The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs.

abstract：:We have recently shown that leptin, the product of the obese gene, can directly influence T-cell function. In the work presented here, we explored the role of leptin in the development of spontaneous autoimmunity in the nonobese diabetic (NOD) mouse, an animal model for the study of human insulin-dependent diabetes me...

journal_title：Diabetes

authors： Matarese G,Sanna V,Lechler RI,Sarvetnick N,Fontana S,Zappacosta S,La Cava A

更新日期：2002-05-01 00:00:00

abstract：:Type 1 diabetes results from the destruction of β-cells by an autoimmune T-cell response assisted by antigen-presenting B cells producing autoantibodies. CD8(+) T-cell responses against islet cell antigens, thought to play a central role in diabetes pathogenesis, can be monitored using enzyme-linked immunosorbent spot...

journal_title：Diabetes

authors： Énée É,Kratzer R,Arnoux JB,Barilleau E,Hamel Y,Marchi C,Beltrand J,Michaud B,Chatenoud L,Robert JJ,van Endert P

更新日期：2012-07-01 00:00:00

abstract：:Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, ...

journal_title：Diabetes

authors： Bamberg F,Hetterich H,Rospleszcz S,Lorbeer R,Auweter SD,Schlett CL,Schafnitzel A,Bayerl C,Schindler A,Saam T,Müller-Peltzer K,Sommer W,Zitzelsberger T,Machann J,Ingrisch M,Selder S,Rathmann W,Heier M,Linkohr B,Meisi

更新日期：2017-01-01 00:00:00

abstract：:Mice respond to fatty acid synthase (FAS) inhibitors by profoundly reducing their food intake and body weight. Evidence indicates that the central nervous system (CNS) may be the critical site of action; however, a peripheral contribution cannot be ruled out. We compared doses of the FAS inhibitor C75 in the CNS (thir...

journal_title：Diabetes

authors： Clegg DJ,Wortman MD,Benoit SC,McOsker CC,Seeley RJ

更新日期：2002-11-01 00:00:00

abstract：:The beta-3 adrenergic receptor (ADRB3) has been implicated as a regulator of energy expenditure, and a polymorphism in codon 64 of this gene (Trp64Arg) has been associated in some studies with obesity and insulin resistance. However, many studies have failed to detect an effect of this variant, and the importance of t...

journal_title：Diabetes

authors： Mitchell BD,Cole SA,Comuzzie AG,Almasy L,Blangero J,MacCluer JW,Hixson JE

更新日期：1999-09-01 00:00:00

abstract：:The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways....

journal_title：Diabetes

authors： Cohen P,Spiegelman BM

更新日期：2015-07-01 00:00:00

abstract：:Increased susceptibility of LDL to oxidation has been shown to be associated with the presence of coronary heart disease and may account for the accelerated vascular disease seen in diabetes. The response of LDL to in vitro oxidative stress has been proposed as a measure of the predisposition of LDL to the in vivo sub...

journal_title：Diabetes

authors： Jenkins AJ,Klein RL,Chassereau CN,Hermayer KL,Lopes-Virella MF

更新日期：1996-06-01 00:00:00

abstract：:Platelet aggregation and related plasma factors have been studied in experimentally diabetic dogs, experimentally galactosemic dogs, and in normal dogs. Platelet aggregation, when induced in vitro by ADP (up to 22 microM) or collagen (up to 4 micrograms/ml), was not significantly different from normal in the diabetic ...

journal_title：Diabetes

authors： Kern TS,Engerman RL

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this work was to determine the pattern of genes regulated by peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1 alpha (PGC-1 alpha) in human adipocytes and the involvement of PPARalpha and PPARgamma in PGC-1 alpha transcriptional action. RESEARCH DESIGN AND METHODS:Primary c...

journal_title：Diabetes

authors： Mazzucotelli A,Viguerie N,Tiraby C,Annicotte JS,Mairal A,Klimcakova E,Lepin E,Delmar P,Dejean S,Tavernier G,Lefort C,Hidalgo J,Pineau T,Fajas L,Clément K,Langin D

更新日期：2007-10-01 00:00:00

abstract：:The endocrine and exocrine pancreas have been studied separately by endocrinologists and gastroenterologists as two organ systems. The pancreatic islet, consisting of 1-2% mass of the whole pancreas, has long been believed to be regulated independently from the surrounding exocrine tissues. Particularly, islet blood f...

journal_title：Diabetes

authors： Dybala MP,Gebien LR,Reyna ME,Yu Y,Hara M

更新日期：2020-12-01 00:00:00

abstract：:It has been suggested that the metabolic syndrome and type 2 diabetes are manifestations of the inflammatory host response. This host response is orchestrated by the production of pro- and anti-inflammatory cytokines that are under genetic control. We therefore hypothesized that a low production capacity of interleuki...

journal_title：Diabetes

authors： van Exel E,Gussekloo J,de Craen AJ,Frölich M,Bootsma-Van Der Wiel A,Westendorp RG,Leiden 85 Plus Study.

更新日期：2002-04-01 00:00:00

abstract：:Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...

journal_title：Diabetes

authors： Thirone AC,Scarlett JA,Gasparetti AL,Araujo EP,Lima MH,Carvalho CR,Velloso LA,Saad MJ

更新日期：2002-07-01 00:00:00

abstract：:Brown adipose tissue oxidizes chemical energy for heat generation and energy expenditure. Promoting brown-like transformation in white adipose tissue (WAT) is a promising strategy for combating obesity. Here, we find that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regu...

journal_title：Diabetes

authors： Chou CF,Lin YY,Wang HK,Zhu X,Giovarelli M,Briata P,Gherzi R,Garvey WT,Chen CY

更新日期：2014-09-01 00:00:00

abstract：:Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific subpopulations with d...

journal_title：Diabetes

authors： Benninger RKP,Hodson DJ

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown. RESEARCH DESIGN AND METHOD...

journal_title：Diabetes

authors： Martinuzzi E,Novelli G,Scotto M,Blancou P,Bach JM,Chaillous L,Bruno G,Chatenoud L,van Endert P,Mallone R

更新日期：2008-05-01 00:00:00

abstract：:Chromogranin A (ChgA) has been identified as the antigen target for three NOD-derived, diabetogenic CD4 T-cell clones, including the well-known BDC-2.5. These T-cell clones respond weakly to the peptide WE14, a naturally occurring proteolytic cleavage product from ChgA. We show here that WE14 can be converted into a h...

journal_title：Diabetes

authors： Delong T,Baker RL,He J,Barbour G,Bradley B,Haskins K

更新日期：2012-12-01 00:00:00

abstract：:Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

journal_title：Diabetes

authors： Mitchell KJ,Tsuboi T,Rutter GA

更新日期：2004-02-01 00:00:00

abstract：:To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and a...

journal_title：Diabetes

authors： Brown CD,Zhao ZH,De Alvaro F,Chan S,Friedman EA

更新日期：1993-04-01 00:00:00

abstract：:The past several years have seen an explosive increase in our understanding of the transcriptional basis of adipose cell differentiation. In particular, a key role has been illustrated for PPAR-gamma, a member of the nuclear hormone receptor superfamily. PPAR-gamma has also been recently identified as the major functi...

journal_title：Diabetes

authors： Spiegelman BM

更新日期：1998-04-01 00:00:00

abstract：:Alterations in renal function and structure are found even at the onset of diabetes mellitus. Studies performed over the last decade now allow definition of a series of stages in the development of renal changes in diabetes. Such a classification may be useful both in clinical work and in research activities. Stage 1 ...

journal_title：Diabetes

authors： Mogensen CE,Christensen CK,Vittinghus E

更新日期：1983-05-01 00:00:00

abstract：:A monoclonal islet cell antibody, HISL-19, reactive with human, bovine, and porcine pancreatic islets has been used to identify and characterize a novel group of islet cell proteins (p120, p69, p67, and p56). Besides the islets, HISL-19-reactive antigenic determinants are also expressed on selected cell types, namely,...

journal_title：Diabetes

authors： Srikanta S,Krisch K,Eisenbarth GS

更新日期：1986-03-01 00:00:00

abstract：:Three hundred and seventy-seven children and adolescents aged 5-17 yr from the biracial (black-white) community of Bogalusa, Louisiana, were evaluated for Tanner stage of sexual development, plasma glucose, and insulin levels during an oral glucose tolerance test. Children of the two races were of similar age, weight,...

journal_title：Diabetes

authors： Svec F,Nastasi K,Hilton C,Bao W,Srinivasan SR,Berenson GS

更新日期：1992-03-01 00:00:00

abstract：:Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPR(dn)) reveal progressive deterioration of glu...

journal_title：Diabetes

authors： Renner S,Römisch-Margl W,Prehn C,Krebs S,Adamski J,Göke B,Blum H,Suhre K,Roscher AA,Wolf E

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Recent studies in humans and animal models of obesity have shown increased adipose tissue activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which amplifies local tissue glucocorticoid concentrations. The reasons for this 11beta-HSD1 dysregulation are unknown. Here, we tested whether 11beta...

journal_title：Diabetes

authors： Nyirenda MJ,Carter R,Tang JI,de Vries A,Schlumbohm C,Hillier SG,Streit F,Oellerich M,Armstrong VW,Fuchs E,Seckl JR

更新日期：2009-12-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that plasma leptin concentrations contributed to the pathophysiology of NIDDM by decreasing both insulin-mediated glucose disposal and glucose-stimulated insulin secretion. The study was performed in 60 women with normal oral glucose tolerance. Differences in insulin-me...

journal_title：Diabetes

authors： Carantoni M,Abbasi F,Azhar S,Chen YD,Klebanov M,Wang PW,Warmerdam F,Reaven GM

更新日期：1998-02-01 00:00:00

abstract：:In vivo voltammetry was used to measure the synaptic release of rat striatal dopamine and serotonin after the administration of the amino acid L-tryptophan to streptozocin-induced diabetic rats. Dopamine and serotonin release from rat striatum was studied at a short-term or acute (3-day) interval and a long-term or ch...

journal_title：Diabetes

authors： Broderick PA,Jacoby JH

更新日期：1988-07-01 00:00:00

abstract：:The hexokinases, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in movement of glucose into cells through the facilitative glucose transporters. GLUT4 and hexokinase (HK) II are the major transporter and hexokinase isoforms in skeletal muscle, heart, and adipose tissue, ...

journal_title：Diabetes

authors： Osawa H,Printz RL,Whitesell RR,Granner DK

更新日期：1995-12-01 00:00:00

abstract：:There is an unexplained excess of type 1 diabetes and other organ-specific autoimmune diseases in children with Down's syndrome, but the immunogenetic characteristics of diabetes in Down's syndrome have not been investigated. We studied the frequency of islet autoantibodies in 106 children with Down's syndrome and no ...

journal_title：Diabetes

authors： Gillespie KM,Dix RJ,Williams AJ,Newton R,Robinson ZF,Bingley PJ,Gale EA,Shield JP

更新日期：2006-11-01 00:00:00

abstract：:It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the plasma membrane of adipocytes and skeletal muscle. Here, we explore whe...

journal_title：Diabetes

authors： Turban S,Beardmore VA,Carr JM,Sakamoto K,Hajduch E,Arthur JS,Hundal HS

更新日期：2005-11-01 00:00:00

abstract：:The introduction of 13C magnetic resonance spectroscopy (MRS) has enabled noninvasive measurement of muscle glycogen synthesis in humans. Conclusions based on measurements by the MRS technique assume that glucose metabolism in gastrocnemius muscle is representative for all skeletal muscles and thus can be extrapolated...

journal_title：Diabetes

authors： Serlie MJ,de Haan JH,Tack CJ,Verberne HJ,Ackermans MT,Heerschap A,Sauerwein HP

更新日期：2005-05-01 00:00:00