Hepatic lipase mRNA, protein, and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone.

abstract：:Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate mechanism remains to be elucidated. Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as major gatekeepers of the gonadotropic axis. Alteration in the hypothalamic KiSS-1...

journal_title：Diabetes

authors： Castellano JM,Navarro VM,Fernández-Fernández R,Roa J,Vigo E,Pineda R,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-09-01 00:00:00

abstract：:The aim of the present study was to evaluate and cor-relate islet to brown and white adipose tissue (WAT) blood perfusion in one obese rat and one nonobese rat with type 2 diabetes (obese Zucker [OZ] and GK rats, respectively). We measured blood perfusion with a microsphere technique in anesthetized animals and subseq...

journal_title：Diabetes

authors： Kampf C,Bodin B,Källskog O,Carlsson C,Jansson L

更新日期：2005-09-01 00:00:00

abstract：:Exogenous ghrelin reduces glucose-stimulated insulin secretion and endogenous ghrelin protects against hypoglycemia during starvation. Islet ε-cells produce ghrelin and δ-cells express growth hormone secretagogue receptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high local...

journal_title：Diabetes

authors： Gray SM,Niu J,Zhang A,Svendsen B,Campbell JE,D'Alessio DA,Tong J

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment in a model of type 1 diabetes. RESEARCH DESIGN AND METHODS:Recombinant TRAIL was added in vitro to primary human and mouse peripheral blood mononuclear cells (PBMC...

journal_title：Diabetes

authors： Zauli G,Toffoli B,di Iasio MG,Celeghini C,Fabris B,Secchiero P

更新日期：2010-05-01 00:00:00

abstract：:Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) often coexist and as such represent a potent risk factor for subsequent development of type 2 diabetes. beta-Cell mass is approximately 50% deficient in IFG and approximately 65% deficient in type 2 diabetes. To establish the effect of a approximately...

journal_title：Diabetes

authors： Matveyenko AV,Veldhuis JD,Butler PC

更新日期：2006-08-01 00:00:00

abstract：:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...

journal_title：Diabetes

authors： Hayward AR,Herberger M

更新日期：1984-04-01 00:00:00

abstract：:Islets from male B10.BR mice (H-2k) were isolated by the collagenase technique, handpicked with a Pasteur pipette, and incubated (either intact or after dispersion with Dispase) for 0, 3, 5, 7, 10, or 14 days in tissue culture medium supplemented with either lymphokine supernatants or recombinant murine interferon-gam...

journal_title：Diabetes

authors： Wright JR Jr,Lacy PE,Unanue ER,Muszynski C,Hauptfeld V

更新日期：1986-10-01 00:00:00

abstract：:NO has been identified recently as the prime islet-toxic product of inflammatory macrophages. The adverse effects of IL-1 on isolated islets also have been reported to involve NO. We now show that exposure of an islet cell suspension to the NO donor nitroprusside or to activated macrophages leads to DNA strand breaks....

journal_title：Diabetes

authors： Fehsel K,Jalowy A,Qi S,Burkart V,Hartmann B,Kolb H

更新日期：1993-03-01 00:00:00

abstract：:Metformin is the most widely prescribed medication for the treatment of type 2 diabetes (T2D). However, gastrointestinal (GI) side effects develop in ~25% of patients treated with metformin, leading to the discontinuation of therapy in ~5% of cases. We hypothesized that reduced transport of metformin via organic catio...

journal_title：Diabetes

authors： Dujic T,Zhou K,Donnelly LA,Tavendale R,Palmer CN,Pearson ER

更新日期：2015-05-01 00:00:00

abstract：:As part of an ongoing search for susceptibility genes in obese families, we performed linkage analyses in 101 French families between qualitative and quantitative traits related to morbid obesity and polymorphisms located in or near 15 candidate genes whose products are involved in body weight regulation. These includ...

journal_title：Diabetes

authors： Clément K,Dina C,Basdevant A,Chastang N,Pelloux V,Lahlou N,Berlan M,Langin D,Guy-Grand B,Froguel P

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing. In humans, a germline mutation in the VHL gene leads to the von Hippel-Lindau disease, a familial syndrome characterized by benign and malignant tumors of the kidney...

journal_title：Diabetes

authors： Puri S,Cano DA,Hebrok M

更新日期：2009-02-01 00:00:00

abstract：:This article examines the role of the autonomic nervous system in mediating the increase of glucagon secretion observed during insulin-induced hypoglycemia (IIH). In the first section, we briefly review the importance of the alpha-cell response in recovery from hypoglycemia under both physiologic conditions and pathop...

journal_title：Diabetes

authors： Taborsky GJ Jr,Ahrén B,Havel PJ

更新日期：1998-07-01 00:00:00

abstract：:Muscle insulin sensitivity for stimulating glucose uptake is enhanced in the period after a single bout of exercise. We recently demonstrated that AMPK is necessary for AICAR, contraction, and exercise to enhance muscle and whole-body insulin sensitivity in mice. Correlative observations from both human and rodent ske...

journal_title：Diabetes

authors： Kjøbsted R,Chadt A,Jørgensen NO,Kido K,Larsen JK,de Wendt C,Al-Hasani H,Wojtaszewski JFP

更新日期：2019-09-01 00:00:00

abstract：:The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical a...

journal_title：Diabetes

authors： Vastani N,Guenther F,Gentry C,Austin AL,King AJ,Bevan S,Andersson DA

更新日期：2018-08-01 00:00:00

abstract：:Amylin, a 37-amino acid peptide hormone co-secreted with insulin, potently governs the rate of gastric emptying. Hypoglycemia, in the absence of agents such as amylin, is reported to accelerate gastric emptying. We asked whether hypoglycemia had a similar action on gastric emptying in the presence of amylin. In prelim...

journal_title：Diabetes

authors： Gedulin BR,Young AA

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Macrophages play an important role in the pathogenesis of insulin resistance via the production of proinflammatory cytokines. Our goal is to decipher the molecular linkage between proinflammatory cytokine production and insulin resistance in macrophages. RESEARCH DESIGN AND METHODS:We determined cytokine pro...

journal_title：Diabetes

authors： Su D,Coudriet GM,Hyun Kim D,Lu Y,Perdomo G,Qu S,Slusher S,Tse HM,Piganelli J,Giannoukakis N,Zhang J,Dong HH

更新日期：2009-11-01 00:00:00

abstract：:Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to...

journal_title：Diabetes

authors： Friedman JE

更新日期：2018-11-01 00:00:00

abstract：:Antibodies to single stranded (SS-) and double stranded (DS-) DNA and RNA were determined by a passive microhemagglutination assay in sera from 80 children with juvenile-onset diabetes mellitus (JDM) and 129 children with asthma. The latter group was chosen for comparison with the JDM group because of their increased ...

journal_title：Diabetes

authors： Huang SW,Maclaren NK

更新日期：1978-11-01 00:00:00

abstract：:The responsiveness of the isolated perfused rat liver to different metabolic effects of insulin was investigated during recycling perfusion. Infusion of porcine insulin at rates of 6, 9, 16 and 33 mU/hr. resulted in stable perfusate insulin levels averaging 41, 72, 120 and 229 muU/ml., respectively. Since the portal v...

journal_title：Diabetes

authors： Mondon CE,Dolkas CB,Olefsky JM,Reaven GM

更新日期：1975-02-01 00:00:00

abstract：:Numerous reports have confirmed the presence of islet cell antibodies in diabetic patients. These are found mostly in newly diagnosed insulin-dependent diabetic patients and in patients who have autoimmune polyendocrine disorders. Antibodies to beta cells, somatostatin, and glucagon-producing cells have been described...

journal_title：Diabetes

authors： Kaldany A

更新日期：1979-02-01 00:00:00

abstract：:The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and atherosclerosis. The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed ...

journal_title：Diabetes

authors： Maeda K,Uysal KT,Makowski L,Görgün CZ,Atsumi G,Parker RA,Brüning J,Hertzel AV,Bernlohr DA,Hotamisligil GS

更新日期：2003-02-01 00:00:00

abstract：:The kinin B1 receptor (B1R) plays a role in inflammatory and metabolic processes. B1R deletion (B1-/-) protects mice from diet-induced obesity and improves insulin and leptin sensitivity. In contrast, genetic reconstitution of B1R exclusively in adipose tissue reverses the lean phenotype of B1-/- mice. To study the ce...

journal_title：Diabetes

authors： Sales VM,Gonçalves-Zillo T,Castoldi A,Burgos M,Branquinho J,Batista C,Oliveira V,Silva E,Castro CHM,Câmara N,Mori MA,Pesquero JB

更新日期：2019-08-01 00:00:00

abstract：:The relationship between the levels of circulating thyroid hormones and the action of insulin on adipose tissue was investigated in 6 hypothyroid patients and 6 hyperthyroid patients, all untreated, and 8 healthy control subjects. All were matched for age, body weight, and fat cell size. Gluteal s.c. adipose tissue wa...

journal_title：Diabetes

authors： Arner P,Bolinder J,Wennlund A,Ostman J

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating skeletal muscle GLUT4 expression remain to be elucidated. The purpose of this study was to examine these mechanisms. RESEARCH DESIGN AND METHODS A...

journal_title：Diabetes

authors： McGee SL,van Denderen BJ,Howlett KF,Mollica J,Schertzer JD,Kemp BE,Hargreaves M

更新日期：2008-04-01 00:00:00

abstract：:In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid. The aim of the present study was to determine the relationship between young children's muscle membrane fatty acid (FA) composition and indices of insulin resist...

journal_title：Diabetes

authors： Baur LA,O'Connor J,Pan DA,Storlien LH

更新日期：1999-01-01 00:00:00

abstract：:The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1.B and RT1.D. The possibility that variant or unique class II MHC molecules m...

journal_title：Diabetes

authors： Holowachuk EW,Greer MK

更新日期：1989-02-01 00:00:00

abstract：:In vivo studies were undertaken in rats to provide evidence of the neural nature, tentative localization and mode of excitation of the insulin-sensitive central nervous system (CSN) glucoregulator center. In rats under light barbiturate anesthesia minute amounts of insulin injected into the carotid artery resulted in ...

journal_title：Diabetes

authors： Szabo O,Szabo AJ

更新日期：1975-04-01 00:00:00

abstract：OBJECTIVE:CD8(+) T-cells specific for islet antigens are essential for the development of type 1 diabetes in the NOD mouse model of the disease. Such T-cells can also be detected in the blood of type 1 diabetic patients, suggesting their importance in the pathogenesis of the human disease as well. The development of pe...

journal_title：Diabetes

authors： Jarchum I,Baker JC,Yamada T,Takaki T,Marron MP,Serreze DV,DiLorenzo TP

更新日期：2007-10-01 00:00:00

abstract：:Fetuin-A interferes with insulin action in animal studies, but data on fetuin-A and diabetes risk in humans are sparse and the role of nonalcoholic fatty liver disease in this association is unknown. From 2000 to 2006, we prospectively identified 470 matched incident diabetes case-control pairs in the Nurses' Health S...

journal_title：Diabetes

authors： Sun Q,Cornelis MC,Manson JE,Hu FB

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Increased intramuscular triacylglycerol (IMTG) storage is a characteristic of the obese insulin-resistant state. We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity. RESEARCH DESIGN AND METHODS:Forearm skeletal musc...

journal_title：Diabetes

authors： Jocken JW,Roepstorff C,Goossens GH,van der Baan P,van Baak M,Saris WH,Kiens B,Blaak EE

更新日期：2008-07-01 00:00:00