Reduced glomerular sodium/potassium adenosine triphosphatase activity in acute streptozocin diabetes and its prevention by oral sorbinil.

abstract：OBJECTIVE:Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K ...

journal_title：Diabetes

authors： Zhou H,Zhang T,Bogdani M,Oseid E,Parazzoli S,Vantyghem MC,Harmon J,Slucca M,Robertson RP

更新日期：2008-06-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis). Recently, we reported that two distinct patterns of insulitis occur in patients with recent-onset ...

journal_title：Diabetes

authors： Leete P,Willcox A,Krogvold L,Dahl-Jørgensen K,Foulis AK,Richardson SJ,Morgan NG

更新日期：2016-05-01 00:00:00

abstract：:The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of r...

journal_title：Diabetes

authors： Miller LL

更新日期：1976-01-01 00:00:00

abstract：:Cultured bovine retinal capillary pericytes (BRP) were used to investigate the effect of an aldose reductase inhibitor, tolrestat, and an inhibitor of advanced glycation end products (AGE) formation, aminoguanidine, on glucose toxicity. Glucose at high concentration reduced the replicative activity of pericytes in a d...

journal_title：Diabetes

authors： Chibber R,Molinatti PA,Wong JS,Mirlees D,Kohner EM

更新日期：1994-06-01 00:00:00

abstract：:Total lymphoid irradiation (TLI) at doses of 2200 rads or greater prevented diabetes in susceptible BB/W rats. Two of 29 (7%) treated rats became diabetic compared with 23 of 39 (59%) controls (P less than 0.001). TLI did not, however, prevent insulitis or thyroiditis in nondiabetic rats, nor did it restore the depres...

journal_title：Diabetes

authors： Rossini AA,Slavin S,Woda BA,Geisberg M,Like AA,Mordes JP

更新日期：1984-06-01 00:00:00

abstract：:Canine pancreata obtained at total pancreatectomy were cannulated via the ducts and perfused with collagenase to prepare a tissue suspension that was isografted into the spleen (preparation congruent to 2 h, mean graft vol = 10 +/- 1 ml containing 24% of the B-cell mass/pancreas). In 13 dogs the tissue was implanted b...

journal_title：Diabetes

authors： Warnock GL,Rajotte RV,Procyshyn AW

更新日期：1983-05-01 00:00:00

abstract：:Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...

journal_title：Diabetes

authors： Araki Y,Solomon BA,Basile RM,Chick WL

更新日期：1985-09-01 00:00:00

abstract：:A simple, direct assay for T-lymphocyte reactivity to islet antigen(s) in human insulin-dependent diabetes mellitus (IDDM) should facilitate preclinical diagnosis and the evaluation of intervention therapy to avert autoimmune-mediated beta-cell destruction. In subjects with preclinical or clinical IDDM, we measured th...

journal_title：Diabetes

authors： Harrison LC,De Aizpurua H,Loudovaris T,Campbell IL,Cebon JS,Tait BD,Colman PG

更新日期：1991-09-01 00:00:00

abstract：:To investigate the effects of insulin on platelets in obesity and in non-insulin-dependent diabetes mellitus (NIDDM)--classic insulin-resistant states--we determined ADP-induced platelet aggregation and platelet cGMP (guanosine 3',5'-cyclic monophosphate) content in platelet-rich plasma obtained from nine obese subjec...

journal_title：Diabetes

authors： Trovati M,Mularoni EM,Burzacca S,Ponziani MC,Massucco P,Mattiello L,Piretto V,Cavalot F,Anfossi G

更新日期：1995-11-01 00:00:00

abstract：:The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...

journal_title：Diabetes

authors： Gambaro G,Baggio B,Cicerello E,Mastrosimone S,Marzaro G,Borsatti A,Crepaldi G

更新日期：1988-06-01 00:00:00

abstract：:We performed a variance components linkage analysis of renal function, measured as glomerular filtration rate (GFR), in 63 extended families with multiple members with type 2 diabetes. GFR was estimated from serum concentrations of cystatin C and creatinine in 406 diabetic and 428 nondiabetic relatives. Results for cy...

journal_title：Diabetes

authors： Placha G,Poznik GD,Dunn J,Smiles A,Krolewski B,Glew T,Puppala S,Schneider J,Rogus JJ,Rich SS,Duggirala R,Warram JH,Krolewski AS

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading f...

journal_title：Diabetes

authors： Tanaka J,Qiang L,Banks AS,Welch CL,Matsumoto M,Kitamura T,Ido-Kitamura Y,DePinho RA,Accili D

更新日期：2009-10-01 00:00:00

abstract：:On the basis of the positive outcome of animal experiments, several large placebo-controlled trials are underway and aiming for the first time at the prevention of an immune-mediated disease, type 1 diabetes. The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical effica...

journal_title：Diabetes

authors： Lampeter EF,Klinghammer A,Scherbaum WA,Heinze E,Haastert B,Giani G,Kolb H

更新日期：1998-06-01 00:00:00

abstract：:We used mouse genetics to model how polygenic thresholds for the transition from impaired glucose tolerance (IGT) to NIDDM are reached. NON/Lt and NZO/Hl are inbred mouse strains selected for IGT and polygenic obesity, respectively. Their F1 male progeny consistently developed NIDDM. Genetic analysis of F2 males from ...

journal_title：Diabetes

authors： Leiter EH,Reifsnyder PC,Flurkey K,Partke HJ,Junger E,Herberg L

更新日期：1998-08-01 00:00:00

abstract：:During the development to overt nephropathy, diabetic patients go through several characteristic stages of renal disease, moving from normo- to micro- to macroalbuminuria. Microalbuminuria is defined as a urinary albumin excretion between 20 and 200 microg/min; values <20 microg/min are designated as normoalbuminuria,...

journal_title：Diabetes

authors： Mogensen CE

更新日期：1997-09-01 00:00:00

abstract：:Prophylactic insulin can prevent diabetes in the BB rat. We evaluated its use to prevent adoptive transfer of diabetes by activated splenocytes. ConA-activated spleen cells from acutely diabetic BB rats were divided into two equal aliquots and injected intravenously in paired diabetes-prone BB rat littermates. At the ...

journal_title：Diabetes

authors： Bertrand S,De Paepe M,Vigeant C,Yale JF

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Emerging data demonstrate that maternal diabetes has long-term health consequences for offspring, including the development of hypertension. In adults, circulating endothelial progenitor cells (EPCs) participate in vascular repair, and EPC numbers and function inversely correlate with the risk of developing v...

journal_title：Diabetes

authors： Ingram DA,Lien IZ,Mead LE,Estes M,Prater DN,Derr-Yellin E,DiMeglio LA,Haneline LS

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects. A series of evidence supports a critical role of exogenous factors in the development of ty...

journal_title：Diabetes

authors： Knip M,Veijola R,Virtanen SM,Hyöty H,Vaarala O,Akerblom HK

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Anti-tissue transglutaminase (TG2) antibodies are the serological marker of celiac disease. Given the close association between celiac disease and type 1 diabetes, we investigated the production and deposition of anti-TG2 antibodies in the jejunal mucosa of type 1 diabetic children. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Maglio M,Florian F,Vecchiet M,Auricchio R,Paparo F,Spadaro R,Zanzi D,Rapacciuolo L,Franzese A,Sblattero D,Marzari R,Troncone R

更新日期：2009-07-01 00:00:00

abstract：:We examined the hypothesis that imprinted genes may affect the propensity to type 2 diabetes and obesity in Pima Indians. Multipoint variance component methods were used to assess linkage of BMI (kg/m(2)) and age-adjusted diabetes to loci derived from either father (LOD(FA)) or mother (LOD(MO)) in a genome-wide scan. ...

journal_title：Diabetes

authors： Lindsay RS,Kobes S,Knowler WC,Bennett PH,Hanson RL

更新日期：2001-12-01 00:00:00

abstract：:Although non-insulin-dependent diabetes mellitus (NIDDM) is associated with defects in insulin action, the molecular basis of this resistance is unknown. We studied fibroblasts from a markedly insulin-resistant patient with NIDDM but without acanthosis nigricans. Her fibroblasts were resistant to insulin when alpha-am...

journal_title：Diabetes

authors： Sbraccia P,Goodman PA,Maddux BA,Wong KY,Chen YD,Reaven GM,Goldfine ID

更新日期：1991-02-01 00:00:00

abstract：:The plasma concentration of 1,5-anhydro-D-glucitol (AG) was measured in 135 newly diagnosed patients who were referred for oral glucose tolerance tests. AG concentrations in the nondiabetic patients indicated that the mean value of normal AG concentration was 21.8 micrograms/ml (SD = 5.9 micrograms/ml, range 9.6-38.8 ...

journal_title：Diabetes

authors： Yamanouchi T,Akanuma H,Asano T,Konishi C,Akaoka I,Akanuma Y

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:The transition of an individual from normoglycemia to diabetes has generally been thought to involve either moderate or rapid changes in glucose over time, although few studies have analyzed these changes. We sought to determine whether a general pattern of glucose change exists in most individuals who become...

journal_title：Diabetes

authors： Mason CC,Hanson RL,Knowler WC

更新日期：2007-08-01 00:00:00

abstract：:To clarify the relationship between abnormality of sorbitol and/or myo-inositol metabolism caused by hyperglycemia and diabetic macroangiopathy, we investigated the effects of high glucose concentrations and epalrestat, an aldose reductase inhibitor, on the metabolism of sorbitol and myo-inositol in cultured rabbit ao...

journal_title：Diabetes

authors： Sakakibara F,Hotta N,Koh N,Sakamoto N

更新日期：1993-11-01 00:00:00

abstract：:The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine sentinel cells that maintain glucose homeostasis in many vertebrates including humans. The glucokinase-containing, insulin-produci...

journal_title：Diabetes

authors： Matschinsky FM,Magnuson MA,Zelent D,Jetton TL,Doliba N,Han Y,Taub R,Grimsby J

更新日期：2006-01-01 00:00:00

abstract：:Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transp...

journal_title：Diabetes

authors： Cabello-Kindelan C,Mackey S,Sands A,Rodriguez J,Vazquez C,Pugliese A,Bayer AL

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00

abstract：:The mechanisms of marked increase in plasma leptin soon after ventromedial hypothalamus (VMH) lesions were investigated. Although rats did not gain body weight or parametrial fat-pad mass 24 h after the operation, the acute VMH-lesioned rats exhibited substantial five- and fourfold increases in plasma leptin levels co...

journal_title：Diabetes

authors： Suga A,Hirano T,Kageyama H,Kashiba M,Oka J,Osaka T,Namba Y,Tsuji M,Miura M,Adachi M,Inoue S

更新日期：1999-10-01 00:00:00

abstract：:Large glucagon immunoreactive substances, extracted from the fetal bovine pancreas and separated by gel filtration in the presence of 6 M guanidinium-hydrochloride, were submitted to lectin-sepharose affinity column chromatograph. Gel-filtered peak I (approximately 45 K delta) and peak II (approximately 10 K delta) in...

journal_title：Diabetes

authors： Tung AK,Cockburn E,Siu KP

更新日期：1982-11-01 00:00:00