Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

abstract：:Vascular complications are the leading causes of morbidity and mortality in diabetic patients. The contribution of platelets to thromboembolic complications is well documented, but their involvement in the initiation of the atherosclerotic process is of rising interest. Thus, the aim of the present study was to evalua...

journal_title：Diabetes

authors： Véricel E,Januel C,Carreras M,Moulin P,Lagarde M

更新日期：2004-04-01 00:00:00

abstract：:Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic gluc...

journal_title：Diabetes

authors： Ott V,Lehnert H,Staub J,Wönne K,Born J,Hallschmid M

更新日期：2015-03-01 00:00:00

abstract：:Coxsackievirus B infections have been associated with clinical manifestation of insulin-dependent diabetes mellitus (IDDM) in several studies, but their initiating role in the slowly progressing beta-cell damage is not known. This is the first prospective study designed to assess the role of coxsackie B and other ente...

journal_title：Diabetes

authors： Hyöty H,Hiltunen M,Knip M,Laakkonen M,Vähäsalo P,Karjalainen J,Koskela P,Roivainen M,Leinikki P,Hovi T

更新日期：1995-06-01 00:00:00

abstract：:The clinical features of the experimental hyperosmolar diabetic (EHD) rat model resemble those seen in the human syndrome--extreme hyperglycemia without ketoacidosis is common to both. The absence of ketoacidosis in the syndrome has been ascribed to both substrate (free fatty acid) deficiency and to interference with ...

journal_title：Diabetes

authors： Gordon EE,Duga J

更新日期：1975-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...

journal_title：Diabetes

authors： Spanier JA,Sahli NL,Wilson JC,Martinov T,Dileepan T,Burrack AL,Finger EB,Blazar BR,Michels AW,Moran A,Jenkins MK,Fife BT

更新日期：2017-12-01 00:00:00

abstract：:Impaired effectiveness of glucose to suppress endogenous glucose production (EGP) is an important cause of worsening hyperglycemia in type 2 diabetes. Elevated free fatty acids (FFAs) may impair glucose effectiveness via several mechanisms, including rapid changes in metabolic fluxes and/or more gradual changes in gen...

journal_title：Diabetes

authors： Kishore P,Tonelli J,Koppaka S,Fratila C,Bose A,Lee DE,Reddy K,Hawkins M

更新日期：2006-06-01 00:00:00

abstract：:Glucose, insulin secretion, and insulin secretory pulses were measured by deconvolution of peripheral C-peptide concentrations in 10 IDDM recipients of a combined kidney-pancreas allograft 6 mo post-transplantation and were compared with 10 matched nondiabetic control subjects. Seven of the 10 recipients were restudie...

journal_title：Diabetes

authors： Blackman JD,Polonsky KS,Jaspan JB,Sturis J,Van Cauter E,Thistlethwaite JR

更新日期：1992-10-01 00:00:00

abstract：:A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of the adjacent gene GLUL encoding glutamine synthase, converting glutamic acid to glutamine. To f...

journal_title：Diabetes

authors： Pipino C,Shah H,Prudente S,Di Pietro N,Zeng L,Park K,Trischitta V,Pennathur S,Pandolfi A,Doria A

更新日期：2020-10-01 00:00:00

abstract：:Concentrations of glycosylated hemoglobin (GHb) are elevated in diabetes mellitus and are believed to reflect previous metabolic control. To better define possible determinants of GHb in man, we investigated the relationship between GHb and both fasting plasma glucose (FPG) and basal insulin (IRI) in 42 normal subject...

journal_title：Diabetes

authors： Graf RJ,Halter JB,Porte D Jr

更新日期：1978-08-01 00:00:00

abstract：:The sulfonylurea receptor (SUR) is the important regulatory subunit of ATP-sensitive K+ channels. It is an ATP-binding cassette protein comprising 17 transmembrane helices. SUR is endowed with binding sites for channel blockers like the antidiabetic sulfonylurea glibenclamide and for the chemically very heterogeneous ...

journal_title：Diabetes

authors： Hambrock A,Kayar T,Stumpp D,Osswald H

更新日期：2004-12-01 00:00:00

abstract：:Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites correlated with insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. The top-ranking metab...

journal_title：Diabetes

authors： Xie W,Wood AR,Lyssenko V,Weedon MN,Knowles JW,Alkayyali S,Assimes TL,Quertermous T,Abbasi F,Paananen J,Häring H,Hansen T,Pedersen O,Smith U,Laakso M,MAGIC Investigators.,DIAGRAM Consortium.,GENESIS Consortium.,RISC Co

更新日期：2013-06-01 00:00:00

abstract：:Monogenic forms of obesity have been identified in ≤10% of severely obese European patients. However, the overall spectrum of deleterious variants (point mutations and structural variants) responsible for childhood severe obesity remains elusive. In this study, we genetically screened 225 severely obese children from ...

journal_title：Diabetes

authors： Saeed S,Arslan M,Manzoor J,Din SM,Janjua QM,Ayesha H,Ain QT,Inam L,Lobbens S,Vaillant E,Durand E,Derhourhi M,Amanzougarene S,Badreddine A,Berberian L,Gaget S,Khan WI,Butt TA,Bonnefond A,Froguel P

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men. RESEARCH DESIGN AND METHODS:Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospectiv...

journal_title：Diabetes

authors： Haring R,Völzke H,Felix SB,Schipf S,Dörr M,Rosskopf D,Nauck M,Schöfl C,Wallaschofski H

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Pharmacogenomics is a key component of personalized medicine. The Israel Cardiovascular Events Reduction with Vitamin E Study, a prospective placebo-controlled study, recently demonstrated that vitamin E could dramatically reduce CVD in individuals with diabetes and the haptoglobin (Hp) 2-2 genotype (40% of d...

journal_title：Diabetes

authors： Asleh R,Blum S,Kalet-Litman S,Alshiek J,Miller-Lotan R,Asaf R,Rock W,Aviram M,Milman U,Shapira C,Abassi Z,Levy AP

更新日期：2008-10-01 00:00:00

abstract：:Rosiglitazone therapy improves insulin sensitivity and glucose uptake in patients with uncomplicated type 2 diabetes. In coronary artery disease (CAD), glucose is an important source of energy and preserved myocardial glucose uptake is essential for the viability of jeopardized myocardium. The aim was to test whether ...

journal_title：Diabetes

authors： Lautamäki R,Airaksinen KE,Seppänen M,Toikka J,Luotolahti M,Ball E,Borra R,Härkönen R,Iozzo P,Stewart M,Knuuti J,Nuutila P

更新日期：2005-09-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia both impair insulin sensitivity in vivo. This may be secondary to stimulation of adipose tissue lipolysis and consequent increased circulating free fatty acids (FFAs). Here we report that neither TNF-alpha nor glucose alone has a pronounced effect on lipolysis ...

journal_title：Diabetes

authors： Green A,Rumberger JM,Stuart CA,Ruhoff MS

更新日期：2004-01-01 00:00:00

abstract：:This is the third in a series of Perspectives on intracellular signaling pathways coupled to proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells with the more limited human database. With the increasing incidence of type 1 diabetes and the recognition that type 2 diabetes is als...

journal_title：Diabetes

authors： Stewart AF,Hussain MA,García-Ocaña A,Vasavada RC,Bhushan A,Bernal-Mizrachi E,Kulkarni RN

更新日期：2015-06-01 00:00:00

abstract：:To treat insulin lipoatrophy, small amounts of dexamethasone (4 micrograms/unit) were added to insulin injections in nine patients. Six cases showed significant improvement of dexamethasone-treated sites over that of control sites in six months. With the continued use of dexamethasone-containing insulin, they remained...

journal_title：Diabetes

authors： Kumar O,Miller L,Mehtalia S

更新日期：1977-04-01 00:00:00

abstract：:The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...

journal_title：Diabetes

authors： Suga A,Hirano T,Kageyama H,Kashiba M,Oka J,Osaka T,Namba Y,Tsuji M,Miura M,Adachi M,Inoue S

更新日期：1999-10-01 00:00:00

abstract：:Studies from several laboratories suggest that oxidized LDL may play an important role in atherogenesis. Our group previously showed that treatment of aortic endothelial cells with low levels of MM-LDL caused increased expression of MCP-1, M-CSF, tissue factor, and a monocyte-binding protein. In these studies MM-LDL w...

journal_title：Diabetes

authors： Berliner JA,Territo M,Navab M,Andalibi A,Parhami F,Liao F,Kim J,Estworthy S,Lusis AJ,Fogelman AM

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity. RESEARCH DESI...

journal_title：Diabetes

authors： Rutanen J,Yaluri N,Modi S,Pihlajamäki J,Vänttinen M,Itkonen P,Kainulainen S,Yamamoto H,Lagouge M,Sinclair DA,Elliott P,Westphal C,Auwerx J,Laakso M

更新日期：2010-04-01 00:00:00

abstract：:There has been a prejudice that diabetes modulates the function of saphenous vein in a manner that predisposes to bypass graft failure, although most of the evidence accrues from animal studies. We have investigated the effect of diabetes on the vasodilator responses and ultrastructure of saphenous vein harvested from...

journal_title：Diabetes

authors： Hicks RC,Moss J,Higman DJ,Greenhalgh RM,Powell JT

更新日期：1997-01-01 00:00:00

abstract：:Insulin replacement therapy in type 1 diabetes is imperfect because proper glycemic control is not always achieved. Most patients develop microvascular, macrovascular, and neurological complications, which increase with the degree of hyperglycemia. Engineered muscle cells continuously secreting basal levels of insulin...

journal_title：Diabetes

authors： Riu E,Mas A,Ferre T,Pujol A,Gros L,Otaegui P,Montoliu L,Bosch F

更新日期：2002-03-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regula...

journal_title：Diabetes

authors： Baboota RK,Blüher M,Smith U

更新日期：2021-02-01 00:00:00

abstract：:Altered proteoglycan metabolism may play a role in the development of diabetic glomerulopathy. This study was conducted to examine the effects of glucose on the production and physical characteristics of proteoglycans generated by rat mesangial cells in culture. Rat mesangial cells were exposed to elevated glucose med...

journal_title：Diabetes

authors： Silbiger S,Schlondorff D,Crowley S,Rosenberg L,Choi H,Hatcher V,Gordon P

更新日期：1993-12-01 00:00:00

abstract：:The possible role of endothelial dysfunction in early stages of uncomplicated diabetes mellitus was investigated in porcine aortic endothelial cells. Prolonged exposure to various D-glucose concentrations resulted in concentration-dependent amplification of agonist-induced Ca2+ mobilization, whereas L-glucose and D-ma...

journal_title：Diabetes

authors： Graier WF,Wascher TC,Lackner L,Toplak H,Krejs GJ,Kukovetz WR

更新日期：1993-10-01 00:00:00

abstract：:Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion f...

journal_title：Diabetes

authors： Laukkanen O,Lindström J,Eriksson J,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Uusitupa M,Laakso M,Finnish Diabetes Prevention Study.

更新日期：2005-07-01 00:00:00

abstract：:Retrospective studies of patients with non-insulin-dependent diabetes mellitus (NIDDM) have suggested that microalbuminuria predicts early all-cause (mainly cardiovascular) mortality independently of arterial blood pressure. These findings have not been confirmed in prospective studies, and it is not known whether the...

journal_title：Diabetes

authors： Mattock MB,Morrish NJ,Viberti G,Keen H,Fitzgerald AP,Jackson G

更新日期：1992-06-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (KDR) plays a critical role in mediating a variety of vasculogenic and angiogenic processes, including diabetic retinopathy. We previously demonstrated that the promoter activity of the KDR gene in retinal capillary endothelial cells (RCECs) was regulated in part by the re...

journal_title：Diabetes

authors： Sassa Y,Hata Y,Aiello LP,Taniguchi Y,Kohno K,Ishibashi T

更新日期：2004-05-01 00:00:00

abstract：:ATP-sensitive potassium (K[ATP]) channels are an essential component of glucose-dependent insulin secretion in pancreatic islet beta-cells. These channels comprise the sulfonylurea receptor (SUR1) and Kir6.2, a member of the inward rectifier K+ channel family. Mutations in the SUR1 subunit are associated with familial...

journal_title：Diabetes

authors： Nestorowicz A,Inagaki N,Gonoi T,Schoor KP,Wilson BA,Glaser B,Landau H,Stanley CA,Thornton PS,Seino S,Permutt MA

更新日期：1997-11-01 00:00:00