Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice.

abstract：:The quantitative insulin-sensitivity check index (QUICKI) has an excellent linear correlation with the glucose clamp index of insulin sensitivity (SI(Clamp)) that is better than that of many other surrogate indexes. However, correlation between a surrogate and reference standard may improve as variability between subj...

journal_title：Diabetes

authors： Chen H,Sullivan G,Quon MJ

更新日期：2005-07-01 00:00:00

abstract：:The current study investigated the fate of a [U-(13)C]palmitate tracer extracted by forearm muscle in type 2 diabetic and control subjects. We studied seven healthy lean male subjects and seven obese male subjects with type 2 diabetes using the forearm muscle balance technique with continuous intravenous infusion of t...

journal_title：Diabetes

authors： Blaak EE,Wagenmakers AJ

更新日期：2002-03-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 alpha-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit (gp130). The IL6R gene maps ...

journal_title：Diabetes

authors： Hamid YH,Urhammer SA,Jensen DP,Glümer C,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2004-12-01 00:00:00

abstract：:Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. We comprehensively examined the relationships between circulating levels of total adiponectin, adiponectin multimers, and the relative distribution (i.e., r...

journal_title：Diabetes

authors： Lara-Castro C,Luo N,Wallace P,Klein RL,Garvey WT

更新日期：2006-01-01 00:00:00

abstract：:The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1.B and RT1.D. The possibility that variant or unique class II MHC molecules m...

journal_title：Diabetes

authors： Holowachuk EW,Greer MK

更新日期：1989-02-01 00:00:00

abstract：:Concentrations of glycosylated hemoglobin (GHb) are elevated in diabetes mellitus and are believed to reflect previous metabolic control. To better define possible determinants of GHb in man, we investigated the relationship between GHb and both fasting plasma glucose (FPG) and basal insulin (IRI) in 42 normal subject...

journal_title：Diabetes

authors： Graf RJ,Halter JB,Porte D Jr

更新日期：1978-08-01 00:00:00

abstract：:Defects in insulin secretion, resulting from loss of function or destruction of pancreatic beta-cells, trigger diabetes. Interleukin (IL)-1beta is a proinflammatory cytokine that is involved in type 1 and type 2 diabetes development and impairs beta-cell survival and function. Because effective insulin signaling is re...

journal_title：Diabetes

authors： Emanuelli B,Glondu M,Filloux C,Peraldi P,Van Obberghen E

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Melanocortin 3 receptor (MC3R) plays a critical role in weight regulation of rodents, but its role in humans remains unclear. The objective of this study was to identify genetic variants of the MC3R gene and determine its association with childhood obesity. RESEARCH DESIGN AND METHODS:We screened 201 obese c...

journal_title：Diabetes

authors： Lee YS,Poh LK,Kek BL,Loke KY

更新日期：2007-10-01 00:00:00

abstract：:Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their islet beta-cells are a model of islet amyloid formation as it occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet amyloid when fed a breeder chow but not regular chow. Because the breeder chow contained incre...

journal_title：Diabetes

authors： Hull RL,Andrikopoulos S,Verchere CB,Vidal J,Wang F,Cnop M,Prigeon RL,Kahn SE

更新日期：2003-02-01 00:00:00

abstract：:Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...

journal_title：Diabetes

authors： Sassy-Prigent C,Heudes D,Mandet C,Bélair MF,Michel O,Perdereau B,Bariéty J,Bruneval P

更新日期：2000-03-01 00:00:00

abstract：:Nondiabetic obese humans adapt to insulin resistance by increasing beta-cell mass. In contrast, obese humans with type 2 diabetes have an approximately 60% deficit in beta-cell mass. Recent studies in rodents reveal that beta-cell mass is regulated, increasing in response to insulin resistance through increased beta-c...

journal_title：Diabetes

authors： Butler AE,Janson J,Soeller WC,Butler PC

更新日期：2003-09-01 00:00:00

abstract：:Oxidative stress is implicated in diabetes complications, during which endogenous antioxidant defenses have important pathophysiological consequences. To date, the significance of endogenous antioxidants such as metallothioneins I and II (MT-I+II) in type 2 diabetes remains unclear. To examine the MT-I+II-mediated ant...

journal_title：Diabetes

authors： Scheede-Bergdahl C,Penkowa M,Hidalgo J,Olsen DB,Schjerling P,Prats C,Boushel R,Dela F

更新日期：2005-11-01 00:00:00

abstract：:Hypofibrinolysis caused by increased plasminogen activator inhibitor 1 (PAI-1) has been implicated in the vasculopathy of type 2 diabetes, typified by increased insulin, glucose, and triglycerides. However, short-term infusions of insulin have not increased PAI-1 in normal subjects. We hypothesized that induction of i...

journal_title：Diabetes

authors： Calles-Escandon J,Mirza SA,Sobel BE,Schneider DJ

更新日期：1998-02-01 00:00:00

abstract：:A workshop sponsored by the National Institute of Child Health and Human Development was held in June 1988 to discuss the initial events in the pathogenesis of insulin-dependent diabetes and to make recommendations for future studies. Better definition of immunological markers to reliably predict the disease will enab...

journal_title：Diabetes

authors： Maclaren N,Schatz D,Drash A,Grave G

更新日期：1989-04-01 00:00:00

abstract：:Insulin-dependent diabetes (type 1 diabetes) in the NOD mouse is a T-cell-mediated autoimmune disease. However, B-cells may also play a critical role in disease pathogenesis, as genetically B-cell-deficient NOD mice (NOD.microMT) have been shown to be protected from type 1 diabetes and to display reduced responses to ...

journal_title：Diabetes

authors： Chiu PP,Serreze DV,Danska JS

更新日期：2001-04-01 00:00:00

abstract：:The receptor-type protein tyrosine kinases in murine pancreatic islets were screened to identify possible growth/differentiation factors in pancreatic beta-cells. The analysis revealed that insulin receptor-related receptor (IRR) is highly expressed in the islets as well as in several highly differentiated beta-cell l...

journal_title：Diabetes

authors： Hirayama I,Tamemoto H,Yokota H,Kubo SK,Wang J,Kuwano H,Nagamachi Y,Takeuchi T,Izumi T

更新日期：1999-06-01 00:00:00

abstract：:Cryopreservation of islets of Langerhans offers a number of important benefits for attempts to cure diabetes by transplantation. In the published literature, a variety of cooling rates, ranging from 0.25 to 75 degrees C/min, in conjunction with warming rates of 4-200 degrees C/min have been proposed to give optimal pr...

journal_title：Diabetes

authors： Taylor MJ,Benton MJ

更新日期：1987-01-01 00:00:00

abstract：:Obesity and type 2 diabetes are emerging global epidemics associated with chronic, low-grade inflammation. A characteristic feature of type 2 diabetes is delayed wound healing, which increases the risk of recurrent infections, tissue necrosis, and limb amputation. In health, inflammation is actively resolved by endoge...

journal_title：Diabetes

authors： Tang Y,Zhang MJ,Hellmann J,Kosuri M,Bhatnagar A,Spite M

更新日期：2013-02-01 00:00:00

abstract：:The influence of cyclic AMP (cAMP) and extracellular calcium on phosphoinositide (PI) hydrolysis in isolated islets was assessed and related to insulin output. Three stimulants were chosen to activate the beta-cell: sulfated cholecystokinin (CCK-8S, 200 nM), high-level glucose (20 mM), and the sulfonylurea tolbutamide...

journal_title：Diabetes

authors： Zawalich WS,Diaz VA,Zawalich KC

更新日期：1988-11-01 00:00:00

abstract：:Two sisters presented with severe insulin resistance and markedly decreased insulin binding to erythrocytes, cultured fibroblasts, and transformed lymphocytes. The dose-response curve of insulin-stimulated amino acid uptake in the fibroblasts was shifted to the right. The molecular weight of the insulin receptor on th...

journal_title：Diabetes

authors： Kobayashi M,Sasaoka T,Takata Y,Hisatomi A,Shigeta Y

更新日期：1988-05-01 00:00:00

abstract：:The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest t...

journal_title：Diabetes

authors： Andersen DK,Korc M,Petersen GM,Eibl G,Li D,Rickels MR,Chari ST,Abbruzzese JL

更新日期：2017-05-01 00:00:00

abstract：:Circulating insulin autoantibodies (INSAAb) were measured in discordant monozygotic twins, first-degree relatives, and other groups at "high risk" for the development of insulin-dependent diabetes mellitus (IDDM), and these results correlated with both islet cell antibody (ICAb) status and beta cell function. INSAAb w...

journal_title：Diabetes

authors： Srikanta S,Ricker AT,McCulloch DK,Soeldner JS,Eisenbarth GS,Palmer JP

更新日期：1986-02-01 00:00:00

abstract：:Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites correlated with insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. The top-ranking metab...

journal_title：Diabetes

authors： Xie W,Wood AR,Lyssenko V,Weedon MN,Knowles JW,Alkayyali S,Assimes TL,Quertermous T,Abbasi F,Paananen J,Häring H,Hansen T,Pedersen O,Smith U,Laakso M,MAGIC Investigators.,DIAGRAM Consortium.,GENESIS Consortium.,RISC Co

更新日期：2013-06-01 00:00:00

abstract：:Neogenesis is crucial for the maintenance of beta-cell mass in the human pancreas and possibly for the outcome of clinical islet transplantation. To date, no studies have reported a stimulation of human beta-cell neogenesis in vivo. Therefore, we investigated whether human alpha-, beta-, and duct cell growth can be st...

journal_title：Diabetes

authors： Tyrberg B,Ustinov J,Otonkoski T,Andersson A

更新日期：2001-02-01 00:00:00

abstract：:It is accepted for insulin-secreting cells in culture that the closure of ATP-sensitive K+ channels causes the glucose-dependent depolarization of pancreatic beta-cells seen at subthreshold levels (less than 100 mg/dl) of glucose. The question remains for the more thoroughly studied beta-cells in freshly dissected int...

journal_title：Diabetes

authors： Cook DL,Ikeuchi M

更新日期：1989-04-01 00:00:00

abstract：:The past decade has witnessed an exponential increase in our ability to search the genome for genetic factors predisposing to cardiovascular disease (CVD) and in particular coronary heart disease (CHD). Identifying these genes could lead to the development of innovative strategies to prevent the cardiovascular complic...

journal_title：Diabetes

authors： Doria A

更新日期：2019-03-01 00:00:00

abstract：:The stimulatory effect of the sodium ionophore, veratridine (10, 25 and 50 microM), on glucagon and insulin secretion was investigated using monolayer cultures of newborn rat pancreas. The results suggest that intracellular accumulation of sodium modulates hormone secretion from both alpha- and beta-cells. The action ...

journal_title：Diabetes

authors： Kawazu S,Ikeuchi M,Kikuchi M,Kanazawa Y,Fujimoto WY,Kosaka K

更新日期：1981-05-01 00:00:00

abstract：:ATP is known to be coreleased with insulin from pancreatic beta-cells. To monitor insulin secretion from single beta-cells, a single beta-cell was surrounded in culture by Fura 2-loaded calf pulmonary artery endothelium (CPAE) cells, which can detect the ATP. CPAE cells did not respond with an elevation in cytoplasmic...

journal_title：Diabetes

authors： Kuromi H,Mizuno N,Seino S

更新日期：1995-10-01 00:00:00

abstract：:A simple method for the elimination of labile glycohemoglobin in the chromatographic quantitation of glycosylated hemoglobin is described. Use is made of the instability of Schiff base adducts in acidic solution. Erythrocytes are lysed with a pH 5 buffer. At this pH dissociation reaches completion during sample prepar...

journal_title：Diabetes

authors： Bissé E,Berger W,Flückiger R

更新日期：1982-07-01 00:00:00