Metabolic endotoxemia initiates obesity and insulin resistance.

abstract：:Despite intensive study, the relation between insulin's action on blood flow and glucose metabolism remains unclear. Insulin-induced changes in microvascular perfusion, independent from effects on total blood flow, could be an important variable contributing to insulin's metabolic action. We hypothesized that modest, ...

journal_title：Diabetes

authors： Coggins M,Lindner J,Rattigan S,Jahn L,Fasy E,Kaul S,Barrett E

更新日期：2001-12-01 00:00:00

abstract：:Eight manufacturing facilities participating in the National Institutes of Health-sponsored Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a harmonized process for the manufacture of allogeneic purified human pancreatic islet (PHPI) product evaluated in a phase 3 trial in subjects wi...

journal_title：Diabetes

authors： Ricordi C,Goldstein JS,Balamurugan AN,Szot GL,Kin T,Liu C,Czarniecki CW,Barbaro B,Bridges ND,Cano J,Clarke WR,Eggerman TL,Hunsicker LG,Kaufman DB,Khan A,Lafontant DE,Linetsky E,Luo X,Markmann JF,Naji A,Korsgren O

更新日期：2016-11-01 00:00:00

abstract：:Type 2 diabetes is characterized by islet amyloid deposits, which are primarily composed of the amyloidogenic human form of islet amyloid polypeptide (IAPP, amylin). The mechanism of islet amyloido-genesis is not known, but other products (e.g., apolipoprotein E and perlecan) contained within islet amyloid may be nece...

journal_title：Diabetes

authors： Andrikopoulos S,Verchere CB,Teague JC,Howell WM,Fujimoto WY,Wight TN,Kahn SE

更新日期：1999-10-01 00:00:00

abstract：:The nutrient-sensitive kinase mammalian target of rapamycin (mTOR) and its downstream target S6 kinase (S6K) are involved in amino acid-induced insulin resistance. Whether the mTOR/S6K pathway directly modulates glucose metabolism in humans is unknown. We studied 11 healthy men (29 years old, BMI 23 kg/m(2)) twice in ...

journal_title：Diabetes

authors： Krebs M,Brunmair B,Brehm A,Artwohl M,Szendroedi J,Nowotny P,Roth E,Fürnsinn C,Promintzer M,Anderwald C,Bischof M,Roden M

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The aim of the current study was to evaluate the long-term effects of leptin on glucose metabolism, diabetes complications, and life span in an insulin-dependent diabetes model, the Akita mouse. RESEARCH DESIGN AND METHODS:We cross-mated Akita mice with leptin-expressing transgenic (LepTg) mice to produce Ak...

journal_title：Diabetes

authors： Naito M,Fujikura J,Ebihara K,Miyanaga F,Yokoi H,Kusakabe T,Yamamoto Y,Son C,Mukoyama M,Hosoda K,Nakao K

更新日期：2011-09-01 00:00:00

abstract：:Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Whether hyperglycemia evolves from normoglycemia gradually over time or as a step increase is not known. We measured plasma glucose and insulin levels during oral glucose testing in 35- to 64-year-old men and nonpregnant women from a p...

journal_title：Diabetes

authors： Ferrannini E,Nannipieri M,Williams K,Gonzales C,Haffner SM,Stern MP

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To characterize normal and malformed embryos within the same litters from control and diabetic rats for expression of genes related to metabolism of reactive oxygen species (ROS) or glucose as well as developmental genes. RESEARCH DESIGN AND METHODS:Embryos from nondiabetic and streptozotocin-induced diabeti...

journal_title：Diabetes

authors： Wentzel P,Gäreskog M,Eriksson UJ

更新日期：2008-12-01 00:00:00

abstract：:In an initial cross-sectional study, 29 female and 25 male nondiabetic weaned nonobese diabetic (NOD) mice of various ages (age range 30-300 days, mean 108 +/- 10 days) and 11 unweaned NOD pups were evaluated for competitive insulin autoantibodies (CIAAs) with a fluid-phase radioassay. Eleven of 54 (20%) weaned NOD mi...

journal_title：Diabetes

authors： Ziegler AG,Vardi P,Ricker AT,Hattori M,Soeldner JS,Eisenbarth GS

更新日期：1989-03-01 00:00:00

abstract：:An A-to-G transition in the mitochondrial tRNALeu(UUR) gene at base pair 3243 has been shown to be associated with the maternally transmitted clinical phenotype of NIDDM and sensorineural hearing loss in white and Japanese pedigrees. We have detected this mutation in 25 of 50 tested members of five white French pedigr...

journal_title：Diabetes

authors： Velho G,Byrne MM,Clément K,Sturis J,Pueyo ME,Blanché H,Vionnet N,Fiet J,Passa P,Robert JJ,Polonsky KS,Froguel P

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this ...

journal_title：Diabetes

authors： Villarreal-Molina MT,Flores-Dorantes MT,Arellano-Campos O,Villalobos-Comparan M,Rodríguez-Cruz M,Miliar-García A,Huertas-Vazquez A,Menjivar M,Romero-Hidalgo S,Wacher NH,Tusie-Luna MT,Cruz M,Aguilar-Salinas CA,Canizales-Quintero

更新日期：2008-02-01 00:00:00

abstract：:In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid. The aim of the present study was to determine the relationship between young children's muscle membrane fatty acid (FA) composition and indices of insulin resist...

journal_title：Diabetes

authors： Baur LA,O'Connor J,Pan DA,Storlien LH

更新日期：1999-01-01 00:00:00

abstract：:Precise timing of the teratogenic period in diabetic pregnancy is of clinical importance since correction of the glucose intolerance during this period may protect the offspring from malformations. An experimental approach to elucidate this problem with regard to skeletal development was made in groups of pregnant str...

journal_title：Diabetes

authors： Eriksson UJ,Dahlström E,Hellerström C

更新日期：1983-12-01 00:00:00

abstract：:The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP-group), and 6 male nondiabetic control subjects. The mean age ...

journal_title：Diabetes

authors： Mäntysaari M,Kuikka J,Mustonen J,Tahvanainen K,Vanninen E,Länsimies E,Uusitupa M

更新日期：1992-09-01 00:00:00

abstract：:Ciglitazone, 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione, is a new hypoglycemic agent orally active in the obese-hyperglycemic animal models. In C57BL/6J-ob/ob mice, treatment with 100 mg/kg ciglitazone for 2 days elicited a drastic fall in blood glucose. It also decreased plasma insulin, triglycer...

journal_title：Diabetes

authors： Chang AY,Wyse BM,Gilchrist BJ,Peterson T,Diani AR

更新日期：1983-09-01 00:00:00

abstract：:Direct methods for measuring the secretion rate of insulin are too cumbersome for clinical application. Since C-peptide is secreted in an equimolar ratio with insulin and is excreted into the urine, measuring the urinary excretion rate of C-peptide (U-C) could serve as an indicator of its secretion rate (SR-C) if its ...

journal_title：Diabetes

authors： Meistas MT,Rendell M,Margolis S,Kowarski AA

更新日期：1982-05-01 00:00:00

abstract：:Our aim was to isolate and determine the contribution of partial pancreatectomy, systemic delivery of pancreatic hormones, and duct obliteration to glucose regulation after segmental pancreas transplantation in dogs. Fasting, postprandial, and intravenous glucose-stimulated glucose, insulin, glucagon, pancreatic polyp...

journal_title：Diabetes

authors： van der Burg MP,Gooszen HG,Guicherit OR,Jansen JB,Frölich M,van Haastert FA,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...

journal_title：Diabetes

authors： Sandler S,Andersson A,Hellerström C,Petersson B,Swenne I,Björkén C,Groth CG

更新日期：1982-03-01 00:00:00

abstract：:Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studi...

journal_title：Diabetes

authors： Bagwell AM,Bento JL,Mychaleckyj JC,Freedman BI,Langefeld CD,Bowden DW

更新日期：2005-04-01 00:00:00

abstract：:High glucose concentrations such as are seen in diabetes mellitus are known to have deleterious effects on cells, but the pathways by which glucose induces these effects are unknown. One hypothesis is that metabolism of glucose to glucosamine might be involved. For example, it has been shown that glucosamine is more p...

journal_title：Diabetes

authors： Crook ED,Daniels MC,Smith TM,McClain DA

更新日期：1993-09-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activate...

journal_title：Diabetes

authors： Coppieters KT,Amirian N,Pagni PP,Baca Jones C,Wiberg A,Lasch S,Hintermann E,Christen U,von Herrath MG

更新日期：2013-07-01 00:00:00

abstract：:We present a patient who developed insulin-requiring diabetes several years after the onset of symptoms of anterior hypopituitarism. It is likely that the hypopituitarism protected him against the development of diabetic retinopathy and glomerular basement membrane thickening but not against neuropathy and atheroma. T...

journal_title：Diabetes

authors： Greenwood RH,Ireland JT,Jones DH,Mahler RF

更新日期：1975-11-01 00:00:00

abstract：:WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade ...

journal_title：Diabetes

authors： Murahovschi V,Pivovarova O,Ilkavets I,Dmitrieva RM,Döcke S,Keyhani-Nejad F,Gögebakan Ö,Osterhoff M,Kemper M,Hornemann S,Markova M,Klöting N,Stockmann M,Weickert MO,Lamounier-Zepter V,Neuhaus P,Konradi A,Dooley S,von L

更新日期：2015-03-01 00:00:00

abstract：:The effect of three calcium antagonists (verapamil, diltiazem, and nifedipine) on insulin effects was investigated in isolated rat soleus muscles. Soleus muscles were incubated in the presence of insulin (100 microU/ml), a concentration that stimulates the rates of lactate formation and glycogen synthesis half-maximal...

journal_title：Diabetes

authors： Foot EA,Leighton B

更新日期：1994-01-01 00:00:00

abstract：:The secretory, metabolic, and signaling aspects of glucose/palmitate interaction on beta-cell function have been studied on rat islets. Palmitate potentiated the glucose-induced insulin response of perifused islets at suprathreshold (>3 mmol/l) sugar concentrations. This potentiating effect could be suppressed by 8-br...

journal_title：Diabetes

authors： Alcázar O,Qiu-yue Z,Giné E,Tamarit-Rodriguez J

更新日期：1997-07-01 00:00:00

abstract：:Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown whether leptin modulates the release of CCK. Here, we demonstrate in vitro that leptin induces the phosphorylation of extracellular signal-related kinase (ERK)-1/2 proteins and increases CCK release (EC(50) = 0.23 nmol/l) in CCK-secr...

journal_title：Diabetes

authors： Guilmeau S,Buyse M,Tsocas A,Laigneau JP,Bado A

更新日期：2003-07-01 00:00:00

abstract：:Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...

journal_title：Diabetes

authors： Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

更新日期：1999-05-01 00:00:00

abstract：:Obesity and family history of diabetes are both risk factors for non-insulin-dependent diabetes mellitus (NIDDM), but it has been proposed that lean individuals with NIDDM have a greater load of diabetes susceptibility genes. If this is the case, one might expect a high prevalence of NIDDM in relatives of diabetic ind...

journal_title：Diabetes

authors： Hanson RL,Pettitt DJ,Bennett PH,Narayan KM,Fernandes R,de Courten M,Knowler WC

更新日期：1995-04-01 00:00:00

abstract：:Diabetes complications are caused by hyperglycemia. Hyperglycemia results in increased concentrations of glucose degradation products. The study of peritoneal dialysis solution biocompatibility has highlighted the adverse effects of glucose degradation products. Recently, 3,4-dideoxyglucosone-3-ene (3,4-DGE) has been ...

journal_title：Diabetes

authors： Justo P,Sanz AB,Egido J,Ortiz A

更新日期：2005-08-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) increases the content and mRNA level of insulin in a mouse beta-cell line, MIN6, and primary-cultured mouse islets. We examined the mechanism of PTHrP-induced insulin expression. The PTHrP effect was markedly augmented by SB203580, a mitogen-activated protein (MAP) kinase in...

journal_title：Diabetes

authors： Zhang B,Hosaka M,Sawada Y,Torii S,Mizutani S,Ogata M,Izumi T,Takeuchi T

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00