Indinavir induces acute and reversible peripheral insulin resistance in rats.

abstract：:The effects of sulfated cholecystokinin (CCK-8S) and glucose on insulin secretion and polyphosphoinositide (PPI) metabolism were studied in isolated rat islets. Both agonists stimulate PPI hydrolysis, inositol phosphate accumulation, 3H efflux from [3H]inositol-prelabeled tissue, and 45Ca efflux from prelabeled cells....

journal_title：Diabetes

authors： Zawalich W,Takuwa N,Takuwa Y,Diaz VA,Rasmussen H

更新日期：1987-04-01 00:00:00

abstract：:Studies were conducted to explore altered substrate utilization and metabolism in GLUT4 null mice. Liver fatty acid synthase mRNA and fatty acid synthesis rates were dramatically increased in GLUT4 null mice compared with control mice and were supported by increased rates of the pentose phosphate pathway oxidative pha...

journal_title：Diabetes

authors： Ranalletta M,Jiang H,Li J,Tsao TS,Stenbit AE,Yokoyama M,Katz EB,Charron MJ

更新日期：2005-04-01 00:00:00

abstract：:Metabolic interactions between glucose and amino acids were studied with isolated rat islets using glucose utilization and lactate formation as indicators. Certain amino acids (8-10 mM) are capable of greatly stimulating lactate formation from 5mM glucose. On a molar basis L-isoleucine is the most potent stimulator in...

journal_title：Diabetes

authors： Pace CS,Ellerman J,Hover BA,Stillings SN,Matschinsky FM

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adi...

journal_title：Diabetes

authors： HAPO Study Cooperative Research Group.

更新日期：2009-02-01 00:00:00

abstract：:In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow. The optimal d...

journal_title：Diabetes

authors： Bar-On H,Roheim PS,Eder HA

更新日期：1976-06-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in the pancreas. Thereby, the chemokine CXC-motif ligand 10 (CXCL10) plays an important role in the recruitment of autoaggressive lymphocytes to the islets of Langerhans. Transplantation of isolated islets as a promising therapy...

journal_title：Diabetes

authors： Bender C,Christen S,Scholich K,Bayer M,Pfeilschifter JM,Hintermann E,Christen U

更新日期：2017-01-01 00:00:00

abstract：:Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially confounded by developmental adaptation of animal physiology. We aimed to adapt the technique of in vivo electrotransfer (IVE) to alter local gene expression in skeletal muscle of rodents as a means of investigating the role ...

journal_title：Diabetes

authors： Cleasby ME,Davey JR,Reinten TA,Graham MW,James DE,Kraegen EW,Cooney GJ

更新日期：2005-09-01 00:00:00

abstract：:Development of a robust insulin secretory response to glucose occurs during the early neonatal period. To determine if neuroendocrine agents play a role during this time, we studied the effects of selected peptides and neurotransmitters on insulin release and polyphosphoinositide metabolism in islets isolated from 1- ...

journal_title：Diabetes

authors： Fletcher DJ,Rowley WH,Pabst SJ,Brinn JE

更新日期：1989-11-01 00:00:00

abstract：:On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...

journal_title：Diabetes

authors： Päth G,Opel A,Knoll A,Seufert J

更新日期：2004-02-01 00:00:00

abstract：:Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...

journal_title：Diabetes

authors： Tan BH,Wilson GL,Schaffer SW

更新日期：1984-12-01 00:00:00

abstract：:Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adip...

journal_title：Diabetes

authors： Vozarova de Courten B,Hanson RL,Funahashi T,Lindsay RS,Matsuzawa Y,Tanaka S,Thameem F,Gruber JD,Froguel P,Wolford JK

更新日期：2005-01-01 00:00:00

abstract：:Cardiac failure is a major cause of death in patients with type 2 diabetes, but the molecular mechanism that links diabetes to heart failure remains unclear. Insulin resistance is a hallmark of type 2 diabetes, and insulin receptor substrates 1 and 2 (IRS1 and IRS2) are the major insulin-signaling components regulatin...

journal_title：Diabetes

authors： Qi Y,Xu Z,Zhu Q,Thomas C,Kumar R,Feng H,Dostal DE,White MF,Baker KM,Guo S

更新日期：2013-11-01 00:00:00

abstract：:Treatment of male sand rats kept on a balanced laboratory chow diet ad libitum with beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) resulted in a hypolipidemic effect accompanied by an extensive reduction in adiposity, with a concomitant hypoglycemic-hypoinsulinemic effect. The overall effect was s...

journal_title：Diabetes

authors： Tzur R,Rose-Kahn G,Adler JH,Bar-Tana J

更新日期：1988-12-01 00:00:00

abstract：:The TaqIB cholesteryl ester transfer protein (CETP) gene polymorphism (B1B2) is a determinant of HDL cholesterol in nondiabetic populations. Remarkably, this gene effect appears to be modified by environmental factors. We evaluated the effect of this polymorphism on HDL cholesterol levels and on the lipoprotein respon...

journal_title：Diabetes

authors： Dullaart RP,Hoogenberg K,Riemens SC,Groener JE,van Tol A,Sluiter WJ,Stulp BK

更新日期：1997-12-01 00:00:00

abstract：:The "M" variant of the encephalomyocarditis (EMC) virus causes a diabetes-like disease in some, but not all, strains of mice. The genetic basis for either resistance or susceptibility to the diabetogenic effect of the virus is not known. After infection with EMC, C57BL/6 mice seldom develop hyperglycemia and the insul...

journal_title：Diabetes

authors： D'Andrea BJ,Wilson GL,Craighead JE

更新日期：1981-05-01 00:00:00

abstract：:Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE recept...

journal_title：Diabetes

authors： Poirier O,Nicaud V,Vionnet N,Raoux S,Tarnow L,Vlassara H,Parving HH,Cambien F

更新日期：2001-05-01 00:00:00

abstract：:Inactivation of the β-cell transcription factor NEUROD1 causes diabetes in mice and humans. In this study, we uncovered novel functions of NEUROD1 during murine islet cell development and during the differentiation of human embryonic stem cells (HESCs) into insulin-producing cells. In mice, we determined that Neurod1 ...

journal_title：Diabetes

authors： Romer AI,Singer RA,Sui L,Egli D,Sussel L

更新日期：2019-12-01 00:00:00

abstract：:The researchers conducted this study to test the hypothesis that risk of type 2 diabetes is less following reductions in body size and central adiposity. The Diabetes Prevention Program (DPP) recruited and randomized individuals with impaired glucose tolerance to treatment with placebo, metformin, or lifestyle modific...

journal_title：Diabetes

authors： Fujimoto WY,Jablonski KA,Bray GA,Kriska A,Barrett-Connor E,Haffner S,Hanson R,Hill JO,Hubbard V,Stamm E,Pi-Sunyer FX,Diabetes Prevention Program Research Group.

更新日期：2007-06-01 00:00:00

abstract：:T-1095A and T-1095 are synthetic agents derived from phlorizin, a specific inhibitor of Na+-glucose cotransporters (SGLTs). Unlike phlorizin, T-1095 is absorbed into the circulation via oral administration, is metabolized to the active form, T-1095A, and suppresses the activity of SGLTs in the kidney. Orally administe...

journal_title：Diabetes

authors： Oku A,Ueta K,Arakawa K,Ishihara T,Nawano M,Kuronuma Y,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T,Kanai Y,Endou H

更新日期：1999-09-01 00:00:00

abstract：:Glucose stimulates insulin secretion by generating triggering and amplifying signals in beta-cells. The triggering pathway is well characterized. It involves the following sequence of events: entry of glucose by facilitated diffusion, metabolism of glucose by oxidative glycolysis, rise in the ATP-to-ADP ratio, closure...

journal_title：Diabetes

authors： Henquin JC

更新日期：2000-11-01 00:00:00

abstract：:beta-Cell cycle progression and proliferation are critical to maintain beta-cell mass in adult mice. Of the cell cycle inhibitors, p27Kip1 is thought to be the primary modulator of the proliferative status in most cell types. p27 plays a role in beta-cell adaptation in genetic models of insulin resistance. To study th...

journal_title：Diabetes

authors： Rachdi L,Balcazar N,Elghazi L,Barker DJ,Krits I,Kiyokawa H,Bernal-Mizrachi E

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Haptoglobin (Hp) is upregulated in both inflammation and obesity. The low chronic inflammatory state, caused by massive adipose tissue macrophage (ATM) infiltration found in obesity, and low adiponectin have been implicated in the development of insulin resistance and hepatosteatosis. The aim of this work was...

journal_title：Diabetes

authors： Lisi S,Gamucci O,Vottari T,Scabia G,Funicello M,Marchi M,Galli G,Arisi I,Brandi R,D'Onofrio M,Pinchera A,Santini F,Maffei M

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment in a model of type 1 diabetes. RESEARCH DESIGN AND METHODS:Recombinant TRAIL was added in vitro to primary human and mouse peripheral blood mononuclear cells (PBMC...

journal_title：Diabetes

authors： Zauli G,Toffoli B,di Iasio MG,Celeghini C,Fabris B,Secchiero P

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K ...

journal_title：Diabetes

authors： Zhou H,Zhang T,Bogdani M,Oseid E,Parazzoli S,Vantyghem MC,Harmon J,Slucca M,Robertson RP

更新日期：2008-06-01 00:00:00

abstract：:Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves end...

journal_title：Diabetes

authors： Rickels MR,Fuller C,Dalton-Bakes C,Markmann E,Palanjian M,Cullison K,Tiao J,Kapoor S,Liu C,Naji A,Teff KL

更新日期：2015-05-01 00:00:00

abstract：:In vivo studies were undertaken in rats to provide evidence of the neural nature, tentative localization and mode of excitation of the insulin-sensitive central nervous system (CSN) glucoregulator center. In rats under light barbiturate anesthesia minute amounts of insulin injected into the carotid artery resulted in ...

journal_title：Diabetes

authors： Szabo O,Szabo AJ

更新日期：1975-04-01 00:00:00

abstract：:Fasting hyperglycemia occurs when an excessive rate of endogenous glucose production (EGP) is not accompanied by an adequate compensatory increase in the rate of glucose disappearance (Rd). The situation following food ingestion is more complex as the amount of glucose that reaches the circulation for disposal is a fu...

journal_title：Diabetes

authors： Rizza RA,Toffolo G,Cobelli C

更新日期：2016-05-01 00:00:00

abstract：:Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene ...

journal_title：Diabetes

authors： Blackman SM,Commander CW,Watson C,Arcara KM,Strug LJ,Stonebraker JR,Wright FA,Rommens JM,Sun L,Pace RG,Norris SA,Durie PR,Drumm ML,Knowles MR,Cutting GR

更新日期：2013-10-01 00:00:00

abstract：:Hepatocyte nuclear factor (HNF)-4alpha is a transcription factor known as a key molecule in the development and functions of the beta-cells. In a previously performed genome-wide scan of Japanese type 2 diabetic sibpairs, we observed linkage of type 2 diabetes to chromosome 20q12-q13, a region in which the HNF4A gene ...

journal_title：Diabetes

authors： Hara K,Horikoshi M,Kitazato H,Ito C,Noda M,Ohashi J,Froguel P,Tokunaga K,Tobe K,Nagai R,Kadowaki T

更新日期：2006-05-01 00:00:00