Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects.

abstract：:These studies of a rat model for non-insulin-dependent diabetes mellitus (NIDDM) were performed to determine whether hyperglycemia occurs when capacity to synthesize insulin is exceeded. The neonatal streptozocin (STZ)-treated rat has acute hyperglycemia with marked destruction of pancreatic beta-cells, followed by gr...

journal_title：Diabetes

authors： Giddings SJ,Orland MJ,Weir GC,Bonner-Weir S,Permutt MA

更新日期：1985-03-01 00:00:00

abstract：:The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...

journal_title：Diabetes

authors： Plengvidhya N,Antonellis A,Wogan LT,Poleev A,Borgschulze M,Warram JH,Ryffel GU,Krolewski AS,Doria A

更新日期：1999-10-01 00:00:00

abstract：:Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. This study was designed to characterize the molecular mechanisms by which AMPK suppresses vascular inflammation. In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the si...

journal_title：Diabetes

authors： He C,Li H,Viollet B,Zou MH,Xie Z

更新日期：2015-12-01 00:00:00

abstract：:Congenital malformations occur more frequently in the offspring of diabetic mothers. These in vivo and in vitro studies investigate the potential adverse effects of hyperglycemia on kidney development in the rat. Female rats were made hyperglycemic throughout gestation with a single injection of streptozotocin (STZ) o...

journal_title：Diabetes

authors： Amri K,Freund N,Vilar J,Merlet-Bénichou C,Lelièvre-Pégorier M

更新日期：1999-11-01 00:00:00

abstract：:Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...

journal_title：Diabetes

authors： Araki Y,Solomon BA,Basile RM,Chick WL

更新日期：1985-09-01 00:00:00

abstract：:We assessed our speculation that 2-cyclohexen-1-one (CHX) impairs glucose-induced insulin secretion through inactivation of glucokinase. Treatment of pancreatic islets with CHX at concentrations (0-5 mM) that caused a dose-dependent inactivation of glucokinase activity similarly inhibited glucose-induced insulin secre...

journal_title：Diabetes

authors： Miwa I,Murata T,Mitsuyama S,Okuda J

更新日期：1990-10-01 00:00:00

abstract：:A group of insulin-dependent diabetic patients was studied in order to determine the possible short-term regulatory effect of insulin and that of an antilipolytic drug on serum triglycerides. Subcutaneous crystalline insulin (one third of the usual morning dose of intermediate long-acting insulin, NPH) and an oral dos...

journal_title：Diabetes

authors： Alvarez-Reynolds M,Dominguez JM

更新日期：1977-07-01 00:00:00

abstract：:Kinetic studies were carried out on liver glycogen synthase and phosphorylase isolated from genetically diabetic db/db mice. Glycogen synthase a and b enzymes from diabetic mice had Vmax values 30% and 20% lower, respectively, than the enzymes from normal mice. Glycogen synthase b from diabetic mice also had a 30% low...

journal_title：Diabetes

authors： Roesler WJ,Khandelwal RL

更新日期：1986-02-01 00:00:00

abstract：:Abdominal visceral fat (AVF), abdominal subcutaneous fat (ASF), and abdominal total fat (ATF) were measured using a computed tomography scan, both before (baseline) and after (post) a 20-week endurance exercise training protocol in the HERITAGE Family Study. Each of the baseline and response (post minus baseline) meas...

journal_title：Diabetes

authors： Rice T,Chagnon YC,Pérusse L,Borecki IB,Ukkola O,Rankinen T,Gagnon J,Leon AS,Skinner JS,Wilmore JH,Bouchard C,Rao DC

更新日期：2002-03-01 00:00:00

abstract：:Because high D-glucose significantly stimulates endothelial cell death, we examined the molecular mechanisms of high D-glucose-induced endothelial apoptosis. Treatment of human aortic endothelial cells with high D-glucose (25 mmol/l), but not mannitol and L-glucose, resulted in a significant decrease in cell number an...

journal_title：Diabetes

authors： Nakagami H,Morishita R,Yamamoto K,Yoshimura SI,Taniyama Y,Aoki M,Matsubara H,Kim S,Kaneda Y,Ogihara T

更新日期：2001-06-01 00:00:00

abstract：:Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phase insulin secretion and improve glucose control. To determine the phys...

journal_title：Diabetes

authors： Kaihara KA,Dickson LM,Jacobson DA,Tamarina N,Roe MW,Philipson LH,Wicksteed B

更新日期：2013-05-01 00:00:00

abstract：:Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity wa...

journal_title：Diabetes

authors： Takahashi K,Brooks RA,Kanse SM,Ghatei MA,Kohner EM,Bloom SR

更新日期：1989-09-01 00:00:00

abstract：:The reduction in blood glucose in non-insulin-dependent diabetes mellitus (NIDDM) brought about by the use of phenobarbital (PB), a hepatic microsomal enzyme inducer, suggests an improvement in insulin sensitivity. The effect of PB on insulin-mediated glucose metabolism was hence investigated using the euglycemic clam...

journal_title：Diabetes

authors： Lahtela JT,Arranto AJ,Sotaniemi EA

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:To determine the role of hepatocyte growth factor (HGF)/c-Met on β-cell survival in diabetogenic conditions in vivo and in response to cytokines in vitro. RESEARCH DESIGN AND METHODS:We generated pancreas-specific c-Met-null (PancMet KO) mice and characterized their response to diabetes induced by multiple l...

journal_title：Diabetes

authors： Mellado-Gil J,Rosa TC,Demirci C,Gonzalez-Pertusa JA,Velazquez-Garcia S,Ernst S,Valle S,Vasavada RC,Stewart AF,Alonso LC,Garcia-Ocaña A

更新日期：2011-02-01 00:00:00

abstract：:Susceptibility to insulin-dependent diabetes mellitus (IDDM) is greatly influenced by polymorphisms in the genes of the class II region of the human leukocyte antigen (HLA) complex. The complexity of this genetic association and the lack of a direct proof of involvement of HLA class II genes in human IDDM have continu...

journal_title：Diabetes

authors： van Endert PM,Liblau RS,Patel SD,Fugger L,Lopez T,Pociot F,Nerup J,McDevitt HO

更新日期：1994-01-01 00:00:00

abstract：:The development of autoimmune diabetes in NOD mice results from selective destruction of beta-cells by a T-cell-dependent autoimmune process. However, the mechanisms that control the generation of beta-cell cytotoxic T-cells in vivo are poorly understood. We recently established 8.3-T-cell receptor (TCR)-beta transgen...

journal_title：Diabetes

authors： Jun HS,Santamaria P,Lim HW,Zhang ML,Yoon JW

更新日期：1999-01-01 00:00:00

abstract：:Using an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression ...

journal_title：Diabetes

authors： Keildson S,Fadista J,Ladenvall C,Hedman ÅK,Elgzyri T,Small KS,Grundberg E,Nica AC,Glass D,Richards JB,Barrett A,Nisbet J,Zheng HF,Rönn T,Ström K,Eriksson KF,Prokopenko I,MAGIC Consortium.,DIAGRAM Consortium.,MuTHER

更新日期：2014-03-01 00:00:00

abstract：:Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide. Podocytes are important for glomerular filtration barrier function and maintenance of size selectivity in protein filtration in the kidney. Podocyte damage is the basis of many glomerular diseases characterized by loss of interdigitatin...

journal_title：Diabetes

authors： Teng B,Schroder P,Müller-Deile J,Schenk H,Staggs L,Tossidou I,Dikic I,Haller H,Schiffer M

更新日期：2016-12-01 00:00:00

abstract：:Insulin resistance is a recently identified mechanism involved in the pathophysiology of chronic heart failure (CHF). We investigated the effects of two insulin-sensitizing drugs (metformin and rosiglitazone) in a genetic model of spontaneously hypertensive, insulin-resistant rats (SHHF). Thirty SHHF rats were randomi...

journal_title：Diabetes

authors： Cittadini A,Napoli R,Monti MG,Rea D,Longobardi S,Netti PA,Walser M,Samà M,Aimaretti G,Isgaard J,Saccà L

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2 diabetes, and transient GLP-1 administration improved cardiac function in humans after acute myocardial infarction (MI) and percutaneous revascularization. However, the consequences of GLP-1R activation before ischemic myocardial inju...

journal_title：Diabetes

authors： Noyan-Ashraf MH,Momen MA,Ban K,Sadi AM,Zhou YQ,Riazi AM,Baggio LL,Henkelman RM,Husain M,Drucker DJ

更新日期：2009-04-01 00:00:00

abstract：:We used mouse genetics to model how polygenic thresholds for the transition from impaired glucose tolerance (IGT) to NIDDM are reached. NON/Lt and NZO/Hl are inbred mouse strains selected for IGT and polygenic obesity, respectively. Their F1 male progeny consistently developed NIDDM. Genetic analysis of F2 males from ...

journal_title：Diabetes

authors： Leiter EH,Reifsnyder PC,Flurkey K,Partke HJ,Junger E,Herberg L

更新日期：1998-08-01 00:00:00

abstract：:The adipocyte-secreted protein adiponectin is associated with insulin sensitivity in observational studies. We aimed to evaluate whether this relationship is causal using a Mendelian randomization approach. In a sample of Swedish men aged 71 years (n = 942) from the Uppsala Longitudinal Study of Adult Men (ULSAM), ins...

journal_title：Diabetes

authors： Gao H,Fall T,van Dam RM,Flyvbjerg A,Zethelius B,Ingelsson E,Hägg S

更新日期：2013-04-01 00:00:00

abstract：:Glucose metabolism affects most major signal pathways in pancreatic beta-cells. Multiple protein kinases, including protein kinase C (PKC) isoenzymes, are involved in these effects; however, their role is poorly defined. Moreover, the dynamics of kinase isoenzyme activation in reference to the biphasic insulin secreti...

journal_title：Diabetes

authors： Warwar N,Efendic S,Ostenson CG,Haber EP,Cerasi E,Nesher R

更新日期：2006-03-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:The effects of variations of glycemia from 1.7 to 35 mM on the activity of glycogen synthase and phosphorylase, on glycogen content, and on U-14C-glucose incorporation into glycogen in the liver of the near-term rat fetus were investigated. Hypoglycemia did not affect the activities of phosphorylase and synthase; tota...

journal_title：Diabetes

authors： Gilbert M,Bourbon J

更新日期：1980-04-01 00:00:00

abstract：:Diet-induced obesity is known to cause peripheral insulin resistance in rodents. We have recently found that feeding cod protein to high-fat-fed rats prevents the development of insulin resistance in skeletal muscle. In the present study, we have further explored the cellular mechanisms behind this beneficial effect o...

journal_title：Diabetes

authors： Tremblay F,Lavigne C,Jacques H,Marette A

更新日期：2003-01-01 00:00:00

abstract：:Glucose tolerance depends on a complex interaction among insulin secretion from the beta-cells, clearance of the hormone, and the actions of insulin to accelerate glucose disappearance and inhibit endogenous glucose production. An additional factor, less well recognized, is the ability of glucose per se, independent o...

journal_title：Diabetes

authors： Bergman RN

更新日期：1989-12-01 00:00:00

abstract：:One month following induction of diabetes with streptozotocin, one half of diabetic and control rats underwent unilateral nephrectomy. Subsequently, all animals were studied with respect to renal function and glomerular alterations of diabetes. Blood pressure levels were similar in all animals. Diabetic and control an...

journal_title：Diabetes

authors： Steffes MW,Brown DM,Mauer SM

更新日期：1978-01-01 00:00:00

abstract：:The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...

journal_title：Diabetes

authors： Heise T,Nosek L,Rønn BB,Endahl L,Heinemann L,Kapitza C,Draeger E

更新日期：2004-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activate...

journal_title：Diabetes

authors： Coppieters KT,Amirian N,Pagni PP,Baca Jones C,Wiberg A,Lasch S,Hintermann E,Christen U,von Herrath MG

更新日期：2013-07-01 00:00:00