Interleukin-18 promoter polymorphisms in type 1 diabetes.

abstract：:Many humans with IDDM eventually lose the capacity to secrete epinephrine from their adrenal medullae. The mechanism for this pathological change is unknown. We hypothesized that this abnormality is attributable to neuropathic changes in the greater splanchnic nerves or in the chromaffin cells that they innervate. To ...

journal_title：Diabetes

authors： Wilke RA,Riley DA,Lelkes PI,Hillard CJ

更新日期：1993-06-01 00:00:00

abstract：:Fatty acids (FAs) and other lipid molecules are important for many cellular functions, including vesicle exocytosis. For the pancreatic beta-cell, while the presence of some FAs is essential for glucose-stimulated insulin secretion, FAs have enormous capacity to amplify glucose-stimulated insulin secretion, which is p...

journal_title：Diabetes

authors： Nolan CJ,Madiraju MS,Delghingaro-Augusto V,Peyot ML,Prentki M

更新日期：2006-12-01 00:00:00

abstract：:Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet-i...

journal_title：Diabetes

authors： Meng W,Liang X,Chen H,Luo H,Bai J,Li G,Zhang Q,Xiao T,He S,Zhang Y,Xu Z,Xiao B,Liu M,Hu F,Liu F

更新日期：2017-05-01 00:00:00

abstract：:The influence of cyclic AMP (cAMP) and extracellular calcium on phosphoinositide (PI) hydrolysis in isolated islets was assessed and related to insulin output. Three stimulants were chosen to activate the beta-cell: sulfated cholecystokinin (CCK-8S, 200 nM), high-level glucose (20 mM), and the sulfonylurea tolbutamide...

journal_title：Diabetes

authors： Zawalich WS,Diaz VA,Zawalich KC

更新日期：1988-11-01 00:00:00

abstract：:Skeletal muscle insulin resistance in type 2 diabetes is associated with a shift from oxidative to glycolytic metabolism in myofibers. However, whether this metabolic switch is detrimental or adaptive for metabolic homeostasis has not been resolved. We recently demonstrated that the Baf60c/Deptor pathway promotes glyc...

journal_title：Diabetes

authors： Meng ZX,Wang L,Xiao Y,Lin JD

更新日期：2014-05-01 00:00:00

abstract：:Type 1 diabetes presents clinically with overt hyperglycemia resulting from progressive immune-mediated destruction of pancreatic β-cells and associated metabolic dysfunction. Combined genetic and immunological studies now highlight deficiencies in both the interleukin-2 (IL-2) receptor and its downstream signaling pa...

journal_title：Diabetes

authors： Hulme MA,Wasserfall CH,Atkinson MA,Brusko TM

更新日期：2012-01-01 00:00:00

abstract：:One of the unique features of beta-cells is their relatively low expression of many antioxidant enzymes. This could render beta-cells susceptible to oxidative damage but may also provide a system that is sensitive to reactive oxygen species as signals. In isolated mouse islets and INS-1(832/13) cells, glucose increase...

journal_title：Diabetes

authors： Pi J,Bai Y,Zhang Q,Wong V,Floering LM,Daniel K,Reece JM,Deeney JT,Andersen ME,Corkey BE,Collins S

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:Physiologically elevated insulin concentrations promote access of macromolecules to skeletal muscle in dogs. We investigated whether insulin has a stimulating effect on the access of macromolecules to insulin-sensitive tissues in humans as well. RESEARCH DESIGN AND METHODS:In a randomized, controlled trial, ...

journal_title：Diabetes

authors： Weinhandl H,Pachler C,Mader JK,Ikeoka D,Mautner A,Falk A,Suppan M,Pieber TR,Ellmerer M

更新日期：2007-09-01 00:00:00

abstract：:The insulin resistance syndrome is characterized by several risk factors for cardiovascular disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside (AICAR) has been shown to augment insulin action, upregulate mitochondrial enz...

journal_title：Diabetes

authors： Buhl ES,Jessen N,Pold R,Ledet T,Flyvbjerg A,Pedersen SB,Pedersen O,Schmitz O,Lund S

更新日期：2002-07-01 00:00:00

abstract：:Recent evidence demonstrates that hypothalamic insulin signaling is required for inhibition of endogenous glucose production. The downstream mechanisms that are responsible for the effects of hypothalamic insulin receptor activation on hepatic fuel flux remain to be determined. To establish whether downregulation of n...

journal_title：Diabetes

authors： van den Hoek AM,Voshol PJ,Karnekamp BN,Buijs RM,Romijn JA,Havekes LM,Pijl H

更新日期：2004-10-01 00:00:00

abstract：:In evaluating therapeutic interventions aimed at preventing diabetic neuropathy, choosing a suitable measure of neural function is difficult, partly because the relation between most available objective measures and the development of symptomatic neuropathy (SN) is unclear. Using data from 67 diabetic patients, we dev...

journal_title：Diabetes

authors： Weinberg CR,Pfeifer MA

更新日期：1986-08-01 00:00:00

abstract：:Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige adipocyte differentiation are essential to implement such therapeutic strategies. We report a straightforward and efficient protocol to generate functional human be...

journal_title：Diabetes

authors： Guénantin AC,Briand N,Capel E,Dumont F,Morichon R,Provost C,Stillitano F,Jeziorowska D,Siffroi JP,Hajjar RJ,Fève B,Hulot JS,Collas P,Capeau J,Vigouroux C

更新日期：2017-06-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1 mediates hypoxia- and chronic kidney disease-induced fibrotic events. Here, we assessed whether HIF-1 blockade attenuates the manifestations of diabetic nephropathy in a type 1 diabetic animal model, OVE26. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an HIF-1 inhibitor, red...

journal_title：Diabetes

authors： Nayak BK,Shanmugasundaram K,Friedrichs WE,Cavaglierii RC,Patel M,Barnes J,Block K

更新日期：2016-05-01 00:00:00

abstract：:Myocardial dysfunction, perfusion abnormalities, and the extent to which these abnormalities may be reversed by C-peptide administration was assessed in type 1 diabetic patients. Eight patients were studied before and during a 0.84-mg/kg dipyridamole administration using a randomized double-blind crossover protocol wi...

journal_title：Diabetes

authors： Hansen A,Johansson BL,Wahren J,von Bibra H

更新日期：2002-10-01 00:00:00

abstract：:The hyperinsulinemia of obese rodents has been associated with a reduced number of hepatic insulin receptors except in hepatocytes from fatty Zucker rats. We isolated liver plasma membranes from 10-11-wk-old lean and fatty Zucker rats, some of which were injected with streptozotocin 2--4 wk earlier. We have determined...

journal_title：Diabetes

authors： Clark JB,Keen S,Clark CM Jr

更新日期：1982-10-01 00:00:00

abstract：:Recent large-scale epidemiological studies demonstrate that blood concentrations of immunoreactive insulin predict the development of NIDDM and IDDM and are associated with the risk of several degenerative diseases, such as coronary and peripheral vessel atherosclerosis, hypertension, and dyslipidemia. The reliability...

journal_title：Diabetes

authors： Robbins DC,Andersen L,Bowsher R,Chance R,Dinesen B,Frank B,Gingerich R,Goldstein D,Widemeyer HM,Haffner S,Hales CN,Jarett L,Polonsky K,Porte D,Skyler J,Webb G,Gallagher K

更新日期：1996-02-01 00:00:00

abstract：:The hexokinases, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in movement of glucose into cells through the facilitative glucose transporters. GLUT4 and hexokinase (HK) II are the major transporter and hexokinase isoforms in skeletal muscle, heart, and adipose tissue, ...

journal_title：Diabetes

authors： Osawa H,Printz RL,Whitesell RR,Granner DK

更新日期：1995-12-01 00:00:00

abstract：:We have reported previously that chronic and systemic administration of a streptococcal preparation (OK-432), an inducer of TNF, or of recombinant hTNF prevented the development of IDDM in the two animal models of IDDM-NOD mice and BB rats. In this study, we examined the effect of LT, which is structurally and functio...

journal_title：Diabetes

authors： Seino H,Takahashi K,Satoh J,Zhu XP,Sagara M,Masuda T,Nobunaga T,Funahashi I,Kajikawa T,Toyota T

更新日期：1993-03-01 00:00:00

abstract：:To evaluate possible advantages of human insulin of recombinant DNA origin (HI) in the treatment of diabetic patients, we compared cellular and humoral immunoreactivities of HI and porcine insulin (PI). Anti-insulin IgE bound equal amounts of 125I-HI and 125I-PI. There was no difference between HI- and PI-stimulated l...

journal_title：Diabetes

authors： Kumar D,Alexander CM,Zeidler A,Rhodes JJ,Boarman CC,Hoopes MT

更新日期：1983-06-01 00:00:00

abstract：:The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of r...

journal_title：Diabetes

authors： Miller LL

更新日期：1976-01-01 00:00:00

abstract：:Mice genetically deficient in the glucagon receptor (Gcgr(-/-)) show improved glucose tolerance, insulin sensitivity, and α-cell hyperplasia. In addition, Gcgr(-/-) mice do not develop diabetes after chemical destruction of β-cells. Since fibroblast growth factor 21 (FGF21) has insulin-independent glucose-lowering pro...

journal_title：Diabetes

authors： Omar BA,Andersen B,Hald J,Raun K,Nishimura E,Ahrén B

更新日期：2014-01-01 00:00:00

abstract：:To establish potential effects of glucagon-like peptide I (GLP-I) on blood glucose control in insulin-deficient states, GLP-I [GLP-I(7-36) amide; 10 pmol x kg(-1) x min(-1)] was infused intravenously in six fasting, canine C-peptide-negative, chronically diabetic dogs for 8 h. Blood samples were saved for the analysis...

journal_title：Diabetes

authors： Freyse EJ,Becher T,El-Hag O,Knospe S,Göke B,Fischer U

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db ...

journal_title：Diabetes

authors： Sloan C,Tuinei J,Nemetz K,Frandsen J,Soto J,Wride N,Sempokuya T,Alegria L,Bugger H,Abel ED

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:We recently showed that leptin has powerful central nervous system (CNS)-mediated antidiabetic and cardiovascular actions. This study tested whether the CNS melanocortin system mediates these actions of leptin in diabetic rats. RESEARCH DESIGN AND METHODS:A cannula was placed in the lateral ventricle of Spra...

journal_title：Diabetes

authors： da Silva AA,do Carmo JM,Freeman JN,Tallam LS,Hall JE

更新日期：2009-08-01 00:00:00

abstract：:An epidemic of obesity and type 2 diabetes is linked with the increase in consumption of fructose-containing sugars, such as sucrose and high-fructose corn syrup. In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. He...

journal_title：Diabetes

authors： Marek G,Pannu V,Shanmugham P,Pancione B,Mascia D,Crosson S,Ishimoto T,Sautin YY

更新日期：2015-02-01 00:00:00

abstract：:Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...

journal_title：Diabetes

authors： Nilsen MS,Jersin RÅ,Ulvik A,Madsen A,McCann A,Svensson PA,Svensson MK,Nedrebø BG,Gudbrandsen OA,Tell GS,Kahn CR,Ueland PM,Mellgren G,Dankel SN

更新日期：2020-09-01 00:00:00

abstract：:Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPR(dn)) reveal progressive deterioration of glu...

journal_title：Diabetes

authors： Renner S,Römisch-Margl W,Prehn C,Krebs S,Adamski J,Göke B,Blum H,Suhre K,Roscher AA,Wolf E

更新日期：2012-08-01 00:00:00

abstract：:Molecular mechanisms underlying lipolysis, as defined by mobilization of fatty acids from adipose tissue, are not fully understood. A database search for enzymes with alpha/beta hydrolase folds, the GXSXG motif for serine esterase and the His-Gly dipeptide motif, has provided a previously unannotated gene that is indu...

journal_title：Diabetes

authors： Okazaki H,Igarashi M,Nishi M,Tajima M,Sekiya M,Okazaki S,Yahagi N,Ohashi K,Tsukamoto K,Amemiya-Kudo M,Matsuzaka T,Shimano H,Yamada N,Aoki J,Morikawa R,Takanezawa Y,Arai H,Nagai R,Kadowaki T,Osuga J,Ishibashi S

更新日期：2006-07-01 00:00:00

abstract：:Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studi...

journal_title：Diabetes

authors： Bagwell AM,Bento JL,Mychaleckyj JC,Freedman BI,Langefeld CD,Bowden DW

更新日期：2005-04-01 00:00:00