Failure of genetically selected miniature swine to model NIDDM.

abstract：:A polymorphic region 5' to the human insulin gene has been associated with diabetes in earlier studies. This polymorphic region is composed of tandem repeats that fall into 3 general size classes, designated class 1 (600 base pairs), class 2 (1300 base pairs), and class 3 (2500 base pairs). Frequencies of these classe...

journal_title：Diabetes

authors： Elbein S,Rotwein P,Permutt MA,Bell GI,Sanz N,Karam JH

更新日期：1985-05-01 00:00:00

abstract：:To investigate the pathophysiology of diabetic osteopenia, circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein (BGP) were measured in streptozocin-induced diabetic rats . Plasma calcium and total protein were significantly decreased (P less than .01) in the diabetic group, and th...

journal_title：Diabetes

authors： Ishida H,Seino Y,Taminato T,Usami M,Takeshita N,Seino Y,Tsutsumi C,Moriuchi S,Akiyama Y,Hara K

更新日期：1988-06-01 00:00:00

abstract：:We demonstrate the presence of specific insulinlike growth factor I (IGF-I) receptors in human adipocytes. Competition studies with 125I-labeled IGF-I and unlabeled IGF-I, IGF-II, and insulin showed the specificity of 125I-IGF-I binding to the IGF-I receptors in adipocytes, membranes, and partially purified detergent-...

journal_title：Diabetes

authors： Sinha MK,Buchanan C,Leggett N,Martin L,Khazanie PG,Dimarchi R,Pories WJ,Caro JF

更新日期：1989-10-01 00:00:00

abstract：:A reduced nocturnal fall in blood pressure (BP) and increased QT dispersion both predict an increased risk of cardiovascular events in diabetic as well as nondiabetic subjects. The relationship between these two parameters remains unclear. The role of diabetic autonomic neuropathy in both QT dispersion and circadian B...

journal_title：Diabetes

authors： Poulsen PL,Ebbehøj E,Arildsen H,Knudsen ST,Hansen KW,Mølgaard H,Mogensen CE

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Diabetic nephropathy clusters in families, suggesting that genetic factors play a role in its pathogenesis. We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes. RESEARCH DESIGN AND METHODS:The FinnDiane Study has character...

journal_title：Diabetes

authors： Hietala K,Forsblom C,Summanen P,Groop PH,FinnDiane Study Group.

更新日期：2008-08-01 00:00:00

abstract：:Chronic hyperglycemia desensitizes beta-cells to glucose. To further define the mechanisms behind desensitization and the role of overstimulation, we tested human pancreatic islets for the effects of long-term elevated glucose levels on cytoplasmic free Ca2+ concentration ([Ca2+]i) and its relationship to overstimulat...

journal_title：Diabetes

authors： Björklund A,Lansner A,Grill VE

更新日期：2000-11-01 00:00:00

abstract：:Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secretion. Mice lacking β-cell ABCA1 have increased islet expression of ABCG1, another cholesterol transpor...

journal_title：Diabetes

authors： Kruit JK,Wijesekara N,Westwell-Roper C,Vanmierlo T,de Haan W,Bhattacharjee A,Tang R,Wellington CL,LütJohann D,Johnson JD,Brunham LR,Verchere CB,Hayden MR

更新日期：2012-03-01 00:00:00

abstract：:Mice respond to fatty acid synthase (FAS) inhibitors by profoundly reducing their food intake and body weight. Evidence indicates that the central nervous system (CNS) may be the critical site of action; however, a peripheral contribution cannot be ruled out. We compared doses of the FAS inhibitor C75 in the CNS (thir...

journal_title：Diabetes

authors： Clegg DJ,Wortman MD,Benoit SC,McOsker CC,Seeley RJ

更新日期：2002-11-01 00:00:00

abstract：:Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell clone from undifferentiated ES cells. The construction used allows the expression of a neomycin selection system under the control of the reg...

journal_title：Diabetes

authors： Soria B,Roche E,Berná G,León-Quinto T,Reig JA,Martín F

更新日期：2000-02-01 00:00:00

abstract：:Secondary hyperlipidemia is a major cardiovascular risk factor in individuals with type 2 diabetes. Increased hepatic production of apolipoprotein B (apoB)-containing lipoproteins contributes to the elevated plasma levels, but the mechanism is poorly understood. Recent results have established that microsomal triglyce...

journal_title：Diabetes

authors： Bartels ED,Lauritsen M,Nielsen LB

更新日期：2002-04-01 00:00:00

abstract：:Targeting of the GLP-1 receptor with (111)In-labeled exendin is an attractive approach to determine the β-cell mass (BCM). Preclinical studies as well as a proof-of-concept study in type 1 diabetic patients and healthy subjects showed a direct correlation between BCM and radiotracer uptake. Despite these promising ini...

journal_title：Diabetes

authors： Brom M,Joosten L,Frielink C,Boerman O,Gotthardt M

更新日期：2015-04-01 00:00:00

abstract：:Type 1 diabetes is characterized by autoimmune destruction of pancreatic β-cells in genetically susceptible individuals. Triggers of islet autoimmunity, time course, and the precise mechanisms responsible for the progressive β-cell failure are not completely understood. The recent escalation of obesity in affluent cou...

journal_title：Diabetes

authors： Galgani M,Nugnes R,Bruzzese D,Perna F,De Rosa V,Procaccini C,Mozzillo E,Cilio CM,Elding Larsson H,Lernmark A,La Cava A,Franzese A,Matarese G

更新日期：2013-07-01 00:00:00

abstract：:Low birth weight is a well-established risk factor for type 2 diabetes, but the risk at high birth weight levels remains uncertain. Potential sex differences in the associations are unexplored. We investigated whether sex influences the association of birth weight and adult type 2 diabetes, using a cohort of 113,801 m...

journal_title：Diabetes

authors： Zimmermann E,Gamborg M,Sørensen TI,Baker JL

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:We sought to examine the molecular mechanisms underlying permanenent neonatal diabetes mellitus (PNDM) in a patient with a heterozygous de novo L225P mutation in the L0 region of the sulfonylurea receptor (SUR)1, the regulatory subunit of the pancreatic ATP-sensitive K(+) channel (K(ATP) channel). RESEARCH D...

journal_title：Diabetes

authors： Masia R,De Leon DD,MacMullen C,McKnight H,Stanley CA,Nichols CG

更新日期：2007-05-01 00:00:00

abstract：:Insulin lispro is a human insulin analog that dissociates more rapidly than human regular insulin after subcutaneous injection, resulting in higher insulin levels at an earlier point in time and a shorter duration of action. The aim of the study was to evaluate if this pharmacokinetic difference would translate into b...

journal_title：Diabetes

authors： Zinman B,Tildesley H,Chiasson JL,Tsui E,Strack T

更新日期：1997-03-01 00:00:00

abstract：:A 21-year-old female patient complaining of frequent hypoglycemic attacks in the presence of a large amount of circulating insulin-binding antibodies without previous known immunization is described. In order to clarify the possible mechanism of the hypoglycemic attacks occurring in this new syndrome, changes in plasm...

journal_title：Diabetes

authors： Ichihara K,Shima K,Saito Y,Nonaka K,Tarui S

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:Leptin released from adipocytes plays a key role in the control of food intake, energy balance, and glucose homeostasis. In addition to its central action, leptin directly affects pancreatic beta-cells, inhibiting insulin secretion, and, thus, modulating glucose homeostasis. However, despite the importance of...

journal_title：Diabetes

authors： Tudurí E,Marroquí L,Soriano S,Ropero AB,Batista TM,Piquer S,López-Boado MA,Carneiro EM,Gomis R,Nadal A,Quesada I

更新日期：2009-07-01 00:00:00

abstract：:Because high D-glucose significantly stimulates endothelial cell death, we examined the molecular mechanisms of high D-glucose-induced endothelial apoptosis. Treatment of human aortic endothelial cells with high D-glucose (25 mmol/l), but not mannitol and L-glucose, resulted in a significant decrease in cell number an...

journal_title：Diabetes

authors： Nakagami H,Morishita R,Yamamoto K,Yoshimura SI,Taniyama Y,Aoki M,Matsubara H,Kim S,Kaneda Y,Ogihara T

更新日期：2001-06-01 00:00:00

abstract：:Glucokinase is a critical component of the physiological glucose sensor found in cell types that are responsive to changes in plasma glucose levels. The acute regulation of glucokinase activity has been shown to occur via a regulatory protein found in liver parenchymal cells (Van Schaftingen E, Detheux M, Da Cunha MV....

journal_title：Diabetes

authors： Mookhtiar KA,Kalinowski SS,Brown KS,Tsay YH,Smith-Monroy C,Robinson GW

更新日期：1996-12-01 00:00:00

abstract：:The virtually fatless A-ZIP/F-1 mouse is profoundly insulin resistant, diabetic, and a good model for humans with severe generalized lipoatrophy. Like a number of other mouse models of diabetes, the A-ZIP/F-1 mouse has elevated serum corticosterone levels. Leptin infusion lowers the corticosterone levels, suggesting t...

journal_title：Diabetes

authors： Haluzik M,Dietz KR,Kim JK,Marcus-Samuels B,Shulman GI,Gavrilova O,Reitman ML

更新日期：2002-07-01 00:00:00

abstract：:Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and hyperinsulinemic. For testing whether chronic activation of the central melanocortin pathway can bypass the defective leptin signaling and normalize altered energy homeostasis in these rats, recombinant adeno-associated virus encoding pro-...

journal_title：Diabetes

authors： Li G,Mobbs CV,Scarpace PJ

更新日期：2003-08-01 00:00:00

abstract：:We identified a heterozygous missense mutation that substituted aspartic acid (GAC) for alanine (GCC) at codon 1048 of the insulin receptor gene in a patient who displayed typical symptoms of Type A syndrome of insulin resistance. The proband's mother and younger brother were also found to be heterozygous for the muta...

journal_title：Diabetes

authors： Haruta T,Takata Y,Iwanishi M,Maegawa H,Imamura T,Egawa K,Itazu T,Kobayashi M

更新日期：1993-12-01 00:00:00

abstract：:The effects of variations of glycemia from 1.7 to 35 mM on the activity of glycogen synthase and phosphorylase, on glycogen content, and on U-14C-glucose incorporation into glycogen in the liver of the near-term rat fetus were investigated. Hypoglycemia did not affect the activities of phosphorylase and synthase; tota...

journal_title：Diabetes

authors： Gilbert M,Bourbon J

更新日期：1980-04-01 00:00:00

abstract：:Clinical studies have suggested that changes in peripheral nerve microcirculation may contribute to nerve damage in diabetic polyneuropathy (DN). High-sensitivity troponin T (hsTNT) assays have been recently shown to provide predictive values for both cardiac and peripheral microangiopathy in type 2 diabetes (T2D). Th...

journal_title：Diabetes

authors： Jende JME,Groener JB,Kender Z,Hahn A,Morgenstern J,Heiland S,Nawroth PP,Bendszus M,Kopf S,Kurz FT

更新日期：2020-04-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-chip was used to dete...

journal_title：Diabetes

authors： Cheung CYY,Tang CS,Xu A,Lee CH,Au KW,Xu L,Fong CHY,Kwok KHM,Chow WS,Woo YC,Yuen MMA,Cherny SS,Hai J,Cheung BMY,Tan KCB,Lam TH,Tse HF,Sham PC,Lam KSL

更新日期：2017-06-01 00:00:00

abstract：:Total lymphoid irradiation (TLI) at doses of 2200 rads or greater prevented diabetes in susceptible BB/W rats. Two of 29 (7%) treated rats became diabetic compared with 23 of 39 (59%) controls (P less than 0.001). TLI did not, however, prevent insulitis or thyroiditis in nondiabetic rats, nor did it restore the depres...

journal_title：Diabetes

authors： Rossini AA,Slavin S,Woda BA,Geisberg M,Like AA,Mordes JP

更新日期：1984-06-01 00:00:00

abstract：:Postheparin plasma hepatic lipase (HL) activity has been shown to correlate with features of the metabolic syndrome and type 2 diabetes in humans. We examined HL postheparin plasma enzyme activity, hepatocyte mRNA, and protein mass in the insulin-resistant, fructose-fed Syrian golden hamster, and the response of the i...

journal_title：Diabetes

authors： Lewis GF,Murdoch S,Uffelman K,Naples M,Szeto L,Albers A,Adeli K,Brunzell JD

更新日期：2004-11-01 00:00:00

abstract：:Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

journal_title：Diabetes

authors： Mitchell KJ,Tsuboi T,Rutter GA

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Based on its role as an energy storage compartment and endocrine organ, white adipose tissue (WAT) fulfills a critical function in the maintenance of whole-body energy homeostasis. Indeed, WAT dysfunction is connected to obesity-related type 2 diabetes triggered at least partly by an inflammatory response in ...

journal_title：Diabetes

authors： Ostertag A,Jones A,Rose AJ,Liebert M,Kleinsorg S,Reimann A,Vegiopoulos A,Berriel Diaz M,Strzoda D,Yamamoto M,Satoh T,Akira S,Herzig S

更新日期：2010-08-01 00:00:00

abstract：:Expression of GLUTs in rat peripheral nerve was first studied at the mRNA level with Northern transfer analysis with cDNAs specific for GLUT1, GLUT2, GLUT3, and GLUT4. GLUT1 mRNA was the only GLUT mRNA detectable in rat sciatic nerve. In situ hybridization localized this mRNA to the perineurium and to some endo- and e...

journal_title：Diabetes

authors： Muona P,Sollberg S,Peltonen J,Uitto J

更新日期：1992-12-01 00:00:00