Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.

abstract：:Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains unclear. Our goal was to elucidate mechanisms underlying the negative correlation between UCP3 and insulin resistance in muscle. We determined effects of physio...

journal_title：Diabetes

authors： MacLellan JD,Gerrits MF,Gowing A,Smith PJ,Wheeler MB,Harper ME

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:Insulin deficiency in type 1 diabetes and in rodent autoimmune diabetes models is caused by beta-cell-specific killing by autoreactive T-cells. Less is known about beta-cell numbers and phenotype remaining at diabetes onset and the fate of other pancreatic endocrine cellular constituents. RESEARCH DESIGN AND...

journal_title：Diabetes

authors： Pechhold K,Zhu X,Harrison VS,Lee J,Chakrabarty S,Koczwara K,Gavrilova O,Harlan DM

更新日期：2009-05-01 00:00:00

abstract：:Skeletal muscle insulin resistance plays a key role in the pathogenesis of type 2 diabetes. It recently has been hypothesized that excessive activity of the inhibitor of kappaB (IkappaB)/nuclear factor kappaB (NFkappaB) inflammatory pathway is a mechanism underlying skeletal muscle insulin resistance. However, it is n...

journal_title：Diabetes

authors： Sriwijitkamol A,Christ-Roberts C,Berria R,Eagan P,Pratipanawatr T,DeFronzo RA,Mandarino LJ,Musi N

更新日期：2006-03-01 00:00:00

abstract：:Members of the tumor necrosis factor receptor superfamily play an important role in the initiation, expansion, and termination of an immune response. It has recently been demonstrated that one member of this family, CD30, plays a central role in maintaining peripheral tolerance by controlling the expansion of autoreac...

journal_title：Diabetes

authors： Siegmund T,Armitage N,Wicker LS,Peterson LB,Todd JA,Lyons PA

更新日期：2000-09-01 00:00:00

abstract：:Hypoglycemia limits optimal glycemic control in type 1 diabetes mellitus (T1DM), making novel strategies to mitigate it desirable. We hypothesized that portal (Po) vein insulin delivery would lessen hypoglycemia. In the conscious dog, insulin was infused into the hepatic Po vein or a peripheral (Pe) vein at a rate fou...

journal_title：Diabetes

authors： Gregory JM,Kraft G,Scott MF,Neal DW,Farmer B,Smith MS,Hastings JR,Allen EJ,Donahue EP,Rivera N,Winnick JJ,Edgerton DS,Nishimura E,Fledelius C,Brand CL,Cherrington AD

更新日期：2015-10-01 00:00:00

abstract：:Metabolic interactions between glucose and amino acids were studied with isolated rat islets using glucose utilization and lactate formation as indicators. Certain amino acids (8-10 mM) are capable of greatly stimulating lactate formation from 5mM glucose. On a molar basis L-isoleucine is the most potent stimulator in...

journal_title：Diabetes

authors： Pace CS,Ellerman J,Hover BA,Stillings SN,Matschinsky FM

更新日期：1975-05-01 00:00:00

abstract：:Expression of muscarinic receptors in rat islets, RINm5F cells, and INS-1 cells was established by reverse transcriptase-polymerase chain reaction (RT-PCR) and quantified by RNase protection. Both methods indicated that m3 and m1 receptors were expressed approximately equally in the various cellular preparations and t...

journal_title：Diabetes

authors： Iismaa TP,Kerr EA,Wilson JR,Carpenter L,Sims N,Biden TJ

更新日期：2000-03-01 00:00:00

abstract：:Leptin resistance has recently been confirmed not only in animal obese models but in human obesity. Evidence is rapidly emerging that suggests that activation of histamine signaling in the hypothalamus may have substantial anti-obesity and antidiabetic actions, particularly in leptin-resistant states. To address this ...

journal_title：Diabetes

authors： Masaki T,Yoshimatsu H,Chiba S,Watanabe T,Sakata T

更新日期：2001-02-01 00:00:00

abstract：:For examining the effects of moderate exercise training on peripheral glucose effectiveness (S(g)(2)*), insulin sensitivity (S(i)(2)*), and endogenous glucose production (EGP), seven men and one woman (24.8 +/- 1.8 years) participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/we...

journal_title：Diabetes

authors： Nishida Y,Tokuyama K,Nagasaka S,Higaki Y,Shirai Y,Kiyonaga A,Shindo M,Kusaka I,Nakamura T,Ishibashi S,Tanaka H

更新日期：2004-02-01 00:00:00

abstract：:The influence of insulin on the intracellular free sodium and potassium ion concentrations ([Na+]i, [K+]i) and resting membrane potential of rat epididymal adipocytes was examined to determine its potential for mediating insulin's action on other cellular processes. Direct intracellular measurements of [Na+]i, [K+]i, ...

journal_title：Diabetes

authors： Stark RJ,Read PD,O'Doherty J

更新日期：1980-12-01 00:00:00

abstract：:We tested the hypothesis that dysfunction of vascular endothelium, indicated by an increase in plasma level of von Willebrand factor (vWF), is present in patients with insulin-dependent diabetes mellitus (IDDM) who develop diabetic nephropathy (DN). DN was classified as absent (urinary albumin excretion [UAE] rate les...

journal_title：Diabetes

authors： Stehouwer CD,Stroes ES,Hackeng WH,Mulder PG,Den Ottolander GJ

更新日期：1991-08-01 00:00:00

abstract：:It is suggested that the maternal transmission of islet autoantibodies increases the risk of autoimmune diabetes in mice. The aim of this study was to determine whether fetal exposure to islet autoantibodies modified the risk of type 1 diabetes in humans. Islet autoantibodies were measured at birth in 720 offspring of...

journal_title：Diabetes

authors： Koczwara K,Bonifacio E,Ziegler AG

更新日期：2004-01-01 00:00:00

abstract：:Signaling pathways activated by leptin in metabolically important organs have largely been studied only in animal and/or cell culture studies. In this study, we examined whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and whether the response would be different in lean and...

journal_title：Diabetes

authors： Moon HS,Huh JY,Dincer F,Schneider BE,Hasselgren PO,Mantzoros CS

更新日期：2015-03-01 00:00:00

abstract：:Diabetes complications are caused by hyperglycemia. Hyperglycemia results in increased concentrations of glucose degradation products. The study of peritoneal dialysis solution biocompatibility has highlighted the adverse effects of glucose degradation products. Recently, 3,4-dideoxyglucosone-3-ene (3,4-DGE) has been ...

journal_title：Diabetes

authors： Justo P,Sanz AB,Egido J,Ortiz A

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00

abstract：:Embryo-culture techniques were used to study the effects of exposure to glucose-deficient culture media on rat embryos during organogenesis. Embryos and their extraembryonic membranes (explants) were cultured either in control media or in media with low or very low glucose concentrations. At the start of the culture t...

journal_title：Diabetes

authors： Ellington SK

更新日期：1987-12-01 00:00:00

abstract：:Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...

journal_title：Diabetes

authors： Nilsen MS,Jersin RÅ,Ulvik A,Madsen A,McCann A,Svensson PA,Svensson MK,Nedrebø BG,Gudbrandsen OA,Tell GS,Kahn CR,Ueland PM,Mellgren G,Dankel SN

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:This study aimed to estimate the current cumulative risk of end-stage renal disease (ESRD) due to diabetic nephropathy in a large, nationwide, population-based prospective type 1 diabetes cohort and specifically study the effects of sex and age at onset. RESEARCH DESIGN AND METHODS:In Sweden, all incident ca...

journal_title：Diabetes

authors： Möllsten A,Svensson M,Waernbaum I,Berhan Y,Schön S,Nyström L,Arnqvist HJ,Dahlquist G,Swedish Childhood Diabetes Study Group.,Diabetes Incidence Study in Sweden.,Swedish Renal Registry.

更新日期：2010-07-01 00:00:00

abstract：:The kinetics of in vivo insulin-mediated glucose uptake in human obesity have not been previously studied. To examine this, we used the glucose-clamp technique to measure whole-body and leg muscle glucose uptake in seven lean and six obese men during hyperinsulinemia (approximately 2000 pM) at four glucose levels (app...

journal_title：Diabetes

authors： Laakso M,Edelman SV,Olefsky JM,Brechtel G,Wallace P,Baron AD

更新日期：1990-08-01 00:00:00

abstract：:Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts...

journal_title：Diabetes

authors： Nilsson E,Jansson PA,Perfilyev A,Volkov P,Pedersen M,Svensson MK,Poulsen P,Ribel-Madsen R,Pedersen NL,Almgren P,Fadista J,Rönn T,Klarlund Pedersen B,Scheele C,Vaag A,Ling C

更新日期：2014-09-01 00:00:00

abstract：:A monoclonal islet cell antibody, HISL-19, reactive with human, bovine, and porcine pancreatic islets has been used to identify and characterize a novel group of islet cell proteins (p120, p69, p67, and p56). Besides the islets, HISL-19-reactive antigenic determinants are also expressed on selected cell types, namely,...

journal_title：Diabetes

authors： Srikanta S,Krisch K,Eisenbarth GS

更新日期：1986-03-01 00:00:00

abstract：:Na+-K+-ATPase or the Na+-K+ pump is essential for some specific properties of muscle and nerve tissue such as contractility and excitability. Previous studies have shown conflicting variations in Na+-K+-ATPase activity or Na+-K+ pump concentration of muscle cells in experimental diabetes. Our study demonstrates that e...

journal_title：Diabetes

authors： Kjeldsen K,Braendgaard H,Sidenius P,Larsen JS,Nørgaard A

更新日期：1987-07-01 00:00:00

abstract：:Resistin is a hormone secreted by adipocytes that acts on skeletal muscle myocytes, hepatocytes, and adipocytes themselves, reducing their sensitivity to insulin. In the present study, we investigated how the expression of resistin is affected by glucose and by mediators known to affect insulin sensitivity, including ...

journal_title：Diabetes

authors： Shojima N,Sakoda H,Ogihara T,Fujishiro M,Katagiri H,Anai M,Onishi Y,Ono H,Inukai K,Abe M,Fukushima Y,Kikuchi M,Oka Y,Asano T

更新日期：2002-06-01 00:00:00

abstract：:The reduction in blood glucose in non-insulin-dependent diabetes mellitus (NIDDM) brought about by the use of phenobarbital (PB), a hepatic microsomal enzyme inducer, suggests an improvement in insulin sensitivity. The effect of PB on insulin-mediated glucose metabolism was hence investigated using the euglycemic clam...

journal_title：Diabetes

authors： Lahtela JT,Arranto AJ,Sotaniemi EA

更新日期：1985-09-01 00:00:00

abstract：:To investigate how the D-cell recognizes the glucose stimulus, the hormone response to (1) glucose, (2) the trioses glyceraldehyde and dihydroxyacetone, (3) the metabolic blocker, mannoheptulose, and (4) the low- or nonmetabolized sugars galactose, fructose, or ribose were studied using the isolated dog pancreas. We f...

journal_title：Diabetes

authors： Hermansen K

更新日期：1981-03-01 00:00:00

abstract：:Improvement of glycemic status by insulin is associated with profound changes in amino acid metabolism in type 1 diabetes. In contrast, a dissociation of insulin effect on glucose and amino acid metabolism has been reported in type 2 diabetes. Type 2 diabetic patients are reported to have reduced muscle oxidative enzy...

journal_title：Diabetes

authors： Halvatsiotis P,Short KR,Bigelow M,Nair KS

更新日期：2002-08-01 00:00:00

abstract：:Adiponectin, an adipocyte protein important in insulin sensitization and cardioprotection, has a strong genetic component. We hypothesized that variants in the adiponectin gene (adipocyte collagen-domain containing [ACDC]) contribute to adiponectin levels in a biracial adolescent cohort. We genotyped 11 ACDC single nu...

journal_title：Diabetes

authors： Woo JG,Dolan LM,Deka R,Kaushal RD,Shen Y,Pal P,Daniels SR,Martin LJ

更新日期：2006-02-01 00:00:00

abstract：:We conducted a prospective study to describe the course of the pancreatic beta-cell function from the time of clinical diagnosis of insulin-dependent (type I) diabetes to determine whether DR type, presence of islet cell antibodies (ICA), presence of insulin antibodies (IA), age at onset, and sex could help in the pre...

journal_title：Diabetes

authors： Schiffrin A,Suissa S,Poussier P,Guttmann R,Weitzner G

更新日期：1988-07-01 00:00:00

abstract：:The early steps of insulin biosynthesis occur in the endoplasmic reticulum (ER), and the beta-cell has a highly developed and active ER. All cells regulate the capacity of their ER to fold and process client proteins and they adapt to an imbalance between client protein load and folding capacity (so-called ER stress)....

journal_title：Diabetes

authors： Harding HP,Ron D

更新日期：2002-12-01 00:00:00

abstract：:Skeletal muscle (SKM) insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Because G-protein-coupled receptors (GPCRs) represent excellent drug targets, we hypothesized that activation of specific functional classes of SKM GPCRs might lead to improved glucose homeostasis in type 2 diabetes. ...

journal_title：Diabetes

authors： Bone DBJ,Meister J,Knudsen JR,Dattaroy D,Cohen A,Lee R,Lu H,Metzger D,Jensen TE,Wess J

更新日期：2019-06-01 00:00:00