Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study.

abstract：:NIDDM has a substantial genetic component, but the nature of the genetic susceptibility is largely unknown. Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous monogenic form of NIDDM characterized by an early age of onset and autosomal dominant inheritance, and linkage studies have identified g...

journal_title：Diabetes

authors： Shaw JT,Lovelock PK,Kesting JB,Cardinal J,Duffy D,Wainwright B,Cameron DP

更新日期：1998-11-01 00:00:00

abstract：:The plasma and tissue concentration of ascorbic acid (AA) is reduced in diabetes. This study was designed to investigate the mechanism and significance of this phenomenon. The low plasma AA concentration of diabetic rats can be normalized by dietary AA supplement (20-40 mg/day), a dosage approximately equal to the max...

journal_title：Diabetes

authors： McLennan S,Yue DK,Fisher E,Capogreco C,Heffernan S,Ross GR,Turtle JR

更新日期：1988-03-01 00:00:00

abstract：:To investigate the effects of insulin on platelets in obesity and in non-insulin-dependent diabetes mellitus (NIDDM)--classic insulin-resistant states--we determined ADP-induced platelet aggregation and platelet cGMP (guanosine 3',5'-cyclic monophosphate) content in platelet-rich plasma obtained from nine obese subjec...

journal_title：Diabetes

authors： Trovati M,Mularoni EM,Burzacca S,Ponziani MC,Massucco P,Mattiello L,Piretto V,Cavalot F,Anfossi G

更新日期：1995-11-01 00:00:00

abstract：:The researchers conducted this study to test the hypothesis that risk of type 2 diabetes is less following reductions in body size and central adiposity. The Diabetes Prevention Program (DPP) recruited and randomized individuals with impaired glucose tolerance to treatment with placebo, metformin, or lifestyle modific...

journal_title：Diabetes

authors： Fujimoto WY,Jablonski KA,Bray GA,Kriska A,Barrett-Connor E,Haffner S,Hanson R,Hill JO,Hubbard V,Stamm E,Pi-Sunyer FX,Diabetes Prevention Program Research Group.

更新日期：2007-06-01 00:00:00

abstract：:The transmission behavior of insulin-dependent juvenile diabetes mellitus (JDM) has been studied with respect to its frequency in the relatives of JDM probands and its possible linkage to the HLA complex. Mathematical analysis shows that under a single locus hypothesis a very restricted range of incidence rates is pos...

journal_title：Diabetes

authors： Suarez B,Hodge SE,Reich T

更新日期：1979-06-01 00:00:00

abstract：:Mutations in the NeuroD/BETA2 gene have been shown to associate with type 2 diabetes. In the present study, we examined mutations in the NeuroD/BETA2 gene for association with either type 1 or 2 diabetes. Three variants were identified in patients with type 2 diabetes: Ala45Thr (allelic frequency 0.36, 95% CI 0.31-0.4...

journal_title：Diabetes

authors： Hansen L,Jensen JN,Urioste S,Petersen HV,Pociot F,Eiberg H,Kristiansen OP,Hansen T,Serup P,Nerup J,Pedersen O

更新日期：2000-05-01 00:00:00

abstract：:The selective impairment of glucose-induced insulin secretion in NIDDM can be attributed to defects in the glucose-signaling system. An alteration in the activity of phosphofructokinase (PFK), a key enzyme in the glycolytic pathway, may play a role in the abnormal glucose-induced insulin secretion. In this study, we e...

journal_title：Diabetes

authors： Knobler H,Weiss Y,Peled M,Groner Y

更新日期：1997-09-01 00:00:00

abstract：:A key pathophysiologic role for activated T-cells in mediating adipose inflammation and insulin resistance (IR) has been recently postulated. However, mechanisms underlying their activation are poorly understood. In this study, we demonstrated a previously unrecognized homeostatic role for the costimulatory B7 molecul...

journal_title：Diabetes

authors： Zhong J,Rao X,Braunstein Z,Taylor A,Narula V,Hazey J,Mikami D,Needleman B,Rutsky J,Sun Q,Deiuliis JA,Satoskar AR,Rajagopalan S

更新日期：2014-04-01 00:00:00

abstract：:Overexpression of hepatocyte growth factor (HGF) in the beta-cell of transgenic mice enhances beta-cell proliferation, survival, and function. In the current studies, we have used conditional ablation of the c-met gene to uncover the physiological role of HGF in beta-cell growth and function. Mice in which c-met is in...

journal_title：Diabetes

authors： Roccisana J,Reddy V,Vasavada RC,Gonzalez-Pertusa JA,Magnuson MA,Garcia-Ocaña A

更新日期：2005-07-01 00:00:00

abstract：:We studied the functional consequences of an enhanced polyol pathway activity, elicited with galactose feeding, on the peripheral nerve of transgenic mice expressing human aldose reductase. Nontransgenic littermate mice were used as controls. With a quantitative immunoassay, the expression level of human aldose reduct...

journal_title：Diabetes

authors： Yagihashi S,Yamagishi S,Wada R,Sugimoto K,Baba M,Wong HG,Fujimoto J,Nishimura C,Kokai Y

更新日期：1996-01-01 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is an α-arrestin that can bind to and inhibit the antioxidant protein thioredoxin (TXN). TXNIP expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. TXNIP is currently studied as a pote...

journal_title：Diabetes

authors： Katsu-Jiménez Y,Vázquez-Calvo C,Maffezzini C,Halldin M,Peng X,Freyer C,Wredenberg A,Giménez-Cassina A,Wedell A,Arnér ESJ

更新日期：2019-04-01 00:00:00

abstract：:Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches to improve systemic energy balance and chronic inflammation in obesity are limited. Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) allevia...

journal_title：Diabetes

authors： Nagata N,Xu L,Kohno S,Ushida Y,Aoki Y,Umeda R,Fuke N,Zhuge F,Ni Y,Nagashimada M,Takahashi C,Suganuma H,Kaneko S,Ota T

更新日期：2017-05-01 00:00:00

abstract：:Diabetes complications are caused by hyperglycemia. Hyperglycemia results in increased concentrations of glucose degradation products. The study of peritoneal dialysis solution biocompatibility has highlighted the adverse effects of glucose degradation products. Recently, 3,4-dideoxyglucosone-3-ene (3,4-DGE) has been ...

journal_title：Diabetes

authors： Justo P,Sanz AB,Egido J,Ortiz A

更新日期：2005-08-01 00:00:00

abstract：:This study measured the accumulation of substance P-like immunoreactivity (SPLI) proximal and distal to 12-h constricting ligatures applied to rat sciatic nerves. There were three separate experiments, and the baseline for each consisted of control and age-matched rats with 3 wk of untreated streptozocin-induced diabe...

journal_title：Diabetes

authors： Tomlinson DR,Robinson JP,Willars GB,Keen P

更新日期：1988-04-01 00:00:00

abstract：:Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific subpopulations with d...

journal_title：Diabetes

authors： Benninger RKP,Hodson DJ

更新日期：2018-04-01 00:00:00

abstract：:Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell autophagy but has not been studied in the context of β-cell antioxidant response. We used a combination of animal models of diabetes and ...

journal_title：Diabetes

authors： Marasco MR,Conteh AM,Reissaus CA,Cupit JE 5th,Appleman EM,Mirmira RG,Linnemann AK

更新日期：2018-08-01 00:00:00

abstract：:Chronic high-fat feeding in rats induces profound whole-body insulin resistance, mainly due to effects in oxidative skeletal muscle. The mechanisms of this reaction remain unclear, but local lipid availability has been implicated. The aim of this study was to examine the influence of three short-term physiological man...

journal_title：Diabetes

authors： Oakes ND,Bell KS,Furler SM,Camilleri S,Saha AK,Ruderman NB,Chisholm DJ,Kraegen EW

更新日期：1997-12-01 00:00:00

abstract：:Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternative to stimulate glucose uptake in insulin-resistant muscle. Both Rac1 and AMPK have been shown to partly regulate contraction-stimulated muscle glucose uptake, but whether those two signali...

journal_title：Diabetes

authors： Sylow L,Møller LLV,Kleinert M,D'Hulst G,De Groote E,Schjerling P,Steinberg GR,Jensen TE,Richter EA

更新日期：2017-06-01 00:00:00

abstract：:Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by t...

journal_title：Diabetes

authors： Blackshear PJ,Rohde TD,Grotting JC,Dorman FD,Perkins PR,Varco RL,Buchwald H

更新日期：1979-07-01 00:00:00

abstract：:The regulation of insulin secretion from pancreatic beta-cells depends critically on the activities of their plasma membrane ion channels. ATP-sensitive K+ channels (K(ATP) channels) are present in many cells and regulate a variety of cellular functions by coupling cell metabolism with membrane potential. The activity...

journal_title：Diabetes

authors： Seino S,Iwanaga T,Nagashima K,Miki T

更新日期：2000-03-01 00:00:00

abstract：:The causes of the increased risk of severe COVID-19 in persons with diabetes are unclear. It has been speculated that renin angiotensin system (RAS) blockers may promote COVID-19 by increasing ACE2, which SARS-CoV-2 uses to enter host cells, along with the host protease TMPRSS2. Taking a reverse translational approach...

journal_title：Diabetes

authors： Batchu SN,Kaur H,Yerra VG,Advani SL,Kabir MG,Liu Y,Klein T,Advani A

更新日期：2020-12-11 00:00:00

abstract：:Agonist-induced activation of peroxisome proliferator-activated receptor-γ (PPARγ) stimulates adipocyte differentiation and insulin sensitivity. Patients with heterozygous PPARγ dominant-negative mutation develop partial lipodystrophy and insulin resistance. Inconsistent with this evidence in humans, it was reported t...

journal_title：Diabetes

authors： Gumbilai V,Ebihara K,Aizawa-Abe M,Ebihara C,Zhao M,Yamamoto Y,Mashimo T,Hosoda K,Serikawa T,Nakao K

更新日期：2016-10-01 00:00:00

abstract：:The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel meta...

journal_title：Diabetes

authors： Sun L,Lin JD

更新日期：2019-05-01 00:00:00

abstract：:The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation, and other factors continues to limit Tx efficacy. In this project, we demonstrate a novel approach aimed at protecting islets before Tx in nonhuman prima...

journal_title：Diabetes

authors： Pomposelli T,Wang P,Takeuchi K,Miyake K,Ariyoshi Y,Watanabe H,Chen X,Shimizu A,Robertson N,Yamada K,Moore A

更新日期：2020-11-01 00:00:00

abstract：:Genes overexpressed in pancreatic islets of patients with new-onset type 1 diabetes are potential candidates for novel disease-related autoantigens. RT-PCR-based subtractive hybridization was used on islets from a patient who died at the onset of type 1 diabetes, and it identified a type 1 diabetes-related cDNA encodi...

journal_title：Diabetes

authors： Gurr W,Yavari R,Wen L,Shaw M,Mora C,Christa L,Sherwin RS

更新日期：2002-02-01 00:00:00

abstract：:A total of 32 pairs of obese fathers or mothers and their obese offsprings, aged 20 yr or younger, from 25 families with established hyperinsulinemic obesity aged 11-20 yr equally showed an insulin hyperresponse to glucose, the offspring 10 yr or younger revealed a rather normal insulin response, despite the presence ...

journal_title：Diabetes

authors： Maruhama Y,Abe R

更新日期：1981-01-01 00:00:00

abstract：:Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adip...

journal_title：Diabetes

authors： Vozarova de Courten B,Hanson RL,Funahashi T,Lindsay RS,Matsuzawa Y,Tanaka S,Thameem F,Gruber JD,Froguel P,Wolford JK

更新日期：2005-01-01 00:00:00

abstract：:We recently showed that a peptide of the M(r) 60,000 heat shock protein molecule, designated peptide p277, is a target of T-cells in autoimmune diabetes in NOD mice. Indeed, the p277 peptide could be used as a therapeutic agent to arrest the autoimmune process even after it was far advanced. The present study was done...

journal_title：Diabetes

authors： Elias D,Cohen IR

更新日期：1995-09-01 00:00:00

abstract：:Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic vesicle priming. We recently showed that Munc13-1 is expressed in rodent and human islet beta-cells and that its levels are reduced in islets of type 2 diabetic humans and rat models, suggesting that Munc13-1 deficiency contributes to the abnor...

journal_title：Diabetes

authors： Kwan EP,Xie L,Sheu L,Nolan CJ,Prentki M,Betz A,Brose N,Gaisano HY

更新日期：2006-05-01 00:00:00

abstract：:Nerve conduction and electromyography (EMG) of insulin-dependent (type 1) diabetic patients with end-stage nephropathy was studied before and up to 10 yr after kidney transplantation (KTx). A series of nondiabetic KTx patients served as a comparison group. Motor nerve conduction velocity (NCV) was measured in the ulna...

journal_title：Diabetes

authors： Van der Vliet JA,Navarro X,Kennedy WR,Goetz FC,Barbosa JJ,Sutherland DE,Najarian JS

更新日期：1988-09-01 00:00:00