Concanavalin A and alloxan interactions on glucose-induced insulin secretion and biosynthesis from islets of Langerhans.

Abstract:

:The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition of glucose-induced insulin biosynthesis in islets exposed to alloxan. The protective action of Con A on alloxan toxicity is likely to be at the beta-cell surface at a membrane recognition site for glucose as a stimulus for secretion. The insulin biosynthetic effect of glucose appears to be mediated through a separate mechanism.

journal_name

Diabetes

journal_title

Diabetes

authors

Virji MA,Steffes MW,Estensen RD

doi

10.2337/diab.33.2.164

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

164-9

issue

2

eissn

0012-1797

issn

1939-327X

journal_volume

33

pub_type

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