Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

abstract：:Insulin resistance and dysregulation of free fatty acid (FFA) metabolism are core defects in type 2 diabetic (T2DM) and obese normal glucose tolerant (NGT) individuals. Impaired muscle mitochondrial function (reduced ATP synthesis) also has been described in insulin-resistant T2DM and obese subjects. We examined wheth...

journal_title：Diabetes

authors： Daniele G,Eldor R,Merovci A,Clarke GD,Xiong J,Tripathy D,Taranova A,Abdul-Ghani M,DeFronzo RA

更新日期：2014-08-01 00:00:00

abstract：:The selective impairment of glucose-induced insulin secretion in NIDDM can be attributed to defects in the glucose-signaling system. An alteration in the activity of phosphofructokinase (PFK), a key enzyme in the glycolytic pathway, may play a role in the abnormal glucose-induced insulin secretion. In this study, we e...

journal_title：Diabetes

authors： Knobler H,Weiss Y,Peled M,Groner Y

更新日期：1997-09-01 00:00:00

abstract：:Plasma and urine fibrinopeptide-A (FPA) levels were investigated in type I and II diabetic patients. Plasma FPA and 24-h urinary excretion of FPA were significantly elevated in diabetic patients compared with normal volunteers, indicating augmented thrombin activity in diabetes. Plasma and urine FPA did not differ bet...

journal_title：Diabetes

authors： Jones RL

更新日期：1985-09-01 00:00:00

abstract：:The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 +/- 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0...

journal_title：Diabetes

authors： Bingham EM,Hopkins D,Smith D,Pernet A,Hallett W,Reed L,Marsden PK,Amiel SA

更新日期：2002-12-01 00:00:00

abstract：:Islet β-cells adapt to insulin resistance through increased insulin secretion and expansion. Type 2 diabetes typically occurs when prolonged insulin resistance exceeds the adaptive capacity of β-cells. Our prior screening efforts led to the discovery that adenosine kinase (ADK) inhibitors stimulate β-cell replication....

journal_title：Diabetes

authors： Navarro G,Abdolazimi Y,Zhao Z,Xu H,Lee S,Armstrong NA,Annes JP

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro conditions is relatively small, and augmenting this effect would be beneficial for the treatment or ...

journal_title：Diabetes

authors： Klinger S,Poussin C,Debril MB,Dolci W,Halban PA,Thorens B

更新日期：2008-03-01 00:00:00

abstract：:Prostaglandin E (PGE) infusion in normal man inhibits the acute insulin response to glucose. In order to determine whether endogenously released PGE might also inhibit insulin secretion, glucose-stimulated insulin responses were investigated in normal volunteers after furosemide (40 mg i.v.), a stimulator of endogenou...

journal_title：Diabetes

authors： Giugliano D,Torella R,Sgambato S,D'Onofrio F

更新日期：1979-09-01 00:00:00

abstract：:WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade ...

journal_title：Diabetes

authors： Murahovschi V,Pivovarova O,Ilkavets I,Dmitrieva RM,Döcke S,Keyhani-Nejad F,Gögebakan Ö,Osterhoff M,Kemper M,Hornemann S,Markova M,Klöting N,Stockmann M,Weickert MO,Lamounier-Zepter V,Neuhaus P,Konradi A,Dooley S,von L

更新日期：2015-03-01 00:00:00

abstract：:Currently, the major indications for solitary islet transplantation are recurrent severe hypoglycemia and labile glucose control. Quantifying these problems remains subjective. We have developed a scoring system for both hypoglycemia and glycemic lability, established normative data, and used them in patients who have...

journal_title：Diabetes

authors： Ryan EA,Shandro T,Green K,Paty BW,Senior PA,Bigam D,Shapiro AM,Vantyghem MC

更新日期：2004-04-01 00:00:00

abstract：:This study was undertaken to test two assumptions critical for use of [2-14C]acetate to measure gluconeogenesis in vivo. For the assumption that incorporation into glucose of products of [14C]acetate metabolism does not affect the distribution of label within the glucose molecule, we infused [2-14C]acetate in 17 healt...

journal_title：Diabetes

authors： Consoli A,Nurjhan N,Capani F,Pangburn T,Lapenna D,Gerich J

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:Monocytes in childhood-onset type 1 diabetes show distinct gene expression. We hypothesize that monocyte activation in monozygotic (MZ) twin pairs discordant for childhood-onset type 1 diabetes could reflect distinct stages of the disease process including diabetes susceptibility (differences between twins, b...

journal_title：Diabetes

authors： Beyan H,Drexhage RC,van der Heul Nieuwenhuijsen L,de Wit H,Padmos RC,Schloot NC,Drexhage HA,Leslie RD

更新日期：2010-07-01 00:00:00

abstract：:The effect of cerebral intraventricular insulin on pancreatic insulin secretion was investigated. An extracorporeal pancreatic blood circuit was established after laparotomy to monitor blood flow and insulin concentration directly from the superior pancreaticoduodenal vein. Phentolamine was infused throughout (0.2 mg....

journal_title：Diabetes

authors： Chen M,Woods SC,Porte D Jr

更新日期：1975-10-01 00:00:00

abstract：OBJECTIVE:Preferential upper-body fat gain, a typical male pattern, is associated with a greater cardiometabolic risk. Regional differences in lipolysis and meal fat storage cannot explain sex differences in body fat distribution. We examined the potential role of the novel free fatty acid (FFA) storage pathway in dete...

journal_title：Diabetes

authors： Koutsari C,Ali AH,Mundi MS,Jensen MD

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Exercise is an important strategy for the treatment of type 2 diabetes. This is due in part to an increase in glucose transport that occurs in the working skeletal muscles. Glucose transport is regulated by GLUT4 translocation in muscle, but the molecular machinery mediating this process is poorly understood....

journal_title：Diabetes

authors： Lauritzen HP,Galbo H,Toyoda T,Goodyear LJ

更新日期：2010-09-01 00:00:00

abstract：:The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest t...

journal_title：Diabetes

authors： Andersen DK,Korc M,Petersen GM,Eibl G,Li D,Rickels MR,Chari ST,Abbruzzese JL

更新日期：2017-05-01 00:00:00

abstract：:We studied certain metabolic requirements for insulin-induced increases in phospholipids, and the relationship of phospholipid changes to the insulin-induced activation of pyruvate dehydrogenase, in rat adipocytes and fat pads in vitro. Increases in the contents of phosphatidylinositol and phosphatidylserine mass were...

journal_title：Diabetes

authors： Farese RV,Farese RV Jr,Sabir MA,Larson RE,Trudeau WL 3rd,Barnes D

更新日期：1984-07-01 00:00:00

abstract：:Ambulatory blood pressure (AMBP) measurements were obtained at 20-min intervals for 24 h in 25 subjects with insulin-dependent (type I) diabetes mellitus and 21 control subjects. The diabetic patients had normal kidney function (glomerular filtration rate 112.1 +/- 7.2 ml.min-1.1.73 m-2, renal plasma flow 459.0 +/- 23...

journal_title：Diabetes

authors： Wiegmann TB,Herron KG,Chonko AM,MacDougall ML,Moore WV

更新日期：1990-12-01 00:00:00

abstract：:Plasma dopamine-beta-hydroxylase (pDBH) activity is markedly elevated in chronic experimental streptozotocin (STZ) diabetes in the rat. Several possible explanations, all potentially relevant to the pathophysiology of diabetes, could explain this observation. The objective of this paper was to further delineate the be...

journal_title：Diabetes

authors： Schmidt RE,Geller DM,Johnson EM Jr

更新日期：1981-05-01 00:00:00

abstract：:Impaired wound healing frequently occurs in patients with diabetes. Interleukin (IL)-8 production by keratinocyte is responsible for recruiting neutrophils during healing. Intense inflammation is associated with diabetic wounds, while reduction of neutrophil infiltration is associated with enhanced healing. We hypothe...

journal_title：Diabetes

authors： Lan CC,Wu CS,Huang SM,Wu IH,Chen GS

更新日期：2013-07-01 00:00:00

abstract：:To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...

journal_title：Diabetes

authors： Trovati M,Massucco P,Mattiello L,Mularoni E,Cavalot F,Anfossi G

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:Recent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Kumashiro N,Tamura Y,Uchida T,Ogihara T,Fujitani Y,Hirose T,Mochizuki H,Kawamori R,Watada H

更新日期：2008-08-01 00:00:00

abstract：:Development of beta-cell lines for cell therapy of diabetes is hindered by functional deviations of the replicating cells from the normal beta-cell phenotype. In a recently developed cell line, denoted betaTC-tet, derived from transgenic mice expressing the SV40 T antigen (Tag) under control of the tetracycline (Tc) g...

journal_title：Diabetes

authors： Fleischer N,Chen C,Surana M,Leiser M,Rossetti L,Pralong W,Efrat S

更新日期：1998-09-01 00:00:00

abstract：:Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate mechanism remains to be elucidated. Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as major gatekeepers of the gonadotropic axis. Alteration in the hypothalamic KiSS-1...

journal_title：Diabetes

authors： Castellano JM,Navarro VM,Fernández-Fernández R,Roa J,Vigo E,Pineda R,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Adipose tissue serves as an integrator of various physiological pathways, energy balance, and glucose homeostasis. Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain unclear. RESEARCH DESIGN...

journal_title：Diabetes

authors： Nakae J,Cao Y,Oki M,Orba Y,Sawa H,Kiyonari H,Iskandar K,Suga K,Lombes M,Hayashi Y

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:The aim of the current study was to evaluate the long-term effects of leptin on glucose metabolism, diabetes complications, and life span in an insulin-dependent diabetes model, the Akita mouse. RESEARCH DESIGN AND METHODS:We cross-mated Akita mice with leptin-expressing transgenic (LepTg) mice to produce Ak...

journal_title：Diabetes

authors： Naito M,Fujikura J,Ebihara K,Miyanaga F,Yokoi H,Kusakabe T,Yamamoto Y,Son C,Mukoyama M,Hosoda K,Nakao K

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading f...

journal_title：Diabetes

authors： Tanaka J,Qiang L,Banks AS,Welch CL,Matsumoto M,Kitamura T,Ido-Kitamura Y,DePinho RA,Accili D

更新日期：2009-10-01 00:00:00

abstract：:The causes of the increased risk of severe COVID-19 in persons with diabetes are unclear. It has been speculated that renin angiotensin system (RAS) blockers may promote COVID-19 by increasing ACE2, which SARS-CoV-2 uses to enter host cells, along with the host protease TMPRSS2. Taking a reverse translational approach...

journal_title：Diabetes

authors： Batchu SN,Kaur H,Yerra VG,Advani SL,Kabir MG,Liu Y,Klein T,Advani A

更新日期：2020-12-11 00:00:00

abstract：:Nondiabetic obese humans adapt to insulin resistance by increasing beta-cell mass. In contrast, obese humans with type 2 diabetes have an approximately 60% deficit in beta-cell mass. Recent studies in rodents reveal that beta-cell mass is regulated, increasing in response to insulin resistance through increased beta-c...

journal_title：Diabetes

authors： Butler AE,Janson J,Soeller WC,Butler PC

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the...

journal_title：Diabetes

authors： Muller YL,Hanson RL,Bian L,Mack J,Shi X,Pakyz R,Shuldiner AR,Knowler WC,Bogardus C,Baier LJ

更新日期：2010-08-01 00:00:00

abstract：:Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a...

journal_title：Diabetes

authors： Jiao Y,Zhao J,Zhang Z,Li M,Yu X,Yang Y,Liu J,Liao S,Li D,Wang Y,Zhang D,Chen Y,Shi G,Liu B,Lu Y,Li X

更新日期：2018-11-01 00:00:00