Abstract:
:Eight dogs with previously established kidney allografts, immunosuppressed with cyclosporin A, received islet allografts from their respective original kidney donors. The median islet-graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving only islet allografts (48.5 days, P less than .05). Three of the eight dogs that received sequential kidney and islet allografts had experienced no kidney-graft rejection episodes before islet transplantation, but their islet grafts were all rejected within 19 days. In the pancreatectomized dog, prior donor-specific kidney transplantation has an adverse effect on subsequent islet-graft survival.
journal_name
Diabetesjournal_title
Diabetesauthors
Guy AJ,Griffin SM,Alderson D,Farndon JRdoi
10.2337/diab.38.1.s179subject
Has Abstractpub_date
1989-01-01 00:00:00pages
179-81eissn
0012-1797issn
1939-327Xjournal_volume
38 Suppl 1pub_type
杂志文章相关文献
DIABETES文献大全abstract:OBJECTIVE:The purpose of this work was to determine the pattern of genes regulated by peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1 alpha (PGC-1 alpha) in human adipocytes and the involvement of PPARalpha and PPARgamma in PGC-1 alpha transcriptional action. RESEARCH DESIGN AND METHODS:Primary c...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1465
更新日期:2007-10-01 00:00:00
abstract::Depletion of cellular antioxidant defense mechanisms and the generation of oxygen free radicals by advanced glycation end products (AGEs) have been proposed to play a major role in the pathogenesis of diabetic vascular complications. Here we demonstrate that incubation of cultured bovine aortic endothelial cells (BAEC...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.9.1481
更新日期:1997-09-01 00:00:00
abstract::Hypoglycemia limits optimal glycemic control in type 1 diabetes mellitus (T1DM), making novel strategies to mitigate it desirable. We hypothesized that portal (Po) vein insulin delivery would lessen hypoglycemia. In the conscious dog, insulin was infused into the hepatic Po vein or a peripheral (Pe) vein at a rate fou...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-0071
更新日期:2015-10-01 00:00:00
abstract::The hyperglycemic patient remains persistently at risk for infectious complications. Whether ascribable to diabetes mellitus, to the administration of glucocorticoids, or to the infusion of hyperalimentation fluids, hyperglycemia may impair several mechanisms of humoral host defense, including such varied neutrophil f...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.39.3.271
更新日期:1990-03-01 00:00:00
abstract::Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1342
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in this phenomenon of...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db07-1252
更新日期:2008-10-01 00:00:00
abstract::Selective peroxisome proliferator-activated receptor (PPAR) gamma modulation is a new pharmacological approach that, based on selective receptor-cofactor interactions and target gene regulation, should result in potent insulin sensitization in the absence of PPARgamma-mediated adverse effects. Here, we characterize tw...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.12.3442
更新日期:2005-12-01 00:00:00
abstract::This study examines whether the loss of metabolic control in initially normalized islet transplants can result from the inadequate composition of the donor tissue. Streptozotocin-induced diabetic rats were followed for 64 weeks after the intraportal injection of islet isografts with different composition. The implanta...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.12.1814
更新日期:1996-12-01 00:00:00
abstract::Membrane glycoprotein plasma cell 1 (PC-1) has been shown to be increased in type 2 diabetes and involved in insulin resistance through inhibiting the insulin receptor tyrosine kinase, which was demonstrated using cultured breast cancer cells. However, other reports have shown contradictory results in Chinese hamster ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.7.1365
更新日期:1999-07-01 00:00:00
abstract::Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.2.455
更新日期:2001-02-01 00:00:00
abstract::Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.10.1666
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:Leukocyte infiltration of adipose is a critical determinant of obesity-related metabolic diseases. Fractalkine (CX3CL1) and its receptor (CX3CR1) comprise a chemokine system involved in leukocyte recruitment and adhesion in atherosclerosis, but its role in adipose inflammation and type 2 diabetes is unknown. ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-0956
更新日期:2011-05-01 00:00:00
abstract::The objective of the U.K. Prospective Diabetes Study is to determine whether improved blood glucose control in type II diabetes will prevent the complications of diabetes and whether any specific therapy is advantageous or disadvantageous. The study will report in 1998, when the median duration from randomization will...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1995-11-01 00:00:00
abstract::Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neuropathology (3xTg-AD...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db14-0375
更新日期:2014-12-01 00:00:00
abstract::Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas ina...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-1296
更新日期:2013-05-01 00:00:00
abstract::The effects of elevated EPI and CORT levels on KG, SI, and SG were studied in dogs with alloxan-induced diabetes. Conscious dogs received SAL, EPI 20 ng.kg-1.min-1 for 30 min (short EPI) or 72 h (long EPI), or CORT 200 micrograms.kg-1.min-1 for 60 min (short CORT) or 72 h (long CORT) before assessment of glucose metab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.11.1446
更新日期:1992-11-01 00:00:00
abstract::Rare mutations in the proopiomelanocortin (POMC) gene cause severe early-onset childhood obesity. However, it is unknown whether common variants in POMC are responsible for variation in body weight or fat distribution within the commonly observed range in the population. We tested for association between three polymor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.8.2492
更新日期:2005-08-01 00:00:00
abstract::The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 +/- 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.12.3384
更新日期:2002-12-01 00:00:00
abstract::Near normal glucoregulation was maintained in 10 patients with insulin-dependent (type I) diabetes mellitus for 6 wk with preprogrammed continuous subcutaneous insulin infusion using a portable battery-powered infusion pump (CSII). This form of therapy resulted in a statistically significant increase in motor nerve co...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.8.668
更新日期:1980-08-01 00:00:00
abstract::Diet-induced obesity is known to cause peripheral insulin resistance in rodents. We have recently found that feeding cod protein to high-fat-fed rats prevents the development of insulin resistance in skeletal muscle. In the present study, we have further explored the cellular mechanisms behind this beneficial effect o...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.1.29
更新日期:2003-01-01 00:00:00
abstract::Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.1.s10
更新日期:1980-01-01 00:00:00
abstract::Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.7.1437
更新日期:1999-07-01 00:00:00
abstract::African Americans are at increased risk of type 2 diabetes and many diabetes complications. We have carried out a genome-wide scan for African American type 2 diabetes using 638 affected sibling pairs (ASPs) from 247 families ascertained through impaired renal function to identify type 2 diabetes loci in this high-ris...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.3.830
更新日期:2004-03-01 00:00:00
abstract::We examined the effects of aldose reductase inhibition (ARI) on glomerular filtration rate (GFR), albuminuria, and kidney histology in partially insulin-treated streptozocin-induced diabetic (STZ-D) rats. After 1 mo of diabetes, GFR was elevated over control values in the STZ-D rats but was not affected by treatment w...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.8.981
更新日期:1989-08-01 00:00:00
abstract::Ghrelin stimulates, while glucagon-like peptide-1 (GLP-1) and peptide YY(3-36) [PYY(3-36)] inhibit, food intake and gastric emptying in rats. We determined the dose-dependent effects of a 3-h intravenous infusion of ghrelin at dark onset on food intake in freely feeding rats, and on the inhibitory effects of intraveno...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0730
更新日期:2006-11-01 00:00:00
abstract::The effect of 4 wk of streptozocin (STZ)-induced diabetes on the transmission time of the auditory-evoked brain stem response (ABR) was examined in conscious male Sprague-Dawley rats. Distal nerve transmission time of the auditory pathway (latency of peak II), which includes conduction along the 8th cranial nerve, inc...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.4.500
更新日期:1987-04-01 00:00:00
abstract::Identifying new causes of permanent neonatal diabetes (PNDM) (diagnosis <6 months) provides important insights into β-cell biology. Patients with Down syndrome (DS) resulting from trisomy 21 are four times more likely to have childhood diabetes with an intermediate HLA association. It is not known whether DS can cause...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0045
更新日期:2019-07-01 00:00:00
abstract::Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.3.284
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:Exercise is an important strategy for the treatment of type 2 diabetes. This is due in part to an increase in glucose transport that occurs in the working skeletal muscles. Glucose transport is regulated by GLUT4 translocation in muscle, but the molecular machinery mediating this process is poorly understood....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-0233
更新日期:2010-09-01 00:00:00
abstract::We have recently shown that leptin, the product of the obese gene, can directly influence T-cell function. In the work presented here, we explored the role of leptin in the development of spontaneous autoimmunity in the nonobese diabetic (NOD) mouse, an animal model for the study of human insulin-dependent diabetes me...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.5.1356
更新日期:2002-05-01 00:00:00