Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview.

abstract：:Counterregulatory hormonal responses were studied in six patients after 4-18 mo treatment with a continuous subcutaneous insulin infusion pump. In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of...

journal_title：Diabetes

authors： Bergenstal RM,Polonsky KS,Pons G,Jaspan JB,Rubenstein AH

更新日期：1983-05-01 00:00:00

abstract：:New cellular-based reagents are needed to diagnose type I diabetes as well as to monitor the outcomes of clinical trials at early time points. Four new monoclonal antibodies (mAbs) have been shown to demonstrate reduced binding to lymphocytes from identical twins with long-term type I diabetes relative to that observe...

journal_title：Diabetes

authors： Pinies JA,Fu Y,Vazquez JA,Faustman D

更新日期：1997-03-01 00:00:00

abstract：:The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...

journal_title：Diabetes

authors： Heise T,Nosek L,Rønn BB,Endahl L,Heinemann L,Kapitza C,Draeger E

更新日期：2004-06-01 00:00:00

abstract：:MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX significantly (P < 0.05) reduced plasma glucose (6.9 +/- 0.3 vs. 19.2 +/- 1.3 mM) and serum triglyceride (0.17 +/- 0.01 vs. 1.82 +/- 0.39 mM) levels in overnight-...

journal_title：Diabetes

authors： Johnson MB,Heineke EW,Rhinehart BL,Sheetz MJ,Barnhart RL,Robinson KM

更新日期：1993-08-01 00:00:00

abstract：:Based on studies of both man and rat, it is proposed that at least three distinct syndromes of hypertriglyceridemia occur as the result of abnormalities of carbohydrate metabolism. We believe that these syndromes are the predictable results of the changes in plasma insulin and/or free fatty acid (FFA) concentration th...

journal_title：Diabetes

authors： Reaven GM,Greenfield MS

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:In humans, it is unclear if insulin resistance at the monocyte level is associated with atherosclerosis in vivo. Here we have studied first-degree relatives of patients with type 2 diabetes to investigate whether a reduction in components of the insulin signal transduction pathways, such as the insulin recept...

journal_title：Diabetes

authors： Cardellini M,Menghini R,Luzi A,Davato F,Cardolini I,D'Alfonso R,Gentileschi P,Rizza S,Marini MA,Porzio O,Lauro D,Sbraccia P,Lauro R,Federici M

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Antecedent hypoglycemia can blunt neuroendocrine and autonomic nervous system responses to next-day exercise in type 1 diabetes. The aim of this study was to determine whether antecedent increase of plasma cortisol is a mechanism responsible for this finding. RESEARCH DESIGN AND METHODS:For this study, 22 ty...

journal_title：Diabetes

authors： Bao S,Briscoe VJ,Tate DB,Davis SN

更新日期：2009-09-01 00:00:00

abstract：:Previous studies have indicated that individuals with type 2 diabetes have an increased resting metabolic rate (RMR) but decreased insulin-induced thermogenesis (IIT) compared with those with normal glucose tolerance (NGT). When and by which mechanisms these abnormalities occur during the development of diabetes remai...

journal_title：Diabetes

authors： Weyer C,Bogardus C,Pratley RE

更新日期：1999-08-01 00:00:00

abstract：:Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release, and thereby glucose homeostasis, is associated with subtle changes in Ca(2+) dynamics in mouse β-cells. We show that these changes are likely to...

journal_title：Diabetes

authors： Li L,Trifunovic A,Köhler M,Wang Y,Petrovic Berglund J,Illies C,Juntti-Berggren L,Larsson NG,Berggren PO

更新日期：2014-12-01 00:00:00

abstract：:Complementary DNA encoding three catalytic subunits of protein phosphatase 1 (PP1 alpha, PP1 beta, and PP1 gamma) and the insulin-stimulated protein kinase 1 (ISPK-1) was analyzed for variations in the coding regions related to insulin-resistant glycogen synthesis in skeletal muscle of 30 patients with non-insulin-dep...

journal_title：Diabetes

authors： Bjørbaek C,Vik TA,Echwald SM,Yang PY,Vestergaard H,Wang JP,Webb GC,Richmond K,Hansen T,Erikson RL

更新日期：1995-01-01 00:00:00

abstract：:We recently showed that a peptide of the M(r) 60,000 heat shock protein molecule, designated peptide p277, is a target of T-cells in autoimmune diabetes in NOD mice. Indeed, the p277 peptide could be used as a therapeutic agent to arrest the autoimmune process even after it was far advanced. The present study was done...

journal_title：Diabetes

authors： Elias D,Cohen IR

更新日期：1995-09-01 00:00:00

abstract：:An epidemic of obesity and type 2 diabetes is linked with the increase in consumption of fructose-containing sugars, such as sucrose and high-fructose corn syrup. In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. He...

journal_title：Diabetes

authors： Marek G,Pannu V,Shanmugham P,Pancione B,Mascia D,Crosson S,Ishimoto T,Sautin YY

更新日期：2015-02-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis). Recently, we reported that two distinct patterns of insulitis occur in patients with recent-onset ...

journal_title：Diabetes

authors： Leete P,Willcox A,Krogvold L,Dahl-Jørgensen K,Foulis AK,Richardson SJ,Morgan NG

更新日期：2016-05-01 00:00:00

abstract：:Adiponectin is an adipose tissue-specific protein with insulin-sensitizing and antiatherogenic properties. Therefore, the adiponectin gene is a promising candidate gene for type 2 diabetes. We investigated the single nucleotide polymorphisms (SNPs) +45T/G and +276G/T of the adiponectin gene as predictors for the conve...

journal_title：Diabetes

authors： Zacharova J,Chiasson JL,Laakso M,STOP-NIDDM Study Group.

更新日期：2005-03-01 00:00:00

abstract：:Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential ...

journal_title：Diabetes

authors： Suzuki K,Hata S,Kawabata Y,Sorimachi H

更新日期：2004-02-01 00:00:00

abstract：:We previously reported a syndrome of severe hyperinsulinemia and early-onset hypertension in three patients with dominant-negative mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR)-gamma. We now report the results of further detailed pathophysiological evaluation of these subj...

journal_title：Diabetes

authors： Savage DB,Tan GD,Acerini CL,Jebb SA,Agostini M,Gurnell M,Williams RL,Umpleby AM,Thomas EL,Bell JD,Dixon AK,Dunne F,Boiani R,Cinti S,Vidal-Puig A,Karpe F,Chatterjee VK,O'Rahilly S

更新日期：2003-04-01 00:00:00

abstract：:A pancreatic alpha-like cell line has been established from a glucagonoma arising in transgenic mice expressing a hybrid gene consisting of the rat glucagon-promoter sequence fused to the sequence encoding the SV40 T-antigen oncoprotein. The alpha-tumor cell 1 (alpha TC1) line maintained many characteristics of differ...

journal_title：Diabetes

authors： Powers AC,Efrat S,Mojsov S,Spector D,Habener JF,Hanahan D

更新日期：1990-04-01 00:00:00

abstract：:Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially confounded by developmental adaptation of animal physiology. We aimed to adapt the technique of in vivo electrotransfer (IVE) to alter local gene expression in skeletal muscle of rodents as a means of investigating the role ...

journal_title：Diabetes

authors： Cleasby ME,Davey JR,Reinten TA,Graham MW,James DE,Kraegen EW,Cooney GJ

更新日期：2005-09-01 00:00:00

abstract：:Insulin receptor substrate (IRS)-1 protein expression is markedly reduced in many insulin-resistant states, although the mechanism for this downregulation is unclear. In this study, we have investigated the early events in the insulin pathway that trigger the degradation of IRS-1. Incubation of the adipocytes with ins...

journal_title：Diabetes

authors： Pederson TM,Kramer DL,Rondinone CM

更新日期：2001-01-01 00:00:00

abstract：:The efficacy of gangliosides in enhancing axonal regeneration and maturation in the early stages of diabetic neuropathy was assessed by quantitative analysis of immunostained serial sections of the sciatic nerve. Sprague-Dawley rats were made diabetic with a single injection of alloxan (100 mg/kg). One week later they...

journal_title：Diabetes

authors： Triban C,Guidolin D,Fabris M,Marini P,Schiavinato A,Donà M,Bortolami MC,Di Giamberardino L,Fiori MG

更新日期：1989-08-01 00:00:00

abstract：:Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces visceral obesity and the metabolic s...

journal_title：Diabetes

authors： Kershaw EE,Morton NM,Dhillon H,Ramage L,Seckl JR,Flier JS

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：:Monocyte-to-macrophage differentiation is a critical event that accentuates atherosclerosis by promoting an inflammatory environment within the vessel wall. In this study, we investigated the molecular mechanisms responsible for monocyte-to-macrophage differentiation and, subsequently, the effect of metformin in regre...

journal_title：Diabetes

authors： Vasamsetti SB,Karnewar S,Kanugula AK,Thatipalli AR,Kumar JM,Kotamraju S

更新日期：2015-06-01 00:00:00

abstract：:We have recently shown that leptin, the product of the obese gene, can directly influence T-cell function. In the work presented here, we explored the role of leptin in the development of spontaneous autoimmunity in the nonobese diabetic (NOD) mouse, an animal model for the study of human insulin-dependent diabetes me...

journal_title：Diabetes

authors： Matarese G,Sanna V,Lechler RI,Sarvetnick N,Fontana S,Zappacosta S,La Cava A

更新日期：2002-05-01 00:00:00

abstract：:Genes play a role in many processes underlying late diabetic complications, but efforts to identify genetic variants have produced disappointing and contradictory results. Here, we evaluate whether the study designs and analytic methods commonly being used are optimal for finding susceptibility genes for diabetic comp...

journal_title：Diabetes

authors： Rogus JJ,Warram JH,Krolewski AS

更新日期：2002-06-01 00:00:00

abstract：:Insulin lispro is a human insulin analog that dissociates more rapidly than human regular insulin after subcutaneous injection, resulting in higher insulin levels at an earlier point in time and a shorter duration of action. The aim of the study was to evaluate if this pharmacokinetic difference would translate into b...

journal_title：Diabetes

authors： Zinman B,Tildesley H,Chiasson JL,Tsui E,Strack T

更新日期：1997-03-01 00:00:00

abstract：:In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with sh...

journal_title：Diabetes

authors： Rodriguez-Calvo T,Krogvold L,Amirian N,Dahl-Jørgensen K,von Herrath M

更新日期：2021-01-07 00:00:00

abstract：:The relative effects of time versus ambient glucose concentration on insulin-stimulated glucose uptake was estimated by performing 5-h insulin clamp studies in patients with NIDDM. Each experimental subject was studied three times, at steady-state plasma insulin levels approximately 2000 microU/ml, but at different st...

journal_title：Diabetes

authors： Liu G,Chen YD,Hollenbeck CB,Lardinois CK,Reaven GM

更新日期：1984-07-01 00:00:00

abstract：:Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic gluc...

journal_title：Diabetes

authors： Ott V,Lehnert H,Staub J,Wönne K,Born J,Hallschmid M

更新日期：2015-03-01 00:00:00

abstract：:Diabetes-induced alterations in heme and hemoproteins, as well as its relationship to drug-mediated induction of ALA Synthase (ALA-S), were examined in female Sprague-Dawley rats. Animals were rendered diabetic by a single i.v. injection of streptozotocin (STZ, 65 mg/kg) and measurements were made at various times aft...

journal_title：Diabetes

authors： Bitar M,Weiner M

更新日期：1984-01-01 00:00:00