Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes.

abstract：:Rat islets contain the acid-labile activator of phosphofructokinase, fructose-2,6-bisphosphate. The islet content in activator is higher in islets exposed to glucose (16.7 mM) than in islets deprived of glucose. The islets display fructose-6-phosphate, 2-kinase activity with a Km for fructose-6-phosphate close to 0.08...

journal_title：Diabetes

authors： Malaisse WJ,Malaisse-Lagae F,Sener A

更新日期：1982-01-01 00:00:00

abstract：:Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose metabolism. Hepatic glucokinase (GK) is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabetic animal models. Here, we explored t...

journal_title：Diabetes

authors： Desai UJ,Slosberg ED,Boettcher BR,Caplan SL,Fanelli B,Stephan Z,Gunther VJ,Kaleko M,Connelly S

更新日期：2001-10-01 00:00:00

abstract：:Insulin resistance associated with altered fat partitioning in liver and adipose tissues is a prediabetic condition in obese adolescents. We investigated interactions between glucose tolerance, insulin sensitivity, and the expression of lipogenic genes in abdominal subcutaneous adipose and liver tissue in 53 obese ado...

journal_title：Diabetes

authors： Kursawe R,Caprio S,Giannini C,Narayan D,Lin A,D'Adamo E,Shaw M,Pierpont B,Cushman SW,Shulman GI

更新日期：2013-03-01 00:00:00

abstract：:We examined the metabolic characteristics that attend the development of type 2 diabetes (T2DM) in 441 impaired glucose tolerance (IGT) subjects who participated in the ACT NOW Study and had complete end-of-study metabolic measurements. Subjects were randomized to receive pioglitazone (PGZ; 45 mg/day) or placebo and w...

journal_title：Diabetes

authors： Defronzo RA,Tripathy D,Schwenke DC,Banerji M,Bray GA,Buchanan TA,Clement SC,Gastaldelli A,Henry RR,Kitabchi AE,Mudaliar S,Ratner RE,Stentz FB,Musi N,Reaven PD,ACT NOW Study.

更新日期：2013-11-01 00:00:00

abstract：:Recent research indicates that islet amyloid pancreatic polypeptide (IAPP) might have a regulatory effect on beta-cell insulin processing and secretion. To study such interaction in more detail, IAPP secretion and kinetics and the serum concentrations of proinsulin were assessed both before and after delivery in lean ...

journal_title：Diabetes

authors： Kautzky-Willer A,Thomaseth K,Ludvik B,Nowotny P,Rabensteiner D,Waldhäusl W,Pacini G,Prager R

更新日期：1997-04-01 00:00:00

abstract：:Abnormalities in the incorporation of heparan sulfate proteoglycan into the glomerular basement membrane have been implicated in the pathogenesis of various proteinuric states, including diabetes mellitus. To understand further the interactions between proteoglycans and glomerular extracellular matrices, glomeruli wer...

journal_title：Diabetes

authors： Klein DJ,Oegema TR Jr,Brown DM

更新日期：1989-01-01 00:00:00

abstract：:The allelic forms of the human leukocyte antigen (HLA)-DQ beta-chain (DQB1) have been recognized as the best markers of insulin-dependent diabetes mellitus (IDDM) susceptibility. We describe a method that allows the recognition of these DQB1 alleles without the use of either allele-specific oligonucleotide probes or r...

journal_title：Diabetes

authors： Trucco G,Fritsch R,Giorda R,Trucco M

更新日期：1989-12-01 00:00:00

abstract：:Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and hyperinsulinemic. For testing whether chronic activation of the central melanocortin pathway can bypass the defective leptin signaling and normalize altered energy homeostasis in these rats, recombinant adeno-associated virus encoding pro-...

journal_title：Diabetes

authors： Li G,Mobbs CV,Scarpace PJ

更新日期：2003-08-01 00:00:00

abstract：:Estrogen-related receptor γ (ERRγ) is a major positive regulator of hepatic gluconeogenesis. Its transcriptional activity is suppressed by phosphorylation signaled by insulin in the fed state, but whether posttranslational modification alters its gluconeogenic activity in the fasted state is not known. Metabolically a...

journal_title：Diabetes

authors： Misra J,Kim DK,Jung YS,Kim HB,Kim YH,Yoo EK,Kim BG,Kim S,Lee IK,Harris RA,Kim JS,Lee CH,Cho JW,Choi HS

更新日期：2016-10-01 00:00:00

abstract：:Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent an early step in T1D onset. Specifically, we observed that in patients with newly...

journal_title：Diabetes

authors： Tezza S,Ben Nasr M,D'Addio F,Vergani A,Usuelli V,Falzoni S,Bassi R,Dellepiane S,Fotino C,Rossi C,Maestroni A,Solini A,Corradi D,Giani E,Mameli C,Bertuzzi F,Pezzolesi MG,Wasserfall CH,Atkinson MA,Füchtbauer EM,Rico

更新日期：2018-10-01 00:00:00

abstract：:Recent evidence demonstrates that hypothalamic insulin signaling is required for inhibition of endogenous glucose production. The downstream mechanisms that are responsible for the effects of hypothalamic insulin receptor activation on hepatic fuel flux remain to be determined. To establish whether downregulation of n...

journal_title：Diabetes

authors： van den Hoek AM,Voshol PJ,Karnekamp BN,Buijs RM,Romijn JA,Havekes LM,Pijl H

更新日期：2004-10-01 00:00:00

abstract：:To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...

journal_title：Diabetes

authors： Trovati M,Massucco P,Mattiello L,Mularoni E,Cavalot F,Anfossi G

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:Observations of elevated circulating concentrations of visfatin (PBEF/Nampt) in obesity and diabetes suggest that this recently described adipokine is involved in the regulation of body weight and metabolism. We examined in humans whether visfatin is found in cerebrospinal fluid (CSF) and, if so, how CSF visf...

journal_title：Diabetes

authors： Hallschmid M,Randeva H,Tan BK,Kern W,Lehnert H

更新日期：2009-03-01 00:00:00

abstract：:To ascertain whether the dawn phenomenon occurs in nondiabetic individuals and, if so, whether it is due to an increase in glucose production or a decrease in glucose utilization, we determined plasma concentrations of glucose, insulin, C-peptide, and counterregulatory hormones, as well as rates of glucose production,...

journal_title：Diabetes

authors： Bolli GB,De Feo P,De Cosmo S,Perriello G,Ventura MM,Calcinaro F,Lolli C,Campbell P,Brunetti P,Gerich JE

更新日期：1984-12-01 00:00:00

abstract：:To determine whether nonglucose nutrient-induced insulin secretion is impaired in pre-diabetes, subjects with impaired or normal fasting glucose were studied after ingesting either a mixed meal containing 75 g glucose or 75 g glucose alone. Despite comparable glucose areas above basal, glucose-induced insulin secretio...

journal_title：Diabetes

authors： Bock G,Dalla Man C,Campioni M,Chittilapilly E,Basu R,Toffolo G,Cobelli C,Rizza R

更新日期：2007-04-01 00:00:00

abstract：:Inactivation of the β-cell transcription factor NEUROD1 causes diabetes in mice and humans. In this study, we uncovered novel functions of NEUROD1 during murine islet cell development and during the differentiation of human embryonic stem cells (HESCs) into insulin-producing cells. In mice, we determined that Neurod1 ...

journal_title：Diabetes

authors： Romer AI,Singer RA,Sui L,Egli D,Sussel L

更新日期：2019-12-01 00:00:00

abstract：:The stimulatory effect of the sodium ionophore, veratridine (10, 25 and 50 microM), on glucagon and insulin secretion was investigated using monolayer cultures of newborn rat pancreas. The results suggest that intracellular accumulation of sodium modulates hormone secretion from both alpha- and beta-cells. The action ...

journal_title：Diabetes

authors： Kawazu S,Ikeuchi M,Kikuchi M,Kanazawa Y,Fujimoto WY,Kosaka K

更新日期：1981-05-01 00:00:00

abstract：:Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or expansion of endog...

journal_title：Diabetes

authors： Dhawan S,Dirice E,Kulkarni RN,Bhushan A

更新日期：2016-05-01 00:00:00

abstract：:Adult, male ICR Swiss mice are susceptible to the diabetogenic effects of the D-variant of encephalomyocarditis virus (EMC-D) in contrast to adult C3H/HeJ male mice, which are relatively resistant. To date, experimental evidence suggests that the immune system plays a role in the pathogenesis of this infection. We hav...

journal_title：Diabetes

authors： Gould CL,McMannama KG,Bigley NJ,Giron DJ

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown. RESEARCH DESIGN AND METHOD...

journal_title：Diabetes

authors： Martinuzzi E,Novelli G,Scotto M,Blancou P,Bach JM,Chaillous L,Bruno G,Chatenoud L,van Endert P,Mallone R

更新日期：2008-05-01 00:00:00

abstract：:Previous studies have demonstrated that the ventromedial hypothalamus (VMH) plays a critical role in sensing and responding to systemic hypoglycemia. To evaluate the mechanisms of defective counterregulation caused by iatrogenic hypoglycemia and diabetes per se, we delivered 2-deoxy-glucose (2-DG) via microdialysis in...

journal_title：Diabetes

authors： Borg MA,Borg WP,Tamborlane WV,Brines ML,Shulman GI,Sherwin RS

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this ...

journal_title：Diabetes

authors： Villarreal-Molina MT,Flores-Dorantes MT,Arellano-Campos O,Villalobos-Comparan M,Rodríguez-Cruz M,Miliar-García A,Huertas-Vazquez A,Menjivar M,Romero-Hidalgo S,Wacher NH,Tusie-Luna MT,Cruz M,Aguilar-Salinas CA,Canizales-Quintero

更新日期：2008-02-01 00:00:00

abstract：:Leptin, the product of the OB gene, is increased in obese individuals, suggesting resistance to its effect. We questioned whether subjects with NIDDM have an altered regulation of serum leptin levels. We used a radioimmunoassay to measure serum leptin levels in three groups from the San Antonio Heart Study: 1) 50 Mexi...

journal_title：Diabetes

authors： Haffner SM,Stern MP,Miettinen H,Wei M,Gingerich RL

更新日期：1996-06-01 00:00:00

abstract：:Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity wa...

journal_title：Diabetes

authors： Takahashi K,Brooks RA,Kanse SM,Ghatei MA,Kohner EM,Bloom SR

更新日期：1989-09-01 00:00:00

abstract：:β-Cell function improves in patients with type 2 diabetes in response to an oral glucose stimulus after Roux-en-Y gastric bypass (RYGB) surgery. This has been linked to the exaggerated secretion of glucagon-like peptide 1 (GLP-1), but causality has not been established. The aim of this study was to investigate the rol...

journal_title：Diabetes

authors： Jørgensen NB,Dirksen C,Bojsen-Møller KN,Jacobsen SH,Worm D,Hansen DL,Kristiansen VB,Naver L,Madsbad S,Holst JJ

更新日期：2013-09-01 00:00:00

abstract：:Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvascular complications of type 2 diabetes. In liver, extracellular hepara...

journal_title：Diabetes

authors： Olsson U,Egnell AC,Lee MR,Lundén GO,Lorentzon M,Salmivirta M,Bondjers G,Camejo G

更新日期：2001-09-01 00:00:00

abstract：:Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

journal_title：Diabetes

authors： Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

更新日期：2019-10-01 00:00:00

abstract：:A corpus of evidence suggests that T-helper type 1 (Th1)-dependent cellular immunity plays a pivotal role in the pathogenesis of autoimmune diabetes. This study was intended to find ways to prevent the development of NOD diabetes using a neutralizing anti-interleukin (IL)-12 antibody (C17.8) that inhibits Thl cell dif...

journal_title：Diabetes

authors： Fujihira K,Nagata M,Moriyama H,Yasuda H,Arisawa K,Nakayama M,Maeda S,Kasuga M,Okumura K,Yagita H,Yokono K

更新日期：2000-12-01 00:00:00

abstract：:In this article, we report on a nonobese C57BL/6 (B6) mouse model of NIDDM named Akita mouse, characterized by early age onset and autosomal dominant mode of inheritance. At 7 weeks of age, the mean morning blood glucose levels (mmol/l) under ad libitum feeding conditions were significantly higher (P < 0.01, analysis ...

journal_title：Diabetes

authors： Yoshioka M,Kayo T,Ikeda T,Koizumi A

更新日期：1997-05-01 00:00:00

abstract：:Cardiovascular (CV) disease fatality rates are higher for women compared with men with diabetes despite lower rates of obstructive coronary artery disease (CAD). Impaired coronary flow reserve (CFR), the ratio of adenosine-stimulated to rest myocardial blood flow (MBF), is an indicator of coronary microvascular dysfun...

journal_title：Diabetes

authors： Haas AV,Rosner BA,Kwong RY,Rao AD,Garg R,Di Carli MF,Adler GK

更新日期：2019-03-01 00:00:00