Abstract:
:Longitudinal electron-microscopic and morphometric studies of autonomic nerves containing predominantly parasympathetic fibers were undertaken in the spontaneously diabetic BB rat. Unmyelinated fibers of the diabetic vagus nerve and myelinated fibers of the penile nerve showed increased numbers of axonal glycogenosomes and axonal sequestration. Morphometric examination of myelinated and unmyelinated fibers of the vagus nerve revealed diminished fiber size compared with age-matched control animals. The distal myenteric nerve showed marked degenerative changes, whereas no structural changes could be demonstrated in intra-myenteric ganglion cells. These changes are similar to those described previously in somatic nerves of this model but different from those seen in sympathetic nerves of the diabetic BB rat.
journal_name
Diabetesjournal_title
Diabetesauthors
Yagihashi S,Sima AAdoi
10.2337/diab.35.7.733subject
Has Abstractpub_date
1986-07-01 00:00:00pages
733-43issue
7eissn
0012-1797issn
1939-327Xjournal_volume
35pub_type
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