Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.S.

abstract：:Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites correlated with insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. The top-ranking metab...

journal_title：Diabetes

authors： Xie W,Wood AR,Lyssenko V,Weedon MN,Knowles JW,Alkayyali S,Assimes TL,Quertermous T,Abbasi F,Paananen J,Häring H,Hansen T,Pedersen O,Smith U,Laakso M,MAGIC Investigators.,DIAGRAM Consortium.,GENESIS Consortium.,RISC Co

更新日期：2013-06-01 00:00:00

abstract：:Muscle insulin sensitivity for stimulating glucose uptake is enhanced in the period after a single bout of exercise. We recently demonstrated that AMPK is necessary for AICAR, contraction, and exercise to enhance muscle and whole-body insulin sensitivity in mice. Correlative observations from both human and rodent ske...

journal_title：Diabetes

authors： Kjøbsted R,Chadt A,Jørgensen NO,Kido K,Larsen JK,de Wendt C,Al-Hasani H,Wojtaszewski JFP

更新日期：2019-09-01 00:00:00

abstract：:Recent data have suggested a key role for tumor necrosis factor (TNF)-alpha in the insulin resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-alpha expression is elevated in the adipose tissue of multiple experimental models of obesity. Neutralization of TNF-alpha in one of these models imp...

journal_title：Diabetes

authors： Hotamisligil GS,Spiegelman BM

更新日期：1994-11-01 00:00:00

abstract：:Elevated levels of advanced glycosylation end products (AGEs) have been found in multiple tissues in association with diabetic vascular complications and during the microalbuminuric phase of diabetic nephropathy. In this study, we have used an AGE-specific enzyme-linked immunosorbent assay (ELISA) to measure skin AGEs...

journal_title：Diabetes

authors： Beisswenger PJ,Makita Z,Curphey TJ,Moore LL,Jean S,Brinck-Johnsen T,Bucala R,Vlassara H

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:Offspring of mothers with diabetes are at risk of obesity and glucose intolerance in later life. In adults, markers of subclinical inflammation (C-reactive protein [CRP] and interleukin [IL]-6) and endothelial activation (intracellular adhesion molecule [ICAM]-1) are associated with obesity and higher risk fo...

journal_title：Diabetes

authors： Nelson SM,Sattar N,Freeman DJ,Walker JD,Lindsay RS

更新日期：2007-11-01 00:00:00

abstract：:This article is divided into two parts. A retrospective overview summarizes some of the work that provided the framework and tools of the more recent studies. The five novel areas of research are related to the indirect effects of insulin. Regulation of plasma glucose is of central importance in health and diabetes. U...

journal_title：Diabetes

authors： Vranic M

更新日期：1992-09-01 00:00:00

abstract：:The effect of combined antisense oligonucleotides (AS-oligos) against overexpression of extracellular matrix (ECM) components, fibronectin, laminin, and collagen IV and on cell monolayer permeability was examined in rat microvascular endothelial cells (RMECs) grown in high glucose medium and on retinal vascular permea...

journal_title：Diabetes

authors： Oshitari T,Polewski P,Chadda M,Li AF,Sato T,Roy S

更新日期：2006-01-01 00:00:00

abstract：:We report on a 26-yr-old patient with an 11-yr history of insulin-dependent diabetes mellitus who exhibited insulin resistance with a requirement of up to 15,000 U of intravenous (i.v.) insulin/day. Attempts to diminish her insulin requirement by administration of sulfated insulin or Trasylol were unsuccessful, with t...

journal_title：Diabetes

authors： Blazar BR,Whitley CB,Kitabchi AE,Tsai MY,Santiago J,White N,Stentz FB,Brown DM

更新日期：1984-12-01 00:00:00

abstract：:GAD is a pancreatic beta-cell autoantigen in humans and nonobese diabetic (NOD) mice. Modulation of GAD expression in pancreatic beta-cells has been suggested to be associated with the development of autoimmune diabetes. Hormonal changes through environmental stimuli are considered to influence the expression of the d...

journal_title：Diabetes

authors： Kim KS,Kang Y,Choi SE,Kim JH,Kim HM,Sun B,Jun HS,Yoon JW

更新日期：2002-09-01 00:00:00

abstract：:Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves end...

journal_title：Diabetes

authors： Rickels MR,Fuller C,Dalton-Bakes C,Markmann E,Palanjian M,Cullison K,Tiao J,Kapoor S,Liu C,Naji A,Teff KL

更新日期：2015-05-01 00:00:00

abstract：:Islets of Langerhans are micro-organs scattered throughout the pancreas that contain insulin-producing cells, called beta-cells. Although new light has been recently shed on beta-cell development, information on the phenotype and location of beta-stem cells remains scarce. Here, we provide evidence that beta-stem cell...

journal_title：Diabetes

authors： Duvillié B,Attali M,Aiello V,Quemeneur E,Scharfmann R

更新日期：2003-08-01 00:00:00

abstract：:The interaction of insulin with the vascular endothelium was studied using bovine aortic endothelial cells in monolayer cultures. Confluent cell cultures exhibited specific binding of 125I-insulin to high- and low-affinity cell surface receptor sites. Binding was reversible, saturable, and accompanied by internalizati...

journal_title：Diabetes

authors： Kaiser N,Vlodavsky I,Tur-Sinai A,Fuks Z,Cerasi E

更新日期：1982-12-01 00:00:00

abstract：:Children with permanent diabetes are usually assumed to have type 1 diabetes. It has recently been shown that there are genetic subgroups of diabetes that are often diagnosed during the neonatal period but may present later. A recent Italian study proposed that type 1 diabetes is rare before 6 months of age. We aimed ...

journal_title：Diabetes

authors： Edghill EL,Dix RJ,Flanagan SE,Bingley PJ,Hattersley AT,Ellard S,Gillespie KM

更新日期：2006-06-01 00:00:00

abstract：:Eight dogs with previously established kidney allografts, immunosuppressed with cyclosporin A, received islet allografts from their respective original kidney donors. The median islet-graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving only islet allo...

journal_title：Diabetes

authors： Guy AJ,Griffin SM,Alderson D,Farndon JR

更新日期：1989-01-01 00:00:00

abstract：:Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here, we provide a comprehensive immunocytochemical "atlas" of G1/S control m...

journal_title：Diabetes

authors： Fiaschi-Taesch NM,Kleinberger JW,Salim FG,Troxell R,Wills R,Tanwir M,Casinelli G,Cox AE,Takane KK,Scott DK,Stewart AF

更新日期：2013-07-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biologi...

journal_title：Diabetes

authors： Mauvais-Jarvis F

更新日期：2020-09-01 00:00:00

abstract：:We have recently shown that leptin, the product of the obese gene, can directly influence T-cell function. In the work presented here, we explored the role of leptin in the development of spontaneous autoimmunity in the nonobese diabetic (NOD) mouse, an animal model for the study of human insulin-dependent diabetes me...

journal_title：Diabetes

authors： Matarese G,Sanna V,Lechler RI,Sarvetnick N,Fontana S,Zappacosta S,La Cava A

更新日期：2002-05-01 00:00:00

abstract：:Obesity is one of the most serious threats to human health today. Although there is general agreement that environmental factors such as diet have largely caused the current obesity pandemic, the environmental changes have not affected all individuals equally. To model gene-by-environment interactions in a mouse model...

journal_title：Diabetes

authors： Ehrich TH,Hrbek T,Kenney-Hunt JP,Pletscher LS,Wang B,Semenkovich CF,Cheverud JM

更新日期：2005-06-01 00:00:00

abstract：:The risk of insulin-dependent diabetes mellitus (IDDM) was examined in siblings of an unselected population (n = 194) of newly diagnosed diabetic individuals less than 30 yr old. From 1 July 1984 to 30 June 1987, diabetic subjects (proband) identified within a geographically defined area of southern Wisconsin were stu...

journal_title：Diabetes

authors： Allen C,Palta M,D'Alessio DJ

更新日期：1991-07-01 00:00:00

abstract：:Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver, muscle, and adipose tissue re...

journal_title：Diabetes

authors： Mayorek N,Kalderon B,Itach E,Bar-Tana J

更新日期：1997-12-01 00:00:00

abstract：:Insulin receptors on viable rat adipocytes were affinity-labeled using a biologically active and photosensitive analogue of insulin, 125I-B2(2-nitro, 4 azidophenylacetyl)-des-PheB1-insulin (125I-NAPA-DP-insulin). The radiolabeled proteins were identified by SDS polyacrylamide gel electrophoresis and autoradiography. B...

journal_title：Diabetes

authors： Heidenreich KA,Berhanu P,Brandenburg D,Olefsky JM

更新日期：1983-11-01 00:00:00

abstract：:Pancreatic β-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable h...

journal_title：Diabetes

authors： Fatehi M,Raja M,Carter C,Soliman D,Holt A,Light PE

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Rosiglitazone (RSG) is an insulin-sensitizing drug used to treat type 2 diabetes mellitus. The A Diabetes Outcome Progression Trial (ADOPT) shows that women taking RSG experienced more fractures than patients taking other type 2 diabetes drugs. These were not osteoporotic vertebral fractures but, rather, occu...

journal_title：Diabetes

authors： Sardone LD,Renlund R,Willett TL,Fantus IG,Grynpas MD

更新日期：2011-12-01 00:00:00

abstract：:The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3',5-triiodothyronine (T3), the disruption of which (Dio2(-/-)) results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal. In the present studies, cold exposure increased Dio2(-/-) BAT sympathetic s...

journal_title：Diabetes

authors： Christoffolete MA,Linardi CC,de Jesus L,Ebina KN,Carvalho SD,Ribeiro MO,Rabelo R,Curcio C,Martins L,Kimura ET,Bianco AC

更新日期：2004-03-01 00:00:00

abstract：:Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic gluc...

journal_title：Diabetes

authors： Ott V,Lehnert H,Staub J,Wönne K,Born J,Hallschmid M

更新日期：2015-03-01 00:00:00

abstract：:Estrogen-related receptor γ (ERRγ) is a major positive regulator of hepatic gluconeogenesis. Its transcriptional activity is suppressed by phosphorylation signaled by insulin in the fed state, but whether posttranslational modification alters its gluconeogenic activity in the fasted state is not known. Metabolically a...

journal_title：Diabetes

authors： Misra J,Kim DK,Jung YS,Kim HB,Kim YH,Yoo EK,Kim BG,Kim S,Lee IK,Harris RA,Kim JS,Lee CH,Cho JW,Choi HS

更新日期：2016-10-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-κB (NF-κB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db(-)/db(-)) and control (db(-)/db(+)) mice with two NF-κB inhibitors (6 mg/kg dehydroxymethylepoxyquinomicin twice a...

journal_title：Diabetes

authors： Kassan M,Choi SK,Galán M,Bishop A,Umezawa K,Trebak M,Belmadani S,Matrougui K

更新日期：2013-06-01 00:00:00

abstract：:A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...

journal_title：Diabetes

authors： Sadoff L,Gordon J,Goldman S

更新日期：1975-06-01 00:00:00

abstract：OBJECTIVE:Adiponectin is an adipocyte-specific secretory protein found in circulation in several different forms and is present at significantly lower levels in the plasma of diabetic patients compared with that of insulin-sensitive individuals. We wanted to test whether insulin per se is a contributing factor toward l...

journal_title：Diabetes

authors： Basu R,Pajvani UB,Rizza RA,Scherer PE

更新日期：2007-08-01 00:00:00

abstract：:We demonstrate the presence of specific insulinlike growth factor I (IGF-I) receptors in human adipocytes. Competition studies with 125I-labeled IGF-I and unlabeled IGF-I, IGF-II, and insulin showed the specificity of 125I-IGF-I binding to the IGF-I receptors in adipocytes, membranes, and partially purified detergent-...

journal_title：Diabetes

authors： Sinha MK,Buchanan C,Leggett N,Martin L,Khazanie PG,Dimarchi R,Pories WJ,Caro JF

更新日期：1989-10-01 00:00:00