Abstract:
:A group of insulin-dependent diabetic patients was studied in order to determine the possible short-term regulatory effect of insulin and that of an antilipolytic drug on serum triglycerides. Subcutaneous crystalline insulin (one third of the usual morning dose of intermediate long-acting insulin, NPH) and an oral dose of 5(3-piridyl) tetrazole, 800 mg., were administered. During the three-hour period of the study, the amount of both substances was sufficient to suppress free fatty acids and to produce a progressive lowering of serum triglycerides without significant changes in serum cholesterol. However, although the level of blood sugar was normalized with insulin, it did not change with the administration of 5(3-piridyl) tetrazole. The rate of fall of plasma free fatty acids and serum triglycerides was similar in both substances and positively correlated with its basal concentration.
journal_name
Diabetesjournal_title
Diabetesauthors
Alvarez-Reynolds M,Dominguez JMdoi
10.2337/diab.26.7.615subject
Has Abstractpub_date
1977-07-01 00:00:00pages
615-8issue
7eissn
0012-1797issn
1939-327Xjournal_volume
26pub_type
杂志文章相关文献
DIABETES文献大全abstract::Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1342
更新日期:2018-08-01 00:00:00
abstract::Fibroblast growth factors (FGFs) and their receptors (FGFRs) are key signaling molecules for pancreas development. Although FGFR3 is a crucial developmental gene, acting as a negative regulator of bone formation, its participation remains unexplored in pancreatic organogenesis. We found that FGFR3 was expressed in the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db05-1073
更新日期:2007-01-01 00:00:00
abstract::WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/db14-0444
更新日期:2015-03-01 00:00:00
abstract::Oxidative stress may contribute to the pathogenesis of diabetic nephropathy. However, the detailed molecular mechanism remains uncertain. Here, we report oxidative mitochondrial DNA (mtDNA) damage and accumulation of mtDNA with a 4,834-bp deletion in kidney of streptozotocin-induced diabetic rats. At 8 weeks after the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.5.1588
更新日期:2002-05-01 00:00:00
abstract::Increased glomerular filtration rate and kidney size early in the course of experimental and human diabetes may be important in the pathogenesis of diabetic nephropathy. Factors causing these renal functional changes are unknown. The isolated, perfused rat kidney (IPRK) was used to study the effects of elevated glucos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.4.360
更新日期:1985-04-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia both impair insulin sensitivity in vivo. This may be secondary to stimulation of adipose tissue lipolysis and consequent increased circulating free fatty acids (FFAs). Here we report that neither TNF-alpha nor glucose alone has a pronounced effect on lipolysis ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.1.74
更新日期:2004-01-01 00:00:00
abstract::The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.6.745
更新日期:1988-06-01 00:00:00
abstract::A 21-year-old female patient complaining of frequent hypoglycemic attacks in the presence of a large amount of circulating insulin-binding antibodies without previous known immunization is described. In order to clarify the possible mechanism of the hypoglycemic attacks occurring in this new syndrome, changes in plasm...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.5.500
更新日期:1977-05-01 00:00:00
abstract::Spleen cells from conventional BALB/c or athymic mice with streptozotocin (SZ)-induced hyperglycemia failed to raise blood sugar levels when injected into athymic or thymus-sufficient recipients. Passive transfer efforts were unsuccessful despite variations in donor-recipient pairs with respect to age, thymic function...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.2.146
更新日期:1980-02-01 00:00:00
abstract::Representative longitudinal muscle strips (6 x 10 mm) from distal small intestine were obtained from rats after 1, 2, and 3 mo of streptozocin-induced diabetes. The strips were stretched to their optimum lengths and subjected to electrical field stimulation (1-ms pulse duration, 30-270 mA, 10 Hz) in the presence of Kr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.8.891
更新日期:1990-08-01 00:00:00
abstract::Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail. This study is a longitudinal study in 60 children (33 male and 27 female subjects; 32 Caucasian and 28 African-American) examined at Tanner s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.11.2444
更新日期:2001-11-01 00:00:00
abstract::As part of an ongoing search for susceptibility genes in obese families, we performed linkage analyses in 101 French families between qualitative and quantitative traits related to morbid obesity and polymorphisms located in or near 15 candidate genes whose products are involved in body weight regulation. These includ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.2.398
更新日期:1999-02-01 00:00:00
abstract::The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.10.2034
更新日期:1999-10-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM), cardiovascular morbidity, and vital prognosis are linked to diabetic nephropathy, which is probably determined by renal hemodynamic abnormalities and by a genetic predisposition. Angiotensin I converting enzyme (ACE) regulates systemic and renal circulations through angioten...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.3.384
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:Bariatric surgery causes durable weight loss. Gut hormones are implicated in obesity pathogenesis, dietary failure, and mediating gastrointestinal bypass (GIBP) surgery weight loss. In mice, we determined the effects of diet-induced obesity (DIO), subsequent dieting, and GIBP surgery on ghrelin, peptide YY (P...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-0566
更新日期:2011-03-01 00:00:00
abstract::The kinin B1 receptor (B1R) plays a role in inflammatory and metabolic processes. B1R deletion (B1-/-) protects mice from diet-induced obesity and improves insulin and leptin sensitivity. In contrast, genetic reconstitution of B1R exclusively in adipose tissue reverses the lean phenotype of B1-/- mice. To study the ce...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1150
更新日期:2019-08-01 00:00:00
abstract::Adults with diabetes are 2-4 times more likely to suffer from heart disease or ischemic stroke than adults without diabetes, yet standard antiplatelet therapy, which is the cornerstone for primary and secondary prevention of cardiovascular disease, fails in many patients with diabetes. Three independent but often inte...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1098
更新日期:2017-01-01 00:00:00
abstract::To explore metabolic changes associated with the sorbitol accumulation and myo-inositol depletion observed in glomeruli of rats with experimental diabetes, we examined total and ouabain-inhibited adenosine triphosphatase (ATPase) activity in glomeruli isolated from control and streptozocin (STZ)-diabetic rats. Glomeru...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.11.1071
更新日期:1985-11-01 00:00:00
abstract::Earlier investigations have revealed that polyethylene glycol-B1-insulin (PEG insulin) causes lower utilization of glucose in fat cells than does the unaltered hormone, even though the blood glucose-lowering activity of both preparations in intact animals is identical. The present study was aimed to establish whether ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.10.953
更新日期:1983-10-01 00:00:00
abstract::GAD autoantibodies (GADAs) are sensitive markers of islet autoimmunity and type 1 diabetes. They form the basis of robust prediction models and are widely used for the recruitment of subjects at high risk of type 1 diabetes to prevention trials. However, GADAs are also found in many individuals at low risk of diabetes...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db14-1693
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:Adiponectin is an adipocyte-specific secretory protein found in circulation in several different forms and is present at significantly lower levels in the plasma of diabetic patients compared with that of insulin-sensitive individuals. We wanted to test whether insulin per se is a contributing factor toward l...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-0185
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men. RESEARCH DESIGN AND METHODS:Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospectiv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-0031
更新日期:2009-09-01 00:00:00
abstract::Complementary DNA encoding three catalytic subunits of protein phosphatase 1 (PP1 alpha, PP1 beta, and PP1 gamma) and the insulin-stimulated protein kinase 1 (ISPK-1) was analyzed for variations in the coding regions related to insulin-resistant glycogen synthesis in skeletal muscle of 30 patients with non-insulin-dep...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.44.1.90
更新日期:1995-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR)gamma is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARgamma display lipodystrophy and extreme insulin resistance. For this reason it was c...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0389
更新日期:2006-10-01 00:00:00
abstract::Insulin and exercise stimulate glucose uptake into skeletal muscle via different pathways. Both stimuli converge on the translocation of the glucose transporter GLUT4 from intracellular vesicles to the cell surface. Two Rab guanosine triphosphatases-activating proteins (GAPs) have been implicated in this process: AS16...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-1489
更新日期:2015-06-01 00:00:00
abstract::Obesity is a strong risk factor for the development of type 2 diabetes. We have previously reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is decreased. When made genetically obese, the BTBR mouse strain is diabetes susceptible and the C57BL/6J (B6) strain is diabetes resistan...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.3.688
更新日期:2003-03-01 00:00:00
abstract::Results from experimental and gene-association studies suggest that IGF-II may influence body weight regulation and that individuals with low IGF-II levels may be more susceptible to weight gain and obesity. We therefore assessed the association between circulating concentrations of IGF-II and subsequent weight gain a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.6.1403
更新日期:2003-06-01 00:00:00
abstract::A total of 32 pairs of obese fathers or mothers and their obese offsprings, aged 20 yr or younger, from 25 families with established hyperinsulinemic obesity aged 11-20 yr equally showed an insulin hyperresponse to glucose, the offspring 10 yr or younger revealed a rather normal insulin response, despite the presence ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.1.14
更新日期:1981-01-01 00:00:00
abstract::Diabetic nephropathy is one of the major microvascular complications in diabetes and is the leading cause of end-stage renal disease worldwide. Among various factors, angiogenesis-associated factors such as vascular endothelial growth factor (VEGF)-A and angiopoietin (Ang)-2 are involved in the development of diabetic...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.10.2891
更新日期:2005-10-01 00:00:00
abstract::Three forms of disulfide-linked insulin receptor complexes are labeled by covalent cross-linking to receptor-bound 125I-insulin in native adipocyte or liver membranes. These receptors of Mr 350,000 Mr 320,000, and Mr 290,000 are composed of alpha (Mr 125,000), beta(Mr 90,000), and beta 1(Mr 49,000) subunits in stoichi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.11.945
更新日期:1980-11-01 00:00:00