Abstract:
:Total lymphoid irradiation (TLI) at doses of 2200 rads or greater prevented diabetes in susceptible BB/W rats. Two of 29 (7%) treated rats became diabetic compared with 23 of 39 (59%) controls (P less than 0.001). TLI did not, however, prevent insulitis or thyroiditis in nondiabetic rats, nor did it restore the depressed concanavalin-A responsiveness of BB rat lymphocytes. T-lymphocyte subset proportions were the same in both groups. TLI was associated with significant radiation-related mortality, and nondiabetic TLI-treated rats weighed significantly less than controls. We conclude that TLI is effective in the prevention of BB rat diabetes. However, TLI fails to correct the subclinical immunologic abnormalities of the model and is associated with significant morbidity.
journal_name
Diabetesjournal_title
Diabetesauthors
Rossini AA,Slavin S,Woda BA,Geisberg M,Like AA,Mordes JPdoi
10.2337/diab.33.6.543subject
Has Abstractpub_date
1984-06-01 00:00:00pages
543-7issue
6eissn
0012-1797issn
1939-327Xjournal_volume
33pub_type
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