Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity.

abstract：:Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphatase (G6Pase), and glucose-6-phosphate dehydrogenase (G6PDHase). The expression of these genes is also abnormally regulated in type 2 diabetes. We demonstrate here that treatment of hepatoma cells with 5-aminoimidazole-4-...

journal_title：Diabetes

authors： Lochhead PA,Salt IP,Walker KS,Hardie DG,Sutherland C

更新日期：2000-06-01 00:00:00

abstract：:The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways....

journal_title：Diabetes

authors： Cohen P,Spiegelman BM

更新日期：2015-07-01 00:00:00

abstract：:Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding selectivity, in vivo potency, and human safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains con...

journal_title：Diabetes

authors： Sun W,Oates PJ,Coutcher JB,Gerhardinger C,Lorenzi M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Insulin stimulates glucose transport in skeletal muscle by GLUT4 translocation from intracellular compartments to sarcolemma and t-tubules. We studied in living animals the recruitment of GLUT4 vesicles in more detail than previously done and, for the first time, analyzed the steady-state recycling and subseq...

journal_title：Diabetes

authors： Lauritzen HP,Galbo H,Brandauer J,Goodyear LJ,Ploug T

更新日期：2008-02-01 00:00:00

abstract：:Hypoglycemia is associated with increased activity in the low-frequency bands in the electroencephalogram (EEG). We investigated whether hypoglycemia awareness and unawareness are associated with different hypoglycemia-associated EEG changes in patients with type 1 diabetes. Twenty-four patients participated in the st...

journal_title：Diabetes

authors： Sejling AS,Kjær TW,Pedersen-Bjergaard U,Diemar SS,Frandsen CS,Hilsted L,Faber J,Holst JJ,Tarnow L,Nielsen MN,Remvig LS,Thorsteinsson B,Juhl CB

更新日期：2015-05-01 00:00:00

abstract：:Different degrees of beta-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has been recently suggested that high glucose-induced beta-cell apoptosis in type 2 diabetes shares a final common pathway with type 1 diabetes, involving interleukin-1beta (IL-1beta) production by beta-cells, nuclear fa...

journal_title：Diabetes

authors： Welsh N,Cnop M,Kharroubi I,Bugliani M,Lupi R,Marchetti P,Eizirik DL

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Progranulin is an important molecule in inflammatory response. Chronic inflammation is frequently associated with central obesity and associated disturbances; however, the role of circulating progranulin in human obesity, type 2 diabetes, and dyslipidemia is unknown. RESEARCH DESIGN AND METHODS:For the measu...

journal_title：Diabetes

authors： Youn BS,Bang SI,Klöting N,Park JW,Lee N,Oh JE,Pi KB,Lee TH,Ruschke K,Fasshauer M,Stumvoll M,Blüher M

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in this phenomenon of...

journal_title：Diabetes

authors： Lovis P,Roggli E,Laybutt DR,Gattesco S,Yang JY,Widmann C,Abderrahmani A,Regazzi R

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Reactive oxygen species (ROS) is one of most important factors in impaired metabolism secretion coupling in pancreatic β-cells. We recently reported that elevated ROS production and impaired ATP production at high glucose in diabetic Goto-Kakizaki (GK) rat islets are effectively ameliorated by Src inhibition,...

journal_title：Diabetes

authors： Mukai E,Fujimoto S,Sato H,Oneyama C,Kominato R,Sato Y,Sasaki M,Nishi Y,Okada M,Inagaki N

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The gene encoding the alpha2 Heremans-Schmid glycoprotein (AHSG) is a credible biological and positional candidate gene for type 2 diabetes and the metabolic syndrome, and previous attempts to relate AHSG variation with type 2 diabetes and obesity in Swedish and French Caucasians have been largely successful....

journal_title：Diabetes

authors： Andersen G,Burgdorf KS,Sparsø T,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2008-05-01 00:00:00

abstract：:The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest t...

journal_title：Diabetes

authors： Andersen DK,Korc M,Petersen GM,Eibl G,Li D,Rickels MR,Chari ST,Abbruzzese JL

更新日期：2017-05-01 00:00:00

abstract：:A new murine model of porcine islet-like cell cluster (ICC) xenograft rejection, avoiding interference of unspecific inflammation, was introduced and used to investigate rejection mechanisms. Athymic (nu/nu) mice were transplanted with syngeneic, allogeneic, or xenogeneic islets under the kidney capsule. After the ori...

journal_title：Diabetes

authors： Schmidt P,Krook H,Maeda A,Korsgren O,Benda B

更新日期：2003-05-01 00:00:00

abstract：:Incubation of 3T3-L1 adipocytes with C2- and C6-ceramides (N-acetyl- and N-hexanoylsphingosines) but not dihydro-C2-ceramide increased 2-deoxyglucose uptake in the absence of insulin. This effect was inhibited by PD 98059, LY 294002, and rapamycin, which block the activation of mitogen-activated protein kinase, phosph...

journal_title：Diabetes

authors： Wang CN,O'Brien L,Brindley DN

更新日期：1998-01-01 00:00:00

abstract：:Although recent studies show that adipose tissue macrophages (ATMs) participate in the inflammatory changes in obesity and contribute to insulin resistance, the properties of these cells are not well understood. We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory prope...

journal_title：Diabetes

authors： Lumeng CN,Deyoung SM,Bodzin JL,Saltiel AR

更新日期：2007-01-01 00:00:00

abstract：:Human CD5+ B lymphocytes produce autoantibodies that bind to self- and exogenous antigens. Extremely high percentages of CD5+ B lymphocytes are present in the fetal and newborn periods, whereas they constitute only a minority of B lymphocytes in healthy adults. Increased percentages of circulating CD5+ lymphocytes hav...

journal_title：Diabetes

authors： Schatz DA,Lang F,Cantor AB,Riley WJ,Maclaren NK,Sleasman JW,Barrett DJ

更新日期：1991-10-01 00:00:00

abstract：:Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) has been implicated in the control of blood glucose by its potent effect on expression and signaling of various nuclear receptors. To understand the role of COUP-TFII in glucose homeostasis, conditional COUP-TFII-deficient mice were generated and ...

journal_title：Diabetes

authors： Bardoux P,Zhang P,Flamez D,Perilhou A,Lavin TA,Tanti JF,Hellemans K,Gomas E,Godard C,Andreelli F,Buccheri MA,Kahn A,Le Marchand-Brustel Y,Burcelin R,Schuit F,Vasseur-Cognet M

更新日期：2005-05-01 00:00:00

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：:Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...

journal_title：Diabetes

authors： Ueda K,Takimoto E,Lu Q,Liu P,Fukuma N,Adachi Y,Suzuki R,Chou S,Baur W,Aronovitz MJ,Greenberg AS,Komuro I,Karas RH

更新日期：2018-08-01 00:00:00

abstract：:This article presents a model for the HLA effect in insulin-dependent diabetes mellitus (IDDM) that is almost the mirror image of a model suggested by Nepom. In the Nepom model, the products of certain HLA alleles are associated with IDDM because they bind and present a specific peptide or peptides so as to induce an ...

journal_title：Diabetes

authors： Sheehy MJ

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db ...

journal_title：Diabetes

authors： Sloan C,Tuinei J,Nemetz K,Frandsen J,Soto J,Wride N,Sempokuya T,Alegria L,Bugger H,Abel ED

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS:Eight subjects with risk-conferring TCF7L2 genotypes (TT o...

journal_title：Diabetes

authors： Villareal DT,Robertson H,Bell GI,Patterson BW,Tran H,Wice B,Polonsky KS

更新日期：2010-02-01 00:00:00

abstract：:Decreased retinal blood flow has been measured in streptozotocin (STZ)-induced diabetes of 1 week's duration, and primary insulin intervention was effective in maintaining normal retinal blood flow in diabetic rats. Retinal blood-flow abnormalities precede clinical diabetic retinopathy in both diabetic animals and pat...

journal_title：Diabetes

authors： Higashi S,Clermont AC,Dhir V,Bursell SE

更新日期：1998-04-01 00:00:00

abstract：:Considerable debate exists about whether alterations in mitochondrial respiratory capacity and/or content play a causal role in the development of insulin resistance during obesity. The current study was undertaken to determine whether such alterations are present during the initial stages of insulin resistance in hum...

journal_title：Diabetes

authors： Fisher-Wellman KH,Weber TM,Cathey BL,Brophy PM,Gilliam LA,Kane CL,Maples JM,Gavin TP,Houmard JA,Neufer PD

更新日期：2014-01-01 00:00:00

abstract：:Insulin resistance associated with altered fat partitioning in liver and adipose tissues is a prediabetic condition in obese adolescents. We investigated interactions between glucose tolerance, insulin sensitivity, and the expression of lipogenic genes in abdominal subcutaneous adipose and liver tissue in 53 obese ado...

journal_title：Diabetes

authors： Kursawe R,Caprio S,Giannini C,Narayan D,Lin A,D'Adamo E,Shaw M,Pierpont B,Cushman SW,Shulman GI

更新日期：2013-03-01 00:00:00

abstract：:Cytoplasmic islet cell antibody-negative (ICA-; less than 20 Juvenile Diabetes Foundation units, n = 1670) and ICA+ (n = 42) first-degree relatives of type I (insulin-dependent) diabetic individuals were studied for competitive insulin autoantibodies (CIAAs) with a radioassay. Overall, 3.7% of first-degree relatives (...

journal_title：Diabetes

authors： Ziegler AG,Ziegler R,Vardi P,Jackson RA,Soeldner JS,Eisenbarth GS

更新日期：1989-10-01 00:00:00

abstract：:Glucagon-like peptide 1 receptor (GLP-1R) imaging with radiolabeled exendin has proven to be a powerful tool to quantify β-cell mass (BCM) in vivo. As GLP-1R expression is thought to be influenced by glycemic control, we examined the effect of blood glucose (BG) levels on GLP-1R-mediated exendin uptake in both murine ...

journal_title：Diabetes

authors： Buitinga M,Cohrs CM,Eter WA,Claessens-Joosten L,Frielink C,Bos D,Sandker G,Brom M,Speier S,Gotthardt M

更新日期：2020-11-01 00:00:00

abstract：:Continuous subcutaneous insulin infusion (CSII) was combined with antirejection therapy in four diabetic recipients of pancreas and kidney grafts with persisting hyperglycemia due to pancreas rejection. In three of the patients, full function of the pancreas was restored after as many as 40, 86, and 139 days of CSII. ...

journal_title：Diabetes

authors： Bartos V,Vanĕk I,Dryáková M,Saudek F,Malý J

更新日期：1989-01-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) and their receptors (FGFRs) are key signaling molecules for pancreas development. Although FGFR3 is a crucial developmental gene, acting as a negative regulator of bone formation, its participation remains unexplored in pancreatic organogenesis. We found that FGFR3 was expressed in the...

journal_title：Diabetes

authors： Arnaud-Dabernat S,Kritzik M,Kayali AG,Zhang YQ,Liu G,Ungles C,Sarvetnick N

更新日期：2007-01-01 00:00:00

abstract：:Adiponectin is an adipose tissue-specific protein with insulin-sensitizing and antiatherogenic properties. Therefore, the adiponectin gene is a promising candidate gene for type 2 diabetes. We investigated the single nucleotide polymorphisms (SNPs) +45T/G and +276G/T of the adiponectin gene as predictors for the conve...

journal_title：Diabetes

authors： Zacharova J,Chiasson JL,Laakso M,STOP-NIDDM Study Group.

更新日期：2005-03-01 00:00:00

abstract：:Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...

journal_title：Diabetes

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1980-01-01 00:00:00