Rosiglitazone (BRL 49653) enhances insulin secretory response via phosphatidylinositol 3-kinase pathway.

abstract：:We have recently demonstrated that the exposure to hyperglycemia in utero impairs nephrogenesis in rat fetuses (Amri K et al., Diabetes 48:2240-2245, 1999). Diabetic pregnancy is commonly associated with alterations in the IGF system in fetal tissues. It has also been shown that both IGF-I and IGF-II are produced with...

journal_title：Diabetes

authors： Amri K,Freund N,Duong Van Huyen JP,Merlet-Bénichou C,Lelièvre-Pégorier M

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...

journal_title：Diabetes

authors： Ko HJ,Zhang Z,Jung DY,Jun JY,Ma Z,Jones KE,Chan SY,Kim JK

更新日期：2009-11-01 00:00:00

abstract：:Clinical studies have suggested that changes in peripheral nerve microcirculation may contribute to nerve damage in diabetic polyneuropathy (DN). High-sensitivity troponin T (hsTNT) assays have been recently shown to provide predictive values for both cardiac and peripheral microangiopathy in type 2 diabetes (T2D). Th...

journal_title：Diabetes

authors： Jende JME,Groener JB,Kender Z,Hahn A,Morgenstern J,Heiland S,Nawroth PP,Bendszus M,Kopf S,Kurz FT

更新日期：2020-04-01 00:00:00

abstract：:Hyperinsulinemia is commonly associated with obesity, but it has not been determined which defect comes first. Some have proposed that hyperinsulinemia may precede obesity in populations prone to NIDDM, such as Pima Indians or Pacific Islanders. In contrast, longitudinal studies in adults show that insulin sensitivity...

journal_title：Diabetes

authors： Odeleye OE,de Courten M,Pettitt DJ,Ravussin E

更新日期：1997-08-01 00:00:00

abstract：:Signaling pathways activated by leptin in metabolically important organs have largely been studied only in animal and/or cell culture studies. In this study, we examined whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and whether the response would be different in lean and...

journal_title：Diabetes

authors： Moon HS,Huh JY,Dincer F,Schneider BE,Hasselgren PO,Mantzoros CS

更新日期：2015-03-01 00:00:00

abstract：:Three forms of disulfide-linked insulin receptor complexes are labeled by covalent cross-linking to receptor-bound 125I-insulin in native adipocyte or liver membranes. These receptors of Mr 350,000 Mr 320,000, and Mr 290,000 are composed of alpha (Mr 125,000), beta(Mr 90,000), and beta 1(Mr 49,000) subunits in stoichi...

journal_title：Diabetes

authors： Massaqué J,Czech MP

更新日期：1980-11-01 00:00:00

abstract：:Apoptosis is a physiological form of cell death that occurs during normal development, and critical mediators of this process include caspases, reactive oxygen species, and Ca2+. Excessive apoptosis of the pancreatic beta-cell has been associated with diabetes. Consequently, apoptosis research has focused on how infil...

journal_title：Diabetes

authors： Chandra J,Zhivotovsky B,Zaitsev S,Juntti-Berggren L,Berggren PO,Orrenius S

更新日期：2001-02-01 00:00:00

abstract：:Glucose tolerance depends on a complex interaction among insulin secretion from the beta-cells, clearance of the hormone, and the actions of insulin to accelerate glucose disappearance and inhibit endogenous glucose production. An additional factor, less well recognized, is the ability of glucose per se, independent o...

journal_title：Diabetes

authors： Bergman RN

更新日期：1989-12-01 00:00:00

abstract：:Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explor...

journal_title：Diabetes

authors： Simó R,Barbosa-Desongles A,Lecube A,Hernandez C,Selva DM

更新日期：2012-02-01 00:00:00

abstract：:Hypofibrinolysis caused by increased plasminogen activator inhibitor 1 (PAI-1) has been implicated in the vasculopathy of type 2 diabetes, typified by increased insulin, glucose, and triglycerides. However, short-term infusions of insulin have not increased PAI-1 in normal subjects. We hypothesized that induction of i...

journal_title：Diabetes

authors： Calles-Escandon J,Mirza SA,Sobel BE,Schneider DJ

更新日期：1998-02-01 00:00:00

abstract：:A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...

journal_title：Diabetes

authors： Sadoff L,Gordon J,Goldman S

更新日期：1975-06-01 00:00:00

abstract：:The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, ap...

journal_title：Diabetes

authors： Eto M,Watanabe K,Iwashima Y,Morikawa A,Chonan N,Oshima E,Sekiguchi M,Ishii K

更新日期：1987-11-01 00:00:00

abstract：:Precise timing of the teratogenic period in diabetic pregnancy is of clinical importance since correction of the glucose intolerance during this period may protect the offspring from malformations. An experimental approach to elucidate this problem with regard to skeletal development was made in groups of pregnant str...

journal_title：Diabetes

authors： Eriksson UJ,Dahlström E,Hellerström C

更新日期：1983-12-01 00:00:00

abstract：OBJECTIVE:Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS:Renal Klotho expression w...

journal_title：Diabetes

authors： Zhao Y,Banerjee S,Dey N,LeJeune WS,Sarkar PS,Brobey R,Rosenblatt KP,Tilton RG,Choudhary S

更新日期：2011-07-01 00:00:00

abstract：:The pancreases of 14 children who died of type I diabetes were studied immunohistochemically for aberrant expression of HLA-DR antigens on islet endocrine cells. Two cases in which no residual insulin-secreting beta-cells were present had no evidence of HLA-DR expression on endocrine cells. Insulin-containing islets w...

journal_title：Diabetes

authors： Foulis AK,Farquharson MA

更新日期：1986-11-01 00:00:00

abstract：:Sirt6 is an NAD+-dependent deacetylase that is involved in the control of energy metabolism. However, the tissue-specific function of Sirt6 in the adipose tissue remains unknown. In this study, we showed that fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to ad...

journal_title：Diabetes

authors： Kuang J,Zhang Y,Liu Q,Shen J,Pu S,Cheng S,Chen L,Li H,Wu T,Li R,Li Y,Zou M,Zhang Z,Jiang W,Xu G,Qu A,Xie W,He J

更新日期：2017-05-01 00:00:00

abstract：:This study investigated how maternal overnutrition and obesity regulate expression and activation of proteins that facilitate lipid transport in the placenta. To create a maternal overnutrition and obesity model, primiparous C57BL/6 mice were fed a high-fat (HF) diet throughout gestation. Fetuses from HF-fed dams had ...

journal_title：Diabetes

authors： Qiao L,Guo Z,Bosco C,Guidotti S,Wang Y,Wang M,Parast M,Schaack J,Hay WW Jr,Moore TR,Shao J

更新日期：2015-09-01 00:00:00

abstract：:Neogenesis is crucial for the maintenance of beta-cell mass in the human pancreas and possibly for the outcome of clinical islet transplantation. To date, no studies have reported a stimulation of human beta-cell neogenesis in vivo. Therefore, we investigated whether human alpha-, beta-, and duct cell growth can be st...

journal_title：Diabetes

authors： Tyrberg B,Ustinov J,Otonkoski T,Andersson A

更新日期：2001-02-01 00:00:00

abstract：:We investigated the significance of the variants of the IRS-2 gene in patients with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by single-strand conformation polymorphism analysis in 40 Chinese and 40 Finnish patients with late-onset type 2 diabetes. The association of the variants of the IR...

journal_title：Diabetes

authors： Wang H,Rissanen J,Miettinen R,Kärkkäinen P,Kekäläinen P,Kuusisto J,Mykkänen L,Karhapää P,Laakso M

更新日期：2001-08-01 00:00:00

abstract：:Dispersed pancreatic endocrine cells (PECs) were recently shown to survive indefinitely in the brain of allogeneic diabetic rat recipients across the major histocompatibility barrier without immunosuppression. Purified PECs (2-3 X 10(6) cells) prepared from Wistar rat islets were transplanted in 10 different sites in ...

journal_title：Diabetes

authors： Tze WJ,Tai J

更新日期：1988-04-01 00:00:00

abstract：:In this study, 92% of patients' serums known to contain antibodies against islet cells, including the Juvenile Diabetes Foundation provisional reference serum, had antibodies reacting with gastrointestinal carcinoid tumors. Twelve percent of the control serums from healthy individuals bound to carcinoid cells, and 2% ...

journal_title：Diabetes

authors： Miettinen A,Holthöfer H,Kontiainen S,Miettinen M,Andersson LC

更新日期：1989-05-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+) concentration ([Ca(2+)](ER)) and the role of SERCA3 in the control of insulin secretion and ER stress. RESEARCH DES...

journal_title：Diabetes

authors： Ravier MA,Daro D,Roma LP,Jonas JC,Cheng-Xue R,Schuit FC,Gilon P

更新日期：2011-10-01 00:00:00

abstract：:Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) ...

journal_title：Diabetes

authors： Nishimura S,Nagasaki M,Okudaira S,Aoki J,Ohmori T,Ohkawa R,Nakamura K,Igarashi K,Yamashita H,Eto K,Uno K,Hayashi N,Kadowaki T,Komuro I,Yatomi Y,Nagai R

更新日期：2014-12-01 00:00:00

abstract：:Development of beta-cell lines for cell therapy of diabetes is hindered by functional deviations of the replicating cells from the normal beta-cell phenotype. In a recently developed cell line, denoted betaTC-tet, derived from transgenic mice expressing the SV40 T antigen (Tag) under control of the tetracycline (Tc) g...

journal_title：Diabetes

authors： Fleischer N,Chen C,Surana M,Leiser M,Rossetti L,Pralong W,Efrat S

更新日期：1998-09-01 00:00:00

abstract：:Impaired effectiveness of glucose to suppress endogenous glucose production (EGP) is an important cause of worsening hyperglycemia in type 2 diabetes. Elevated free fatty acids (FFAs) may impair glucose effectiveness via several mechanisms, including rapid changes in metabolic fluxes and/or more gradual changes in gen...

journal_title：Diabetes

authors： Kishore P,Tonelli J,Koppaka S,Fratila C,Bose A,Lee DE,Reddy K,Hawkins M

更新日期：2006-06-01 00:00:00

abstract：:This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats treated with a p38 inhibitor, an aldose redu...

journal_title：Diabetes

authors： Price SA,Agthong S,Middlemas AB,Tomlinson DR

更新日期：2004-07-01 00:00:00

abstract：:Ectopic lipid accumulation in the liver is an almost universal feature of human and rodent models of generalized lipodystrophy and is also a common feature of type 2 diabetes, obesity, and metabolic syndrome. Here we explore the progression of fatty liver disease using a mouse model of lipodystrophy created by a fat-s...

journal_title：Diabetes

authors： Softic S,Boucher J,Solheim MH,Fujisaka S,Haering MF,Homan EP,Winnay J,Perez-Atayde AR,Kahn CR

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2 diabetes, and transient GLP-1 administration improved cardiac function in humans after acute myocardial infarction (MI) and percutaneous revascularization. However, the consequences of GLP-1R activation before ischemic myocardial inju...

journal_title：Diabetes

authors： Noyan-Ashraf MH,Momen MA,Ban K,Sadi AM,Zhou YQ,Riazi AM,Baggio LL,Henkelman RM,Husain M,Drucker DJ

更新日期：2009-04-01 00:00:00

abstract：:Lifestyle modification reduces the risk of developing type 2 diabetes and may have its effect through improving insulin sensitivity, beta-cell function, or both. To determine whether diet and exercise improve insulin sensitivity and/or beta-cell function and to evaluate these effects over time, we quantified insulin s...

journal_title：Diabetes

authors： Carr DB,Utzschneider KM,Boyko EJ,Asberry PJ,Hull RL,Kodama K,Callahan HS,Matthys CC,Leonetti DL,Schwartz RS,Kahn SE,Fujimoto WY

更新日期：2005-02-01 00:00:00