Lack of glucagon response to hypoglycemia in type I diabetics after long-term optimal therapy with a continuous subcutaneous insulin infusion pump.

Abstract:

:Counterregulatory hormonal responses were studied in six patients after 4-18 mo treatment with a continuous subcutaneous insulin infusion pump. In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of the six patients glucagon levels did not increase at all. The persistence of these abnormal glucagon responses despite long-term optimal glucose control suggests that they are not due to hyperglycemia per se, but are due rather to a specific alpha cell abnormality. The high incidence of asymptomatic hypoglycemia in these patients emphasizes that caution is necessary to avoid serious hypoglycemia when striving for near-normal glucose control with insulin infusion pump therapy.

journal_name

Diabetes

journal_title

Diabetes

authors

Bergenstal RM,Polonsky KS,Pons G,Jaspan JB,Rubenstein AH

doi

10.2337/diab.32.5.398

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

398-402

issue

5

eissn

0012-1797

issn

1939-327X

journal_volume

32

pub_type

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