Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians.

abstract：OBJECTIVE:Insulin resistance in skeletal muscle is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (PCOS). However, the molecular mechanisms underlying skeletal muscle insulin resistance and the insulin-sensitizing effect of thiazolidinediones in PCOS in vivo are less well characterized....

journal_title：Diabetes

authors： Højlund K,Glintborg D,Andersen NR,Birk JB,Treebak JT,Frøsig C,Beck-Nielsen H,Wojtaszewski JF

更新日期：2008-02-01 00:00:00

abstract：:Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress. The oxidative stress attacks DNA, lipids, and proteins and is also tho...

journal_title：Diabetes

authors： Taniguchi N,Kaneto H,Asahi M,Takahashi M,Wenyi C,Higashiyama S,Fujii J,Suzuki K,Kayanoki Y

更新日期：1996-07-01 00:00:00

abstract：:To test whether treatment with aminoguanidine, a drug known to prevent cross-linking between glycated proteins, is effective in improving reduced erythrocyte deformability in diabetes, we studied a group (n = 6) of ALX-induced long-term (12.7 +/- 2.2 mo of hyperglycemia) diabetic New Zealand white rabbits before and a...

journal_title：Diabetes

authors： Brown CD,Zhao ZH,De Alvaro F,Chan S,Friedman EA

更新日期：1993-04-01 00:00:00

abstract：:Insulin resistance is a recently identified mechanism involved in the pathophysiology of chronic heart failure (CHF). We investigated the effects of two insulin-sensitizing drugs (metformin and rosiglitazone) in a genetic model of spontaneously hypertensive, insulin-resistant rats (SHHF). Thirty SHHF rats were randomi...

journal_title：Diabetes

authors： Cittadini A,Napoli R,Monti MG,Rea D,Longobardi S,Netti PA,Walser M,Samà M,Aimaretti G,Isgaard J,Saccà L

更新日期：2012-04-01 00:00:00

abstract：:Continuous subcutaneous insulin infusion (CSII) was combined with antirejection therapy in four diabetic recipients of pancreas and kidney grafts with persisting hyperglycemia due to pancreas rejection. In three of the patients, full function of the pancreas was restored after as many as 40, 86, and 139 days of CSII. ...

journal_title：Diabetes

authors： Bartos V,Vanĕk I,Dryáková M,Saudek F,Malý J

更新日期：1989-01-01 00:00:00

abstract：:Numerous reports have confirmed the presence of islet cell antibodies in diabetic patients. These are found mostly in newly diagnosed insulin-dependent diabetic patients and in patients who have autoimmune polyendocrine disorders. Antibodies to beta cells, somatostatin, and glucagon-producing cells have been described...

journal_title：Diabetes

authors： Kaldany A

更新日期：1979-02-01 00:00:00

abstract：:Because it is unknown whether 24-h energy expenditure (EE) responses to dietary extremes will identify phenotypes associated with weight regulation, the aim of this study was to determine whether such responses to fasting or overfeeding are associated with future weight change. The 24-h EE during energy balance, fasti...

journal_title：Diabetes

authors： Schlögl M,Piaggi P,Pannacciuli N,Bonfiglio SM,Krakoff J,Thearle MS

更新日期：2015-11-01 00:00:00

abstract：:Obesity is a common problem in Western society and is associated with significant morbidity and mortality. Energy homeostasis is regulated by a complex system involving both peripheral signals such as leptin and a number of orexigenic and anorectic neuropeptides. Obesity can result from dysregulation of the peripheral...

journal_title：Diabetes

authors： Bradley RL,Kokkotou EG,Maratos-Flier E,Cheatham B

更新日期：2000-07-01 00:00:00

abstract：:In the transgenic mouse, a specific gene can be transduced or deleted to study its function and relation to human diseases. Recently, various lines of transgenic mice that overexpress or lack a specific gene have been established and are available to study the pathophysiology of human diseases, including atheroscleros...

journal_title：Diabetes

authors： Harada K,Shimano H,Ishibashi S,Yamada N

更新日期：1996-07-01 00:00:00

abstract：:Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail. This study is a longitudinal study in 60 children (33 male and 27 female subjects; 32 Caucasian and 28 African-American) examined at Tanner s...

journal_title：Diabetes

authors： Goran MI,Gower BA

更新日期：2001-11-01 00:00:00

abstract：:To investigate the early events in insulin signal transmission in liver, isolated rat hepatocytes were labeled with 32P, and proteins phosphorylated in response to insulin were detected by immunoprecipitation with anti-phosphotyrosine and anti-receptor antibodies and analyzed by sodium dodecyl sulfate (SDS)-polyacryla...

journal_title：Diabetes

authors： Okamoto M,Karasik A,White MF,Kahn CR

更新日期：1991-01-01 00:00:00

abstract：:A chronic diabetic state was produced in Macaca fuscatus , and these diabetic monkeys were kept without insulin treatment for up to 25 mo. The metabolic derangements were characterized by hyperglycemia, insulinopenia, hyperglucagonemia, ketonemia, and hyperlipidemia. Significant thickening of the capillary basement me...

journal_title：Diabetes

authors： Yasuda H,Harano Y,Kosugi K,Nakano T,Suzuki M,Tsuruoka Y,Taniguchi Y,Nishimori T,Kikkawa R,Shigeta Y

更新日期：1984-05-01 00:00:00

abstract：:Neonatal rats injected with streptozocin (STZ, 100 mg/kg) at birth exhibited an acute diabetes followed by a spontaneous remission. We have previously shown that this recovery from neonatal diabetes is due to B-cell regeneration and reaccumulation of pancreatic insulin stores starting from 3 to 5 days after birth. The...

journal_title：Diabetes

authors： Portha B,Kergoat M

更新日期：1985-06-01 00:00:00

abstract：:O-linked N-acetylglucosamine transferase (OGT) catalyzes the attachment ofN-acetylglucosamine (GlcNAc) monosaccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway. Glucose-induced insulin resistance is mediated by increased ac...

journal_title：Diabetes

authors： Akimoto Y,Kreppel LK,Hirano H,Hart GW

更新日期：1999-12-01 00:00:00

abstract：:Adult, male ICR Swiss mice are susceptible to the diabetogenic effects of the D-variant of encephalomyocarditis virus (EMC-D) in contrast to adult C3H/HeJ male mice, which are relatively resistant. To date, experimental evidence suggests that the immune system plays a role in the pathogenesis of this infection. We hav...

journal_title：Diabetes

authors： Gould CL,McMannama KG,Bigley NJ,Giron DJ

更新日期：1985-12-01 00:00:00

abstract：:Signaling pathways activated by leptin in metabolically important organs have largely been studied only in animal and/or cell culture studies. In this study, we examined whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and whether the response would be different in lean and...

journal_title：Diabetes

authors： Moon HS,Huh JY,Dincer F,Schneider BE,Hasselgren PO,Mantzoros CS

更新日期：2015-03-01 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is an α-arrestin that can bind to and inhibit the antioxidant protein thioredoxin (TXN). TXNIP expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. TXNIP is currently studied as a pote...

journal_title：Diabetes

authors： Katsu-Jiménez Y,Vázquez-Calvo C,Maffezzini C,Halldin M,Peng X,Freyer C,Wredenberg A,Giménez-Cassina A,Wedell A,Arnér ESJ

更新日期：2019-04-01 00:00:00

abstract：:Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The antidiabetic thiazolidinediones shift the energy balance toward storage, leading to an increase in whole-body adiposity. These studies examine the effects of pioglitazone (Pio) on adipose tissue phy...

journal_title：Diabetes

authors： de Souza CJ,Eckhardt M,Gagen K,Dong M,Chen W,Laurent D,Burkey BF

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:Short sleep duration is associated with impaired glucose tolerance and an increased risk of diabetes. The effects of sleep restriction on insulin sensitivity have not been established. This study tests the hypothesis that decreasing nighttime sleep duration reduces insulin sensitivity and assesses the effects...

journal_title：Diabetes

authors： Buxton OM,Pavlova M,Reid EW,Wang W,Simonson DC,Adler GK

更新日期：2010-09-01 00:00:00

abstract：:Agonist-induced activation of peroxisome proliferator-activated receptor-γ (PPARγ) stimulates adipocyte differentiation and insulin sensitivity. Patients with heterozygous PPARγ dominant-negative mutation develop partial lipodystrophy and insulin resistance. Inconsistent with this evidence in humans, it was reported t...

journal_title：Diabetes

authors： Gumbilai V,Ebihara K,Aizawa-Abe M,Ebihara C,Zhao M,Yamamoto Y,Mashimo T,Hosoda K,Serikawa T,Nakao K

更新日期：2016-10-01 00:00:00

abstract：:The acquisition of T-cell tolerance in the thymus is limited to those antigens expressed in the thymus at the time of T-cell development. Normally, islet antigens that are involved in insulin-dependent diabetes mellitus (IDDM) are not present in the thymus, but we have previously shown that transplantation of islets e...

journal_title：Diabetes

authors： Baumann EE,Buckingham F,Herold KC

更新日期：1995-08-01 00:00:00

abstract：:A significant increase in CO2 production, reflecting carbohydrate oxidation and/or fat synthesis, is observed in normal subjects after the ingestion of glucose. The anatomic site(s) of this CO2 production has not yet been localized, although liver and muscle are logical considerations. To assess the contribution of sk...

journal_title：Diabetes

authors： Meistas MT,Vlachokosta FV,Gleason RE,Arcangeli M,Aoki TT

更新日期：1985-10-01 00:00:00

abstract：:RT6 is a glycosyl-phosphatidylinositol-linked surface molecule present on most mature rat T-cells. RT6+ T-cells can prevent the expression of autoimmune diabetes in the BB rat, but the mechanism is unknown. Because cross-linking of other glycosyl-phosphatidylinositol-linked T-cell proteins is known to activate T-cells...

journal_title：Diabetes

authors： Rigby MR,Bortell R,Greiner DL,Czech MP,Klarlund JK,Mordes JP,Rossini AA

更新日期：1996-10-01 00:00:00

abstract：:Depletion of cellular antioxidant defense mechanisms and the generation of oxygen free radicals by advanced glycation end products (AGEs) have been proposed to play a major role in the pathogenesis of diabetic vascular complications. Here we demonstrate that incubation of cultured bovine aortic endothelial cells (BAEC...

journal_title：Diabetes

authors： Bierhaus A,Chevion S,Chevion M,Hofmann M,Quehenberger P,Illmer T,Luther T,Berentshtein E,Tritschler H,Müller M,Wahl P,Ziegler R,Nawroth PP

更新日期：1997-09-01 00:00:00

abstract：:The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical a...

journal_title：Diabetes

authors： Vastani N,Guenther F,Gentry C,Austin AL,King AJ,Bevan S,Andersson DA

更新日期：2018-08-01 00:00:00

abstract：:Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Whether hyperglycemia evolves from normoglycemia gradually over time or as a step increase is not known. We measured plasma glucose and insulin levels during oral glucose testing in 35- to 64-year-old men and nonpregnant women from a p...

journal_title：Diabetes

authors： Ferrannini E,Nannipieri M,Williams K,Gonzales C,Haffner SM,Stern MP

更新日期：2004-01-01 00:00:00

abstract：:Diabetes is characterized by altered metabolism of key molecules and regulatory pathways. The phenotypic expression of diabetes and associated complications encompasses complex interactions between genetic, environmental, and tissue-specific factors that require an integrated understanding of perturbations in the netw...

journal_title：Diabetes

authors： Sas KM,Karnovsky A,Michailidis G,Pennathur S

更新日期：2015-03-01 00:00:00

abstract：:We have recently reported an A to G transition at nucleotide position 3243 in the mitochondrial DNA (mtDNA) tRNA(Leu(UUR)) gene in a large family with non-insulin-dependent diabetes mellitus (NIDDM). Characteristic was its maternal transmission and an associated sensorineural hearing loss. In a screening of a Dutch an...

journal_title：Diabetes

authors： van den Ouweland JM,Lemkes HH,Trembath RC,Ross R,Velho G,Cohen D,Froguel P,Maassen JA

更新日期：1994-06-01 00:00:00

abstract：:The clinical features of the experimental hyperosmolar diabetic (EHD) rat model resemble those seen in the human syndrome--extreme hyperglycemia without ketoacidosis is common to both. The absence of ketoacidosis in the syndrome has been ascribed to both substrate (free fatty acid) deficiency and to interference with ...

journal_title：Diabetes

authors： Gordon EE,Duga J

更新日期：1975-03-01 00:00:00

abstract：:Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct tissues is not clear. Here we tested the hypothesis that exercise...

journal_title：Diabetes

authors： Schafer MJ,White TA,Evans G,Tonne JM,Verzosa GC,Stout MB,Mazula DL,Palmer AK,Baker DJ,Jensen MD,Torbenson MS,Miller JD,Ikeda Y,Tchkonia T,van Deursen JM,Kirkland JL,LeBrasseur NK

更新日期：2016-06-01 00:00:00