FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.

abstract：:Genes overexpressed in pancreatic islets of patients with new-onset type 1 diabetes are potential candidates for novel disease-related autoantigens. RT-PCR-based subtractive hybridization was used on islets from a patient who died at the onset of type 1 diabetes, and it identified a type 1 diabetes-related cDNA encodi...

journal_title：Diabetes

authors： Gurr W,Yavari R,Wen L,Shaw M,Mora C,Christa L,Sherwin RS

更新日期：2002-02-01 00:00:00

abstract：:The incretin effect denominates the phenomenon that oral glucose elicits a higher insulin response than does intravenous glucose. The two hormones responsible for the incretin effect, glucose-dependent insulinotropic hormone (GIP) and glucagon-like peptide-1 (GLP-1), are secreted after oral glucose loads and augment i...

journal_title：Diabetes

authors： Nauck MA,Baller B,Meier JJ

更新日期：2004-12-01 00:00:00

abstract：:Obesity and type 2 diabetes are associated with impaired mitochondrial function in adipose tissue. To study the effects of primary deficiency of mitochondrial energy metabolism in fat, we generated mice with adipose-specific deficiency of fumarate hydratase (FH), an integral Krebs cycle enzyme (AFHKO mice). AFHKO mice...

journal_title：Diabetes

authors： Yang H,Wu JW,Wang SP,Severi I,Sartini L,Frizzell N,Cinti S,Yang G,Mitchell GA

更新日期：2016-11-01 00:00:00

abstract：:Improvement of glycemic status by insulin is associated with profound changes in amino acid metabolism in type 1 diabetes. In contrast, a dissociation of insulin effect on glucose and amino acid metabolism has been reported in type 2 diabetes. Type 2 diabetic patients are reported to have reduced muscle oxidative enzy...

journal_title：Diabetes

authors： Halvatsiotis P,Short KR,Bigelow M,Nair KS

更新日期：2002-08-01 00:00:00

abstract：:Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...

journal_title：Diabetes

authors： Tan BH,Wilson GL,Schaffer SW

更新日期：1984-12-01 00:00:00

abstract：:To determine the effect of inhibition of gluconeogenesis on liver glycogen stores in patients with non-insulin-dependent diabetes mellitus (NIDDM) after a 3-day fast, 10% ethanol (EtOH) was administered intravenously to nine obese patients with NIDDM and six obese nondiabetic subjects. Rates of glucose appearance (3-[...

journal_title：Diabetes

authors： Clore JN,Blackard WG

更新日期：1994-02-01 00:00:00

abstract：:Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic gluc...

journal_title：Diabetes

authors： Ott V,Lehnert H,Staub J,Wönne K,Born J,Hallschmid M

更新日期：2015-03-01 00:00:00

abstract：:To test the general applicability of the hypothesis that diabetes mellitus causes increased polyol pathway activity, decreased tissue free myo-inositol, and resultant pathological changes in tissues susceptible to the ravages of diabetes, we measured glucose, sorbitol, and myo-inositol with quantitative histochemical ...

journal_title：Diabetes

authors： Loy A,Lurie KG,Ghosh A,Wilson JM,MacGregor LC,Matschinsky FM

更新日期：1990-10-01 00:00:00

abstract：:Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, ...

journal_title：Diabetes

authors： Bamberg F,Hetterich H,Rospleszcz S,Lorbeer R,Auweter SD,Schlett CL,Schafnitzel A,Bayerl C,Schindler A,Saam T,Müller-Peltzer K,Sommer W,Zitzelsberger T,Machann J,Ingrisch M,Selder S,Rathmann W,Heier M,Linkohr B,Meisi

更新日期：2017-01-01 00:00:00

abstract：:Hepatocyte nuclear factor-1alpha (HNF-1alpha) mutations are the most common cause of maturity-onset diabetes of the young. HNF-1alpha homozygous knockout mice exhibit a renal Fanconi syndrome with glucosuria and generalized aminoaciduria in addition to diabetes. We investigated glucosuria and aminoaciduria in patients...

journal_title：Diabetes

authors： Bingham C,Ellard S,Nicholls AJ,Pennock CA,Allen J,James AJ,Satchell SC,Salzmann MB,Hattersley AT

更新日期：2001-09-01 00:00:00

abstract：:The use of HIV protease inhibitors (PIs) has been associated with several metabolic changes, including lipodystrophy, hyperlipidemia, and insulin resistance. The etiology of these adverse effects remains unknown. PIs have recently been found to cause acute and reversible inhibition of GLUT4 activity in vitro. To deter...

journal_title：Diabetes

authors： Hruz PW,Murata H,Qiu H,Mueckler M

更新日期：2002-04-01 00:00:00

abstract：:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...

journal_title：Diabetes

authors： Hayward AR,Herberger M

更新日期：1984-04-01 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of ...

journal_title：Diabetes

authors： Berglund LM,Lyssenko V,Ladenvall C,Kotova O,Edsfeldt A,Pilgaard K,Alkayyali S,Brøns C,Forsblom C,Jonsson A,Zetterqvist AV,Nitulescu M,McDavitt CR,Dunér P,Stancáková A,Kuusisto J,Ahlqvist E,Lajer M,Tarnow L,Madsbad S

更新日期：2016-01-01 00:00:00

abstract：:The inhibitory actions of somatostatin (100 ng./ml.) on insulin release, stimulated by high glucose (20 mM), and on glucagon release, stimulated by arginine (15 mM), were studied with two in vitro systems: the isolated perifused rat islets prepared by the collagenase procedure and the isolated perfused rat pancreas. S...

journal_title：Diabetes

authors： Norfleet WT,Pagliara AS,Haymond MW,Matschinsky F

更新日期：1975-11-01 00:00:00

abstract：:Glucagonlike peptide I (7-37) [GLP-I-(7-37)], encoded with glucagon and glucagonlike peptide II and intervening peptide II in the rat and human glucagon gene, is processed from proglucagon in both pancreas and intestine and is a potent stimulator of insulin secretion. Unequivocal insulin release from the isolated perf...

journal_title：Diabetes

authors： Weir GC,Mojsov S,Hendrick GK,Habener JF

更新日期：1989-03-01 00:00:00

abstract：:Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) ...

journal_title：Diabetes

authors： Nishimura S,Nagasaki M,Okudaira S,Aoki J,Ohmori T,Ohkawa R,Nakamura K,Igarashi K,Yamashita H,Eto K,Uno K,Hayashi N,Kadowaki T,Komuro I,Yatomi Y,Nagai R

更新日期：2014-12-01 00:00:00

abstract：:The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells in type 1 diabetes. However, transient transgene expression and the tendency...

journal_title：Diabetes

authors： Flotte T,Agarwal A,Wang J,Song S,Fenjves ES,Inverardi L,Chesnut K,Afione S,Loiler S,Wasserfall C,Kapturczak M,Ellis T,Nick H,Atkinson M

更新日期：2001-03-01 00:00:00

abstract：:Direct methods for measuring the secretion rate of insulin are too cumbersome for clinical application. Since C-peptide is secreted in an equimolar ratio with insulin and is excreted into the urine, measuring the urinary excretion rate of C-peptide (U-C) could serve as an indicator of its secretion rate (SR-C) if its ...

journal_title：Diabetes

authors： Meistas MT,Rendell M,Margolis S,Kowarski AA

更新日期：1982-05-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (KDR) plays a critical role in mediating a variety of vasculogenic and angiogenic processes, including diabetic retinopathy. We previously demonstrated that the promoter activity of the KDR gene in retinal capillary endothelial cells (RCECs) was regulated in part by the re...

journal_title：Diabetes

authors： Sassa Y,Hata Y,Aiello LP,Taniguchi Y,Kohno K,Ishibashi T

更新日期：2004-05-01 00:00:00

abstract：:The TaqIB cholesteryl ester transfer protein (CETP) gene polymorphism (B1B2) is a determinant of HDL cholesterol in nondiabetic populations. Remarkably, this gene effect appears to be modified by environmental factors. We evaluated the effect of this polymorphism on HDL cholesterol levels and on the lipoprotein respon...

journal_title：Diabetes

authors： Dullaart RP,Hoogenberg K,Riemens SC,Groener JE,van Tol A,Sluiter WJ,Stulp BK

更新日期：1997-12-01 00:00:00

abstract：:Pancreatic beta-cell survival is critical in the setting of diabetes as well as in islet transplantation. Transgenic mice overexpressing parathyroid hormone-related protein (PTHrP) targeted to beta-cells using the rat insulin II promoter (RIP) display hyperinsulinemia, hypoglycemia, and islet hyperplasia, without a co...

journal_title：Diabetes

authors： Cebrian A,García-Ocaña A,Takane KK,Sipula D,Stewart AF,Vasavada RC

更新日期：2002-10-01 00:00:00

abstract：:Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene ...

journal_title：Diabetes

authors： Blackman SM,Commander CW,Watson C,Arcara KM,Strug LJ,Stonebraker JR,Wright FA,Rommens JM,Sun L,Pace RG,Norris SA,Durie PR,Drumm ML,Knowles MR,Cutting GR

更新日期：2013-10-01 00:00:00

abstract：:The acquisition of T-cell tolerance in the thymus is limited to those antigens expressed in the thymus at the time of T-cell development. Normally, islet antigens that are involved in insulin-dependent diabetes mellitus (IDDM) are not present in the thymus, but we have previously shown that transplantation of islets e...

journal_title：Diabetes

authors： Baumann EE,Buckingham F,Herold KC

更新日期：1995-08-01 00:00:00

abstract：:Both pancreatic volume reduction and lipomatosis have been observed in subjects with diabetes. The underlying molecular and pathological mechanisms are, however, poorly known, and it has been speculated that both features are secondary to diabetes. We have recently described pancreatic atrophy and lipomatosis in diabe...

journal_title：Diabetes

authors： Raeder H,Haldorsen IS,Ersland L,Grüner R,Taxt T,Søvik O,Molven A,Njølstad PR

更新日期：2007-02-01 00:00:00

abstract：:Hyperglycemia-induced alterations in mesangial (MES) cell function and extracellular matrix protein accumulation are seen in diabetic glomerulopathy. Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which...

journal_title：Diabetes

authors： Singh LP,Andy J,Anyamale V,Greene K,Alexander M,Crook ED

更新日期：2001-10-01 00:00:00

abstract：:The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, ap...

journal_title：Diabetes

authors： Eto M,Watanabe K,Iwashima Y,Morikawa A,Chonan N,Oshima E,Sekiguchi M,Ishii K

更新日期：1987-11-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia both impair insulin sensitivity in vivo. This may be secondary to stimulation of adipose tissue lipolysis and consequent increased circulating free fatty acids (FFAs). Here we report that neither TNF-alpha nor glucose alone has a pronounced effect on lipolysis ...

journal_title：Diabetes

authors： Green A,Rumberger JM,Stuart CA,Ruhoff MS

更新日期：2004-01-01 00:00:00

abstract：:The newly inbred Cohen diabetic rat is an exceptional experimental model of diet-induced type 2 diabetes mellitus that is the result of secondary inbreeding nearly 30 years after it originally had been established. Animals from the original colony were selectively inbred by stringent criteria for 10 additional generat...

journal_title：Diabetes

authors： Weksler-Zangen S,Yagil C,Zangen DH,Ornoy A,Jacob HJ,Yagil Y

更新日期：2001-11-01 00:00:00

abstract：:The researchers conducted this study to test the hypothesis that risk of type 2 diabetes is less following reductions in body size and central adiposity. The Diabetes Prevention Program (DPP) recruited and randomized individuals with impaired glucose tolerance to treatment with placebo, metformin, or lifestyle modific...

journal_title：Diabetes

authors： Fujimoto WY,Jablonski KA,Bray GA,Kriska A,Barrett-Connor E,Haffner S,Hanson R,Hill JO,Hubbard V,Stamm E,Pi-Sunyer FX,Diabetes Prevention Program Research Group.

更新日期：2007-06-01 00:00:00

abstract：:Antibodies to an islet protein of 64,000 Mr (64K antibodies) were measured in 15 diabetic children who were followed prospectively for up to 3 yr after onset of type I (insulin-dependent) diabetes. Of the 15 children, 12 were positive for 64K antibodies at diagnosis. Those patients who were negative for these antibodi...

journal_title：Diabetes

authors： Christie MR,Daneman D,Champagne P,Delovitch TL

更新日期：1990-06-01 00:00:00