The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells.

abstract：:Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressed primarily in leukocytes, has been the subject of substantial research for its role in inflammatory diseases. However, the ro...

journal_title：Diabetes

authors： Azzi J,Moore RF,Elyaman W,Mounayar M,El Haddad N,Yang S,Jurewicz M,Takakura A,Petrelli A,Fiorina P,Ruckle T,Abdi R

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Insulin stimulates glucose transport in skeletal muscle by GLUT4 translocation from intracellular compartments to sarcolemma and t-tubules. We studied in living animals the recruitment of GLUT4 vesicles in more detail than previously done and, for the first time, analyzed the steady-state recycling and subseq...

journal_title：Diabetes

authors： Lauritzen HP,Galbo H,Brandauer J,Goodyear LJ,Ploug T

更新日期：2008-02-01 00:00:00

abstract：:To elucidate the direct effect of rosiglitazone (RSG), a new thiazolidinedione antihyperglycemic agent, on pancreatic insulin secretion, an in situ investigation by rat pancreatic perfusion was performed. At a basal glucose concentration of 6 mmol/l, RSG (0.045-4.5 micromol/l) stimulated insulin release in a dose-depe...

journal_title：Diabetes

authors： Yang C,Chang TJ,Chang JC,Liu MW,Tai TY,Hsu WH,Chuang LM

更新日期：2001-11-01 00:00:00

abstract：:Dispersed pancreatic endocrine cells (PECs) were recently shown to survive indefinitely in the brain of allogeneic diabetic rat recipients across the major histocompatibility barrier without immunosuppression. Purified PECs (2-3 X 10(6) cells) prepared from Wistar rat islets were transplanted in 10 different sites in ...

journal_title：Diabetes

authors： Tze WJ,Tai J

更新日期：1988-04-01 00:00:00

abstract：:Brown adipose tissue oxidizes chemical energy for heat generation and energy expenditure. Promoting brown-like transformation in white adipose tissue (WAT) is a promising strategy for combating obesity. Here, we find that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regu...

journal_title：Diabetes

authors： Chou CF,Lin YY,Wang HK,Zhu X,Giovarelli M,Briata P,Gherzi R,Garvey WT,Chen CY

更新日期：2014-09-01 00:00:00

abstract：:Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) ...

journal_title：Diabetes

authors： Nishimura S,Nagasaki M,Okudaira S,Aoki J,Ohmori T,Ohkawa R,Nakamura K,Igarashi K,Yamashita H,Eto K,Uno K,Hayashi N,Kadowaki T,Komuro I,Yatomi Y,Nagai R

更新日期：2014-12-01 00:00:00

abstract：:The early renal growth in streptozotocin (STZ)-induced diabetic rats is preceded by a transient rise in renal tissue insulin-like growth factor (IGF)-I concentration. Administration of the long-acting somatostatin analog octreotide to STZ diabetic rats inhibits the early increase in kidney IGF-I and the increase in ki...

journal_title：Diabetes

authors： Raz I,Rubinger D,Popovtzer M,Grønbaek H,Weiss O,Flyvbjerg A

更新日期：1998-06-01 00:00:00

abstract：:Diabetes induces the activation of several protein kinase C (PKC) isoforms in the renal glomeruli. We used PKC-beta(-/-) mice to examine the action of PKC-beta isoforms in diabetes-induced oxidative stress and renal injury at 8 and 24 weeks of disease. Diabetes increased PKC activity in renal cortex of wild-type mice ...

journal_title：Diabetes

authors： Ohshiro Y,Ma RC,Yasuda Y,Hiraoka-Yamamoto J,Clermont AC,Isshiki K,Yagi K,Arikawa E,Kern TS,King GL

更新日期：2006-11-01 00:00:00

abstract：:NIDDM has a substantial genetic component, but the nature of the genetic susceptibility is largely unknown. Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous monogenic form of NIDDM characterized by an early age of onset and autosomal dominant inheritance, and linkage studies have identified g...

journal_title：Diabetes

authors： Shaw JT,Lovelock PK,Kesting JB,Cardinal J,Duffy D,Wainwright B,Cameron DP

更新日期：1998-11-01 00:00:00

abstract：:To elucidate the precise significance of pancreatic A-cell hypersecretion in the pathogenesis of diabetes mellitus, the change in the immunoreactive glucagon (IRG) response to intravenous arginine was studied in both nonobese, hypoinsulinemic non-insulin-dependent (NIDDM) and insulin-dependent diabetic (IDDM) subjects...

journal_title：Diabetes

authors： Kawamori R,Shichiri M,Kikuchi M,Yamasaki Y,Abe H

更新日期：1980-09-01 00:00:00

abstract：:Peripheral somatic and autonomic nerve function have been studied in 79 teenage (16-19 yr) diabetics and 20 age- and sex-matched normal controls. Almost three-quarters of the diabetics (72%) had abnormal peripheral somatic nerve function tests, and one-third (31%) had abnormal cardiac parasympathetic tests. Both motor...

journal_title：Diabetes

authors： Young RJ,Ewing DJ,Clarke BF

更新日期：1983-02-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a mitogen required for β-cell replication during pregnancy. To determine whether HGF/c-Met signaling is required for β-cell regeneration, we characterized mice with pancreatic deletion of the HGF receptor, c-Met (PancMet KO mice), in two models of reduced β-cell mass and regeneration:...

journal_title：Diabetes

authors： Alvarez-Perez JC,Ernst S,Demirci C,Casinelli GP,Mellado-Gil JM,Rausell-Palamos F,Vasavada RC,Garcia-Ocaña A

更新日期：2014-01-01 00:00:00

abstract：:Glucagonlike peptide I (7-37) [GLP-I-(7-37)], encoded with glucagon and glucagonlike peptide II and intervening peptide II in the rat and human glucagon gene, is processed from proglucagon in both pancreas and intestine and is a potent stimulator of insulin secretion. Unequivocal insulin release from the isolated perf...

journal_title：Diabetes

authors： Weir GC,Mojsov S,Hendrick GK,Habener JF

更新日期：1989-03-01 00:00:00

abstract：:Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail. This study is a longitudinal study in 60 children (33 male and 27 female subjects; 32 Caucasian and 28 African-American) examined at Tanner s...

journal_title：Diabetes

authors： Goran MI,Gower BA

更新日期：2001-11-01 00:00:00

abstract：:New cellular-based reagents are needed to diagnose type I diabetes as well as to monitor the outcomes of clinical trials at early time points. Four new monoclonal antibodies (mAbs) have been shown to demonstrate reduced binding to lymphocytes from identical twins with long-term type I diabetes relative to that observe...

journal_title：Diabetes

authors： Pinies JA,Fu Y,Vazquez JA,Faustman D

更新日期：1997-03-01 00:00:00

abstract：:Insulin receptors on viable rat adipocytes were affinity-labeled using a biologically active and photosensitive analogue of insulin, 125I-B2(2-nitro, 4 azidophenylacetyl)-des-PheB1-insulin (125I-NAPA-DP-insulin). The radiolabeled proteins were identified by SDS polyacrylamide gel electrophoresis and autoradiography. B...

journal_title：Diabetes

authors： Heidenreich KA,Berhanu P,Brandenburg D,Olefsky JM

更新日期：1983-11-01 00:00:00

abstract：:Several recent reports claim the generation of insulin-producing cells from embryonic stem cells via the differentiation of progenitors that express nestin. Here, we investigate further the properties of these insulin-containing cells. We find that although differentiated cells contain immunoreactive insulin, they do ...

journal_title：Diabetes

authors： Hansson M,Tonning A,Frandsen U,Petri A,Rajagopal J,Englund MC,Heller RS,Håkansson J,Fleckner J,Sköld HN,Melton D,Semb H,Serup P

更新日期：2004-10-01 00:00:00

abstract：:Although epinephrine stimulates insulin release by activation of beta-adrenergic receptors, its dominant effect (mediated by stimulation of alpha-adrenergic receptors) is an inhibition of insulin secretion that is powerful enough to suppress the secretory activity of insulin's most potent stimulants. The insulin-secre...

journal_title：Diabetes

authors： Hiatt N,Davidson MB,Chapman LW,Sheinkopf JA

更新日期：1978-05-01 00:00:00

abstract：:Insulin resistance associated with altered fat partitioning in liver and adipose tissues is a prediabetic condition in obese adolescents. We investigated interactions between glucose tolerance, insulin sensitivity, and the expression of lipogenic genes in abdominal subcutaneous adipose and liver tissue in 53 obese ado...

journal_title：Diabetes

authors： Kursawe R,Caprio S,Giannini C,Narayan D,Lin A,D'Adamo E,Shaw M,Pierpont B,Cushman SW,Shulman GI

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:A number of studies have found that reduced birth weight is associated with type 2 diabetes later in life; however, the underlying mechanism for this correlation remains unresolved. Recently, association has been demonstrated between low birth weight and single nucleotide polymorphisms (SNPs) at the CDKAL1 an...

journal_title：Diabetes

authors： Zhao J,Li M,Bradfield JP,Wang K,Zhang H,Sleiman P,Kim CE,Annaiah K,Glaberson W,Glessner JT,Otieno FG,Thomas KA,Garris M,Hou C,Frackelton EC,Chiavacci RM,Berkowitz RI,Hakonarson H,Grant SF

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Circulating glucose inhibits glucose production in normal rodents and humans, but this glucose effectiveness is disrupted in diabetes due partly to sustained hyperglycemia. We hypothesize that hyperglycemia in diabetes impairs hypothalamic glucose sensing to lower glucose production, and changes of glucose tr...

journal_title：Diabetes

authors： Chari M,Yang CS,Lam CK,Lee K,Mighiu P,Kokorovic A,Cheung GW,Lai TY,Wang PY,Lam TK

更新日期：2011-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathogenesis of diabetic vascular complications. In the present study, we investigated whether expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that has been proposed to recruit leukocytes to sites of inflammation, ...

journal_title：Diabetes

authors： Marumo T,Schini-Kerth VB,Busse R

更新日期：1999-05-01 00:00:00

abstract：:Proliferation of vascular smooth muscle is thought to be involved in the major diabetic complication atherosclerosis. We have previously reported an increase of growth-promoting activity (GA) in platelets from insulin-dependent diabetics. In this study, GA was measured in the platelet extract (PE) from eight diabetic ...

journal_title：Diabetes

authors： Sugimoto H,Franks DJ,Lecavalier L,Chiasson JL,Hamet P

更新日期：1987-05-01 00:00:00

abstract：:The cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) gene is implicated as an important regulator of body weight in mice and humans and is therefore a candidate gene for human obesity. Here, we characterize common CIDEA gene polymorphisms and investigate them for association with obesi...

journal_title：Diabetes

authors： Dahlman I,Kaaman M,Jiao H,Kere J,Laakso M,Arner P

更新日期：2005-10-01 00:00:00

abstract：:Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistanc...

journal_title：Diabetes

authors： Kanatani Y,Usui I,Ishizuka K,Bukhari A,Fujisaka S,Urakaze M,Haruta T,Kishimoto T,Naka T,Kobayashi M

更新日期：2007-03-01 00:00:00

abstract：:Platelets from diabetic subjects with circulating immune complexes (CIC) synthesized greater amounts of thromboxane than did platelets from CIC-negative patients or controls. In view of the known action of CIC on platelet function, a relationship between these two factors may be suggested in the initiation and progres...

journal_title：Diabetes

authors： Triolo G,Davi' G,Giardina E,Cardella F,Meli F,La Grutta A,Strano A,Bompiani GD

更新日期：1984-08-01 00:00:00

abstract：:The relationship between the levels of circulating thyroid hormones and the action of insulin on adipose tissue was investigated in 6 hypothyroid patients and 6 hyperthyroid patients, all untreated, and 8 healthy control subjects. All were matched for age, body weight, and fat cell size. Gluteal s.c. adipose tissue wa...

journal_title：Diabetes

authors： Arner P,Bolinder J,Wennlund A,Ostman J

更新日期：1984-04-01 00:00:00

abstract：:Groups of young adult rats with body weights of 125-135 g (group A) or 300-400 g (group B) were subjected to one bout of prolonged exercise to exhaustion on a treadmill and were studied 2 h postexercise. Liver glycogen levels were markedly depleted in the exercised rats. Adipocytes from group A exercised rats showed a...

journal_title：Diabetes

authors： Begum N,Terjung RL,Tepperman HM,Tepperman J

更新日期：1986-07-01 00:00:00

abstract：:Improvement of glycemic status by insulin is associated with profound changes in amino acid metabolism in type 1 diabetes. In contrast, a dissociation of insulin effect on glucose and amino acid metabolism has been reported in type 2 diabetes. Type 2 diabetic patients are reported to have reduced muscle oxidative enzy...

journal_title：Diabetes

authors： Halvatsiotis P,Short KR,Bigelow M,Nair KS

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:The gut environment modulates the pathogenesis of type 1 diabetes (T1D), but how it affects autoimmunity toward pancreatic β-cells, a self-tissue located outside the intestine, is still unclear. In the small intestine, lamina propria dendritic cells (LPDCs) induce peripheral differentiation of FoxP3(+) regula...

journal_title：Diabetes

authors： Badami E,Sorini C,Coccia M,Usuelli V,Molteni L,Bolla AM,Scavini M,Mariani A,King C,Bosi E,Falcone M

更新日期：2011-08-01 00:00:00