Abstract:
:Hypoglycemia is associated with increased activity in the low-frequency bands in the electroencephalogram (EEG). We investigated whether hypoglycemia awareness and unawareness are associated with different hypoglycemia-associated EEG changes in patients with type 1 diabetes. Twenty-four patients participated in the study: 10 with normal hypoglycemia awareness and 14 with hypoglycemia unawareness. The patients were studied at normoglycemia (5-6 mmol/L) and hypoglycemia (2.0-2.5 mmol/L), and during recovery (5-6 mmol/L) by hyperinsulinemic glucose clamp. During each 1-h period, EEG, cognitive function, and hypoglycemia symptom scores were recorded, and the counterregulatory hormonal response was measured. Quantitative EEG analysis showed that the absolute amplitude of the θ band and α-θ band up to doubled during hypoglycemia with no difference between the two groups. In the recovery period, the θ amplitude remained increased. Cognitive function declined equally during hypoglycemia in both groups and during recovery reaction time was still prolonged in a subset of tests. The aware group reported higher hypoglycemia symptom scores and had higher epinephrine and cortisol responses compared with the unaware group. In patients with type 1 diabetes, EEG changes and cognitive performance during hypoglycemia are not affected by awareness status during a single insulin-induced episode with hypoglycemia.
journal_name
Diabetesjournal_title
Diabetesauthors
Sejling AS,Kjær TW,Pedersen-Bjergaard U,Diemar SS,Frandsen CS,Hilsted L,Faber J,Holst JJ,Tarnow L,Nielsen MN,Remvig LS,Thorsteinsson B,Juhl CBdoi
10.2337/db14-1359subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1760-9issue
5eissn
0012-1797issn
1939-327Xpii
db14-1359journal_volume
64pub_type
杂志文章相关文献
DIABETES文献大全abstract::Nerve conduction and electromyography (EMG) of insulin-dependent (type 1) diabetic patients with end-stage nephropathy was studied before and up to 10 yr after kidney transplantation (KTx). A series of nondiabetic KTx patients served as a comparison group. Motor nerve conduction velocity (NCV) was measured in the ulna...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.9.1247
更新日期:1988-09-01 00:00:00
abstract::We investigated the significance of the variants of the IRS-2 gene in patients with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by single-strand conformation polymorphism analysis in 40 Chinese and 40 Finnish patients with late-onset type 2 diabetes. The association of the variants of the IR...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.8.1949
更新日期:2001-08-01 00:00:00
abstract::By closing ATP-sensitive K+ (K+-ATP) channels, glucose promotes depolarization-dependent Ca2+ entry and cytoplasmic free Ca2+ concentration ([Ca2+]i) rise in beta-cells. Ca2+-dependent exocytosis of insulin granules is then potentiated by a K+-ATP channel-independent action of glucose. The underlying mechanisms of thi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.47.11.1713
更新日期:1998-11-01 00:00:00
abstract::Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1342
更新日期:2018-08-01 00:00:00
abstract::Myoblasts from human skeletal muscle were isolated from needle biopsy samples of vastus lateralis and fused to differentiated multinucleated myotubes. Specific high-affinity insulin and insulin-like growth factor I (IGF-I) binding, glucose transporter proteins GLUT1 and GLUT4, glycogen synthase and pyruvate dehydrogen...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.8.936
更新日期:1995-08-01 00:00:00
abstract::Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0666
更新日期:2017-12-01 00:00:00
abstract::To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.8.1015
更新日期:1994-08-01 00:00:00
abstract::It has been suggested that the hemodynamic derangements present in diabetic ketoacidosis are the results not only of profound volume depletion but also of the effects of increased production of vasodilating prostaglandins (PGs), principally PGI2, released by adipose tissue. In animal and in vitro models, prostaglandin...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.45.5.602
更新日期:1996-05-01 00:00:00
abstract::Obesity is one of the most serious threats to human health today. Although there is general agreement that environmental factors such as diet have largely caused the current obesity pandemic, the environmental changes have not affected all individuals equally. To model gene-by-environment interactions in a mouse model...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.6.1863
更新日期:2005-06-01 00:00:00
abstract::WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/db14-0444
更新日期:2015-03-01 00:00:00
abstract::The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to test whether this relationship is more pronounced among individuals with diabetes....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.12.3524
更新日期:2002-12-01 00:00:00
abstract::Mutation of tub gene in mice induces obesity, suggesting that tub could be an important regulator of energy balance. In the current study, we investigated whether insulin, leptin, and obesity can modulate Tub in vivo in hypothalamic nuclei, and we investigated possible consequences on energy balance, neuropeptide expr...
journal_title:Diabetes
pub_type: 杂志文章,收录出版
doi:10.2337/db11-1388
更新日期:2013-01-01 00:00:00
abstract::The selective impairment of glucose-induced insulin secretion in NIDDM can be attributed to defects in the glucose-signaling system. An alteration in the activity of phosphofructokinase (PFK), a key enzyme in the glycolytic pathway, may play a role in the abnormal glucose-induced insulin secretion. In this study, we e...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.9.1414
更新日期:1997-09-01 00:00:00
abstract::Both impaired glucose tolerance (IGT) (as defined by the 1985 World Health Organization criteria) and impaired fasting glucose (IFG) (as defined by the 1997 American Diabetes Association criteria) represent intermediate metabolic states between normal and diabetic glucose homeostasis. Cardiovascular disease may be rel...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.6.1549
更新日期:2004-06-01 00:00:00
abstract::There has been great interest in the browning of fat for the treatment of obesity. Although β-lapachone (BLC) has potential therapeutic effects on obesity, the fat-browning effect and thermogenic capacity of BLC on obesity have never been demonstrated. Here, we showed that BLC stimulated the browning of white adipose ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-1423
更新日期:2016-09-01 00:00:00
abstract::To elucidate the direct effect of rosiglitazone (RSG), a new thiazolidinedione antihyperglycemic agent, on pancreatic insulin secretion, an in situ investigation by rat pancreatic perfusion was performed. At a basal glucose concentration of 6 mmol/l, RSG (0.045-4.5 micromol/l) stimulated insulin release in a dose-depe...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.11.2598
更新日期:2001-11-01 00:00:00
abstract::Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.2.455
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To determine the role of hepatocyte growth factor (HGF)/c-Met on β-cell survival in diabetogenic conditions in vivo and in response to cytokines in vitro. RESEARCH DESIGN AND METHODS:We generated pancreas-specific c-Met-null (PancMet KO) mice and characterized their response to diabetes induced by multiple l...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1305
更新日期:2011-02-01 00:00:00
abstract::Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secretion. Mice lacking β-cell ABCA1 have increased islet expression of ABCG1, another cholesterol transpor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-1341
更新日期:2012-03-01 00:00:00
abstract::Hypothalamic "metabolic-sensing" neurons sense glucose and fatty acids (FAs) and play an integral role in the regulation of glucose, energy homeostasis, and the development of obesity and diabetes. Using pharmacologic agents, we previously found that ~50% of these neurons responded to oleic acid (OA) by using the FA t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-1689
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Human islet amyloid polypeptide (hIAPP) aggregation plays a major role in the development of islet amyloidosis in type 2 diabetes. It is known that extracellular hIAPP oligomers are toxic to pancreatic beta-cells and associated with apoptosis. We therefore investigated the molecular mechanism by which extrace...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-0178
更新日期:2007-09-01 00:00:00
abstract::The clearing of monoclonal and polyclonal and anti-insulin antibodies from homogeneous solutions at 100,000 X g was used to estimate the size of soluble insulin-antibody complexes at physiologic concentrations. Monoclonal antibodies cleared as a uniform population of 6.6 S independent of the insulin concentration. Pol...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.8.799
更新日期:1985-08-01 00:00:00
abstract::Nine offspring of two diabetic parents and 18 normals were studied with two intravenous glucose loads (o.5 gm./kg. body weight), 60 minutes apart. By thus stressing the beta cell, subtle defects could be identified in the prediabetics: (1) An inverse relationship between insulin peak response and insulin concentration...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.12.1184
更新日期:1977-12-01 00:00:00
abstract::In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, an...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.6.1986
更新日期:2002-06-01 00:00:00
abstract::Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endoto...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1491
更新日期:2007-07-01 00:00:00
abstract::The effect of nonenzymatic glycosylation on the biologic function of human antithrombin III was evaluated using a chromogenic thrombin substrate assay in the presence of catalytic amounts of heparin. Experimental conditions that increased the rate of nonenzymatic protein glycosylation were associated with decreases in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.6.532
更新日期:1984-06-01 00:00:00
abstract::This study addressed the controversial question of whether a negative-insulin-feedback loop exists in vivo. We utilized prehepatic insulin production, calculated by computerized deconvolution analysis of peripheral C-peptide concentration, as a measure of endogenous insulin secretion. Prehepatic insulin production was...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.36.8.959
更新日期:1987-08-01 00:00:00
abstract::In nonobese diabetic (NOD) mice, a deficiency in the number and function of invariant natural killer T-cells (iNKT cells) contributes to the onset of type 1 diabetes. The activation of CD1d-restricted iNKT cells by alpha-galactosylceramide (alpha-GalCer) corrects these deficiencies and protects against spontaneous and...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.5.1303
更新日期:2004-05-01 00:00:00
abstract::The responsiveness of the isolated perfused rat liver to different metabolic effects of insulin was investigated during recycling perfusion. Infusion of porcine insulin at rates of 6, 9, 16 and 33 mU/hr. resulted in stable perfusate insulin levels averaging 41, 72, 120 and 229 muU/ml., respectively. Since the portal v...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.2.225
更新日期:1975-02-01 00:00:00
abstract::Little information is available on cholesterol absorption and synthesis in human type 1 diabetes. We studied these variables using serum cholesterol precursor sterol ratios to cholesterol as surrogate markers of cholesterol synthesis and those of cholestanol and plant sterols to reflect cholesterol absorption in seven...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.9.2217
更新日期:2004-09-01 00:00:00