Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.

abstract：:We studied certain metabolic requirements for insulin-induced increases in phospholipids, and the relationship of phospholipid changes to the insulin-induced activation of pyruvate dehydrogenase, in rat adipocytes and fat pads in vitro. Increases in the contents of phosphatidylinositol and phosphatidylserine mass were...

journal_title：Diabetes

authors： Farese RV,Farese RV Jr,Sabir MA,Larson RE,Trudeau WL 3rd,Barnes D

更新日期：1984-07-01 00:00:00

abstract：:Because successful human islet transplantation requires large quantities of viable islets that must be separated from the highly immunogenic exocrine tissue and because handpicking is too time-consuming and laborious to be clinically relevant, a new approach for solving this problem has been established in rat models....

journal_title：Diabetes

authors： Winoto-Morbach S,Ulrichs K,Leyhausen G,Müller-Ruchholtz W

更新日期：1989-01-01 00:00:00

abstract：:A polymorphism in the interleukin 12B gene was recently reported to be strongly associated with type 1 diabetes in 422 Australian and British families. We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease. ...

journal_title：Diabetes

authors： Nisticò L,Giorgi G,Giordano M,Galgani A,Petrone A,D'Alfonso S,Federici M,Di Mario U,Pozzilli P,Buzzetti R,Cascino I

更新日期：2002-05-01 00:00:00

abstract：:Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in human liver would ...

journal_title：Diabetes

authors： Valenti L,Mendoza RM,Rametta R,Maggioni M,Kitajewski C,Shawber CJ,Pajvani UB

更新日期：2013-12-01 00:00:00

abstract：:Kir6.2 is an inwardly rectifying potassium channel that is expressed in pancreatic beta-cells and cardiac and skeletal muscle. Expressed together with the high-affinity sulphonylurea receptor, it reconstitutes a sulphonylurea- and also ATP-sensitive potassium channel resembling the native beta-cell channel. The object...

journal_title：Diabetes

authors： Hansen L,Echwald SM,Hansen T,Urhammer SA,Clausen JO,Pedersen O

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:We evaluated the impact on diabetes-related intermediary traits of common novel type 2 diabetes-associated variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of ...

journal_title：Diabetes

authors： Grarup N,Andersen G,Krarup NT,Albrechtsen A,Schmitz O,Jørgensen T,Borch-Johnsen K,Hansen T,Pedersen O

更新日期：2008-09-01 00:00:00

abstract：:Longitudinal electron-microscopic and morphometric studies of autonomic nerves containing predominantly parasympathetic fibers were undertaken in the spontaneously diabetic BB rat. Unmyelinated fibers of the diabetic vagus nerve and myelinated fibers of the penile nerve showed increased numbers of axonal glycogenosome...

journal_title：Diabetes

authors： Yagihashi S,Sima AA

更新日期：1986-07-01 00:00:00

abstract：:Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose metabolism. Hepatic glucokinase (GK) is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabetic animal models. Here, we explored t...

journal_title：Diabetes

authors： Desai UJ,Slosberg ED,Boettcher BR,Caplan SL,Fanelli B,Stephan Z,Gunther VJ,Kaleko M,Connelly S

更新日期：2001-10-01 00:00:00

abstract：:The Diabetes Association of greater Cleveland screened 307,000 individuals in the metropolitan area for diabetes with a 75-gm. oral load of carbohydrate. Of these subjects 12,600 (4.1 per cent) had a two-capillary blood glucose level of greater than 139 mg. per cent and were defined as positive. Seventy per cent of th...

journal_title：Diabetes

authors： Genuth SM,Houser HB,Carter JR Jr,Merkatz I,Price JW,Schumacher OP,Wieland RG

更新日期：1976-12-01 00:00:00

abstract：OBJECTIVE:The liver plays a critical role in integrating and controlling glucose metabolism. Thus, it is important that the liver receive and react to signals from other tissues regarding the nutrient status of the body. Leptin, which is produced and secreted from adipose tissue, is a hormone that relays information re...

journal_title：Diabetes

authors： Huynh FK,Levi J,Denroche HC,Gray SL,Voshol PJ,Neumann UH,Speck M,Chua SC,Covey SD,Kieffer TJ

更新日期：2010-12-01 00:00:00

abstract：:Insulin resistance and dysregulation of free fatty acid (FFA) metabolism are core defects in type 2 diabetic (T2DM) and obese normal glucose tolerant (NGT) individuals. Impaired muscle mitochondrial function (reduced ATP synthesis) also has been described in insulin-resistant T2DM and obese subjects. We examined wheth...

journal_title：Diabetes

authors： Daniele G,Eldor R,Merovci A,Clarke GD,Xiong J,Tripathy D,Taranova A,Abdul-Ghani M,DeFronzo RA

更新日期：2014-08-01 00:00:00

abstract：:Little information is available on cholesterol absorption and synthesis in human type 1 diabetes. We studied these variables using serum cholesterol precursor sterol ratios to cholesterol as surrogate markers of cholesterol synthesis and those of cholestanol and plant sterols to reflect cholesterol absorption in seven...

journal_title：Diabetes

authors： Gylling H,Tuominen JA,Koivisto VA,Miettinen TA

更新日期：2004-09-01 00:00:00

abstract：:Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

journal_title：Diabetes

authors： Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

更新日期：2019-10-01 00:00:00

abstract：:Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Loss of GBM HS in dia...

journal_title：Diabetes

authors： Gil N,Goldberg R,Neuman T,Garsen M,Zcharia E,Rubinstein AM,van Kuppevelt T,Meirovitz A,Pisano C,Li JP,van der Vlag J,Vlodavsky I,Elkin M

更新日期：2012-01-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a mitogen required for β-cell replication during pregnancy. To determine whether HGF/c-Met signaling is required for β-cell regeneration, we characterized mice with pancreatic deletion of the HGF receptor, c-Met (PancMet KO mice), in two models of reduced β-cell mass and regeneration:...

journal_title：Diabetes

authors： Alvarez-Perez JC,Ernst S,Demirci C,Casinelli GP,Mellado-Gil JM,Rausell-Palamos F,Vasavada RC,Garcia-Ocaña A

更新日期：2014-01-01 00:00:00

abstract：:Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...

journal_title：Diabetes

authors： Araki Y,Solomon BA,Basile RM,Chick WL

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:Increased intramuscular triacylglycerol (IMTG) storage is a characteristic of the obese insulin-resistant state. We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity. RESEARCH DESIGN AND METHODS:Forearm skeletal musc...

journal_title：Diabetes

authors： Jocken JW,Roepstorff C,Goossens GH,van der Baan P,van Baak M,Saris WH,Kiens B,Blaak EE

更新日期：2008-07-01 00:00:00

abstract：:The TaqIB cholesteryl ester transfer protein (CETP) gene polymorphism (B1B2) is a determinant of HDL cholesterol in nondiabetic populations. Remarkably, this gene effect appears to be modified by environmental factors. We evaluated the effect of this polymorphism on HDL cholesterol levels and on the lipoprotein respon...

journal_title：Diabetes

authors： Dullaart RP,Hoogenberg K,Riemens SC,Groener JE,van Tol A,Sluiter WJ,Stulp BK

更新日期：1997-12-01 00:00:00

abstract：:Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas ina...

journal_title：Diabetes

authors： Tsuchiya K,Accili D

更新日期：2013-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is associated with hepatic insulin resistance and may result primarily from increased hepatic de novo lipogenesis (PRIM) or secondarily from adipose tissue lipolysis (SEC). We studied mice with hepatocyte- or adipocyte-specific SREBP-1c overexpression as models of PRIM and SEC. PRIM mi...

journal_title：Diabetes

authors： Jelenik T,Kaul K,Séquaris G,Flögel U,Phielix E,Kotzka J,Knebel B,Fahlbusch P,Hörbelt T,Lehr S,Reinbeck AL,Müller-Wieland D,Esposito I,Shulman GI,Szendroedi J,Roden M

更新日期：2017-08-01 00:00:00

abstract：:Type 1 diabetes is believed to be a Th1 lymphocyte-mediated disease, and both environmental and genetic factors play a role in its pathogenesis. It was recently found that interleukin (IL)-18 acts as a proinflammatory cytokine and, in synergy with IL-12, promotes development of Th1 lymphocyte response by induction of ...

journal_title：Diabetes

authors： Kretowski A,Mironczuk K,Karpinska A,Bojaryn U,Kinalski M,Puchalski Z,Kinalska I

更新日期：2002-11-01 00:00:00

abstract：:C57BL/6 (B6) mice develop glucose intolerance with age, whereas C3H/He (C3H) mice do not. In this study, we examined whether this differential glucose homeostasis was associated with differences of proteolytic activation of pancreatic prohormones. Radioimmunoassays showed comparable levels of fasting plasma insulin be...

journal_title：Diabetes

authors： Schmidt G,Sirois F,Anini Y,Kauri LM,Gyamera-Acheampong C,Fleck E,Scott FW,Chrétien M,Mbikay M

更新日期：2006-02-01 00:00:00

abstract：:The possible role of endothelial dysfunction in early stages of uncomplicated diabetes mellitus was investigated in porcine aortic endothelial cells. Prolonged exposure to various D-glucose concentrations resulted in concentration-dependent amplification of agonist-induced Ca2+ mobilization, whereas L-glucose and D-ma...

journal_title：Diabetes

authors： Graier WF,Wascher TC,Lackner L,Toplak H,Krejs GJ,Kukovetz WR

更新日期：1993-10-01 00:00:00

abstract：:Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications. Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, and inflammation of adipose tissue. Here, we report that delayed interv...

journal_title：Diabetes

authors： Maessen DE,Brouwers O,Gaens KH,Wouters K,Cleutjens JP,Janssen BJ,Miyata T,Stehouwer CD,Schalkwijk CG

更新日期：2016-04-01 00:00:00

abstract：:The relative effects of time versus ambient glucose concentration on insulin-stimulated glucose uptake was estimated by performing 5-h insulin clamp studies in patients with NIDDM. Each experimental subject was studied three times, at steady-state plasma insulin levels approximately 2000 microU/ml, but at different st...

journal_title：Diabetes

authors： Liu G,Chen YD,Hollenbeck CB,Lardinois CK,Reaven GM

更新日期：1984-07-01 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is an α-arrestin that can bind to and inhibit the antioxidant protein thioredoxin (TXN). TXNIP expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. TXNIP is currently studied as a pote...

journal_title：Diabetes

authors： Katsu-Jiménez Y,Vázquez-Calvo C,Maffezzini C,Halldin M,Peng X,Freyer C,Wredenberg A,Giménez-Cassina A,Wedell A,Arnér ESJ

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing. In humans, a germline mutation in the VHL gene leads to the von Hippel-Lindau disease, a familial syndrome characterized by benign and malignant tumors of the kidney...

journal_title：Diabetes

authors： Puri S,Cano DA,Hebrok M

更新日期：2009-02-01 00:00:00

abstract：:Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen desi...

journal_title：Diabetes

authors： Young AA,Bogardus C,Wolfe-Lopez D,Mott DM

更新日期：1988-03-01 00:00:00

abstract：:Receptors for bradykinin (BK) were characterized in primary cultures of beating neonatal rat cardiomyocytes using [3H]BK was radioligand. Degradation studies demonstrated that [3H]BK was stable for at least 2 h when incubated with cardiomyocytes at 2 and 37 degrees C in the presence of bacitracin in combination with c...

journal_title：Diabetes

authors： Kasel AM,Faussner A,Pfeifer A,Müller U,Werdan K,Roscher AA

更新日期：1996-01-01 00:00:00

abstract：:We conducted a prospective study to describe the course of the pancreatic beta-cell function from the time of clinical diagnosis of insulin-dependent (type I) diabetes to determine whether DR type, presence of islet cell antibodies (ICA), presence of insulin antibodies (IA), age at onset, and sex could help in the pre...

journal_title：Diabetes

authors： Schiffrin A,Suissa S,Poussier P,Guttmann R,Weitzner G

更新日期：1988-07-01 00:00:00