Effects of differing antecedent increases of plasma cortisol on counterregulatory responses during subsequent exercise in type 1 diabetes.

abstract：:Hyperglycemia upon hospital admission in patients with ST-segment elevation myocardial infarction (STEMI) occurs frequently and is associated with adverse outcomes. It is, however, unsettled as to whether an elevated blood glucose level is the cause or consequence of increased myocardial damage. In addition, whether t...

journal_title：Diabetes

authors： Lønborg J,Vejlstrup N,Kelbæk H,Nepper-Christensen L,Jørgensen E,Helqvist S,Holmvang L,Saunamäki K,Bøtker HE,Kim WY,Clemmensen P,Treiman M,Engstrøm T

更新日期：2014-07-01 00:00:00

abstract：:Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige adipocyte differentiation are essential to implement such therapeutic strategies. We report a straightforward and efficient protocol to generate functional human be...

journal_title：Diabetes

authors： Guénantin AC,Briand N,Capel E,Dumont F,Morichon R,Provost C,Stillitano F,Jeziorowska D,Siffroi JP,Hajjar RJ,Fève B,Hulot JS,Collas P,Capeau J,Vigouroux C

更新日期：2017-06-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Regulation of obesity development is an important issue to prevent metabolic syndromes. Gene-disrupted mice of phospholipase Cδ1 (PLCδ1), a key enzyme of phosphoinositide turnover, seemed to show leanness. Here we examined whether and how PLCδ1 is involved in obesity. RESEARCH DESIGN AND METHODS:Weight gain,...

journal_title：Diabetes

authors： Hirata M,Suzuki M,Ishii R,Satow R,Uchida T,Kitazumi T,Sasaki T,Kitamura T,Yamaguchi H,Nakamura Y,Fukami K

更新日期：2011-07-01 00:00:00

abstract：:This study examined the suitability of commercial U.S.P. insulin as a bacterial growth medium. Purified port insulin (Iletin II, Eli Lilly & Co., Indianapolis, Indiana) was inoculated with approximately 500,000 bacteria per ml of: (1) Staphylococcus epidermidis, (2) Staphylococcus aureus, or (3) Escherichia coli. All ...

journal_title：Diabetes

authors： Schade DS,Eaton RP

更新日期：1982-01-01 00:00:00

abstract：:Rat pancreatic islets were incubated in vitro with L-[4,5-3H]leucine or with L-[2,3-3H]tryptophan in Krebs-Ringer bicarbonate buffer, containing 0, 5, or 20 mM glucose. Incorporation of labeled amino acids in islet cells was evaluated quantitatively by a validated radioautographic procedure. Incorporation of labeled l...

journal_title：Diabetes

authors： Logothetopoulos J,Jain K

更新日期：1980-10-01 00:00:00

abstract：:Previous studies have provided evidence for the transcripts of Cx43 and Cx45 within pancreatic islets. As of yet, however, it has proven difficult to unambiguously demonstrate the expression of these proteins by islet cells. We have investigated whether Cx36, a new connexin species recently identified in mammalian bra...

journal_title：Diabetes

authors： Serre-Beinier V,Le Gurun S,Belluardo N,Trovato-Salinaro A,Charollais A,Haefliger JA,Condorelli DF,Meda P

更新日期：2000-05-01 00:00:00

abstract：:Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31+CD14+CD34+ monocyte subset via three-dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the effica...

journal_title：Diabetes

authors： Oh BJ,Jin SM,Hwang Y,Choi JM,Lee HS,Kim G,Kim G,Park HJ,Kim P,Kim SJ,Kim JH

更新日期：2018-03-01 00:00:00

abstract：:A major goal of the study was to assess the methodologies available for the quantification of retinal lesions suitable for application in trials of metabolic management. We describe the methods used for grading stereoscopic color fundus photographs. Overall retinopathy severity level for each eye ranging from normal (...

journal_title：Diabetes

authors： Davis MD,Hubbard LD,Trautman J,Klein R

更新日期：1985-08-01 00:00:00

abstract：:Twenty-four-hour patterns of plasma growth hormone concentrations were evaluated during 50 studies of 42 subjects with juvenile-onset diabetes mellitus. Blood was sampled continuously over 24 h using a portable peristaltic pump under conditions in which subjects remained ambulatory and maintained their daily dietary a...

journal_title：Diabetes

authors： Hayford JT,Danney MM,Hendrix JA,Thompson RG

更新日期：1980-05-01 00:00:00

abstract：:Because it is unknown whether 24-h energy expenditure (EE) responses to dietary extremes will identify phenotypes associated with weight regulation, the aim of this study was to determine whether such responses to fasting or overfeeding are associated with future weight change. The 24-h EE during energy balance, fasti...

journal_title：Diabetes

authors： Schlögl M,Piaggi P,Pannacciuli N,Bonfiglio SM,Krakoff J,Thearle MS

更新日期：2015-11-01 00:00:00

abstract：:The effect of metabolic near-normalization, induced by continuous subcutaneous insulin infusion, on the exaggerated microalbuminuria of exercise was studied in eight insulin-dependent diabetic men selected for normal resting albuminuria. Patients were studied in randomized order during the ordinary glycemic control of...

journal_title：Diabetes

authors： Viberti G,Pickup JC,Bilous RW,Keen H,Mackintosh D

更新日期：1981-10-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients with type 2 diabetes. In...

journal_title：Diabetes

authors： Hansen SL,Bojsen-Møller KN,Lundsgaard AM,Hendrich FL,Nilas L,Sjøberg KA,Hingst JR,Serup AK,Olguín CH,Carl CS,Wernblad LF,Henneberg M,Lustrup KM,Hansen C,Jensen TE,Madsbad S,Wojtaszewski JFP,Richter EA,Kiens B

更新日期：2020-11-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00

abstract：:The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic gl...

journal_title：Diabetes

authors： Simonson DC,Ferrannini E,Bevilacqua S,Smith D,Barrett E,Carlson R,DeFronzo RA

更新日期：1984-09-01 00:00:00

abstract：:The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, ap...

journal_title：Diabetes

authors： Eto M,Watanabe K,Iwashima Y,Morikawa A,Chonan N,Oshima E,Sekiguchi M,Ishii K

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:CD8(+) T-cells specific for islet antigens are essential for the development of type 1 diabetes in the NOD mouse model of the disease. Such T-cells can also be detected in the blood of type 1 diabetic patients, suggesting their importance in the pathogenesis of the human disease as well. The development of pe...

journal_title：Diabetes

authors： Jarchum I,Baker JC,Yamada T,Takaki T,Marron MP,Serreze DV,DiLorenzo TP

更新日期：2007-10-01 00:00:00

abstract：:Methylglyoxal (MGO), a major precursor for advanced glycation end products, is increased in diabetes. In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD). Whether plasma MGO levels are associated with incident CVD in people with type 1 diabetes is unknown. We included 159 individuals with pers...

journal_title：Diabetes

authors： Hanssen NMJ,Scheijen JLJM,Jorsal A,Parving HH,Tarnow L,Rossing P,Stehouwer CDA,Schalkwijk CG

更新日期：2017-08-01 00:00:00

abstract：:There has been great interest in the browning of fat for the treatment of obesity. Although β-lapachone (BLC) has potential therapeutic effects on obesity, the fat-browning effect and thermogenic capacity of BLC on obesity have never been demonstrated. Here, we showed that BLC stimulated the browning of white adipose ...

journal_title：Diabetes

authors： Choi WH,Ahn J,Jung CH,Jang YJ,Ha TY

更新日期：2016-09-01 00:00:00

abstract：:Results from experimental and gene-association studies suggest that IGF-II may influence body weight regulation and that individuals with low IGF-II levels may be more susceptible to weight gain and obesity. We therefore assessed the association between circulating concentrations of IGF-II and subsequent weight gain a...

journal_title：Diabetes

authors： Sandhu MS,Gibson JM,Heald AH,Dunger DB,Wareham NJ

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:We have developed a novel platform for display and delivery of bioactive peptides that links the biological properties of the peptide to the pharmacokinetic properties of an antibody. Peptides engineered in the MIMETIBODY platform have improved biochemical and biophysical properties that are quite distinct fr...

journal_title：Diabetes

authors： Picha KM,Cunningham MR,Drucker DJ,Mathur A,Ort T,Scully M,Soderman A,Spinka-Doms T,Stojanovic-Susulic V,Thomas BA,O'Neil KT

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Polymerase I and transcript release factor (PTRF) is a protein highly expressed in adipose tissue and is an integral structural component of caveolae. Here, we report on a novel role of PTRF in lipid mobilization. RESEARCH DESIGN AND METHODS:PTRF expression was examined in different adipose depots of mice du...

journal_title：Diabetes

authors： Aboulaich N,Chui PC,Asara JM,Flier JS,Maratos-Flier E

更新日期：2011-03-01 00:00:00

abstract：:To determine the role of prolactin in increasing junctional communication among islet beta-cells, we studied dye coupling in pancreatic islets exposed to elevated levels of prolactin in vivo and in vitro. Islets were isolated from rats immediately after lactation or from rats bearing mammosomatotropic tumors (MtTW15),...

journal_title：Diabetes

authors： Michaels RL,Sorenson RL,Parsons JA,Sheridan JD

更新日期：1987-10-01 00:00:00

abstract：:A genome scan for B10-derived loci that reduce the frequency of diabetes and insulitis in NOD mice demonstrated a large region (34 cM) of linkage on the proximal end of chromosome 1. This locus was designated Idd5 and encompassed candidate genes including Il1r1, Il1r2, Stat1, Stat4, Nramp1, and Bcl2. In the current st...

journal_title：Diabetes

authors： Hill NJ,Lyons PA,Armitage N,Todd JA,Wicker LS,Peterson LB

更新日期：2000-10-01 00:00:00

abstract：:The effects of oral vanadate supplementation on intestinal morphometry and glucose transport were examined in STZ-induced diabetic and age-matched control male Sprague-Dawley rats. Animals received 0.1 mg/ml vanadium pentoxide in their drinking water over 14 days. Vanadate reduced intestinal glucose maximal transport ...

journal_title：Diabetes

authors： Madsen KL,Porter VM,Fedorak RN

更新日期：1993-08-01 00:00:00

abstract：:To clarify the relationship between abnormality of sorbitol and/or myo-inositol metabolism caused by hyperglycemia and diabetic macroangiopathy, we investigated the effects of high glucose concentrations and epalrestat, an aldose reductase inhibitor, on the metabolism of sorbitol and myo-inositol in cultured rabbit ao...

journal_title：Diabetes

authors： Sakakibara F,Hotta N,Koh N,Sakamoto N

更新日期：1993-11-01 00:00:00

abstract：:Antibodies to islet cell proteins detected as 37,000 and 40,000 M(r), tryptic fragments (37- and 40-kDa antigens) are strongly associated with progression to IDDM. The 40-kDa antigen has recently been identified as the tyrosine phosphatase-like protein IA-2 (ICA512) whereas the 37-kDa antigen has been suggested to be ...

journal_title：Diabetes

authors： Hawkes CJ,Wasmeier C,Christie MR,Hutton JC

更新日期：1996-09-01 00:00:00

abstract：:Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release, and thereby glucose homeostasis, is associated with subtle changes in Ca(2+) dynamics in mouse β-cells. We show that these changes are likely to...

journal_title：Diabetes

authors： Li L,Trifunovic A,Köhler M,Wang Y,Petrovic Berglund J,Illies C,Juntti-Berggren L,Larsson NG,Berggren PO

更新日期：2014-12-01 00:00:00

abstract：:Ciglitazone, 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione, is a new hypoglycemic agent orally active in the obese-hyperglycemic animal models. In C57BL/6J-ob/ob mice, treatment with 100 mg/kg ciglitazone for 2 days elicited a drastic fall in blood glucose. It also decreased plasma insulin, triglycer...

journal_title：Diabetes

authors： Chang AY,Wyse BM,Gilchrist BJ,Peterson T,Diani AR

更新日期：1983-09-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that adrenergic activation, cholinergic activation, or both, mediate the effect of recent antecedent hypoglycemia to reduce the sympathoadrenal response to subsequent hypoglycemia, the key feature of hypoglycemia-associated autonomic failure in diabetes, in humans. RESEARCH DESIGN AN...

journal_title：Diabetes

authors： Ramanathan R,Cryer PE

更新日期：2011-02-01 00:00:00