Insulin suppresses its own secretion in vivo.

abstract：:Plasma phospholipid transfer protein (PLTP) plays an important role in lipoprotein metabolism. PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. The aim of this study was to test the hypothesis that statins reduce PLTP activity and to examine the p...

journal_title：Diabetes

authors： Dallinga-Thie GM,van Tol A,Hattori H,Rensen PC,Sijbrands EJ

更新日期：2006-05-01 00:00:00

abstract：:Ectopic lipids in peripheral tissues have been implicated in attenuating insulin action in vivo. The botanical extract of Artemisia dracunculus L. (PMI 5011) improves insulin action, yet the precise mechanism is not known. We sought to determine whether the mechanism by which PMI 5011 improves insulin signaling is thr...

journal_title：Diabetes

authors： Obanda DN,Hernandez A,Ribnicky D,Yu Y,Zhang XH,Wang ZQ,Cefalu WT

更新日期：2012-03-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential interest for the treatment of type 2 diabetes. To evaluate actions of NN2211, a long-acting GLP-1 derivative, we examined 11 patients with type 2 diabetes, age 59 +/- 7 years (mean +/- SD), BMI 28.9 +/- 3.0 kg/m(2), HbA(1c) 6.5 +/- 0.6%, i...

journal_title：Diabetes

authors： Juhl CB,Hollingdal M,Sturis J,Jakobsen G,Agersø H,Veldhuis J,Pørksen N,Schmitz O

更新日期：2002-02-01 00:00:00

abstract：:Adult, male ICR Swiss mice are susceptible to the diabetogenic effects of the D-variant of encephalomyocarditis virus (EMC-D) in contrast to adult C3H/HeJ male mice, which are relatively resistant. To date, experimental evidence suggests that the immune system plays a role in the pathogenesis of this infection. We hav...

journal_title：Diabetes

authors： Gould CL,McMannama KG,Bigley NJ,Giron DJ

更新日期：1985-12-01 00:00:00

abstract：:In IDDM, the gluconeogenic turnover of amino acids is increased even if glycemia is well controlled and may be restored to normal by means of prehepatic insulin substitution. Therefore, the present study was designed 1) to investigate the influence of route of insulin administration (portal versus peripheral) on the u...

journal_title：Diabetes

authors： Freyse EJ,Rebrin K,Schneider T,Petrzika M,Fischer U

更新日期：1996-05-01 00:00:00

abstract：:Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treat...

journal_title：Diabetes

authors： Sorenson RL,Grouse LH,Elde RP

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:Mutations in the insulin (INS) gene can cause neonatal diabetes. We hypothesized that mutations in INS could also cause maturity-onset diabetes of the young (MODY) and autoantibody-negative type 1 diabetes. RESEARCH DESIGN AND METHODS:We screened INS in 62 probands with MODY, 30 probands with suspected MODY,...

journal_title：Diabetes

authors： Molven A,Ringdal M,Nordbø AM,Raeder H,Støy J,Lipkind GM,Steiner DF,Philipson LH,Bergmann I,Aarskog D,Undlien DE,Joner G,Søvik O,Norwegian Childhood Diabetes Study Group.,Bell GI,Njølstad PR

更新日期：2008-04-01 00:00:00

abstract：:The sustained expression of the MAFB transcription factor in human islet β-cells represents a distinct difference in mice. Moreover, mRNA expression of closely related and islet β-cell-enriched MAFA does not peak in humans until after 9 years of age. We show that the MAFA protein also is weakly produced within the juv...

journal_title：Diabetes

authors： Cyphert HA,Walker EM,Hang Y,Dhawan S,Haliyur R,Bonatakis L,Avrahami D,Brissova M,Kaestner KH,Bhushan A,Powers AC,Stein R

更新日期：2019-02-01 00:00:00

abstract：:Many individuals with diabetes experience impaired cardiac contractility that cannot be explained by hypertension and atherosclerosis. This cardiomyopathy may be due to either organ-based damage, such as fibrosis, or to direct damage to cardiomyocytes. Reactive oxygen species (ROS) have been proposed to contribute to ...

journal_title：Diabetes

authors： Ye G,Metreveli NS,Ren J,Epstein PN

更新日期：2003-03-01 00:00:00

abstract：:Islet duodenal homeobox 1 (IDX-1/PF-1/STF-1/PDX-1), a homeodomain protein that transactivates the insulin promoter, has been shown by targeted gene ablation to be required for pancreatic development. After 90% pancreatectomy (Px), the adult pancreas regenerates in a process recapitulating embryonic development, starti...

journal_title：Diabetes

authors： Sharma A,Zangen DH,Reitz P,Taneja M,Lissauer ME,Miller CP,Weir GC,Habener JF,Bonner-Weir S

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of preexisting autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigated the role of a key pregnancy hormone...

journal_title：Diabetes

authors： Ueno A,Cho S,Cheng L,Wang J,Hou S,Nakano H,Santamaria P,Yang Y

更新日期：2007-06-01 00:00:00

abstract：:To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model of type 2 diabetes, were mated with either heterozygous knockout mice or two types of transgenic mice of 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone located in the ER. Systemic expression of ORP150 in Ak...

journal_title：Diabetes

authors： Ozawa K,Miyazaki M,Matsuhisa M,Takano K,Nakatani Y,Hatazaki M,Tamatani T,Yamagata K,Miyagawa J,Kitao Y,Hori O,Yamasaki Y,Ogawa S

更新日期：2005-03-01 00:00:00

abstract：:Microinflammation is a common major mechanism in the pathogenesis of diabetic vascular complications, including diabetic nephropathy. Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages. This study aimed to determine the role of SR-A in diabetic nephropathy using SR-A-deficien...

journal_title：Diabetes

authors： Usui HK,Shikata K,Sasaki M,Okada S,Matsuda M,Shikata Y,Ogawa D,Kido Y,Nagase R,Yozai K,Ohga S,Tone A,Wada J,Takeya M,Horiuchi S,Kodama T,Makino H

更新日期：2007-02-01 00:00:00

abstract：:Type 1 diabetes appears to progress not as an uncontrolled autoimmune attack on the pancreatic islet beta-cells, but rather in a highly regulated manner. Leukocytic infiltration of the pancreatic islets by autoimmune cells, or insulitis, can persist for long periods of time before the terminal destruction of beta-cell...

journal_title：Diabetes

authors： Matos M,Park R,Mathis D,Benoist C

更新日期：2004-09-01 00:00:00

abstract：:Class IIa histone deacetylases (HDACs), such as HDAC4, HDAC5, and HDAC7, provide critical mechanisms for regulating glucose homeostasis. Here we report that HDAC9, another class IIa HDAC, regulates hepatic gluconeogenesis via deacetylation of a Forkhead box O (FoxO) family transcription factor, FoxO1, together with HD...

journal_title：Diabetes

authors： Chen J,Wang N,Dong M,Guo M,Zhao Y,Zhuo Z,Zhang C,Chi X,Pan Y,Jiang J,Tang H,Niu J,Yang D,Li Z,Han X,Wang Q,Chen X

更新日期：2015-12-01 00:00:00

abstract：:A number of patients with type 2 diabetes are GAD antibody positive. A Diabetes Outcome Progression Trial (ADOPT) is a randomized, double-blind clinical trial in recently diagnosed drug-naive patients with type 2 diabetes that allows for the evaluation of GAD positivity in the context of anthropometric and biochemical...

journal_title：Diabetes

authors： Zinman B,Kahn SE,Haffner SM,O'Neill MC,Heise MA,Freed MI,ADOPT Study Group.

更新日期：2004-12-01 00:00:00

abstract：:The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells in type 1 diabetes. However, transient transgene expression and the tendency...

journal_title：Diabetes

authors： Flotte T,Agarwal A,Wang J,Song S,Fenjves ES,Inverardi L,Chesnut K,Afione S,Loiler S,Wasserfall C,Kapturczak M,Ellis T,Nick H,Atkinson M

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic beta-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the beta-cell mass and reverse hyperglycemia in NOD mice with autoimmune diabetes. RESEARCH DESIGN AND METHODS:Acutely diabetic NOD mice were tr...

journal_title：Diabetes

authors： Suarez-Pinzon WL,Power RF,Yan Y,Wasserfall C,Atkinson M,Rabinovitch A

更新日期：2008-12-01 00:00:00

abstract：:Monolayer cultures of islet B-cells were established from neonatal rat pancreas. Serum-free media conditioned by these cultures for 72 h were concentrated and fractionated on Sephadex G-50 at acid pH into a high-molecular-weight pool containing binding protein for insulin-like growth factors (IGFs) and a low-molecular...

journal_title：Diabetes

authors： Romanus JA,Rabinovitch A,Rechler MM

更新日期：1985-07-01 00:00:00

abstract：:Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) ...

journal_title：Diabetes

authors： Nishimura S,Nagasaki M,Okudaira S,Aoki J,Ohmori T,Ohkawa R,Nakamura K,Igarashi K,Yamashita H,Eto K,Uno K,Hayashi N,Kadowaki T,Komuro I,Yatomi Y,Nagai R

更新日期：2014-12-01 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is an α-arrestin that can bind to and inhibit the antioxidant protein thioredoxin (TXN). TXNIP expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. TXNIP is currently studied as a pote...

journal_title：Diabetes

authors： Katsu-Jiménez Y,Vázquez-Calvo C,Maffezzini C,Halldin M,Peng X,Freyer C,Wredenberg A,Giménez-Cassina A,Wedell A,Arnér ESJ

更新日期：2019-04-01 00:00:00

abstract：:To evaluate the effects of gestational hyperglycemia on glucose metabolism and its regulation in the fasted rat during the early postnatal period, unrestrained rats were continuously infused with glucose during the last week of pregnancy. Control rats were infused with distilled water. Newborns were studied during the...

journal_title：Diabetes

authors： Nurjhan N,Ktorza A,Ferre P,Girard JR,Picon L

更新日期：1985-10-01 00:00:00

abstract：:Groups of young adult rats with body weights of 125-135 g (group A) or 300-400 g (group B) were subjected to one bout of prolonged exercise to exhaustion on a treadmill and were studied 2 h postexercise. Liver glycogen levels were markedly depleted in the exercised rats. Adipocytes from group A exercised rats showed a...

journal_title：Diabetes

authors： Begum N,Terjung RL,Tepperman HM,Tepperman J

更新日期：1986-07-01 00:00:00

abstract：:Exercise-induced hyperinsulinism (EIHI) is an autosomal dominant disorder characterized by inappropriate insulin secretion in response to vigorous physical exercise or pyruvate injection. Activating mutations in the monocarboxylate transporter-1 (MCT1, SLC16A1) promoter have been linked to EIHI. Expression of this pyr...

journal_title：Diabetes

authors： Pullen TJ,Sylow L,Sun G,Halestrap AP,Richter EA,Rutter GA

更新日期：2012-07-01 00:00:00

abstract：:We have biochemically treated (periodate, borohydride, neuraminidase, organic solvents) frozen sections of human pancreas and studied the reactivity of islet-cell-antibody-positive human sera and monoclonal antibodies. The autoantigen of pancreatic sections has the properties of sialic acid containing glycolipid. ...

journal_title：Diabetes

authors： Nayak RC,Omar MA,Rabizadeh A,Srikanta S,Eisenbarth GS

更新日期：1985-06-01 00:00:00

abstract：:Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE recept...

journal_title：Diabetes

authors： Poirier O,Nicaud V,Vionnet N,Raoux S,Tarnow L,Vlassara H,Parving HH,Cambien F

更新日期：2001-05-01 00:00:00

abstract：:This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogeneous Chinese sample with a total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage to type 2 diabetes/IGH in the Chinese. The region showin...

journal_title：Diabetes

authors： Xiang K,Wang Y,Zheng T,Jia W,Li J,Chen L,Shen K,Wu S,Lin X,Zhang G,Wang C,Wang S,Lu H,Fang Q,Shi Y,Zhang R,Xu J,Weng Q

更新日期：2004-01-01 00:00:00

abstract：:Members of the tumor necrosis factor receptor superfamily play an important role in the initiation, expansion, and termination of an immune response. It has recently been demonstrated that one member of this family, CD30, plays a central role in maintaining peripheral tolerance by controlling the expansion of autoreac...

journal_title：Diabetes

authors： Siegmund T,Armitage N,Wicker LS,Peterson LB,Todd JA,Lyons PA

更新日期：2000-09-01 00:00:00

abstract：:The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of 111In-diethylenetriaminepentaacetic acid-exendin-3 (111In-exendin) in a rat model that closely mimics the...

journal_title：Diabetes

authors： Brom M,Joosten L,Frielink C,Peeters H,Bos D,van Zanten M,Boerman O,Gotthardt M

更新日期：2018-10-01 00:00:00

abstract：:Currently, the major indications for solitary islet transplantation are recurrent severe hypoglycemia and labile glucose control. Quantifying these problems remains subjective. We have developed a scoring system for both hypoglycemia and glycemic lability, established normative data, and used them in patients who have...

journal_title：Diabetes

authors： Ryan EA,Shandro T,Green K,Paty BW,Senior PA,Bigam D,Shapiro AM,Vantyghem MC

更新日期：2004-04-01 00:00:00