Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion.

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic co...

journal_title：Diabetes

authors： Sun H,Lee P,Yan C,Gao N,Wang J,Fan X,Yu FS

更新日期：2018-06-01 00:00:00

abstract：:The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to test whether this relationship is more pronounced among individuals with diabetes....

journal_title：Diabetes

authors： Liao D,Carnethon M,Evans GW,Cascio WE,Heiss G

更新日期：2002-12-01 00:00:00

abstract：:The effect of 4 wk of streptozocin (STZ)-induced diabetes on the transmission time of the auditory-evoked brain stem response (ABR) was examined in conscious male Sprague-Dawley rats. Distal nerve transmission time of the auditory pathway (latency of peak II), which includes conduction along the 8th cranial nerve, inc...

journal_title：Diabetes

authors： Notvest RR,Inserra JJ

更新日期：1987-04-01 00:00:00

abstract：:The relative effects of time versus ambient glucose concentration on insulin-stimulated glucose uptake was estimated by performing 5-h insulin clamp studies in patients with NIDDM. Each experimental subject was studied three times, at steady-state plasma insulin levels approximately 2000 microU/ml, but at different st...

journal_title：Diabetes

authors： Liu G,Chen YD,Hollenbeck CB,Lardinois CK,Reaven GM

更新日期：1984-07-01 00:00:00

abstract：:Impaired skeletal muscle fatty acid oxidation has been suggested to contribute to insulin resistance and glucose intolerance. However, increasing muscle fatty acid oxidation may cause a reciprocal decrease in glucose oxidation, which might impair insulin sensitivity and glucose tolerance. We therefore investigated wha...

journal_title：Diabetes

authors： Keung W,Ussher JR,Jaswal JS,Raubenheimer M,Lam VH,Wagg CS,Lopaschuk GD

更新日期：2013-03-01 00:00:00

abstract：:Enhanced platelet functions have been demonstrated in patients with non-insulin-dependent diabetes mellitus (NIDDM). This study evaluated abnormalities in platelet signal transduction in diabetic patients, including turnover of phosphoinositides, mobilization of intracellular Ca2+, and phosphorylation of 20,000- and 4...

journal_title：Diabetes

authors： Ishii H,Umeda F,Hashimoto T,Nawata H

更新日期：1990-12-01 00:00:00

abstract：:In type 2 diabetes, impaired insulin-induced Akt/endothelial nitric oxide synthase (eNOS) signaling may decrease the vascular relaxation response. Previously, we reported that this response was negatively regulated by G protein-coupled receptor kinase 2 (GRK2). In this study, we investigated whether/how in aortas from...

journal_title：Diabetes

authors： Taguchi K,Matsumoto T,Kamata K,Kobayashi T

更新日期：2012-08-01 00:00:00

abstract：:It is well established that patients with non-insulin-dependent diabetes mellitus (NIDDM) are resistant to insulin. However, the contribution of hepatic and extrahepatic tissues to insulin resistance remains controversial. The uncertainty may be at least in part due to errors introduced by the unknowing use in previou...

journal_title：Diabetes

authors： Butler PC,Kryshak EJ,Schwenk WF,Haymond MW,Rizza RA

更新日期：1990-02-01 00:00:00

abstract：:T-1095A and T-1095 are synthetic agents derived from phlorizin, a specific inhibitor of Na+-glucose cotransporters (SGLTs). Unlike phlorizin, T-1095 is absorbed into the circulation via oral administration, is metabolized to the active form, T-1095A, and suppresses the activity of SGLTs in the kidney. Orally administe...

journal_title：Diabetes

authors： Oku A,Ueta K,Arakawa K,Ishihara T,Nawano M,Kuronuma Y,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T,Kanai Y,Endou H

更新日期：1999-09-01 00:00:00

abstract：:Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic vesicle priming. We recently showed that Munc13-1 is expressed in rodent and human islet beta-cells and that its levels are reduced in islets of type 2 diabetic humans and rat models, suggesting that Munc13-1 deficiency contributes to the abnor...

journal_title：Diabetes

authors： Kwan EP,Xie L,Sheu L,Nolan CJ,Prentki M,Betz A,Brose N,Gaisano HY

更新日期：2006-05-01 00:00:00

abstract：:Identifying new causes of permanent neonatal diabetes (PNDM) (diagnosis <6 months) provides important insights into β-cell biology. Patients with Down syndrome (DS) resulting from trisomy 21 are four times more likely to have childhood diabetes with an intermediate HLA association. It is not known whether DS can cause...

journal_title：Diabetes

authors： Johnson MB,De Franco E,Greeley SAW,Letourneau LR,Gillespie KM,International DS-PNDM Consortium.,Wakeling MN,Ellard S,Flanagan SE,Patel KA,Hattersley AT

更新日期：2019-07-01 00:00:00

abstract：:beta-Cell cycle progression and proliferation are critical to maintain beta-cell mass in adult mice. Of the cell cycle inhibitors, p27Kip1 is thought to be the primary modulator of the proliferative status in most cell types. p27 plays a role in beta-cell adaptation in genetic models of insulin resistance. To study th...

journal_title：Diabetes

authors： Rachdi L,Balcazar N,Elghazi L,Barker DJ,Krits I,Kiyokawa H,Bernal-Mizrachi E

更新日期：2006-12-01 00:00:00

abstract：:The IGF system has been associated with development and progression of diabetic retinopathy. We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. A prospective observational study was performed in 103 pregnan...

journal_title：Diabetes

authors： Lauszus FF,Klebe JG,Bek T,Flyvbjerg A

更新日期：2003-03-01 00:00:00

abstract：:Altered muscle fatty acid (FA) metabolism may contribute to the presence of muscle insulin resistance in the genetically obese Zucker rat. To determine whether FA uptake and disposal are altered in insulin-resistant muscle, we measured palmitate uptake, oxidation, and incorporation into di- and triglycerides in isolat...

journal_title：Diabetes

authors： Turcotte LP,Swenberger JR,Zavitz Tucker M,Yee AJ

更新日期：2001-06-01 00:00:00

abstract：:Genetic susceptibility to type I diabetes is partly determined by genes located in the human leukocyte antigen (HLA) region on chromosome 6. It has been claimed that the transmission of HLA-encoded susceptibility is influenced by parental sex. Fathers are reported to transmit HLA-DR4 haplotypes more frequently to thei...

journal_title：Diabetes

authors： Bain SC,Rowe BR,Barnett AH,Todd JA

更新日期：1994-12-01 00:00:00

abstract：:Earlier investigations have revealed that polyethylene glycol-B1-insulin (PEG insulin) causes lower utilization of glucose in fat cells than does the unaltered hormone, even though the blood glucose-lowering activity of both preparations in intact animals is identical. The present study was aimed to establish whether ...

journal_title：Diabetes

authors： Neubauer HP,Obermeier R,Schöne HH

更新日期：1983-10-01 00:00:00

abstract：:Recent evidence supports the strong overlap between genes implicated in monogenic diabetes and susceptibility to type 2 diabetes. Transient neonatal diabetes mellitus (TNDM) is a rare disorder associated with overexpression of genes at a paternally expressed imprinted locus on chromosome 6q24. There are two overlappin...

journal_title：Diabetes

authors： Gloyn AL,Mackay DJ,Weedon MN,McCarthy MI,Walker M,Hitman G,Knight BA,Owen KR,Hattersley AT,Frayling TM

更新日期：2006-08-01 00:00:00

abstract：:Peptidic glucagon antagonists have been shown to lower blood glucose levels in diabetic models (1-3), but attempts to identify small molecular weight glucagon receptor-binding antagonists have met with little success. Skyrin, a fungal bisanthroquinone, exhibits functional glucagon antagonism by uncoupling the glucagon...

journal_title：Diabetes

authors： Parker JC,McPherson RK,Andrews KM,Levy CB,Dubins JS,Chin JE,Perry PV,Hulin B,Perry DA,Inagaki T,Dekker KA,Tachikawa K,Sugie Y,Treadway JL

更新日期：2000-12-01 00:00:00

abstract：:Enhancement of arachidonic acid metabolism results in increased insulin secretion. To determine which pathways of arachidonic acid metabolism were involved in this stimulation, we studied the effects of various inhibitors of arachidonate metabolism on arginine-induced insulin and glucagon secretion in the isolated, pe...

journal_title：Diabetes

authors： Walsh MF,Pek SB

更新日期：1984-10-01 00:00:00

abstract：:Selective peroxisome proliferator-activated receptor (PPAR) gamma modulation is a new pharmacological approach that, based on selective receptor-cofactor interactions and target gene regulation, should result in potent insulin sensitization in the absence of PPARgamma-mediated adverse effects. Here, we characterize tw...

journal_title：Diabetes

authors： Schupp M,Clemenz M,Gineste R,Witt H,Janke J,Helleboid S,Hennuyer N,Ruiz P,Unger T,Staels B,Kintscher U

更新日期：2005-12-01 00:00:00

abstract：:Embryo-culture techniques were used to study the effects of exposure to glucose-deficient culture media on rat embryos during organogenesis. Embryos and their extraembryonic membranes (explants) were cultured either in control media or in media with low or very low glucose concentrations. At the start of the culture t...

journal_title：Diabetes

authors： Ellington SK

更新日期：1987-12-01 00:00:00

abstract：:Endothelial cells in culture retain many of the functional properties of the endothelium in vivo. At high cell density, they become contact-inhibited. Endothelial cells, like vascular smooth muscle cells and fibroblasts, express binding sites for low density lipoprotein when depleted of sterol. In contact-inhibited en...

journal_title：Diabetes

authors： Fielding CJ

更新日期：1981-01-01 00:00:00

abstract：:NOD mice, a model strain for human type 1 diabetes, express proinsulin (PI) in the thymus. However, insulin-reactive T cells escape negative selection, and subsequent activation of the CD8(+) T-cell clonotype G9C8, which recognizes insulin B15-23 via an αβ T-cell receptor (TCR) incorporating TRAV8-1/TRAJ9 and TRBV19/T...

journal_title：Diabetes

authors： Pearson JA,Thayer TC,McLaren JE,Ladell K,De Leenheer E,Phillips A,Davies J,Kakabadse D,Miners K,Morgan P,Wen L,Price DA,Wong FS

更新日期：2016-06-01 00:00:00

abstract：:Polyalkylcyanoacrylate nanocapsules (mean size 220 nm), composed of spheric polymeric structures, have been used as a drug carrier for insulin. The rate of encapsulation of insulin is 54.9%, and we studied the therapeutic efficiency of the nanocapsules in diabetic and normal rats. When administered subcutaneously, ins...

journal_title：Diabetes

authors： Damgé C,Michel C,Aprahamian M,Couvreur P

更新日期：1988-02-01 00:00:00

abstract：:We have applied cell-attached capacitance measurements to investigate whether synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma and primary pancreatic beta-cells. SLMV and large dense-core vesicle (LDCV) exocytosis was increased 1.6- and 2.4-fold upon stimulation with 10 mmol/l glucose in ...

journal_title：Diabetes

authors： MacDonald PE,Obermüller S,Vikman J,Galvanovskis J,Rorsman P,Eliasson L

更新日期：2005-03-01 00:00:00

abstract：:Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endoto...

journal_title：Diabetes

authors： Cani PD,Amar J,Iglesias MA,Poggi M,Knauf C,Bastelica D,Neyrinck AM,Fava F,Tuohy KM,Chabo C,Waget A,Delmée E,Cousin B,Sulpice T,Chamontin B,Ferrières J,Tanti JF,Gibson GR,Casteilla L,Delzenne NM,Alessi MC,Burceli

更新日期：2007-07-01 00:00:00

abstract：:The risk of insulin-dependent diabetes mellitus (IDDM) was examined in siblings of an unselected population (n = 194) of newly diagnosed diabetic individuals less than 30 yr old. From 1 July 1984 to 30 June 1987, diabetic subjects (proband) identified within a geographically defined area of southern Wisconsin were stu...

journal_title：Diabetes

authors： Allen C,Palta M,D'Alessio DJ

更新日期：1991-07-01 00:00:00

abstract：:Syngeneic pancreatic islet grafts in diabetic NOD mice are infiltrated by mononuclear leukocytes, beta-cells are selectively destroyed, and autoimmune diabetes recurs. This model was used to identify islet graft-infiltrating mononuclear leukocytes associated with beta-cell destruction and diabetes recurrence. We compa...

journal_title：Diabetes

authors： Suarez-Pinzon W,Rajotte RV,Mosmann TR,Rabinovitch A

更新日期：1996-10-01 00:00:00

abstract：:On the basis of the positive outcome of animal experiments, several large placebo-controlled trials are underway and aiming for the first time at the prevention of an immune-mediated disease, type 1 diabetes. The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical effica...

journal_title：Diabetes

authors： Lampeter EF,Klinghammer A,Scherbaum WA,Heinze E,Haastert B,Giani G,Kolb H

更新日期：1998-06-01 00:00:00