Adrenergic mediation of hypoglycemia-associated autonomic failure.

abstract：:Myocardial dysfunction, perfusion abnormalities, and the extent to which these abnormalities may be reversed by C-peptide administration was assessed in type 1 diabetic patients. Eight patients were studied before and during a 0.84-mg/kg dipyridamole administration using a randomized double-blind crossover protocol wi...

journal_title：Diabetes

authors： Hansen A,Johansson BL,Wahren J,von Bibra H

更新日期：2002-10-01 00:00:00

abstract：:On the basis of the positive outcome of animal experiments, several large placebo-controlled trials are underway and aiming for the first time at the prevention of an immune-mediated disease, type 1 diabetes. The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical effica...

journal_title：Diabetes

authors： Lampeter EF,Klinghammer A,Scherbaum WA,Heinze E,Haastert B,Giani G,Kolb H

更新日期：1998-06-01 00:00:00

abstract：:The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...

journal_title：Diabetes

authors： Plengvidhya N,Antonellis A,Wogan LT,Poleev A,Borgschulze M,Warram JH,Ryffel GU,Krolewski AS,Doria A

更新日期：1999-10-01 00:00:00

abstract：:In humans, low levels of growth hormone (GH) and its mediator, IGF-1, associate with hepatic lipid accumulation. In mice, congenital liver-specific ablation of the GH receptor (GHR) results in reductions in circulating IGF-1 and hepatic steatosis, associated with systemic insulin resistance. Due to the intricate relat...

journal_title：Diabetes

authors： Liu Z,Cordoba-Chacon J,Kineman RD,Cronstein BN,Muzumdar R,Gong Z,Werner H,Yakar S

更新日期：2016-12-01 00:00:00

abstract：:In pancreatic β-cells, closure of the ATP-sensitive K(+) (K(ATP)) channel is an initial process triggering glucose-stimulated insulin secretion. In addition, constitutive opening of background nonselective cation channels (NSCCs) is essentially required to effectively evoke depolarization as a consequence of K(ATP) ch...

journal_title：Diabetes

authors： Yosida M,Dezaki K,Uchida K,Kodera S,Lam NV,Ito K,Rita RS,Yamada H,Shimomura K,Ishikawa SE,Sugawara H,Kawakami M,Tominaga M,Yada T,Kakei M

更新日期：2014-10-01 00:00:00

abstract：:A recent study has demonstrated secondary amyloidosis in dogs treated with continuous intravenous insulin infusion. Since elevated levels of serum amyloid A protein (SAA) and diminished amyloid fibril degrading activity (AFDA) are associated with amyloidosis, we measured SAA and AFDA in ten type I diabetics treated wi...

journal_title：Diabetes

authors： Koivisto VA,Teppo AM,Maury CP,Taskinen MR

更新日期：1983-01-01 00:00:00

abstract：:Hyperglycemia-triggered vascular abnormalities are the most serious complications of diabetes mellitus (DM). The major cause of vascular dysfunction in DM is endothelial injury and dysfunction associated with the reduced number and dysfunction of endothelial progenitor cells (EPCs). A major challenge is to identify ke...

journal_title：Diabetes

authors： Yao Y,Li Y,Song Q,Hu C,Xie W,Xu C,Chen Q,Wang QK

更新日期：2019-08-01 00:00:00

abstract：:Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve insulin sensitivity....

journal_title：Diabetes

authors： Hivert MF,Christophi CA,Franks PW,Jablonski KA,Ehrmann DA,Kahn SE,Horton ES,Pollin TI,Mather KJ,Perreault L,Barrett-Connor E,Knowler WC,Florez JC,Diabetes Prevention Program Research Group.

更新日期：2016-02-01 00:00:00

abstract：:Two major metabolic perturbations, increased polyol (sorbitol) pathway activity and reduced tissue myo-inositol content, are induced in peripheral nerve by hyperglycemia. Although they are commonly invoked as alternative biochemical pathogenetic mechanisms for diabetic neuropathy, their possible interrelationship has ...

journal_title：Diabetes

authors： Finegold D,Lattimer SA,Nolle S,Bernstein M,Greene DA

更新日期：1983-11-01 00:00:00

abstract：OBJECTIVE:Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS:To efficiently search for genomic regions harborin...

journal_title：Diabetes

authors： Rogus JJ,Poznik GD,Pezzolesi MG,Smiles AM,Dunn J,Walker W,Wanic K,Moczulski D,Canani L,Araki S,Makita Y,Warram JH,Krolewski AS

更新日期：2008-09-01 00:00:00

abstract：:Severe resistance to subcutaneous insulin but sensitivity to intravenous insulin persisted for 15 months in a 17-year-old diabetic girl. Heat-labile insulin-degrading activity was present in the patient's ketotic sera and in the 100,000 g fraction (soluble fraction) of adipose tissue. Serum-degrading activity was not ...

journal_title：Diabetes

authors： Paulsen EP,Courtney JW 3rd,Duckworth WC

更新日期：1979-07-01 00:00:00

abstract：:The GK rat model of type 2 diabetes is especially convenient to dissect the pathogenic mechanism necessary for the emergence of overt diabetes because all adult rats obtained in our department (GK/Par colony) to date have stable basal mild hyperglycemia and because overt diabetes is preceded by a period of normoglycem...

journal_title：Diabetes

authors： Portha B,Giroix MH,Serradas P,Gangnerau MN,Movassat J,Rajas F,Bailbe D,Plachot C,Mithieux G,Marie JC

更新日期：2001-02-01 00:00:00

abstract：:The development of autoimmune diabetes in NOD mice results from selective destruction of beta-cells by a T-cell-dependent autoimmune process. However, the mechanisms that control the generation of beta-cell cytotoxic T-cells in vivo are poorly understood. We recently established 8.3-T-cell receptor (TCR)-beta transgen...

journal_title：Diabetes

authors： Jun HS,Santamaria P,Lim HW,Zhang ML,Yoon JW

更新日期：1999-01-01 00:00:00

abstract：:We have attempted to define the nature of insulin secretory defect(s) in aged animals. In these studies, pancreatic islets were isolated from 2- and 18-mo-old Fischer 344 rats. Margination of secretion vesicles during exocytosis was assessed by measuring the recruitment of somatostatin (SRIF) receptors to the surface ...

journal_title：Diabetes

authors： Draznin B,Steinberg JP,Leitner JW,Sussman KE

更新日期：1985-11-01 00:00:00

abstract：:In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow. The optimal d...

journal_title：Diabetes

authors： Bar-On H,Roheim PS,Eder HA

更新日期：1976-06-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a mitogen required for β-cell replication during pregnancy. To determine whether HGF/c-Met signaling is required for β-cell regeneration, we characterized mice with pancreatic deletion of the HGF receptor, c-Met (PancMet KO mice), in two models of reduced β-cell mass and regeneration:...

journal_title：Diabetes

authors： Alvarez-Perez JC,Ernst S,Demirci C,Casinelli GP,Mellado-Gil JM,Rausell-Palamos F,Vasavada RC,Garcia-Ocaña A

更新日期：2014-01-01 00:00:00

abstract：:The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP-group), and 6 male nondiabetic control subjects. The mean age ...

journal_title：Diabetes

authors： Mäntysaari M,Kuikka J,Mustonen J,Tahvanainen K,Vanninen E,Länsimies E,Uusitupa M

更新日期：1992-09-01 00:00:00

abstract：:Rat pancreatic islets were incubated in vitro with L-[4,5-3H]leucine or with L-[2,3-3H]tryptophan in Krebs-Ringer bicarbonate buffer, containing 0, 5, or 20 mM glucose. Incorporation of labeled amino acids in islet cells was evaluated quantitatively by a validated radioautographic procedure. Incorporation of labeled l...

journal_title：Diabetes

authors： Logothetopoulos J,Jain K

更新日期：1980-10-01 00:00:00

abstract：:Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing or be secondary to increased demand on β-cells (hyperinsulinemia secondary to insulin resistance). An alternative way to investigate the relation between rel...

journal_title：Diabetes

authors： Mezza T,Ferraro PM,Sun VA,Moffa S,Cefalo CMA,Quero G,Cinti F,Sorice GP,Pontecorvi A,Folli F,Mari A,Alfieri S,Giaccari A

更新日期：2018-11-01 00:00:00

abstract：:IA-2, a member of the protein tyrosine phosphatase family, represents a major target autoantigen in type 1 diabetes. To study the regulation of IA-2 gene expression, we used INS-1 insulinoma cells to analyze beta-cell signal transduction pathways as well as the effect of metabolic and hormonal factors involved in the ...

journal_title：Diabetes

authors： Seissler J,Nguyen TB,Aust G,Steinbrenner H,Scherbaum WA

更新日期：2000-07-01 00:00:00

abstract：:We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic male subjects were used for assessment of 3-hydroxy-Acyl-CoA-dehydrogenase (HAD) and cit...

journal_title：Diabetes

authors： Mogensen M,Sahlin K,Fernström M,Glintborg D,Vind BF,Beck-Nielsen H,Højlund K

更新日期：2007-06-01 00:00:00

abstract：:Skeletal muscle insulin resistance in type 2 diabetes is associated with a shift from oxidative to glycolytic metabolism in myofibers. However, whether this metabolic switch is detrimental or adaptive for metabolic homeostasis has not been resolved. We recently demonstrated that the Baf60c/Deptor pathway promotes glyc...

journal_title：Diabetes

authors： Meng ZX,Wang L,Xiao Y,Lin JD

更新日期：2014-05-01 00:00:00

abstract：:Proliferation of vascular smooth muscle is thought to be involved in the major diabetic complication atherosclerosis. We have previously reported an increase of growth-promoting activity (GA) in platelets from insulin-dependent diabetics. In this study, GA was measured in the platelet extract (PE) from eight diabetic ...

journal_title：Diabetes

authors： Sugimoto H,Franks DJ,Lecavalier L,Chiasson JL,Hamet P

更新日期：1987-05-01 00:00:00

abstract：:Although diabetes is the most common cause of end-stage renal disease (ESRD) worldwide, most people with diabetic nephropathy will never develop ESRD but will instead die of cardiovascular (CV) disease (CVD). The first evidence of kidney injury in diabetes is often microalbuminuria, itself also an independent risk mar...

journal_title：Diabetes

authors： Siddiqi FS,Advani A

更新日期：2013-11-01 00:00:00

abstract：:Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially confounded by developmental adaptation of animal physiology. We aimed to adapt the technique of in vivo electrotransfer (IVE) to alter local gene expression in skeletal muscle of rodents as a means of investigating the role ...

journal_title：Diabetes

authors： Cleasby ME,Davey JR,Reinten TA,Graham MW,James DE,Kraegen EW,Cooney GJ

更新日期：2005-09-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：:Monolayer cultures of islet B-cells were established from neonatal rat pancreas. Serum-free media conditioned by these cultures for 72 h were concentrated and fractionated on Sephadex G-50 at acid pH into a high-molecular-weight pool containing binding protein for insulin-like growth factors (IGFs) and a low-molecular...

journal_title：Diabetes

authors： Romanus JA,Rabinovitch A,Rechler MM

更新日期：1985-07-01 00:00:00

abstract：:Hyperglycemia alters cardiac function and often leads to diabetic cardiomyopathy as cardiomyocyte apoptosis causes a hypertrophied heart to deteriorate to dilation and failure. Paradoxically, many short-term animal models of hyperglycemia protect against ischemia-induced damage, including apoptosis, by limiting Ca(2+)...

journal_title：Diabetes

authors： Pang Y,Hunton DL,Bounelis P,Marchase RB

更新日期：2002-12-01 00:00:00

abstract：:Hepatocyte nuclear factor (HNF)-4alpha is a transcription factor known as a key molecule in the development and functions of the beta-cells. In a previously performed genome-wide scan of Japanese type 2 diabetic sibpairs, we observed linkage of type 2 diabetes to chromosome 20q12-q13, a region in which the HNF4A gene ...

journal_title：Diabetes

authors： Hara K,Horikoshi M,Kitazato H,Ito C,Noda M,Ohashi J,Froguel P,Tokunaga K,Tobe K,Nagai R,Kadowaki T

更新日期：2006-05-01 00:00:00

abstract：:Arterial stiffness affects cardiac functions, peripheral circulation, and cardiovascular mortality. We examined whether arterial stiffness in different regions is equally affected by diabetes and other factors. The subjects were 161 patients with type 2 diabetes and 129 healthy subjects comparable in age and sex. Arte...

journal_title：Diabetes

authors： Kimoto E,Shoji T,Shinohara K,Inaba M,Okuno Y,Miki T,Koyama H,Emoto M,Nishizawa Y

更新日期：2003-02-01 00:00:00