Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion.

abstract：:Glucose homeostasis, a defining characteristic of physiological glucose metabolism, is the result of complex feedback relationships with both genetic and environmental determinants that influence insulin sensitivity and beta-cell function. Relatively little is known about the genetic basis of glucose homeostasis pheno...

journal_title：Diabetes

authors： Palmer ND,Langefeld CD,Campbell JK,Williams AH,Saad M,Norris JM,Haffner SM,Rotter JI,Wagenknecht LE,Bergman RN,Rich SS,Bowden DW

更新日期：2006-04-01 00:00:00

abstract：:In man a small dose of somatostatin (50 micrograms/h) suppressed moderately basal insulin (5 microU/ml) and glucagon (40 pg/ml) levels. This resulted in a short-lasting hypoglycemia, which was then followed by marginal hyperglycemia throughout the experiment. The addition of a minimal dose of glucagon (0.50 ng/kg/min)...

journal_title：Diabetes

authors： Lins PE,Wajngot A,Adamson U,Vranic M,Efendić S

更新日期：1983-07-01 00:00:00

abstract：:Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through de novo adipogenesis; however, how "beiging" characteristics are...

journal_title：Diabetes

authors： Wang Y,Paulo E,Wu D,Wu Y,Huang W,Chawla A,Wang B

更新日期：2017-12-01 00:00:00

abstract：:Elevated levels of advanced glycosylation end products (AGEs) have been found in multiple tissues in association with diabetic vascular complications and during the microalbuminuric phase of diabetic nephropathy. In this study, we have used an AGE-specific enzyme-linked immunosorbent assay (ELISA) to measure skin AGEs...

journal_title：Diabetes

authors： Beisswenger PJ,Makita Z,Curphey TJ,Moore LL,Jean S,Brinck-Johnsen T,Bucala R,Vlassara H

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:Normal human myocardium switches substrate metabolism preference, adapting to the prevailing plasma substrate levels and hormonal milieu, but in type 1 diabetes, the myocardium relies heavily on fatty acid metabolism for energy. Whether conditions that affect myocardial glucose use and fatty acid utilization,...

journal_title：Diabetes

authors： Peterson LR,Herrero P,McGill J,Schechtman KB,Kisrieva-Ware Z,Lesniak D,Gropler RJ

更新日期：2008-01-01 00:00:00

abstract：:Considerable debate exists about whether alterations in mitochondrial respiratory capacity and/or content play a causal role in the development of insulin resistance during obesity. The current study was undertaken to determine whether such alterations are present during the initial stages of insulin resistance in hum...

journal_title：Diabetes

authors： Fisher-Wellman KH,Weber TM,Cathey BL,Brophy PM,Gilliam LA,Kane CL,Maples JM,Gavin TP,Houmard JA,Neufer PD

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Phogrin and IA-2, autoantigens in insulin-dependent diabetes, have been shown to be involved in insulin secretion in pancreatic beta-cells; however, implications at a molecular level are confusing from experiment to experiment. We analyzed biological functions of phogrin in beta-cells by an RNA interference t...

journal_title：Diabetes

authors： Torii S,Saito N,Kawano A,Hou N,Ueki K,Kulkarni RN,Takeuchi T

更新日期：2009-03-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is associated with hepatic insulin resistance and may result primarily from increased hepatic de novo lipogenesis (PRIM) or secondarily from adipose tissue lipolysis (SEC). We studied mice with hepatocyte- or adipocyte-specific SREBP-1c overexpression as models of PRIM and SEC. PRIM mi...

journal_title：Diabetes

authors： Jelenik T,Kaul K,Séquaris G,Flögel U,Phielix E,Kotzka J,Knebel B,Fahlbusch P,Hörbelt T,Lehr S,Reinbeck AL,Müller-Wieland D,Esposito I,Shulman GI,Szendroedi J,Roden M

更新日期：2017-08-01 00:00:00

abstract：:The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...

journal_title：Diabetes

authors： Gambaro G,Baggio B,Cicerello E,Mastrosimone S,Marzaro G,Borsatti A,Crepaldi G

更新日期：1988-06-01 00:00:00

abstract：:Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explor...

journal_title：Diabetes

authors： Simó R,Barbosa-Desongles A,Lecube A,Hernandez C,Selva DM

更新日期：2012-02-01 00:00:00

abstract：:The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...

journal_title：Diabetes

authors： Heise T,Nosek L,Rønn BB,Endahl L,Heinemann L,Kapitza C,Draeger E

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Anti-tissue transglutaminase (TG2) antibodies are the serological marker of celiac disease. Given the close association between celiac disease and type 1 diabetes, we investigated the production and deposition of anti-TG2 antibodies in the jejunal mucosa of type 1 diabetic children. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Maglio M,Florian F,Vecchiet M,Auricchio R,Paparo F,Spadaro R,Zanzi D,Rapacciuolo L,Franzese A,Sblattero D,Marzari R,Troncone R

更新日期：2009-07-01 00:00:00

abstract：:Susceptibility of mice to experimental insulin-dependent diabetes as induced by multiple subdiabetogenic doses of streptozotocin has been shown to be strongly gender-dependent, males being much more susceptible than females. We examined this gender difference further in two strains of genetically susceptible mice to d...

journal_title：Diabetes

authors： Paik SG,Michelis MA,Kim YT,Shin S

更新日期：1982-08-01 00:00:00

abstract：:Three hundred and seventy-seven children and adolescents aged 5-17 yr from the biracial (black-white) community of Bogalusa, Louisiana, were evaluated for Tanner stage of sexual development, plasma glucose, and insulin levels during an oral glucose tolerance test. Children of the two races were of similar age, weight,...

journal_title：Diabetes

authors： Svec F,Nastasi K,Hilton C,Bao W,Srinivasan SR,Berenson GS

更新日期：1992-03-01 00:00:00

abstract：:Nerve regeneration in diabetic animals is delayed and qualitatively impaired, but the mechanisms responsible for these defects have not been elucidated. The extracellular matrix protein laminin promotes the extension of neuronal processes, and recent studies have localized neurite-promoting activity to a lysine-contai...

journal_title：Diabetes

authors： Federoff HJ,Lawrence D,Brownlee M

更新日期：1993-04-01 00:00:00

abstract：:Recent evidence highlights the therapeutic potential of peroxisome proliferator-activated receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, the role of PPARδ in regulating vascular function is incompletely characterized. We investigate whether PPARδ activation improves endothelial funct...

journal_title：Diabetes

authors： Tian XY,Wong WT,Wang N,Lu Y,Cheang WS,Liu J,Liu L,Liu Y,Lee SS,Chen ZY,Cooke JP,Yao X,Huang Y

更新日期：2012-12-01 00:00:00

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：:The past decade has witnessed an exponential increase in our ability to search the genome for genetic factors predisposing to cardiovascular disease (CVD) and in particular coronary heart disease (CHD). Identifying these genes could lead to the development of innovative strategies to prevent the cardiovascular complic...

journal_title：Diabetes

authors： Doria A

更新日期：2019-03-01 00:00:00

abstract：:The adipocyte-secreted protein adiponectin is associated with insulin sensitivity in observational studies. We aimed to evaluate whether this relationship is causal using a Mendelian randomization approach. In a sample of Swedish men aged 71 years (n = 942) from the Uppsala Longitudinal Study of Adult Men (ULSAM), ins...

journal_title：Diabetes

authors： Gao H,Fall T,van Dam RM,Flyvbjerg A,Zethelius B,Ingelsson E,Hägg S

更新日期：2013-04-01 00:00:00

abstract：:We aimed to investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk. A Mendelian randomization study was performed using a genetic score with 24 uric acid-associated loci. We used data of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort ...

journal_title：Diabetes

authors： Sluijs I,Holmes MV,van der Schouw YT,Beulens JW,Asselbergs FW,Huerta JM,Palmer TM,Arriola L,Balkau B,Barricarte A,Boeing H,Clavel-Chapelon F,Fagherazzi G,Franks PW,Gavrila D,Kaaks R,Khaw KT,Kühn T,Molina-Montes E,Mo

更新日期：2015-08-01 00:00:00

abstract：:Rats with classic Goldblatt (two-kidney) hypertension had diabetes induced by streptozotocin. After four months of diabetes, glomeruli of the unclipped kidney of hypertensive diabetic rats had markedly increased diabetic changes, including mesangial matrix thickening and mesangial immunoglobulin (IgG and IgM) and comp...

journal_title：Diabetes

authors： Mauer SM,Steffes MW,Azar S,Sandberg SK,Brown DM

更新日期：1978-07-01 00:00:00

abstract：:Altered muscle fatty acid (FA) metabolism may contribute to the presence of muscle insulin resistance in the genetically obese Zucker rat. To determine whether FA uptake and disposal are altered in insulin-resistant muscle, we measured palmitate uptake, oxidation, and incorporation into di- and triglycerides in isolat...

journal_title：Diabetes

authors： Turcotte LP,Swenberger JR,Zavitz Tucker M,Yee AJ

更新日期：2001-06-01 00:00:00

abstract：:The peripheral nerve disorders associated with diabetes are complex and probably involve a variety of causative mechanisms. This may give rise to difficulty in the classification of individual cases. A broad separation into rapidly reversible or more persistent phenomena is helpful. The former, which can be categorize...

journal_title：Diabetes

authors： Thomas PK

更新日期：1997-09-01 00:00:00

abstract：:In pancreatic β-cells, closure of the ATP-sensitive K(+) (K(ATP)) channel is an initial process triggering glucose-stimulated insulin secretion. In addition, constitutive opening of background nonselective cation channels (NSCCs) is essentially required to effectively evoke depolarization as a consequence of K(ATP) ch...

journal_title：Diabetes

authors： Yosida M,Dezaki K,Uchida K,Kodera S,Lam NV,Ito K,Rita RS,Yamada H,Shimomura K,Ishikawa SE,Sugawara H,Kawakami M,Tominaga M,Yada T,Kakei M

更新日期：2014-10-01 00:00:00

abstract：:Cytoplasmic islet cell antibody-negative (ICA-; less than 20 Juvenile Diabetes Foundation units, n = 1670) and ICA+ (n = 42) first-degree relatives of type I (insulin-dependent) diabetic individuals were studied for competitive insulin autoantibodies (CIAAs) with a radioassay. Overall, 3.7% of first-degree relatives (...

journal_title：Diabetes

authors： Ziegler AG,Ziegler R,Vardi P,Jackson RA,Soeldner JS,Eisenbarth GS

更新日期：1989-10-01 00:00:00

abstract：:The current study investigated the fate of a [U-(13)C]palmitate tracer extracted by forearm muscle in type 2 diabetic and control subjects. We studied seven healthy lean male subjects and seven obese male subjects with type 2 diabetes using the forearm muscle balance technique with continuous intravenous infusion of t...

journal_title：Diabetes

authors： Blaak EE,Wagenmakers AJ

更新日期：2002-03-01 00:00:00

abstract：:This study examines whether the loss of metabolic control in initially normalized islet transplants can result from the inadequate composition of the donor tissue. Streptozotocin-induced diabetic rats were followed for 64 weeks after the intraportal injection of islet isografts with different composition. The implanta...

journal_title：Diabetes

authors： Keymeulen B,Korbutt G,De Paepe M,Gorus F,Klöppel G,Pipeleers DG

更新日期：1996-12-01 00:00:00

abstract：:The effect of metabolic near-normalization, induced by continuous subcutaneous insulin infusion, on the exaggerated microalbuminuria of exercise was studied in eight insulin-dependent diabetic men selected for normal resting albuminuria. Patients were studied in randomized order during the ordinary glycemic control of...

journal_title：Diabetes

authors： Viberti G,Pickup JC,Bilous RW,Keen H,Mackintosh D

更新日期：1981-10-01 00:00:00

abstract：:Glucose tolerance depends on a complex interaction among insulin secretion from the beta-cells, clearance of the hormone, and the actions of insulin to accelerate glucose disappearance and inhibit endogenous glucose production. An additional factor, less well recognized, is the ability of glucose per se, independent o...

journal_title：Diabetes

authors： Bergman RN

更新日期：1989-12-01 00:00:00

abstract：:Protein kinase C (PKC) has been suggested as a mediator of insulin's effect on glucose transport, and PKC-mediated modulation of tyrosine kinase activity in the insulin receptor has been implicated in regulating the insulin sensitivity of tissues. Because skeletal muscle is a major target of insulin action, we examine...

journal_title：Diabetes

authors： Sowell MO,Treutelaar MK,Burant CF,Buse MG

更新日期：1988-05-01 00:00:00