Abstract:
:In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid. The aim of the present study was to determine the relationship between young children's muscle membrane fatty acid (FA) composition and indices of insulin resistance in their mothers. Muscle biopsy specimens obtained at the time of elective surgery from 83 children (54 boys), aged 0.78 +/- 0.05 year (mean +/- SE), were analyzed for phospholipid FA composition. Fasting blood samples were collected from the mothers of the children, and maternal BMIs were calculated. Stepwise multiple regression analysis showed that after accounting for the effect of breast-feeding, log maternal insulin levels were inversely associated with the child's muscle membrane docosahexaenoic acid (22:6 n-3; R2 = 0.29, P = 0.0006) and the sum of the n-3 PUFAs (R2 = 0.23, P = 0.0016) but positively associated with the sum of the n-6 PUFAs (R2 = 0.05, P = 0.03) and the n-6/n-3 PUFA ratio (R2 = 0.20, P = 0.007). Independent of breast-feeding, log maternal triglyceride levels were inversely associated with the child's muscle membrane unsaturation index (a measure of unsaturation) (R2 = 0.08, P = 0.005). Maternal BMI; total, LDL, and HDL cholesterol; and the child's age, sex, and birth weight were not significant predictors of the child's muscle membrane FA composition. Thus, maternal fasting insulin and triglyceride levels are significant predictors of the FA composition of the child's muscle membrane. The less unsaturated muscle membranes in children whose mothers have higher fasting insulin and triglyceride levels may reflect a genetic reluctance to incorporate PUFAs into membranes, thus predisposing them to insulin resistance syndromes.
journal_name
Diabetesjournal_title
Diabetesauthors
Baur LA,O'Connor J,Pan DA,Storlien LHdoi
10.2337/diabetes.48.1.112subject
Has Abstractpub_date
1999-01-01 00:00:00pages
112-6issue
1eissn
0012-1797issn
1939-327Xjournal_volume
48pub_type
杂志文章相关文献
DIABETES文献大全abstract::Diabetic hypoglycemia produces cognitive-motor slowing, which is assumed to increase risk of automobile crashes. This study investigated driving decrements during and after hypoglycemia, and the patients' awareness of driving decrements. We used a randomized, single-blind, crossover design and conducted the study at t...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.42.2.239
更新日期:1993-02-01 00:00:00
abstract::Ectopic lipid accumulation in the liver is an almost universal feature of human and rodent models of generalized lipodystrophy and is also a common feature of type 2 diabetes, obesity, and metabolic syndrome. Here we explore the progression of fatty liver disease using a mouse model of lipodystrophy created by a fat-s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0213
更新日期:2016-08-01 00:00:00
abstract::WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/db14-0444
更新日期:2015-03-01 00:00:00
abstract::Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Whether hyperglycemia evolves from normoglycemia gradually over time or as a step increase is not known. We measured plasma glucose and insulin levels during oral glucose testing in 35- to 64-year-old men and nonpregnant women from a p...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.1.160
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:FUT2 encodes the α(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are nonsecretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces. This mutation has been reported to provide...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0638
更新日期:2011-11-01 00:00:00
abstract::Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD i...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1181
更新日期:2017-05-01 00:00:00
abstract::Insulin-dependent diabetes (type 1 diabetes) in the NOD mouse is a T-cell-mediated autoimmune disease. However, B-cells may also play a critical role in disease pathogenesis, as genetically B-cell-deficient NOD mice (NOD.microMT) have been shown to be protected from type 1 diabetes and to display reduced responses to ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.4.763
更新日期:2001-04-01 00:00:00
abstract::The acquisition of T-cell tolerance in the thymus is limited to those antigens expressed in the thymus at the time of T-cell development. Normally, islet antigens that are involved in insulin-dependent diabetes mellitus (IDDM) are not present in the thymus, but we have previously shown that transplantation of islets e...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.8.871
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:A number of studies have found that reduced birth weight is associated with type 2 diabetes later in life; however, the underlying mechanism for this correlation remains unresolved. Recently, association has been demonstrated between low birth weight and single nucleotide polymorphisms (SNPs) at the CDKAL1 an...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-0506
更新日期:2009-10-01 00:00:00
abstract::Diet-induced obesity is the primary determinant of the current epidemic of diabetes. We have explored the role of genetics in this phenomenon, using C57Bl/6 (B6), 129S6/SvEvTac (129), and intercross (B6 x 129)F2 mice on a low- or high-fat diet. Over an 18-week period, B6 and F2 mice gained more weight, had higher leve...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.12.3274
更新日期:2004-12-01 00:00:00
abstract::The use of HIV protease inhibitors (PIs) has been associated with several metabolic changes, including lipodystrophy, hyperlipidemia, and insulin resistance. The etiology of these adverse effects remains unknown. PIs have recently been found to cause acute and reversible inhibition of GLUT4 activity in vitro. To deter...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.4.937
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS:To efficiently search for genomic regions harborin...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-1086
更新日期:2008-09-01 00:00:00
abstract::The association of type 1 diabetes with the insulin gene (IDDM2 locus) has been mapped to a short haplotype encompassing two single nucleotide polymorphisms (SNPs) in perfect linkage disequilibrium (r(2) = 1) with each other and with the two allele classes at the variable number of tandem repeats (VNTR) polymorphism u...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0402
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...
journal_title:Diabetes
pub_type: 杂志文章,多中心研究
doi:10.2337/db07-0874
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this ...
journal_title:Diabetes
pub_type: 杂志文章,多中心研究
doi:10.2337/db07-0484
更新日期:2008-02-01 00:00:00
abstract::A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis of insulin resistance. We have developed a highly specific small molecule inhibitor of glucosylceramide synthase, an enzyme that catalyzes a necessary step in the conversion of ceramide to glycosphingolipids. In...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1619
更新日期:2007-05-01 00:00:00
abstract::The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel meta...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi18-0009
更新日期:2019-05-01 00:00:00
abstract::Oxidative stress may contribute to the pathogenesis of diabetic nephropathy. However, the detailed molecular mechanism remains uncertain. Here, we report oxidative mitochondrial DNA (mtDNA) damage and accumulation of mtDNA with a 4,834-bp deletion in kidney of streptozotocin-induced diabetic rats. At 8 weeks after the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.5.1588
更新日期:2002-05-01 00:00:00
abstract::The experiments reported here investigate the effects of two conditions of elevated lactogen activity on the threshold of glucose stimulation of insulin secretion and suprathreshold, glucose-stimulated insulin secretion in the isolated, perfused rat pancreas. In both the tumor-bearing animals and pregnant animals, the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.4.337
更新日期:1985-04-01 00:00:00
abstract::Diabetes is characterized by altered metabolism of key molecules and regulatory pathways. The phenotypic expression of diabetes and associated complications encompasses complex interactions between genetic, environmental, and tissue-specific factors that require an integrated understanding of perturbations in the netw...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/db14-0509
更新日期:2015-03-01 00:00:00
abstract::The clearing of monoclonal and polyclonal and anti-insulin antibodies from homogeneous solutions at 100,000 X g was used to estimate the size of soluble insulin-antibody complexes at physiologic concentrations. Monoclonal antibodies cleared as a uniform population of 6.6 S independent of the insulin concentration. Pol...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.8.799
更新日期:1985-08-01 00:00:00
abstract::Glucokinase is a critical component of the physiological glucose sensor found in cell types that are responsive to changes in plasma glucose levels. The acute regulation of glucokinase activity has been shown to occur via a regulatory protein found in liver parenchymal cells (Van Schaftingen E, Detheux M, Da Cunha MV....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.12.1670
更新日期:1996-12-01 00:00:00
abstract::Fed male Wistar rats were eviscerated by two procedures. The first group of eviscerated rats were left with a nonfunctional liver in situ while the second group were eviscerated by a newer technic, developed in this laboratory, that preserves liver function. The animals were maintained on a regimen of saline and antib...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.7.637
更新日期:1975-07-01 00:00:00
abstract:OBJECTIVE:Metformin can decrease adiposity and ameliorate obesity-related comorbid conditions, including abnormalities in glucose homeostasis in adolescents, but there are few data evaluating the efficacy of metformin among younger children. Our objective was to determine whether metformin treatment causes weight loss ...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db10-1185
更新日期:2011-02-01 00:00:00
abstract::Hyperglycemia alters cardiac function and often leads to diabetic cardiomyopathy as cardiomyocyte apoptosis causes a hypertrophied heart to deteriorate to dilation and failure. Paradoxically, many short-term animal models of hyperglycemia protect against ischemia-induced damage, including apoptosis, by limiting Ca(2+)...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.12.3461
更新日期:2002-12-01 00:00:00
abstract::The dysregulation of receptor tyrosine kinases (RTKs) in multiple cell types during chronic inflammation is indicative of their pathogenic role in autoimmune diseases. Among the many RTKs, vascular endothelial growth factor receptor (VEGFR) stands out for its multiple effects on immunity, vascularization, and cell mig...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-1619
更新日期:2013-08-01 00:00:00
abstract::Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able to briskly respond to other beta-cell secretagogues. To investigate whether this is a defect specific for glucose or represents a more general phenomenon, we mea...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.12.1314
更新日期:1986-12-01 00:00:00
abstract::The IGF system has been associated with development and progression of diabetic retinopathy. We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. A prospective observational study was performed in 103 pregnan...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.3.852
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To ascertain the importance and mechanisms underlying the role of brain glucagon-like peptide (GLP)-1 in the control of metabolic and cardiovascular function. GLP-1 is a gut hormone secreted in response to oral glucose absorption that regulates glucose metabolism and cardiovascular function. GLP-1 is also pro...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-0121
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Preferential upper-body fat gain, a typical male pattern, is associated with a greater cardiometabolic risk. Regional differences in lipolysis and meal fat storage cannot explain sex differences in body fat distribution. We examined the potential role of the novel free fatty acid (FFA) storage pathway in dete...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0154
更新日期:2011-08-01 00:00:00