Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects.

abstract：:We studied the cross-sectional relationship between HbA1c and cardiovascular disease (CVD) in the survivors of the original cohort of the Framingham Heart Study (n = 1045). HbA1c was significantly related to prevalent CVD among women but not men. HbA1c was also related to hypertension and to the ratio of total to high...

journal_title：Diabetes

authors： Singer DE,Nathan DM,Anderson KM,Wilson PW,Evans JC

更新日期：1992-02-01 00:00:00

abstract：:Impaired skeletal muscle fatty acid oxidation has been suggested to contribute to insulin resistance and glucose intolerance. However, increasing muscle fatty acid oxidation may cause a reciprocal decrease in glucose oxidation, which might impair insulin sensitivity and glucose tolerance. We therefore investigated wha...

journal_title：Diabetes

authors： Keung W,Ussher JR,Jaswal JS,Raubenheimer M,Lam VH,Wagg CS,Lopaschuk GD

更新日期：2013-03-01 00:00:00

abstract：:Identifying new causes of permanent neonatal diabetes (PNDM) (diagnosis <6 months) provides important insights into β-cell biology. Patients with Down syndrome (DS) resulting from trisomy 21 are four times more likely to have childhood diabetes with an intermediate HLA association. It is not known whether DS can cause...

journal_title：Diabetes

authors： Johnson MB,De Franco E,Greeley SAW,Letourneau LR,Gillespie KM,International DS-PNDM Consortium.,Wakeling MN,Ellard S,Flanagan SE,Patel KA,Hattersley AT

更新日期：2019-07-01 00:00:00

abstract：:Expression of GLUTs in rat peripheral nerve was first studied at the mRNA level with Northern transfer analysis with cDNAs specific for GLUT1, GLUT2, GLUT3, and GLUT4. GLUT1 mRNA was the only GLUT mRNA detectable in rat sciatic nerve. In situ hybridization localized this mRNA to the perineurium and to some endo- and e...

journal_title：Diabetes

authors： Muona P,Sollberg S,Peltonen J,Uitto J

更新日期：1992-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator implicated in transcriptional programs of hepatic gluconeogenesis, oxidative phosphorylation, and insulin release by beta-cells. To study associations of the PGC-1alpha gene locus with carbohydrate metabolism an...

journal_title：Diabetes

authors： Oberkofler H,Linnemayr V,Weitgasser R,Klein K,Xie M,Iglseder B,Krempler F,Paulweber B,Patsch W

更新日期：2004-05-01 00:00:00

abstract：:Clinical studies have shown a link between hyperuricemia (HU) and diabetes, while the exact effect of soluble serum urate on glucose metabolism remains elusive. This study aims to characterize the glucose metabolic phenotypes and investigate the underlying molecular mechanisms using a novel spontaneous HU mouse model ...

journal_title：Diabetes

authors： Lu J,He Y,Cui L,Xing X,Liu Z,Li X,Zhang H,Li H,Sun W,Ji A,Wang Y,Yin H,Li C

更新日期：2020-06-01 00:00:00

abstract：:The secretion of insulin from β-cells depends on extracellular factors, in particular glucose and other small molecules, some of which act on G-protein-coupled receptors. Fatty acids (FAs) have been discussed as exogenous secretagogues of insulin for decades, especially after the FA receptor GPR40 (G-protein-coupled r...

journal_title：Diabetes

authors： Hauke S,Keutler K,Phapale P,Yushchenko DA,Schultz C

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing. In humans, a germline mutation in the VHL gene leads to the von Hippel-Lindau disease, a familial syndrome characterized by benign and malignant tumors of the kidney...

journal_title：Diabetes

authors： Puri S,Cano DA,Hebrok M

更新日期：2009-02-01 00:00:00

abstract：:Although many studies using rodent islets and insulinoma cell lines have been performed to determine the role of insulin in the regulation of islet function, the autocrine effect of insulin on insulin gene expression is still controversial, and no consensus has yet been achieved. Because very little is known about the...

journal_title：Diabetes

authors： Muller D,Huang GC,Amiel S,Jones PM,Persaud SJ

更新日期：2006-10-01 00:00:00

abstract：:Recent research indicates that islet amyloid pancreatic polypeptide (IAPP) might have a regulatory effect on beta-cell insulin processing and secretion. To study such interaction in more detail, IAPP secretion and kinetics and the serum concentrations of proinsulin were assessed both before and after delivery in lean ...

journal_title：Diabetes

authors： Kautzky-Willer A,Thomaseth K,Ludvik B,Nowotny P,Rabensteiner D,Waldhäusl W,Pacini G,Prager R

更新日期：1997-04-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (KDR) plays a critical role in mediating a variety of vasculogenic and angiogenic processes, including diabetic retinopathy. We previously demonstrated that the promoter activity of the KDR gene in retinal capillary endothelial cells (RCECs) was regulated in part by the re...

journal_title：Diabetes

authors： Sassa Y,Hata Y,Aiello LP,Taniguchi Y,Kohno K,Ishibashi T

更新日期：2004-05-01 00:00:00

abstract：:Diabetes complications are caused by hyperglycemia. Hyperglycemia results in increased concentrations of glucose degradation products. The study of peritoneal dialysis solution biocompatibility has highlighted the adverse effects of glucose degradation products. Recently, 3,4-dideoxyglucosone-3-ene (3,4-DGE) has been ...

journal_title：Diabetes

authors： Justo P,Sanz AB,Egido J,Ortiz A

更新日期：2005-08-01 00:00:00

abstract：:Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the adipocytes. This may enable them to participate in both anabolic and catabolic processes. The adiponutrin gene (ADPN) is down...

journal_title：Diabetes

authors： Johansson LE,Hoffstedt J,Parikh H,Carlsson E,Wabitsch M,Bondeson AG,Hedenbro J,Tornqvist H,Groop L,Ridderstråle M

更新日期：2006-03-01 00:00:00

abstract：:Obesity is one of the most serious threats to human health today. Although there is general agreement that environmental factors such as diet have largely caused the current obesity pandemic, the environmental changes have not affected all individuals equally. To model gene-by-environment interactions in a mouse model...

journal_title：Diabetes

authors： Ehrich TH,Hrbek T,Kenney-Hunt JP,Pletscher LS,Wang B,Semenkovich CF,Cheverud JM

更新日期：2005-06-01 00:00:00

abstract：:Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...

journal_title：Diabetes

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1980-01-01 00:00:00

abstract：:The receptor-type protein tyrosine kinases in murine pancreatic islets were screened to identify possible growth/differentiation factors in pancreatic beta-cells. The analysis revealed that insulin receptor-related receptor (IRR) is highly expressed in the islets as well as in several highly differentiated beta-cell l...

journal_title：Diabetes

authors： Hirayama I,Tamemoto H,Yokota H,Kubo SK,Wang J,Kuwano H,Nagamachi Y,Takeuchi T,Izumi T

更新日期：1999-06-01 00:00:00

abstract：:Type 2 diabetes is characterized by islet amyloid deposits, which are primarily composed of the amyloidogenic human form of islet amyloid polypeptide (IAPP, amylin). The mechanism of islet amyloido-genesis is not known, but other products (e.g., apolipoprotein E and perlecan) contained within islet amyloid may be nece...

journal_title：Diabetes

authors： Andrikopoulos S,Verchere CB,Teague JC,Howell WM,Fujimoto WY,Wight TN,Kahn SE

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RE...

journal_title：Diabetes

authors： White PJ,Arita M,Taguchi R,Kang JX,Marette A

更新日期：2010-12-01 00:00:00

abstract：:Diurnal variation in insulin sensitivity in patients with NIDDM has long been suspected but has been difficult to document mainly because of the interdependence of changes in glucose and insulin. Stable serum insulin levels during hyperglycemic clamping in patients with NIDDM in the present study provided the opportun...

journal_title：Diabetes

authors： Boden G,Chen X,Urbain JL

更新日期：1996-08-01 00:00:00

abstract：:One of the unique features of beta-cells is their relatively low expression of many antioxidant enzymes. This could render beta-cells susceptible to oxidative damage but may also provide a system that is sensitive to reactive oxygen species as signals. In isolated mouse islets and INS-1(832/13) cells, glucose increase...

journal_title：Diabetes

authors： Pi J,Bai Y,Zhang Q,Wong V,Floering LM,Daniel K,Reece JM,Deeney JT,Andersen ME,Corkey BE,Collins S

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:Adipose tissue serves as an integrator of various physiological pathways, energy balance, and glucose homeostasis. Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain unclear. RESEARCH DESIGN...

journal_title：Diabetes

authors： Nakae J,Cao Y,Oki M,Orba Y,Sawa H,Kiyonari H,Iskandar K,Suga K,Lombes M,Hayashi Y

更新日期：2008-03-01 00:00:00

abstract：:The time course of islet cell antibodies (ICA) and serum C-peptides responses (CPRs) to oral glucose tolerance tests (OGTTs) were studied prospectively up to 60 (mean 35) mo in 32 ICA-positive subjects [28 with non-insulin-dependent diabetes (NIDDM) and 4 subjects with impaired glucose tolerance (IGT); mean age 45 yr]...

journal_title：Diabetes

authors： Kobayashi T,Itoh T,Kosaka K,Sato K,Tsuji K

更新日期：1987-04-01 00:00:00

abstract：:Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Whether hyperglycemia evolves from normoglycemia gradually over time or as a step increase is not known. We measured plasma glucose and insulin levels during oral glucose testing in 35- to 64-year-old men and nonpregnant women from a p...

journal_title：Diabetes

authors： Ferrannini E,Nannipieri M,Williams K,Gonzales C,Haffner SM,Stern MP

更新日期：2004-01-01 00:00:00

abstract：:The molecular underpinnings of β-cell dysfunction and death leading to diabetes are not fully elucidated. The objective of the current study was to investigate the role of endoplasmic reticulum-associated degradation (ERAD) in pancreatic β-cells. Chemically induced ERAD deficiency in the rat insulinoma cell line INS-1...

journal_title：Diabetes

authors： Hu Y,Gao Y,Zhang M,Deng KY,Singh R,Tian Q,Gong Y,Pan Z,Liu Q,Boisclair YR,Long Q

更新日期：2019-04-01 00:00:00

abstract：:The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition o...

journal_title：Diabetes

authors： Virji MA,Steffes MW,Estensen RD

更新日期：1984-02-01 00:00:00

abstract：:Subjects with overt non-insulin-dependent diabetes mellitus (NIDDM) were studied in comparison to obese nondiabetic control subjects and patients with subclinical diabetes. Pancreatic insulin secretion rates were measured by deconvolution of peripheral C-peptide over a 24-h period while subjects consumed an isocaloric...

journal_title：Diabetes

authors： Polonsky KS,Gumbiner B,Ostrega D,Griver K,Tager H,Henry RR

更新日期：1994-07-01 00:00:00

abstract：:Several studies have indicated that insulin resistance, elevated blood pressure (BP), and dyslipidemia precede the onset of non-insulin-dependent diabetes mellitus (NIDDM). Little data, however, exist on the presence of renal disease in prediabetic subjects. We measured albumin excretion in a cross-sectional populatio...

journal_title：Diabetes

authors： Mykkänen L,Haffner SM,Kuusisto J,Pyorälä K,Laakso M

更新日期：1994-04-01 00:00:00

abstract：:In patients with diabetes, altered diurnal blood pressure (BP) regulation (high night-to-day [N/D] ratio, or "nondipping") is associated with increases in albumin excretion and a decline in the glomerular filtration rate (GFR) by an unknown mechanism. Because it is known that renin angiotensin system (RAS) activation ...

journal_title：Diabetes

authors： Miller JA,Curtis JR,Sochett EB

更新日期：2003-07-01 00:00:00

abstract：:Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen desi...

journal_title：Diabetes

authors： Young AA,Bogardus C,Wolfe-Lopez D,Mott DM

更新日期：1988-03-01 00:00:00

abstract：:WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade ...

journal_title：Diabetes

authors： Murahovschi V,Pivovarova O,Ilkavets I,Dmitrieva RM,Döcke S,Keyhani-Nejad F,Gögebakan Ö,Osterhoff M,Kemper M,Hornemann S,Markova M,Klöting N,Stockmann M,Weickert MO,Lamounier-Zepter V,Neuhaus P,Konradi A,Dooley S,von L

更新日期：2015-03-01 00:00:00