Prevention of autoimmune diabetes with lymphotoxin in NOD mice.

abstract：:Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transp...

journal_title：Diabetes

authors： Cabello-Kindelan C,Mackey S,Sands A,Rodriguez J,Vazquez C,Pugliese A,Bayer AL

更新日期：2020-02-01 00:00:00

abstract：:We have examined the effects of underfeeding and obesity on the density of hypothalamic melanocortin MC3 and MC4 receptors (MC3-R and MC4-R, respectively), which may mediate the hypophagic effects of alpha-melanocyte-stimulating hormone (MSH) in the rat. MC3-R and MC4-R were measured by quantitative autoradiography in...

journal_title：Diabetes

authors： Harrold JA,Widdowson PS,Williams G

更新日期：1999-02-01 00:00:00

abstract：:Long before reaching diagnostic cutoff levels for type 2 diabetes, fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young European sib-pairs including obese children, with adjustment for sex, age, and BMI. We identified...

journal_title：Diabetes

authors： Fradin D,Heath S,Lathrop M,Bougnères P

更新日期：2007-06-01 00:00:00

abstract：:Type 2 diabetes is characterized by increased plasma triglyceride levels and a fourfold increase in ischemic heart disease, but the mechanism is unclear. CD36 is a receptor/transporter that binds fatty acids of lipoproteins. CD36 deficiency has been linked with insulin resistance. There is strong evidence of in vivo i...

journal_title：Diabetes

authors： Englyst NA,Taube JM,Aitman TJ,Baglin TP,Byrne CD

更新日期：2003-05-01 00:00:00

abstract：:Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...

journal_title：Diabetes

authors： Tan BH,Wilson GL,Schaffer SW

更新日期：1984-12-01 00:00:00

abstract：:Obesity and body fat distribution are important risk factors for the development of type 2 diabetes and metabolic syndrome. Evidence has accumulated that this risk is related to intrinsic differences in behavior of adipocytes in different fat depots. In the current study, we demonstrate that adipocyte precursor cells ...

journal_title：Diabetes

authors： Macotela Y,Emanuelli B,Mori MA,Gesta S,Schulz TJ,Tseng YH,Kahn CR

更新日期：2012-07-01 00:00:00

abstract：:RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity resides in the cytosol and is similar to the insulin-specific proteases previously described in muscle and other tissues. It has an apparent Km of 0.15 microM for p...

journal_title：Diabetes

authors： Bhathena SJ,Timmers KI,Oie HK,Voyles NR,Recant L

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:Increased intramuscular triacylglycerol (IMTG) storage is a characteristic of the obese insulin-resistant state. We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity. RESEARCH DESIGN AND METHODS:Forearm skeletal musc...

journal_title：Diabetes

authors： Jocken JW,Roepstorff C,Goossens GH,van der Baan P,van Baak M,Saris WH,Kiens B,Blaak EE

更新日期：2008-07-01 00:00:00

abstract：:Neogenesis is crucial for the maintenance of beta-cell mass in the human pancreas and possibly for the outcome of clinical islet transplantation. To date, no studies have reported a stimulation of human beta-cell neogenesis in vivo. Therefore, we investigated whether human alpha-, beta-, and duct cell growth can be st...

journal_title：Diabetes

authors： Tyrberg B,Ustinov J,Otonkoski T,Andersson A

更新日期：2001-02-01 00:00:00

abstract：:The adipocyte hormone adiponectin is negatively correlated with obesity and insulin resistance and may exert an important antidiabetes function. In this study, primary human skeletal muscle cells were cocultured with human fat cells or incubated with adipocyte-conditioned medium in the presence or absence of the globu...

journal_title：Diabetes

authors： Dietze-Schroeder D,Sell H,Uhlig M,Koenen M,Eckel J

更新日期：2005-07-01 00:00:00

abstract：:Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown whether leptin modulates the release of CCK. Here, we demonstrate in vitro that leptin induces the phosphorylation of extracellular signal-related kinase (ERK)-1/2 proteins and increases CCK release (EC(50) = 0.23 nmol/l) in CCK-secr...

journal_title：Diabetes

authors： Guilmeau S,Buyse M,Tsocas A,Laigneau JP,Bado A

更新日期：2003-07-01 00:00:00

abstract：:The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of r...

journal_title：Diabetes

authors： Miller LL

更新日期：1976-01-01 00:00:00

abstract：:The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways....

journal_title：Diabetes

authors： Cohen P,Spiegelman BM

更新日期：2015-07-01 00:00:00

abstract：:Pancreatogenic diabetes (PD), secondary either to chronic calcific pancreatitis or to pancreatectomy, is characterized by higher frequency of hypoglycemic events during insulin therapy in comparison with type I insulin-dependent diabetes (IDD). Not only glucagon deficiency, but an enhanced peripheral tissue sensitivit...

journal_title：Diabetes

authors： Nosadini R,del Prato S,Tiengo A,Duner E,Toffolo G,Cobelli C,Faronato PP,Moghetti P,Muggeo M

更新日期：1982-04-01 00:00:00

abstract：:The rapid conversion of glucose to sorbitol by aldose reductase and the consequent hyperosmolarity of the cytoplasm has been shown to be the primary cause of the so-called "sugar" or "osmotic" cataract in many animal lenses. It is not as clear, however, that hyperosmolarity is the principal factor in the etiology of c...

journal_title：Diabetes

authors： Barnett PA,González RG,Chylack LT Jr,Cheng HM

更新日期：1986-04-01 00:00:00

abstract：:Autoantibodies to glutamic acid decarboxylase (GAD) are frequent at or before the onset of insulin-dependent diabetes mellitus (IDDM). We have developed a simple, reproducible, and quantitative immunoprecipitation radioligand assay using as antigen in vitro transcribed and translated [35S]methionine-labeled human isle...

journal_title：Diabetes

authors： Petersen JS,Hejnaes KR,Moody A,Karlsen AE,Marshall MO,Høier-Madsen M,Boel E,Michelsen BK,Dyrberg T

更新日期：1994-03-01 00:00:00

abstract：:Plasma phospholipid transfer protein (PLTP) plays an important role in lipoprotein metabolism. PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. The aim of this study was to test the hypothesis that statins reduce PLTP activity and to examine the p...

journal_title：Diabetes

authors： Dallinga-Thie GM,van Tol A,Hattori H,Rensen PC,Sijbrands EJ

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:FUT2 encodes the α(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are nonsecretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces. This mutation has been reported to provide...

journal_title：Diabetes

authors： Smyth DJ,Cooper JD,Howson JM,Clarke P,Downes K,Mistry T,Stevens H,Walker NM,Todd JA

更新日期：2011-11-01 00:00:00

abstract：:The preferential channeling of different fuels to fat and changes in the transcription profile of adipose tissue and skeletal muscle are poorly understood processes involved in the pathogenesis of obesity and insulin resistance. Carbohydrate and lipid metabolism may play relevant roles in this context. Freely moving l...

journal_title：Diabetes

authors： Fabris R,Nisoli E,Lombardi AM,Tonello C,Serra R,Granzotto M,Cusin I,Rohner-Jeanrenaud F,Federspil G,Carruba MO,Vettor R

更新日期：2001-03-01 00:00:00

abstract：:Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the adipocytes. This may enable them to participate in both anabolic and catabolic processes. The adiponutrin gene (ADPN) is down...

journal_title：Diabetes

authors： Johansson LE,Hoffstedt J,Parikh H,Carlsson E,Wabitsch M,Bondeson AG,Hedenbro J,Tornqvist H,Groop L,Ridderstråle M

更新日期：2006-03-01 00:00:00

abstract：:Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific subpopulations with d...

journal_title：Diabetes

authors： Benninger RKP,Hodson DJ

更新日期：2018-04-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00

abstract：:Recent data have suggested a key role for tumor necrosis factor (TNF)-alpha in the insulin resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-alpha expression is elevated in the adipose tissue of multiple experimental models of obesity. Neutralization of TNF-alpha in one of these models imp...

journal_title：Diabetes

authors： Hotamisligil GS,Spiegelman BM

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Pharmacogenomics is a key component of personalized medicine. The Israel Cardiovascular Events Reduction with Vitamin E Study, a prospective placebo-controlled study, recently demonstrated that vitamin E could dramatically reduce CVD in individuals with diabetes and the haptoglobin (Hp) 2-2 genotype (40% of d...

journal_title：Diabetes

authors： Asleh R,Blum S,Kalet-Litman S,Alshiek J,Miller-Lotan R,Asaf R,Rock W,Aviram M,Milman U,Shapira C,Abassi Z,Levy AP

更新日期：2008-10-01 00:00:00

abstract：:The ATP-sensitive potassium channel, K(ATP) channel, a functional complex of the sulfonylurea receptor 1, SUR1, and an inward rectifier potassium channel subunit, Kir6.2, regulates insulin secretion in the pancreas. Mutations in both the Kir6.2 and SUR1 genes are associated with persistent hyperinsulinemic hypoglycemi...

journal_title：Diabetes

authors： Shyng SL,Ferrigni T,Shepard JB,Nestorowicz A,Glaser B,Permutt MA,Nichols CG

更新日期：1998-07-01 00:00:00

abstract：:Susceptibility of mice to experimental insulin-dependent diabetes as induced by multiple subdiabetogenic doses of streptozotocin has been shown to be strongly gender-dependent, males being much more susceptible than females. We examined this gender difference further in two strains of genetically susceptible mice to d...

journal_title：Diabetes

authors： Paik SG,Michelis MA,Kim YT,Shin S

更新日期：1982-08-01 00:00:00

abstract：:Clinical studies have shown a link between hyperuricemia (HU) and diabetes, while the exact effect of soluble serum urate on glucose metabolism remains elusive. This study aims to characterize the glucose metabolic phenotypes and investigate the underlying molecular mechanisms using a novel spontaneous HU mouse model ...

journal_title：Diabetes

authors： Lu J,He Y,Cui L,Xing X,Liu Z,Li X,Zhang H,Li H,Sun W,Ji A,Wang Y,Yin H,Li C

更新日期：2020-06-01 00:00:00

abstract：:Variation at the variable number tandem repeat (VNTR) minisatellite 5' of the insulin gene (INS) is associated with several phenotypes, including type 1 diabetes, polycystic ovary syndrome, and birth weight. Case-control studies have suggested that class III VNTR alleles are also associated with type 2 diabetes, but r...

journal_title：Diabetes

authors： Huxtable SJ,Saker PJ,Haddad L,Walker M,Frayling TM,Levy JC,Hitman GA,O'Rahilly S,Hattersley AT,McCarthy MI

更新日期：2000-01-01 00:00:00

abstract：:To develop somatic gene therapy for diabetes, we studied an animal model with proinsulin-producing fibroblasts with an immunological safety system. Cultured mouse fibroblasts of the Ltk- cell line were transfected first with the efficient human proinsulin expression vector pBMG-Neo-Ins. Initially, 2 x 10(6) cells with...

journal_title：Diabetes

authors： Kawakami Y,Yamaoka T,Hirochika R,Yamashita K,Itakura M,Nakauchi H

更新日期：1992-08-01 00:00:00

abstract：:The soluble plant fiber psyllium significantly reduced fasting glucose and total cholesterol levels in the C57BL/KsJ db/db diabetic mouse relative to placebo-fed mice. Insulin levels were significantly higher in psyllium-fed than placebo-fed animals, indicating this fiber may delay the progression of diabetes in the a...

journal_title：Diabetes

authors： Watters K,Blaisdell P

更新日期：1989-12-01 00:00:00