Abstract:
:The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways. We discuss here some of the thermodynamic and cellular aspects of recent progress in brown fat research. This includes studies of developmental lineages of UCP1(+) adipocytes, including the discovery of beige fat cells, a new thermogenic cell type. We also discuss the physiology and transcriptional control of brown and beige cells in rodents and the state of current knowledge about human brown fat.
journal_name
Diabetesjournal_title
Diabetesauthors
Cohen P,Spiegelman BMdoi
10.2337/db15-0318subject
Has Abstractpub_date
2015-07-01 00:00:00pages
2346-51issue
7eissn
0012-1797issn
1939-327Xpii
db15-0318journal_volume
64pub_type
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