Abstract:
:Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a transcription factor that regulates cell proliferation and differentiation, plays an important role in hepatic TG metabolism. Sox4 expression levels are markedly upregulated in livers of obese rodents and humans. Adenovirus-medicated overexpression of Sox4 in the livers of lean mice promotes liver steatosis, whereas liver-specific knockdown of Sox4 ameliorates TG accumulation and improves insulin resistance in obese mice. At the molecular level, we show that Sox4 could directly control the transcription of SREBP-1c gene through binding to its proximal promoter region. Thus, we have identified Sox4 as an important component of hepatic TG metabolism.
journal_name
Diabetesjournal_title
Diabetesauthors
Jiao Y,Zhao J,Zhang Z,Li M,Yu X,Yang Y,Liu J,Liao S,Li D,Wang Y,Zhang D,Chen Y,Shi G,Liu B,Lu Y,Li Xdoi
10.2337/db18-0184subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2227-2238issue
11eissn
0012-1797issn
1939-327Xpii
db18-0184journal_volume
67pub_type
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