Abstract:
:Counterregulatory hormonal responses were studied in six patients after 4-18 mo treatment with a continuous subcutaneous insulin infusion pump. In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of the six patients glucagon levels did not increase at all. The persistence of these abnormal glucagon responses despite long-term optimal glucose control suggests that they are not due to hyperglycemia per se, but are due rather to a specific alpha cell abnormality. The high incidence of asymptomatic hypoglycemia in these patients emphasizes that caution is necessary to avoid serious hypoglycemia when striving for near-normal glucose control with insulin infusion pump therapy.
journal_name
Diabetesjournal_title
Diabetesauthors
Bergenstal RM,Polonsky KS,Pons G,Jaspan JB,Rubenstein AHdoi
10.2337/diab.32.5.398subject
Has Abstractpub_date
1983-05-01 00:00:00pages
398-402issue
5eissn
0012-1797issn
1939-327Xjournal_volume
32pub_type
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