky KS,Pons G,Jaspan JB,Rubenstein AH

更新日期：1983-05-01 00:00:00

abstract：:To elucidate the direct effect of rosiglitazone (RSG), a new thiazolidinedione antihyperglycemic agent, on pancreatic insulin secretion, an in situ investigation by rat pancreatic perfusion was performed. At a basal glucose concentration of 6 mmol/l, RSG (0.045-4.5 micromol/l) stimulated insulin release in a dose-depe...

journal_title：Diabetes

authors： Yang C,Chang TJ,Chang JC,Liu MW,Tai TY,Hsu WH,Chuang LM

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression and organ formation. They participate in the pathogenesis of several autoimmune diseases, but the nature of miRNAs contributing to β-cell death in T1D and their target ...

journal_title：Diabetes

authors： Grieco FA,Sebastiani G,Juan-Mateu J,Villate O,Marroqui L,Ladrière L,Tugay K,Regazzi R,Bugliani M,Marchetti P,Dotta F,Eizirik DL

更新日期：2017-01-01 00:00:00

abstract：:The inhibitory actions of somatostatin (100 ng./ml.) on insulin release, stimulated by high glucose (20 mM), and on glucagon release, stimulated by arginine (15 mM), were studied with two in vitro systems: the isolated perifused rat islets prepared by the collagenase procedure and the isolated perfused rat pancreas. S...

journal_title：Diabetes

authors： Norfleet WT,Pagliara AS,Haymond MW,Matschinsky F

更新日期：1975-11-01 00:00:00

abstract：:The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of 111In-diethylenetriaminepentaacetic acid-exendin-3 (111In-exendin) in a rat model that closely mimics the...

journal_title：Diabetes

authors： Brom M,Joosten L,Frielink C,Peeters H,Bos D,van Zanten M,Boerman O,Gotthardt M

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Elevated fasting glucose level is associated with increased carotid intima-media thickness (IMT), a measure of subclinical atherosclerosis. It is unclear if this association is causal. Using the principle of Mendelian randomization, we sought to explore the causal association between circulating glucose and I...

journal_title：Diabetes

authors： Rasmussen-Torvik LJ,Li M,Kao WH,Couper D,Boerwinkle E,Bielinski SJ,Folsom AR,Pankow JS

更新日期：2011-01-01 00:00:00

abstract：:These studies of a rat model for non-insulin-dependent diabetes mellitus (NIDDM) were performed to determine whether hyperglycemia occurs when capacity to synthesize insulin is exceeded. The neonatal streptozocin (STZ)-treated rat has acute hyperglycemia with marked destruction of pancreatic beta-cells, followed by gr...

journal_title：Diabetes

authors： Giddings SJ,Orland MJ,Weir GC,Bonner-Weir S,Permutt MA

更新日期：1985-03-01 00:00:00

abstract：:We report a genomewide linkage analysis of a large consanguineous family segregating autosomal recessively inherited neonatal diabetes and the identification of a novel neonatal diabetes locus. Neonatal diabetes was characterized by low levels of circulating C-peptide with very low to undetectable levels of insulin in...

journal_title：Diabetes

authors： Sellick GS,Garrett C,Houlston RS

更新日期：2003-10-01 00:00:00

abstract：:The molecular and cellular level reaches of the metabolic dysregulations that characterize diabetes are yet to be fully discovered. As mechanisms underlying management of reactive oxygen species (ROS) gain interest as crucial factors in cell integrity, questions arise about the role of redox cues in the regulation and...

journal_title：Diabetes

authors： Rabbani PS,Soares MA,Hameedi SG,Kadle RL,Mubasher A,Kowzun M,Ceradini DJ

更新日期：2019-01-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regula...

journal_title：Diabetes

authors： Baboota RK,Blüher M,Smith U

更新日期：2021-02-01 00:00:00

abstract：:The impaired Na(+)-K(+)-ATPase activity in peripheral nerve from diabetic rats is prevented by dietary myo-inositol (MI) supplementation in vivo and corrected by protein kinase C (PKC) agonists in vitro, suggesting that PKC may mediate the effects of nerve MI depletion on Na(+)-K(+)-ATPase activity. However, little is...

journal_title：Diabetes

authors： Kim J,Rushovich EH,Thomas TP,Ueda T,Agranoff BW,Greene DA

更新日期：1991-11-01 00:00:00

abstract：:Receptors for bradykinin (BK) were characterized in primary cultures of beating neonatal rat cardiomyocytes using [3H]BK was radioligand. Degradation studies demonstrated that [3H]BK was stable for at least 2 h when incubated with cardiomyocytes at 2 and 37 degrees C in the presence of bacitracin in combination with c...

journal_title：Diabetes

authors： Kasel AM,Faussner A,Pfeifer A,Müller U,Werdan K,Roscher AA

更新日期：1996-01-01 00:00:00

abstract：:Obesity is associated with an increase in the fractional contribution of gluconeogenesis (GNG) to glucose production. We tested if this was related to the altered protein metabolism in obesity. GNG(PEP) (via phosphoenol pyruvate [PEP]) was measured after a 17-h fast using the deuterated water method and 2H nuclear mag...

journal_title：Diabetes

authors： Chevalier S,Burgess SC,Malloy CR,Gougeon R,Marliss EB,Morais JA

更新日期：2006-03-01 00:00:00

abstract：:Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the most recently approved class of diabetes drugs. Unlike other agents, SGLT2 inhibitors act on the kidney to promote urinary glucose excretion. SGLT2 inhibitors provide multiple benefits, including decreased HbA1c, body weight, and blood pressure. These drugs hav...

journal_title：Diabetes

authors： Beitelshees AL,Leslie BR,Taylor SI

更新日期：2019-06-01 00:00:00

abstract：:The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in several populations; the rat homolog has been directly implicated in diabetes susceptibility; and known functions of IDE...

journal_title：Diabetes

authors： Groves CJ,Wiltshire S,Smedley D,Owen KR,Frayling TM,Walker M,Hitman GA,Levy JC,O'Rahilly S,Menzel S,Hattersley AT,McCarthy MI

更新日期：2003-05-01 00:00:00

abstract：:Fifty male rats were made diabetic by a single injection of streptozotocin and were killed at periods varying from 1 to 12 mo. Ten saline-injected rats and three rats treated with 3-O-methylglucose and streptozotocin served as controls. Intraluminal changes in retinal vessels were studied by electron microscopy. In di...

journal_title：Diabetes

authors： Ishibashi T,Tanaka K,Taniguchi Y

更新日期：1981-07-01 00:00:00

abstract：:To develop somatic gene therapy for diabetes, we studied an animal model with proinsulin-producing fibroblasts with an immunological safety system. Cultured mouse fibroblasts of the Ltk- cell line were transfected first with the efficient human proinsulin expression vector pBMG-Neo-Ins. Initially, 2 x 10(6) cells with...

journal_title：Diabetes

authors： Kawakami Y,Yamaoka T,Hirochika R,Yamashita K,Itakura M,Nakauchi H

更新日期：1992-08-01 00:00:00

abstract：:To establish potential effects of glucagon-like peptide I (GLP-I) on blood glucose control in insulin-deficient states, GLP-I [GLP-I(7-36) amide; 10 pmol x kg(-1) x min(-1)] was infused intravenously in six fasting, canine C-peptide-negative, chronically diabetic dogs for 8 h. Blood samples were saved for the analysis...

journal_title：Diabetes

authors： Freyse EJ,Becher T,El-Hag O,Knospe S,Göke B,Fischer U

更新日期：1997-05-01 00:00:00

abstract：:Enhanced platelet functions have been demonstrated in patients with non-insulin-dependent diabetes mellitus (NIDDM). This study evaluated abnormalities in platelet signal transduction in diabetic patients, including turnover of phosphoinositides, mobilization of intracellular Ca2+, and phosphorylation of 20,000- and 4...

journal_title：Diabetes

authors： Ishii H,Umeda F,Hashimoto T,Nawata H

更新日期：1990-12-01 00:00:00

abstract：:Susceptibility of mice to experimental insulin-dependent diabetes as induced by multiple subdiabetogenic doses of streptozotocin has been shown to be strongly gender-dependent, males being much more susceptible than females. We examined this gender difference further in two strains of genetically susceptible mice to d...

journal_title：Diabetes

authors： Paik SG,Michelis MA,Kim YT,Shin S

更新日期：1982-08-01 00:00:00

abstract：:Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose metabolism. Hepatic glucokinase (GK) is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabetic animal models. Here, we explored t...

journal_title：Diabetes

authors： Desai UJ,Slosberg ED,Boettcher BR,Caplan SL,Fanelli B,Stephan Z,Gunther VJ,Kaleko M,Connelly S

更新日期：2001-10-01 00:00:00

abstract：:To examine the impact of diabetes and its treatment on plasma free-fatty acid (FFA) and oxidative fuel metabolism during hypoglycemia, we combined indirect calorimetry with [3-3H]glucose during a 4-h low-dose insulin infusion (plasma insulin approximately 2-fold above basal) in six poorly controlled and nine well-cont...

journal_title：Diabetes

authors： Caprio S,Amiel S,Tamborlane WV,Gelfand RA,Sherwin RS

更新日期：1990-02-01 00:00:00

abstract：:Acute elevations of plasma free fatty acid (FFA) levels augment glucose-stimulated insulin secretion (GSIS). Prolonged elevations of FFA levels reportedly impair GSIS, but no one has previously compared GSIS after prolonged exposure to saturated or unsaturated fat. Rats received a low-fat diet (Low-Fat) or one enriche...

journal_title：Diabetes

authors： Dobbins RL,Szczepaniak LS,Myhill J,Tamura Y,Uchino H,Giacca A,McGarry JD

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：:To clarify the relationship between variations in beta-cell mass and pancreatic function, we investigated the possibility to analyze, quantify, and sort beta-cell subpopulations with different functional maturity. To this aim, we tested the reliability of the sialylated form of neural cell adhesion molecule (NCAM) (PS...

journal_title：Diabetes

authors： Bernard-Kargar C,Kassis N,Berthault MF,Pralong W,Ktorza A

更新日期：2001-02-01 00:00:00

abstract：:Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (+/+) (n = 55, 12 weeks old) and age-matched control db/db (+/-) mice (n = 45) on two diets that differed only in AGE content (high [H-A...

journal_title：Diabetes

authors： Peppa M,Brem H,Ehrlich P,Zhang JG,Cai W,Li Z,Croitoru A,Thung S,Vlassara H

更新日期：2003-11-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00