Age-dependent stimulation of neonatal insulin release and inositol phosphate accumulation by CCK-8 and carbachol.

abstract：:Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phase insulin secretion and improve glucose control. To determine the phys...

journal_title：Diabetes

authors： Kaihara KA,Dickson LM,Jacobson DA,Tamarina N,Roe MW,Philipson LH,Wicksteed B

更新日期：2013-05-01 00:00:00

abstract：:We have recently demonstrated that the exposure to hyperglycemia in utero impairs nephrogenesis in rat fetuses (Amri K et al., Diabetes 48:2240-2245, 1999). Diabetic pregnancy is commonly associated with alterations in the IGF system in fetal tissues. It has also been shown that both IGF-I and IGF-II are produced with...

journal_title：Diabetes

authors： Amri K,Freund N,Duong Van Huyen JP,Merlet-Bénichou C,Lelièvre-Pégorier M

更新日期：2001-05-01 00:00:00

abstract：:This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats treated with a p38 inhibitor, an aldose redu...

journal_title：Diabetes

authors： Price SA,Agthong S,Middlemas AB,Tomlinson DR

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance. RESEARCH DESIGN AND METHODS:TSP1 gene expression was quantified in subcutaneous adipose tiss...

journal_title：Diabetes

authors： Varma V,Yao-Borengasser A,Bodles AM,Rasouli N,Phanavanh B,Nolen GT,Kern EM,Nagarajan R,Spencer HJ 3rd,Lee MJ,Fried SK,McGehee RE Jr,Peterson CA,Kern PA

更新日期：2008-02-01 00:00:00

abstract：:In patients with diabetes, altered diurnal blood pressure (BP) regulation (high night-to-day [N/D] ratio, or "nondipping") is associated with increases in albumin excretion and a decline in the glomerular filtration rate (GFR) by an unknown mechanism. Because it is known that renin angiotensin system (RAS) activation ...

journal_title：Diabetes

authors： Miller JA,Curtis JR,Sochett EB

更新日期：2003-07-01 00:00:00

abstract：:Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvascular complications of type 2 diabetes. In liver, extracellular hepara...

journal_title：Diabetes

authors： Olsson U,Egnell AC,Lee MR,Lundén GO,Lorentzon M,Salmivirta M,Bondjers G,Camejo G

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:The gut environment modulates the pathogenesis of type 1 diabetes (T1D), but how it affects autoimmunity toward pancreatic β-cells, a self-tissue located outside the intestine, is still unclear. In the small intestine, lamina propria dendritic cells (LPDCs) induce peripheral differentiation of FoxP3(+) regula...

journal_title：Diabetes

authors： Badami E,Sorini C,Coccia M,Usuelli V,Molteni L,Bolla AM,Scavini M,Mariani A,King C,Bosi E,Falcone M

更新日期：2011-08-01 00:00:00

abstract：:The efficacy of gangliosides in enhancing axonal regeneration and maturation in the early stages of diabetic neuropathy was assessed by quantitative analysis of immunostained serial sections of the sciatic nerve. Sprague-Dawley rats were made diabetic with a single injection of alloxan (100 mg/kg). One week later they...

journal_title：Diabetes

authors： Triban C,Guidolin D,Fabris M,Marini P,Schiavinato A,Donà M,Bortolami MC,Di Giamberardino L,Fiori MG

更新日期：1989-08-01 00:00:00

abstract：:Glucose tolerance depends on a complex interaction among insulin secretion from the beta-cells, clearance of the hormone, and the actions of insulin to accelerate glucose disappearance and inhibit endogenous glucose production. An additional factor, less well recognized, is the ability of glucose per se, independent o...

journal_title：Diabetes

authors： Bergman RN

更新日期：1989-12-01 00:00:00

abstract：:Antibodies against islet cell antigens are used as predictive markers of type 1 diabetes, but it is unknown whether they reflect an ongoing autoimmune process in islet tissue. We investigated whether organs from adult donors that are positive for autoantibodies (aAbs) against islet cell antigens exhibit insulitis and/...

journal_title：Diabetes

authors： In't Veld P,Lievens D,De Grijse J,Ling Z,Van der Auwera B,Pipeleers-Marichal M,Gorus F,Pipeleers D

更新日期：2007-09-01 00:00:00

abstract：:Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion f...

journal_title：Diabetes

authors： Laukkanen O,Lindström J,Eriksson J,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Uusitupa M,Laakso M,Finnish Diabetes Prevention Study.

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kina...

journal_title：Diabetes

authors： Kowluru A,Veluthakal R,Rhodes CJ,Kamath V,Syed I,Koch BJ

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Emerging data demonstrate that maternal diabetes has long-term health consequences for offspring, including the development of hypertension. In adults, circulating endothelial progenitor cells (EPCs) participate in vascular repair, and EPC numbers and function inversely correlate with the risk of developing v...

journal_title：Diabetes

authors： Ingram DA,Lien IZ,Mead LE,Estes M,Prater DN,Derr-Yellin E,DiMeglio LA,Haneline LS

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...

journal_title：Diabetes

authors： Ko HJ,Zhang Z,Jung DY,Jun JY,Ma Z,Jones KE,Chan SY,Kim JK

更新日期：2009-11-01 00:00:00

abstract：:For examining the effects of moderate exercise training on peripheral glucose effectiveness (S(g)(2)*), insulin sensitivity (S(i)(2)*), and endogenous glucose production (EGP), seven men and one woman (24.8 +/- 1.8 years) participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/we...

journal_title：Diabetes

authors： Nishida Y,Tokuyama K,Nagasaka S,Higaki Y,Shirai Y,Kiyonaga A,Shindo M,Kusaka I,Nakamura T,Ishibashi S,Tanaka H

更新日期：2004-02-01 00:00:00

abstract：:The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3',5-triiodothyronine (T3), the disruption of which (Dio2(-/-)) results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal. In the present studies, cold exposure increased Dio2(-/-) BAT sympathetic s...

journal_title：Diabetes

authors： Christoffolete MA,Linardi CC,de Jesus L,Ebina KN,Carvalho SD,Ribeiro MO,Rabelo R,Curcio C,Martins L,Kimura ET,Bianco AC

更新日期：2004-03-01 00:00:00

abstract：:Human CD5+ B lymphocytes produce autoantibodies that bind to self- and exogenous antigens. Extremely high percentages of CD5+ B lymphocytes are present in the fetal and newborn periods, whereas they constitute only a minority of B lymphocytes in healthy adults. Increased percentages of circulating CD5+ lymphocytes hav...

journal_title：Diabetes

authors： Schatz DA,Lang F,Cantor AB,Riley WJ,Maclaren NK,Sleasman JW,Barrett DJ

更新日期：1991-10-01 00:00:00

abstract：:Insulin secretion from the pancreas is pulsatile. The precise site and function of the pacemaker that regulates insulin periodicity in humans have not been determined. We isolated human pancreatic islets from five cadaver organ donors by collagenase digestion and density gradient purification. After 24 h of culture in...

journal_title：Diabetes

authors： Marchetti P,Scharp DW,Mclear M,Gingerich R,Finke E,Olack B,Swanson C,Giannarelli R,Navalesi R,Lacy PE

更新日期：1994-06-01 00:00:00

abstract：:Nearly 20 years ago, it was suggested that individuals exist who are not obese on the basis of height and weight, but who, like people with overt obesity, are hyperinsulinemic, insulin-resistant, and predisposed to type 2 diabetes, hypertriglyceridemia, and premature coronary heart disease. Since then it has become in...

journal_title：Diabetes

authors： Ruderman N,Chisholm D,Pi-Sunyer X,Schneider S

更新日期：1998-05-01 00:00:00

abstract：:It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the plasma membrane of adipocytes and skeletal muscle. Here, we explore whe...

journal_title：Diabetes

authors： Turban S,Beardmore VA,Carr JM,Sakamoto K,Hajduch E,Arthur JS,Hundal HS

更新日期：2005-11-01 00:00:00

abstract：:Arterial stiffness affects cardiac functions, peripheral circulation, and cardiovascular mortality. We examined whether arterial stiffness in different regions is equally affected by diabetes and other factors. The subjects were 161 patients with type 2 diabetes and 129 healthy subjects comparable in age and sex. Arte...

journal_title：Diabetes

authors： Kimoto E,Shoji T,Shinohara K,Inaba M,Okuno Y,Miki T,Koyama H,Emoto M,Nishizawa Y

更新日期：2003-02-01 00:00:00

abstract：:Rosiglitazone therapy improves insulin sensitivity and glucose uptake in patients with uncomplicated type 2 diabetes. In coronary artery disease (CAD), glucose is an important source of energy and preserved myocardial glucose uptake is essential for the viability of jeopardized myocardium. The aim was to test whether ...

journal_title：Diabetes

authors： Lautamäki R,Airaksinen KE,Seppänen M,Toikka J,Luotolahti M,Ball E,Borra R,Härkönen R,Iozzo P,Stewart M,Knuuti J,Nuutila P

更新日期：2005-09-01 00:00:00

abstract：:Based on studies of both man and rat, it is proposed that at least three distinct syndromes of hypertriglyceridemia occur as the result of abnormalities of carbohydrate metabolism. We believe that these syndromes are the predictable results of the changes in plasma insulin and/or free fatty acid (FFA) concentration th...

journal_title：Diabetes

authors： Reaven GM,Greenfield MS

更新日期：1981-01-01 00:00:00

abstract：:RT6 is a glycosyl-phosphatidylinositol-linked surface molecule present on most mature rat T-cells. RT6+ T-cells can prevent the expression of autoimmune diabetes in the BB rat, but the mechanism is unknown. Because cross-linking of other glycosyl-phosphatidylinositol-linked T-cell proteins is known to activate T-cells...

journal_title：Diabetes

authors： Rigby MR,Bortell R,Greiner DL,Czech MP,Klarlund JK,Mordes JP,Rossini AA

更新日期：1996-10-01 00:00:00

abstract：:The past decade has witnessed an exponential increase in our ability to search the genome for genetic factors predisposing to cardiovascular disease (CVD) and in particular coronary heart disease (CHD). Identifying these genes could lead to the development of innovative strategies to prevent the cardiovascular complic...

journal_title：Diabetes

authors： Doria A

更新日期：2019-03-01 00:00:00

abstract：:The effect of diabetes control on the activities of hydroxymethylglutaryl-CoA reductase (HMG-CoA reductase), cholesterol acyltransferase (ACAT), and phenol 2-monooxygenase, the major enzymes regulating cholesterol metabolism, was determined in alloxan-induced diabetic rabbits, and the results obtained were correlated ...

journal_title：Diabetes

authors： O'Meara NM,Devery RA,Owens D,Collins PB,Johnson AH,Tomkin GH

更新日期：1990-05-01 00:00:00

abstract：:The secretory, metabolic, and signaling aspects of glucose/palmitate interaction on beta-cell function have been studied on rat islets. Palmitate potentiated the glucose-induced insulin response of perifused islets at suprathreshold (>3 mmol/l) sugar concentrations. This potentiating effect could be suppressed by 8-br...

journal_title：Diabetes

authors： Alcázar O,Qiu-yue Z,Giné E,Tamarit-Rodriguez J

更新日期：1997-07-01 00:00:00

abstract：:Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen desi...

journal_title：Diabetes

authors： Young AA,Bogardus C,Wolfe-Lopez D,Mott DM

更新日期：1988-03-01 00:00:00

abstract：:Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...

journal_title：Diabetes

authors： Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

更新日期：1999-05-01 00:00:00

abstract：:Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Whether hyperglycemia evolves from normoglycemia gradually over time or as a step increase is not known. We measured plasma glucose and insulin levels during oral glucose testing in 35- to 64-year-old men and nonpregnant women from a p...

journal_title：Diabetes

authors： Ferrannini E,Nannipieri M,Williams K,Gonzales C,Haffner SM,Stern MP

更新日期：2004-01-01 00:00:00