Abstract:
:The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1.B and RT1.D. The possibility that variant or unique class II MHC molecules may be associated with IDDM susceptibility was directly examined by determining the nucleotide sequences of class II mRNAs and/or cDNAs from the diabetes-prone (DP) BB rat, the diabetes-resistant (DR) BB rat, the normal histocompatible Wistar-Furth (WF) rat, and the Lewis rat. Sequence analysis indicates that the beta-chains of the RT1.B and RT1.D molecules of the u haplotype from DP-BB, DR-BB, and WF rats are identical but that they are different from other rat alleles and published mouse class II sequences. At the nucleotide level, the NH2-terminal domain of RT1.D beta of the BB and WF rats differs by a single silent nucleotide substitution. Comparisons with the sequences of the Lewis rat indicate hypervariable allelic differences and that the u and I haplotypes are remarkably similar. These findings establish that the class II molecules of the DP-BB rat are not variant or unique and that unaltered class II molecules of the u haplotype support the autoimmune response in the BB rat.
journal_name
Diabetesjournal_title
Diabetesauthors
Holowachuk EW,Greer MKdoi
10.2337/diab.38.2.267subject
Has Abstractpub_date
1989-02-01 00:00:00pages
267-71issue
2eissn
0012-1797issn
1939-327Xjournal_volume
38pub_type
杂志文章相关文献
DIABETES文献大全abstract::A 5-day culture of adult rat islets with human recombinant IL-1 beta (3 U/ml) resulted in the death of most alpha-cells and 50% of beta-cells. The IL-1--exposed islet tissue contained--in addition to poorly granulated beta-cells--patches of outgrowing monolayers and dispersed activated macrophages. In purified alpha- ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.1.56
更新日期:1993-01-01 00:00:00
abstract::It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the plasma membrane of adipocytes and skeletal muscle. Here, we explore whe...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.11.3161
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:The gene encoding the alpha2 Heremans-Schmid glycoprotein (AHSG) is a credible biological and positional candidate gene for type 2 diabetes and the metabolic syndrome, and previous attempts to relate AHSG variation with type 2 diabetes and obesity in Swedish and French Caucasians have been largely successful....
journal_title:Diabetes
pub_type: 杂志文章,多中心研究
doi:10.2337/db07-0558
更新日期:2008-05-01 00:00:00
abstract::The kinetics of in vivo insulin-mediated glucose uptake in human obesity have not been previously studied. To examine this, we used the glucose-clamp technique to measure whole-body and leg muscle glucose uptake in seven lean and six obese men during hyperinsulinemia (approximately 2000 pM) at four glucose levels (app...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.8.965
更新日期:1990-08-01 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase (CaMK) activation induces mitochondrial biogenesis in response to increasing cytosolic calcium concentrations. Calcium leak from the ryanodine receptor (RyR) is regulated by reactive oxygen species (ROS), which is increased with high-fat feeding. We examined whether ROS-indu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-0816
更新日期:2014-06-01 00:00:00
abstract::The appearance of type 1 diabetes (T1D)-associated autoantibodies is the first and only measurable parameter to predict progression toward T1D in genetically susceptible individuals. However, autoantibodies indicate an active autoimmune reaction, wherein the immune tolerance is already broken. Therefore, there is a cl...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0287
更新日期:2019-10-01 00:00:00
abstract::To determine the mechanism of hyperchloremic acidosis during recovery from diabetic ketoacidosis (DKA), serial measurements were made in eight patients of serum and urinary electrolytes and organic acids, and of urinary net acid. On admission, the average decrease in serum total CO2 was 17.5 mmol/L, corresponding to t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.4.310
更新日期:1981-04-01 00:00:00
abstract::Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.1.s10
更新日期:1980-01-01 00:00:00
abstract::Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications. Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, and inflammation of adipose tissue. Here, we report that delayed interv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-1390
更新日期:2016-04-01 00:00:00
abstract::Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this "glucose effectiveness" is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous system have been shown to regulate EGP in humans and rodents. We examined the ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-1256
更新日期:2020-06-01 00:00:00
abstract::Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Loss of GBM HS in dia...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-1024
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance. RESEARCH DESIGN AND METHODS:TSP1 gene expression was quantified in subcutaneous adipose tiss...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-0840
更新日期:2008-02-01 00:00:00
abstract::Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves end...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/db14-1620
更新日期:2015-05-01 00:00:00
abstract::Clinical studies indicate that significant loss of functional islet mass occurs in the peritransplant period. Islets are injured as a result of detrimental effects of brain death, pancreas preservation, islet isolation, hypoxia, hyperglycemia, and immune-mediated events. In addition, recent studies demonstrated that i...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.11.2804
更新日期:2004-11-01 00:00:00
abstract::We aimed to investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk. A Mendelian randomization study was performed using a genetic score with 24 uric acid-associated loci. We used data of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db14-0742
更新日期:2015-08-01 00:00:00
abstract::To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.8.1015
更新日期:1994-08-01 00:00:00
abstract::Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in the pancreas. Thereby, the chemokine CXC-motif ligand 10 (CXCL10) plays an important role in the recruitment of autoaggressive lymphocytes to the islets of Langerhans. Transplantation of isolated islets as a promising therapy...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0547
更新日期:2017-01-01 00:00:00
abstract::Accumulation of brown products in long-lived proteins might be an important factor in determining long-term diabetic complications. Fluorescent chromophore 2-(2-furoyl)-4-(5)-(2-furanyl)-1H-imidazole (FFI), isolated from hydrolyzed brown products synthesized in vitro, was proposed as a specific brown product responsib...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diacare.39.1.57
更新日期:1990-01-01 00:00:00
abstract::IDDM results from immune-mediated destruction of insulin-producing pancreatic beta-cells in individuals genetically susceptible for the disease. There is evidence that the 65-kDa isoform of GAD plays a critical role in the induction of autoimmune diabetes in NOD mice. In humans, it is still unclear when and to what be...
journal_title:Diabetes
pub_type: 杂志文章,多中心研究
doi:10.2337/diab.45.7.967
更新日期:1996-07-01 00:00:00
abstract::Platelets from diabetic subjects with circulating immune complexes (CIC) synthesized greater amounts of thromboxane than did platelets from CIC-negative patients or controls. In view of the known action of CIC on platelet function, a relationship between these two factors may be suggested in the initiation and progres...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.8.728
更新日期:1984-08-01 00:00:00
abstract::In nonobese diabetic (NOD) mice, a deficiency in the number and function of invariant natural killer T-cells (iNKT cells) contributes to the onset of type 1 diabetes. The activation of CD1d-restricted iNKT cells by alpha-galactosylceramide (alpha-GalCer) corrects these deficiencies and protects against spontaneous and...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.5.1303
更新日期:2004-05-01 00:00:00
abstract::In the oral glucose tolerance test (OGTT), divergent doses of glucose remain in use by virtue of the prevailing conviction that the size of the loading dose hardly affects the outcome of the test. We compared the results of OGTTs with 100-gm. and 50-gm. loads in 85 patients, who were selected for slightly impaired glu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.27.1.42
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:To examine whether the inflammatory phenotype found in obese and diabetic individuals is preserved in isolated, cultured myocytes and to assess the effectiveness of pharmacological AMP-activated protein kinase (AMPK) activation upon the attenuation of inflammation in these myocytes. RESEARCH DESIGN AND METHO...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0263
更新日期:2011-11-01 00:00:00
abstract::Peripheral neuropathy and insensate limbs and digits cause significant morbidity in diabetic individuals. Previous studies showed that deletion of the receptor for advanced end-glycation products (RAGE) in mice was protective in long-term diabetic neuropathy. Here, we tested the hypothesis that RAGE suppresses effecti...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0632
更新日期:2013-03-01 00:00:00
abstract::Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS) production, and oxidative stress in pancreatic beta-cells may be tightly linked processes. Here we suggest that the same pathways used in the activation of GDIS (increased glycolytic flux, ATP-to-ADP ratio, and intracellular Ca2+ concentration) ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.53.8.1942
更新日期:2004-08-01 00:00:00
abstract::Microinflammation is a common major mechanism in the pathogenesis of diabetic vascular complications, including diabetic nephropathy. Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages. This study aimed to determine the role of SR-A in diabetic nephropathy using SR-A-deficien...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0359
更新日期:2007-02-01 00:00:00
abstract::Recent evidence highlights the therapeutic potential of peroxisome proliferator-activated receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, the role of PPARδ in regulating vascular function is incompletely characterized. We investigate whether PPARδ activation improves endothelial funct...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0117
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-1361
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men. RESEARCH DESIGN AND METHODS:Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospectiv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-0031
更新日期:2009-09-01 00:00:00
abstract::Insulin resistance associated with altered fat partitioning in liver and adipose tissues is a prediabetic condition in obese adolescents. We investigated interactions between glucose tolerance, insulin sensitivity, and the expression of lipogenic genes in abdominal subcutaneous adipose and liver tissue in 53 obese ado...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0889
更新日期:2013-03-01 00:00:00