Abstract:
:Abdominal visceral fat (AVF), abdominal subcutaneous fat (ASF), and abdominal total fat (ATF) were measured using a computed tomography scan, both before (baseline) and after (post) a 20-week endurance exercise training protocol in the HERITAGE Family Study. Each of the baseline and response (post minus baseline) measures was adjusted for several covariates, including total fat mass, and responses to training were further adjusted for baseline levels. Multipoint variance components linkage analysis using a genomewide scan of 344 markers was conducted separately by race using race-specific allele frequencies. Several promising results (P < 0.0023) were obtained. For baseline AVF, the best evidence was on 2q22.1 and 2q33.2-q36.3 (including the IRS1 locus) in whites, with suggestive findings on 7q22.2-q31.3 (including the LEP locus) in blacks. Although several regions were indicated for baseline ASF, only 4q31.22-q32.2 and 11p15.4-p11.2 replicated the results of another study. For responses to training, promising results were limited to ASF and ATF primarily on 7q36.2 (including NOS3) in blacks, with suggestive regions (P < 0.01) on 1q21.2-q24.1 (S100A, ATP1A2, and ATP1B1), 10q25.2 (ADRA2A), and 11p15.5 (IGF2). In summary, the 4q and 11p regions have now been implicated in two independent studies for ASF; further research is warranted to identify the genes and mutations in these regions that are responsible for fat accumulation in the abdominal depot. Additional work in an independent sample is needed to verify the linkages for baseline AVF as well as the response measures.
journal_name
Diabetesjournal_title
Diabetesauthors
Rice T,Chagnon YC,Pérusse L,Borecki IB,Ukkola O,Rankinen T,Gagnon J,Leon AS,Skinner JS,Wilmore JH,Bouchard C,Rao DCdoi
10.2337/diabetes.51.3.848subject
Has Abstractpub_date
2002-03-01 00:00:00pages
848-55issue
3eissn
0012-1797issn
1939-327Xjournal_volume
51pub_type
杂志文章相关文献
DIABETES文献大全abstract::A major goal of the study was to assess the methodologies available for the quantification of retinal lesions suitable for application in trials of metabolic management. We describe the methods used for grading stereoscopic color fundus photographs. Overall retinopathy severity level for each eye ranging from normal (...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.3.s42
更新日期:1985-08-01 00:00:00
abstract::Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternative to stimulate glucose uptake in insulin-resistant muscle. Both Rac1 and AMPK have been shown to partly regulate contraction-stimulated muscle glucose uptake, but whether those two signali...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1138
更新日期:2017-06-01 00:00:00
abstract::The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of 111In-diethylenetriaminepentaacetic acid-exendin-3 (111In-exendin) in a rat model that closely mimics the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1312
更新日期:2018-10-01 00:00:00
abstract::Recent research indicates that islet amyloid pancreatic polypeptide (IAPP) might have a regulatory effect on beta-cell insulin processing and secretion. To study such interaction in more detail, IAPP secretion and kinetics and the serum concentrations of proinsulin were assessed both before and after delivery in lean ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.4.607
更新日期:1997-04-01 00:00:00
abstract::Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism and are also involved in glucose metabolism. However, the functional role of LXRs in human skeletal muscle is at present unknown. This study demonstrates that chronic ligand activation of LXRs by a synthetic LXR agonist increases the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.4.1108
更新日期:2005-04-01 00:00:00
abstract::Estrogen-related receptor γ (ERRγ) is a major positive regulator of hepatic gluconeogenesis. Its transcriptional activity is suppressed by phosphorylation signaled by insulin in the fed state, but whether posttranslational modification alters its gluconeogenic activity in the fasted state is not known. Metabolically a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-1523
更新日期:2016-10-01 00:00:00
abstract::Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-1174
更新日期:2020-09-01 00:00:00
abstract::The effect of Ca2+ and calmodulin has been studied on adenylate cyclase activity in homogenates of rat islets of Langerhans. EGTA had a stimulatory effect on the enzyme in accord with the known inhibitory effect of Ca2+. In contrast, the addition of Ca2+ together with calmodulin is stimulatory and demonstrates the exi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.1.74
更新日期:1980-01-01 00:00:00
abstract::Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activate...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-1370
更新日期:2013-07-01 00:00:00
abstract::Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and is mutated in the db/db mouse so that it lacks the cytoplasmic domain. We show that the full-length leptin receptor (Ob-Rb), which is believed to transmit the l...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.2.313
更新日期:1997-02-01 00:00:00
abstract::Bcl-2 mRNA expression was detected in rat blastocysts by in situ hybridization. The distribution of mRNA expression was rather heterogenous, with approximately 2% of high-expressing cells. In vitro exposure to 28 mmol/l D-glucose for 24 h resulted in a significant increase in the proportion of these cells compared wit...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.1.143
更新日期:2001-01-01 00:00:00
abstract::We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors effici...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.4.745
更新日期:1999-04-01 00:00:00
abstract::On the basis of the positive outcome of animal experiments, several large placebo-controlled trials are underway and aiming for the first time at the prevention of an immune-mediated disease, type 1 diabetes. The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical effica...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diabetes.47.6.980
更新日期:1998-06-01 00:00:00
abstract::The pancreases of 14 children who died of type I diabetes were studied immunohistochemically for aberrant expression of HLA-DR antigens on islet endocrine cells. Two cases in which no residual insulin-secreting beta-cells were present had no evidence of HLA-DR expression on endocrine cells. Insulin-containing islets w...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.11.1215
更新日期:1986-11-01 00:00:00
abstract::The farnesoid X receptor (FXR) and the liver x receptors (LXRs) are bile acid-activated receptors that are highly expressed in the enterohepatic tissues. The mechanisms that support the beneficial effects of bariatric surgery are only partially defined. We have investigated the effects of ileal interposition (IT), a s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-0299
更新日期:2013-10-01 00:00:00
abstract::In people with diabetes, the concentration of an individual lipoprotein or apolipoprotein can be highly variable and is totally different in the two major forms of the disease. Alterations in the concentrations of major lipids and lipoproteins are well characterized in both IDDM and NIDDM. In general, the lipoprotein ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.41.2.s12
更新日期:1992-10-01 00:00:00
abstract::A genome scan for B10-derived loci that reduce the frequency of diabetes and insulitis in NOD mice demonstrated a large region (34 cM) of linkage on the proximal end of chromosome 1. This locus was designated Idd5 and encompassed candidate genes including Il1r1, Il1r2, Stat1, Stat4, Nramp1, and Bcl2. In the current st...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.10.1744
更新日期:2000-10-01 00:00:00
abstract::A new approach has been developed to examine insulin sensitivity and resistance in vivo in man. In it, tracer methods are used, which permit the assessment of nonsteady state glucose kinetics by a method that is noninvasive and does not use pharmacologic agents. Graded doses of glucagon, infused intravenously, are use...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.3.169
更新日期:1980-03-01 00:00:00
abstract::Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondia...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/db11-1478
更新日期:2012-11-01 00:00:00
abstract::Glucose, insulin secretion, and insulin secretory pulses were measured by deconvolution of peripheral C-peptide concentrations in 10 IDDM recipients of a combined kidney-pancreas allograft 6 mo post-transplantation and were compared with 10 matched nondiabetic control subjects. Seven of the 10 recipients were restudie...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.10.1346
更新日期:1992-10-01 00:00:00
abstract::The transcription factor regulatory factor X (RFX)-3 regulates the expression of genes required for the growth and function of cilia. We show here that mouse RFX3 is expressed in developing and mature pancreatic endocrine cells during embryogenesis and in adults. RFX3 expression already is evident in early Ngn3-positi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1187
更新日期:2007-04-01 00:00:00
abstract::The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition o...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.2.164
更新日期:1984-02-01 00:00:00
abstract::Islet transplantation is a promising treatment for type 1 diabetes. However, islet grafts are submitted to multiple injuries, including immunosuppressive drug toxicity, hyperglycemia, hypoxia, unspecific inflammatory reactions, as well as allo- and autoimmune destruction. Therapeutic approaches to these damage mechani...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.3.557
更新日期:2002-03-01 00:00:00
abstract::We recently showed that a peptide of the M(r) 60,000 heat shock protein molecule, designated peptide p277, is a target of T-cells in autoimmune diabetes in NOD mice. Indeed, the p277 peptide could be used as a therapeutic agent to arrest the autoimmune process even after it was far advanced. The present study was done...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.9.1132
更新日期:1995-09-01 00:00:00
abstract::There is controversy over the extent to which fatty acids (FAs) derived from plasma free FAs (FFAs) or from hydrolysis of plasma triglycerides (TGFAs) form communal or separate pools and what the contribution of each FA source is to cellular FA metabolism. Chylomicrons and lipid emulsions were labeled with [(3)H]triol...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.3.614
更新日期:2003-03-01 00:00:00
abstract::We previously showed that pancreatic beta-cells express a neuronal isoform of nitric oxide synthase (nNOS) that controls insulin secretion by exerting two enzymatic activities: nitric oxide (NO) production and cytochrome c reductase activity. We now bring evidence that two inhibitors of nNOS, N-omega-nitro-l-arginine ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.6.1467
更新日期:2004-06-01 00:00:00
abstract::The interaction between insulin and its receptor was investigated using both monoclonal and polyclonal anti-insulin antibodies. After covalent cross-linking of 125I-insulin to the insulin receptor on cultured human lymphocytes (IM-9 cells) using disuccinimidyl suberate, we inquired whether the insulin-receptor complex...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.8.778
更新日期:1984-08-01 00:00:00
abstract::To characterize the differentiation events that selectively target insulin-producing cells to interleukin (IL)-1beta-induced apoptosis, we studied IL-1beta signaling via mitogen-activated protein kinase (MAPK) and stress-activated protein kinase in 2 pancreatic endocrine cell lines. We studied the glucagon-secreting A...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.9.1468
更新日期:2000-09-01 00:00:00
abstract::A polymorphic region 5' to the human insulin gene has been associated with diabetes in earlier studies. This polymorphic region is composed of tandem repeats that fall into 3 general size classes, designated class 1 (600 base pairs), class 2 (1300 base pairs), and class 3 (2500 base pairs). Frequencies of these classe...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.5.433
更新日期:1985-05-01 00:00:00
abstract::Skeletal muscle (SKM) insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Because G-protein-coupled receptors (GPCRs) represent excellent drug targets, we hypothesized that activation of specific functional classes of SKM GPCRs might lead to improved glucose homeostasis in type 2 diabetes. ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0796
更新日期:2019-06-01 00:00:00