The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

abstract：:Obesity is increasing, yet despite the necessity of maintaining muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ± 1.1 kg · m(-2)) and 15 healthy-weight (BMI 23.4 ± 0.3 kg · m(-2)) older men (55-75 years old) participated in a s...

journal_title：Diabetes

authors： Murton AJ,Marimuthu K,Mallinson JE,Selby AL,Smith K,Rennie MJ,Greenhaff PL

更新日期：2015-09-01 00:00:00

abstract：:The flavonoid naringenin improves hyperlipidemia and hyperglycemia in streptozotocin-treated rats. In HepG2 human hepatoma cells, naringenin inhibits apolipoprotein B (apoB) secretion primarily by inhibiting microsomal triglyceride transfer protein and enhances LDL receptor (LDLr)-mediated apoB-containing lipoprotein ...

journal_title：Diabetes

authors： Borradaile NM,de Dreu LE,Huff MW

更新日期：2003-10-01 00:00:00

abstract：:The sustained expression of the MAFB transcription factor in human islet β-cells represents a distinct difference in mice. Moreover, mRNA expression of closely related and islet β-cell-enriched MAFA does not peak in humans until after 9 years of age. We show that the MAFA protein also is weakly produced within the juv...

journal_title：Diabetes

authors： Cyphert HA,Walker EM,Hang Y,Dhawan S,Haliyur R,Bonatakis L,Avrahami D,Brissova M,Kaestner KH,Bhushan A,Powers AC,Stein R

更新日期：2019-02-01 00:00:00

abstract：:The IGF system is increasingly implicated in the development of cardiovascular disease. The effects of circulating IGFs on the vasculature are largely modulated by IGFBPs, which control their access to cell-surface IGF receptors. IGFBP-1 has been proposed as the acute regulator of IGF bioavailability because of its me...

journal_title：Diabetes

authors： Heald AH,Siddals KW,Fraser W,Taylor W,Kaushal K,Morris J,Young RJ,White A,Gibson JM

更新日期：2002-08-01 00:00:00

abstract：:Prostaglandin E (PGE) infusion in normal man inhibits the acute insulin response to glucose. In order to determine whether endogenously released PGE might also inhibit insulin secretion, glucose-stimulated insulin responses were investigated in normal volunteers after furosemide (40 mg i.v.), a stimulator of endogenou...

journal_title：Diabetes

authors： Giugliano D,Torella R,Sgambato S,D'Onofrio F

更新日期：1979-09-01 00:00:00

abstract：:Neonatal morbidity was assessed in the offspring of 878 mothers with gestational diabetes mellitus (GDM), 132 mothers with pre-GDM, and 380 control subjects. Compared with the control group, the GDM group had a higher incidence of complications, including macrosomia, hypoglycemia, hyperbilirubinemia, hypocalcemia, pol...

journal_title：Diabetes

authors： Hod M,Merlob P,Friedman S,Schoenfeld A,Ovadia J

更新日期：1991-12-01 00:00:00

abstract：:Elevated urinary albumin excretion (UAE) is a predictor of the development of nephropathy and cardiovascular mortality. To study whether genetic factors may determine UAE, we examined familial aggregation of UAE in 96 large multigenerational pedigrees ascertained for type 2 diabetes. A total of 1,269 subjects had UAE ...

journal_title：Diabetes

authors： Fogarty DG,Hanna LS,Wantman M,Warram JH,Krolewski AS,Rich SS

更新日期：2000-06-01 00:00:00

abstract：:The possible contribution of HLA-DRB3, -DRB4, and -DRB5 alleles to type 1 diabetes risk and to insulin autoantibody (IAA), GAD65 (GAD autoantibody [GADA]), IA-2 antigen (IA-2A), or ZnT8 against either of the three amino acid variants R, W, or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical dia...

journal_title：Diabetes

authors： Zhao LP,Alshiekh S,Zhao M,Carlsson A,Larsson HE,Forsander G,Ivarsson SA,Ludvigsson J,Kockum I,Marcus C,Persson M,Samuelsson U,Örtqvist E,Pyo CW,Nelson WC,Geraghty DE,Lernmark Å,Better Diabetes Diagnosis (BDD) Study Grou

更新日期：2016-03-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotoci...

journal_title：Diabetes

authors： Kim YB,Kim WB,Jung WW,Jin X,Kim YS,Kim B,Han HC,Block GD,Colwell CS,Kim YI

更新日期：2018-03-01 00:00:00

abstract：:Livers from 9-10-wk-old genetically obese and hyperinsulinemic (fa/fa) rats contained more DNA, proteins, and lipids than livers of age-matched controls. Actually, the increase in liver mass of fa/fa rats was mainly due to an increased cell number. On perfusion with insulin (1.75-16 nM), livers of obese fa/fa rats rem...

journal_title：Diabetes

authors： Karakash C,Jeanrenaud B

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:Based on its role as an energy storage compartment and endocrine organ, white adipose tissue (WAT) fulfills a critical function in the maintenance of whole-body energy homeostasis. Indeed, WAT dysfunction is connected to obesity-related type 2 diabetes triggered at least partly by an inflammatory response in ...

journal_title：Diabetes

authors： Ostertag A,Jones A,Rose AJ,Liebert M,Kleinsorg S,Reimann A,Vegiopoulos A,Berriel Diaz M,Strzoda D,Yamamoto M,Satoh T,Akira S,Herzig S

更新日期：2010-08-01 00:00:00

abstract：:Mutations in several genes cause nonautoimmune diabetes, but numerous patients still have unclear genetic defects, hampering our understanding of the development of the disease and preventing pathogenesis-oriented treatment. We used whole-genome sequencing with linkage analysis to study a consanguineous family with ea...

journal_title：Diabetes

authors： Simaite D,Kofent J,Gong M,Rüschendorf F,Jia S,Arn P,Bentler K,Ellaway C,Kühnen P,Hoffmann GF,Blau N,Spagnoli FM,Hübner N,Raile K

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:The Diabetes Control and Complications Trial (Diabetes 44:968-983, 1995) presented statistical models suggesting that subjects with similar A1C levels had a higher risk of retinopathy progression in the conventional treatment group than in the intensive treatment group. That analysis has been cited to support...

journal_title：Diabetes

authors： Lachin JM,Genuth S,Nathan DM,Zinman B,Rutledge BN,DCCT\/EDIC Research Group.

更新日期：2008-04-01 00:00:00

abstract：:Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of proinflammatory cytokines. Whether obesity engages an adaptive mechanism...

journal_title：Diabetes

authors： Wang GX,Cho KW,Uhm M,Hu CR,Li S,Cozacov Z,Xu AE,Cheng JX,Saltiel AR,Lumeng CN,Lin JD

更新日期：2014-04-01 00:00:00

abstract：:To ascertain whether the dawn phenomenon occurs in nondiabetic individuals and, if so, whether it is due to an increase in glucose production or a decrease in glucose utilization, we determined plasma concentrations of glucose, insulin, C-peptide, and counterregulatory hormones, as well as rates of glucose production,...

journal_title：Diabetes

authors： Bolli GB,De Feo P,De Cosmo S,Perriello G,Ventura MM,Calcinaro F,Lolli C,Campbell P,Brunetti P,Gerich JE

更新日期：1984-12-01 00:00:00

abstract：:Recent studies have shown that two different voltage-dependent Ca2+ channels are expressed in pancreatic islets, the beta-cell/neuroendocrine-brain and the cardiac subtypes. The effects of chronic hyperglycemia on the levels in pancreatic islets of the mRNAs encoding the alpha 1-subunits of the beta-cell and cardiac s...

journal_title：Diabetes

authors： Iwashima Y,Pugh W,Depaoli AM,Takeda J,Seino S,Bell GI,Polonsky KS

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Leptin is an adipocyte hormone that plays a major role in energy balance. Leptin receptors in the hypothalamus are known to signal via distinct mechanisms, including signal transducer and activator of transcription-3 (STAT3) and phosphoinositol-3 kinase (PI 3-kinase). Here, we tested the hypothesis that extra...

journal_title：Diabetes

authors： Rahmouni K,Sigmund CD,Haynes WG,Mark AL

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of interleukin-1 receptor I (IL-1RI)-mediated signals to this phenotype has not been defined. We hypothesized that lack of IL-1RI may ameliorate HFD-induced IR by at...

journal_title：Diabetes

authors： McGillicuddy FC,Harford KA,Reynolds CM,Oliver E,Claessens M,Mills KH,Roche HM

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Insulin resistance in skeletal muscle is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (PCOS). However, the molecular mechanisms underlying skeletal muscle insulin resistance and the insulin-sensitizing effect of thiazolidinediones in PCOS in vivo are less well characterized....

journal_title：Diabetes

authors： Højlund K,Glintborg D,Andersen NR,Birk JB,Treebak JT,Frøsig C,Beck-Nielsen H,Wojtaszewski JF

更新日期：2008-02-01 00:00:00

abstract：:Nonhuman primates have been used for a variety of studies on diabetes mellitus. Spontaneous, natural forms of diabetes have been well documented in several species; there are limited data on numerous other species that indicate diabetes or a diabetes-like syndrome. The causes and manifestations of spontaneous diabetes...

journal_title：Diabetes

authors： Howard CF Jr

更新日期：1982-01-01 00:00:00

abstract：:Treatment of isolated, perifused rat islets with exogenous PLA2 in amounts ranging from 1 to 1000 mU/ml caused a dose-dependent increase in the rate of insulin secretion. This effect of PLA2 was rapid and seen in the absence of added exogenous fuel. It differed from glucose-induced insulin release in temporal pattern:...

journal_title：Diabetes

authors： Zawalich W,Zawalich K

更新日期：1985-05-01 00:00:00

abstract：:Accumulation of brown products in long-lived proteins might be an important factor in determining long-term diabetic complications. Fluorescent chromophore 2-(2-furoyl)-4-(5)-(2-furanyl)-1H-imidazole (FFI), isolated from hydrolyzed brown products synthesized in vitro, was proposed as a specific brown product responsib...

journal_title：Diabetes

authors： Lapolla A,Gerhardinger C,Pelli B,Sturaro A,Del Favero E,Traldi P,Crepaldi G,Fedele D

更新日期：1990-01-01 00:00:00

abstract：:The significance of the portohepatic glucosensors for counterregulation in deep hypoglycemia (i.e., glycemia < 2.8 mM) was studied in chronically cannulated male mongrel dogs in the conscious state. A total of 16 experiments were carried out on 6 dogs using the liver clamp technique under hyperinsulinemic conditions (...

journal_title：Diabetes

authors： Hamilton-Wessler M,Bergman RN,Halter JB,Watanabe RM,Donovan CM

更新日期：1994-08-01 00:00:00

abstract：:In the oral glucose tolerance test (OGTT), divergent doses of glucose remain in use by virtue of the prevailing conviction that the size of the loading dose hardly affects the outcome of the test. We compared the results of OGTTs with 100-gm. and 50-gm. loads in 85 patients, who were selected for slightly impaired glu...

journal_title：Diabetes

authors： de Nobel E,van't Laar A

更新日期：1978-01-01 00:00:00

abstract：:The preferential channeling of different fuels to fat and changes in the transcription profile of adipose tissue and skeletal muscle are poorly understood processes involved in the pathogenesis of obesity and insulin resistance. Carbohydrate and lipid metabolism may play relevant roles in this context. Freely moving l...

journal_title：Diabetes

authors： Fabris R,Nisoli E,Lombardi AM,Tonello C,Serra R,Granzotto M,Cusin I,Rohner-Jeanrenaud F,Federspil G,Carruba MO,Vettor R

更新日期：2001-03-01 00:00:00

abstract：:Caloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We evaluated the effect of 16 weeks of CR on whole-body insulin sensitivity by pancreatic clamp before and after CR in 11 ob...

journal_title：Diabetes

authors： Johnson ML,Distelmaier K,Lanza IR,Irving BA,Robinson MM,Konopka AR,Shulman GI,Nair KS

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...

journal_title：Diabetes

authors： Ko HJ,Zhang Z,Jung DY,Jun JY,Ma Z,Jones KE,Chan SY,Kim JK

更新日期：2009-11-01 00:00:00

abstract：:We conducted a prospective study to describe the course of the pancreatic beta-cell function from the time of clinical diagnosis of insulin-dependent (type I) diabetes to determine whether DR type, presence of islet cell antibodies (ICA), presence of insulin antibodies (IA), age at onset, and sex could help in the pre...

journal_title：Diabetes

authors： Schiffrin A,Suissa S,Poussier P,Guttmann R,Weitzner G

更新日期：1988-07-01 00:00:00

abstract：:Type 1 diabetes appears to progress not as an uncontrolled autoimmune attack on the pancreatic islet beta-cells, but rather in a highly regulated manner. Leukocytic infiltration of the pancreatic islets by autoimmune cells, or insulitis, can persist for long periods of time before the terminal destruction of beta-cell...

journal_title：Diabetes

authors： Matos M,Park R,Mathis D,Benoist C

更新日期：2004-09-01 00:00:00

abstract：:It is often stated that type 1 diabetes results from a complex interplay between varying degrees of genetic susceptibility and environmental factors. While agreeing with this principal, our desire is that this Perspectives article will highlight another complex interplay potentially associated with this disease involv...

journal_title：Diabetes

authors： Vaarala O,Atkinson MA,Neu J

更新日期：2008-10-01 00:00:00