Perifusion and culture of human fetal pancreas.

abstract：:We investigated the expression of Th1- and Th2-associated chemokine receptors on peripheral blood lymphocytes at diagnosis and in the first phase of type 1 diabetes. Peripheral blood mononuclear cells (PBMCs) of 25 patients with newly diagnosed type 1 diabetes, 10 patients with longstanding type 1 diabetes, and 35 hea...

journal_title：Diabetes

authors： Lohmann T,Laue S,Nietzschmann U,Kapellen TM,Lehmann I,Schroeder S,Paschke R,Kiess W

更新日期：2002-08-01 00:00:00

abstract：:Because it is unknown whether 24-h energy expenditure (EE) responses to dietary extremes will identify phenotypes associated with weight regulation, the aim of this study was to determine whether such responses to fasting or overfeeding are associated with future weight change. The 24-h EE during energy balance, fasti...

journal_title：Diabetes

authors： Schlögl M,Piaggi P,Pannacciuli N,Bonfiglio SM,Krakoff J,Thearle MS

更新日期：2015-11-01 00:00:00

abstract：:Type 1 diabetes is believed to be a Th1 lymphocyte-mediated disease, and both environmental and genetic factors play a role in its pathogenesis. It was recently found that interleukin (IL)-18 acts as a proinflammatory cytokine and, in synergy with IL-12, promotes development of Th1 lymphocyte response by induction of ...

journal_title：Diabetes

authors： Kretowski A,Mironczuk K,Karpinska A,Bojaryn U,Kinalski M,Puchalski Z,Kinalska I

更新日期：2002-11-01 00:00:00

abstract：:In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, an...

journal_title：Diabetes

authors： Feng Y,Niu T,Xu X,Chen C,Li Q,Qian R,Wang G,Xu X

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:A major feature of type 1 diabetes is the appearance of islet autoantibodies before diagnosis. However, although the genetics of type 1 diabetes is advanced, the genetics of islet autoantibodies needs further investigation. The primary susceptibility loci in type 1 diabetes, the HLA class I and II genes, are ...

journal_title：Diabetes

authors： Howson JM,Stevens H,Smyth DJ,Walker NM,Chandler KA,Bingley PJ,Todd JA

更新日期：2011-10-01 00:00:00

abstract：:Concentrations of glycosylated hemoglobin (GHb) are elevated in diabetes mellitus and are believed to reflect previous metabolic control. To better define possible determinants of GHb in man, we investigated the relationship between GHb and both fasting plasma glucose (FPG) and basal insulin (IRI) in 42 normal subject...

journal_title：Diabetes

authors： Graf RJ,Halter JB,Porte D Jr

更新日期：1978-08-01 00:00:00

abstract：:The identity of the cells responsible for beta-cell destruction in type I (insulin-dependent) diabetes is still uncertain. L3T4+ T-lymphocytes have a role in the initiation of insulitis and in damaging transplanted allogeneic islets in nonobese diabetic (NOD) mice. The role of L3T4+ T-lymphocytes in destruction of bet...

journal_title：Diabetes

authors： Charlton B,Mandel TE

更新日期：1988-08-01 00:00:00

abstract：:Near normal glucoregulation was maintained in 10 patients with insulin-dependent (type I) diabetes mellitus for 6 wk with preprogrammed continuous subcutaneous insulin infusion using a portable battery-powered infusion pump (CSII). This form of therapy resulted in a statistically significant increase in motor nerve co...

journal_title：Diabetes

authors： Pietri A,Ehle AL,Raskin P

更新日期：1980-08-01 00:00:00

abstract：:We studied the cross-sectional relationship between HbA1c and cardiovascular disease (CVD) in the survivors of the original cohort of the Framingham Heart Study (n = 1045). HbA1c was significantly related to prevalent CVD among women but not men. HbA1c was also related to hypertension and to the ratio of total to high...

journal_title：Diabetes

authors： Singer DE,Nathan DM,Anderson KM,Wilson PW,Evans JC

更新日期：1992-02-01 00:00:00

abstract：:Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly affect mitochondrial f...

journal_title：Diabetes

authors： van de Weijer T,Phielix E,Bilet L,Williams EG,Ropelle ER,Bierwagen A,Livingstone R,Nowotny P,Sparks LM,Paglialunga S,Szendroedi J,Havekes B,Moullan N,Pirinen E,Hwang JH,Schrauwen-Hinderling VB,Hesselink MK,Auwerx J,Ro

更新日期：2015-04-01 00:00:00

abstract：:Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The antidiabetic thiazolidinediones shift the energy balance toward storage, leading to an increase in whole-body adiposity. These studies examine the effects of pioglitazone (Pio) on adipose tissue phy...

journal_title：Diabetes

authors： de Souza CJ,Eckhardt M,Gagen K,Dong M,Chen W,Laurent D,Burkey BF

更新日期：2001-08-01 00:00:00

abstract：:Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucagon-lik...

journal_title：Diabetes

authors： Gotfredsen CF,Mølck AM,Thorup I,Nyborg NC,Salanti Z,Knudsen LB,Larsen MO

更新日期：2014-07-01 00:00:00

abstract：:Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPR(dn)) reveal progressive deterioration of glu...

journal_title：Diabetes

authors： Renner S,Römisch-Margl W,Prehn C,Krebs S,Adamski J,Göke B,Blum H,Suhre K,Roscher AA,Wolf E

更新日期：2012-08-01 00:00:00

abstract：:Fed male Wistar rats were eviscerated by two procedures. The first group of eviscerated rats were left with a nonfunctional liver in situ while the second group were eviscerated by a newer technic, developed in this laboratory, that preserves liver function. The animals were maintained on a regimen of saline and antib...

journal_title：Diabetes

authors： Penhos JC,Ezequiel M,Lepp A,Ramey ER

更新日期：1975-07-01 00:00:00

abstract：:We examined the effects of aldose reductase inhibition (ARI) on glomerular filtration rate (GFR), albuminuria, and kidney histology in partially insulin-treated streptozocin-induced diabetic (STZ-D) rats. After 1 mo of diabetes, GFR was elevated over control values in the STZ-D rats but was not affected by treatment w...

journal_title：Diabetes

authors： Daniels BS,Hostetter TH

更新日期：1989-08-01 00:00:00

abstract：:Large glucagon immunoreactive substances, extracted from the fetal bovine pancreas and separated by gel filtration in the presence of 6 M guanidinium-hydrochloride, were submitted to lectin-sepharose affinity column chromatograph. Gel-filtered peak I (approximately 45 K delta) and peak II (approximately 10 K delta) in...

journal_title：Diabetes

authors： Tung AK,Cockburn E,Siu KP

更新日期：1982-11-01 00:00:00

abstract：:The allelic forms of the human leukocyte antigen (HLA)-DQ beta-chain (DQB1) have been recognized as the best markers of insulin-dependent diabetes mellitus (IDDM) susceptibility. We describe a method that allows the recognition of these DQB1 alleles without the use of either allele-specific oligonucleotide probes or r...

journal_title：Diabetes

authors： Trucco G,Fritsch R,Giorda R,Trucco M

更新日期：1989-12-01 00:00:00

abstract：:We report the results of cross-sectional, prospective, and longitudinal studies identifying etiologic metabolic factors in the susceptibility to type 2 diabetes mellitus of the Pima Indians of Arizona, whose prevalence and incidence rates of the disease are the highest in the world. Diabetic Pima Indians are metabolic...

journal_title：Diabetes

authors： Bogardus C,Tataranni PA

更新日期：2002-02-01 00:00:00

abstract：:GAD is a pancreatic beta-cell autoantigen in humans and nonobese diabetic (NOD) mice. Modulation of GAD expression in pancreatic beta-cells has been suggested to be associated with the development of autoimmune diabetes. Hormonal changes through environmental stimuli are considered to influence the expression of the d...

journal_title：Diabetes

authors： Kim KS,Kang Y,Choi SE,Kim JH,Kim HM,Sun B,Jun HS,Yoon JW

更新日期：2002-09-01 00:00:00

abstract：:A pancreatic alpha-like cell line has been established from a glucagonoma arising in transgenic mice expressing a hybrid gene consisting of the rat glucagon-promoter sequence fused to the sequence encoding the SV40 T-antigen oncoprotein. The alpha-tumor cell 1 (alpha TC1) line maintained many characteristics of differ...

journal_title：Diabetes

authors： Powers AC,Efrat S,Mojsov S,Spector D,Habener JF,Hanahan D

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kina...

journal_title：Diabetes

authors： Kowluru A,Veluthakal R,Rhodes CJ,Kamath V,Syed I,Koch BJ

更新日期：2010-04-01 00:00:00

abstract：:The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, ap...

journal_title：Diabetes

authors： Eto M,Watanabe K,Iwashima Y,Morikawa A,Chonan N,Oshima E,Sekiguchi M,Ishii K

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:Elevated fasting glucose level is associated with increased carotid intima-media thickness (IMT), a measure of subclinical atherosclerosis. It is unclear if this association is causal. Using the principle of Mendelian randomization, we sought to explore the causal association between circulating glucose and I...

journal_title：Diabetes

authors： Rasmussen-Torvik LJ,Li M,Kao WH,Couper D,Boerwinkle E,Bielinski SJ,Folsom AR,Pankow JS

更新日期：2011-01-01 00:00:00

abstract：:Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and is mutated in the db/db mouse so that it lacks the cytoplasmic domain. We show that the full-length leptin receptor (Ob-Rb), which is believed to transmit the l...

journal_title：Diabetes

authors： Emilsson V,Liu YL,Cawthorne MA,Morton NM,Davenport M

更新日期：1997-02-01 00:00:00

abstract：:Although recent studies show that adipose tissue macrophages (ATMs) participate in the inflammatory changes in obesity and contribute to insulin resistance, the properties of these cells are not well understood. We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory prope...

journal_title：Diabetes

authors： Lumeng CN,Deyoung SM,Bodzin JL,Saltiel AR

更新日期：2007-01-01 00:00:00

abstract：:Adults with diabetes are 2-4 times more likely to suffer from heart disease or ischemic stroke than adults without diabetes, yet standard antiplatelet therapy, which is the cornerstone for primary and secondary prevention of cardiovascular disease, fails in many patients with diabetes. Three independent but often inte...

journal_title：Diabetes

authors： Arthur JF,Jandeleit-Dahm K,Andrews RK

更新日期：2017-01-01 00:00:00

abstract：:Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control of the porcine insul...

journal_title：Diabetes

authors： Klymiuk N,van Buerck L,Bähr A,Offers M,Kessler B,Wuensch A,Kurome M,Thormann M,Lochner K,Nagashima H,Herbach N,Wanke R,Seissler J,Wolf E

更新日期：2012-06-01 00:00:00

abstract：:We have suggested that altered maternal metabolism may affect the subsequent anthropometric and neuropsychological development of children who were in utero during disturbances in maternal fuel economy. This study reports the physical growth through 8 yr of age and the neuropsychological development through 4 yr of ag...

journal_title：Diabetes

authors： Silverman BL,Rizzo T,Green OC,Cho NH,Winter RJ,Ogata ES,Richards GE,Metzger BE

更新日期：1991-12-01 00:00:00

abstract：:Insulin levels in humans were measured by a new assay, the isotope dilution assay (IDA), based on stable isotope dilution mass spectrometry. A known amount of a deuterated analog of insulin was used as an internal standard and added to the serum samples before sample processing. After isolation by immunoaffinity chrom...

journal_title：Diabetes

authors： Stöcklin R,Vu L,Vadas L,Cerini F,Kippen AD,Offord RE,Rose K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:The G-protein-coupled receptor Gpr40 is expressed in beta-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion. However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 was recently shown to bi...

journal_title：Diabetes

authors： Edfalk S,Steneberg P,Edlund H

更新日期：2008-09-01 00:00:00